| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| A region of CRAF 1 was similar to the TNF alpha receptor associated factors TRAF 1 and TRAF 2 and so defined a shared TRAF C domain that was necessary and sufficient for CD 40 binding and homodimerization . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| LAP 1 binds to the p 80 TNFR , CD 40 , and the lymphotoxin beta receptor , while EBI 6 associates with the p 80 TNFR . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| We have also identified putative signal transducers of CD 40 , designated TRAF 5 and TRAF 6 , in addition to TRAF 1 , 2 and 3 demonstrated by others . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Clones corresponding to genes coding for TRAF 1 , TRAF 2 , and TRAF 3 molecules , postulated to be involved in signalling via the TNF and CD 40 receptors , were isolated . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| The binding was strongly inhibited by a CD 30 oligopeptide centered around a PXQXT ( where 10 is any amino acid ) motif shared with CD 40 and the Epstein Barr virus transforming protein LMP 1 , indicating that this motif in CD 30 is an important determinant of TRAF 1 , 2 or 3 interaction . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 6 , but not TRAF 4 or TRAF 5 , bound directly to the CD 40 cytoplasmic domain . ^^^ CD 40 interactions with TRAF 2 and TRAF 3 were stronger than the interactions with TRAF 1 and TRAF 6 . ^^^ Using peptides with progressive deletions , a minimal TRAF 1 , TRAF 2 , and TRAF 3 binding region was mapped to the PVQET sequence in the CD 40 cytoplasmic domain . ^^^ These studies demonstrate that the CD 40 cytoplasmic domain contains two nonoverlapping TRAF binding regions and suggest that TRAF 1 , TRAF 2 , and TRAF 3 could bind competitively to one site . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Thus , TRAF binding to the PXQXT / S motif has a nonessential role in up regulating Fas , ICAM 1 , CD 40 , and LFA 3 expression and a critical role in up regulating TRAF 1 , EBI 3 , and EGF R expression . ^^^ Further , D 1 LMP1 , an LMP 1 mutant that does not aggregate failed to induce TRAF 1 , EBI 3 , Fas , ICAM 1 , CD 40 , and LFA 3 expression confirming the essential role for aggregation in LMP 1 signaling . ^^^ Overexpression of a dominant form of IkappaBalpha blocked LMP 1 mediated TRAF 1 , EBI 3 , Fas , ICAM 1 , CD 40 , and LFA 3 up regulation , indicating that NF kappaB is an important component of LMP 1 mediated gene induction from both the TRAF and TRADD interacting sites . . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In addition , SB 203580 selectively reduced CD 40 induced CD54 / ICAM 1 expression , whereas CD 40 dependent expression of CD 40 and CD95 / Fas and four newly defined CD 40 responsive genes cIAP 2 , TRAF 1 , TRAF4 / CART and DR 3 were unaffected . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| This amino acid alignment contains the EEEG sequence , which is essential for interaction of CD 30 or CD 40 with TRAFs ( TRAF 1 and TRAF 2 , but not TRAF 3 ) , and also contains the PIQED sequence , which is similar to PXQXT that is known to be necessary for interaction of TNF receptor 2 and CD 30 with TRAFs ( TRAF 1 , 2 , and 3 ) . . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| To identify the cells in which TRAF 1 is active in vivo , we studied TRAF 1 transcripts in normal lymphoid tissue , in Epstein Barr virus ( EBV ) induced lymphoproliferations , and in malignant lymphomas with special reference to those that overexpress the cytokine receptor CD 30 and CD 40 of the TNF receptor family at the single cell level using a radioactive in situ hybridization . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| The core binding site for TRAF 1 , TRAF 2 , and TRAF 3 in CD 40 could be minimally substituted . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Nik is able to interact with members of the TRAF family ( Traf 1 , 2 , 3 , 5 and 6 ) , suggesting it acts downstream of TRAF associating receptor signalling pathways , including Tnfr , Cd 40 , Cd 30 and Ltbeta r . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Moreover , triggering of TNF R 1 , CD 40 , and the interleukin 1 receptor resulted in transcription of the TRAF 1 gene , whereas receptors that are not activators or only poor activators of NF kappaB in HeLa cells failed to show a significant TRAF 1 induction . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In contrast to TRAF 2 and TRAF 3 , direct binding of TRAF 1 , TRAF 4 , TRAF 5 , or TRAF 6 to CD 40 was not detected . