| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.74286645 |
| TRAF 1 and TRAF 3 also interacted with CD 30 , and > 90 % of in vitro translated TRAF 1 or 2 , or 50 % of TRAF 3 , bound to the CD 30 cytoplasmic domain . 0.74286645^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| The ability of TRAF 1 , TRAF 2 , and CRAF 1 to associate with CD 30 was confirmed using an in vitro coprecipitation assay , further demonstrating that the interaction was specific and direct . ^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Induction of nuclear factor kappaB by the CD 30 receptor is mediated by TRAF 1 and TRAF 2 . ^^^ Coexpression of CD 30 with TRAF 1 or TRAF 2 but not TRAF 3 augmented NF kappaB activation through domain 2 but not domain 1 . ^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In this study , we report that two members of the TNFR associated factor ( TRAF ) family of proteins , TRAF 1 and TRAF 2 , independently bind to the intracellular domain of CD 30 ( CD30IC ) . ^^^ Moreover , dominant negative mutants consisting of the TRAF domain of TRAF 1 and TRAF 2 inhibited CD 30 induction of NF kappaB activation and HIV 1 transcription . ^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Binding sites of cytoplasmic effectors TRAF 1 , 2 , and 3 on CD 30 and other members of the TNF receptor superfamily . ^^^ |
|
| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| During CD 30 signal transduction , we found that binding of TRAF 2 to the cytoplasmic domain of CD 30 results in the rapid depletion of TRAF 2 and the associated protein TRAF 1 by proteolysis . ^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| This amino acid alignment contains the EEEG sequence , which is essential for interaction of CD 30 or CD 40 with TRAFs ( TRAF 1 and TRAF 2 , but not TRAF 3 ) , and also contains the PIQED sequence , which is similar to PXQXT that is known to be necessary for interaction of TNF receptor 2 and CD 30 with TRAFs ( TRAF 1 , 2 , and 3 ) . . ^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Signal transduction of CD 30 utilizes signal transducers , TNFR associated factors ( TRAF 1 , 2 , 3 and 5 ) , which are shared by other TNFR family members . ^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| To identify the cells in which TRAF 1 is active in vivo , we studied TRAF 1 transcripts in normal lymphoid tissue , in Epstein Barr virus ( EBV ) induced lymphoproliferations , and in malignant lymphomas with special reference to those that overexpress the cytokine receptor CD 30 and CD 40 of the TNF receptor family at the single cell level using a radioactive in situ hybridization . ^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Nik is able to interact with members of the TRAF family ( Traf 1 , 2 , 3 , 5 and 6 ) , suggesting it acts downstream of TRAF associating receptor signalling pathways , including Tnfr , Cd 40 , Cd 30 and Ltbeta r . ^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor receptor associated factor 1 ( TRAF 1 ) participates in the signal transduction of various members of the tumor necrosis factor receptor ( TNFR ) family , including TNFR 2 , CD 40 , CD 30 , and the Epstein Barr virus ( EBV ) encoded latent membrane protein 1 ( LMP 1 ) . ^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Differential expression and function of A 20 and TRAF 1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD 30 stimulation . ^^^ CD 30 stimulation induced A 20 and TRAF 1 expression . ^^^ Immunohistological studies of reactive lymphoid blasts in tonsillar tissue demonstrated that co expression of CD 30 , A 20 , and TRAF 1 also occurs in vivo . ^^^ Cell lines with high basal A 20 and TRAF 1 expression were resistant to CD 30 mediated apoptosis . ^^^ TRAF 1 transfection decreased CD 30 induced apoptosis . ^^^ |
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| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| We demonstrate that the expression of TRAF 1 and activated c Rel , two proteins that function in signaling events downstream of activated CD 30 in Reed Sternberg cells , reliably distinguish classical Hodgkin lymphoma from anaplastic large cell lymphoma , nodular lymphocyte predominant Hodgkin lymphoma , and nonmediastinal diffuse large B cell lymphoma . ^^^ |
|
| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|