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In surface plasmon resonance studies , a hierarchy of affinity of trimeric TRAFs for trimeric CD 40 was found to be TRAF 2 > TRAF 3 > > TRAF 1 and TRAF 6 . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| TRAF 1 was also highly inducible by CD 40 ligand in cultured germinal center B cells , whereas TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 were relatively unchanged . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In human monocytes , all TRAF mRNAs were expressed constitutively and CD 40 ligation resulted in a strong up regulation of TRAF 1 mRNA . ^^^ In THP 1 cells , CD 40 ligation induced expression of TRAF 1 and TRAF 5 mRNAs . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| A surprisingly small but characteristic set of genes , including the cell cycle regulatory protein cyclin D 2 , the antiapoptotic proteins Bfl 1 / A1 , c IAP 2 , TRAF 1 , and Bcl 10 ( L ) , and the cell surface receptors CD 86 and CD 40 were identified . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Identification and characterization of two CD 40 inducible enhancers in the mouse TRAF 1 gene locus . ^^^ We have shown that CD 40 engagement induces TRAF 1 gene expression in B lymphocytes . ^^^ Here we report that CD 40 dependent TRAF 1 gene transcription in murine B cells is controlled by two enhancer regions . ^^^ When cloned together into reporter constructs , the two TRAF 1 enhancers do not synergize , suggesting that each enhancer may separately participate in the induction of TRAF 1 transcription in B cells following CD 40 activation . . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| The tumor necrosis factor receptor associated factor 1 ( TRAF 1 ) participates in the signal transduction of various members of the tumor necrosis factor receptor ( TNFR ) family , including TNFR 2 , CD 40 , CD 30 , and the Epstein Barr virus ( EBV ) encoded latent membrane protein 1 ( LMP 1 ) . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Although TRAF 1 can displace TRAF 2 and CD 40 from raft fractions , it promotes the ability of TRAF 2 activate signaling over a sustained period of time . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| TRAF 1 is a critical regulator of JNK signaling by the TRAF binding domain of the Epstein Barr virus encoded latent infection membrane protein 1 but not CD 40 . ^^^ The critical role of TRAF 1 in the regulation of TRAF 2 dependent JNK signaling is particular to the TRAF binding domain of LMP 1 , since a homologous region in the cytoplasmic tail of CD 40 or the TRADD interacting domain of LMP 1 signal on the JNK axis independently of TRAF 1 status . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| The majority of cytoplasmic TRAF 2 GFP and , to a lesser extent , TRAF 3 GFP , but not TRAF 1 GFP or TRAF 4 GFP , translocated into CD 40 signaling complexes within a few minutes after CD 40 triggering with the CD 40 ligand . ^^^ An excess of TRAF 2 allowed recruitment of TRAF 1 GFP to sites of CD 40 signaling , whereas an excess of TRAF 1 abrogated the interaction of TRAF 2 and CD 40 . ^^^ Accordingly , TRAF 1 inhibited CD 40 dependent but not TNF R 1 dependent NF kappaB activation . ^^^ Because of the trimeric organization of TRAF proteins , we propose that the stoichiometry of TRAF 1 TRAF2 heteromeric complexes ( ( TRAF 2 ) 2 TRAF 1 versus TRAF 2 ( TRAF 1 ) 2 ) determines their capability to mediate CD 40 signaling but has no major effect on TNF signaling . . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Using a new method for gene targeting by homologous recombination in somatic cells , we produced and studied signaling by CD 40 and its viral oncogenic mimic , latent membrane protein 1 ( LMP 1 ) in mouse B cell lines lacking TRAF 1 , TRAF 2 , or both TRAFs . ^^^ In the absence of TRAF 1 , an increased amount of TRAF 2 was recruited to lipid rafts , and subsequently , more robust degradation of TRAF 2 and TRAF 3 was induced in response to CD 40 signaling . ^^^ Taken together , our findings indicate that TRAF 1 and TRAF 2 cooperate in CD 40 but not LMP 1 signaling and suggest that cellular levels of TRAF 1 may play an important role in modulating the degradation of TRAF 2 and TRAF 3 in response to signals from the TNFR superfamily . . ^^^ |
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| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P25942 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
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