| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Casper interacts with FADD , caspase 8 , caspase 3 , TRAF 1 , and TRAF 2 through distinct domains . ^^^ |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Multiple survival factor genes , including cellular inhibitor of apoptosis protein ( c IAP 1 ) , c IAP 2 , TNF receptor associated factor 1 ( TRAF 1 ) , TRAF 2 , B cell leukemia / lymphoma 2 ( Bcl 2 ) , Bcl 10 , A 1 , and cellular Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme like inhibitory protein ( c FLIP ) , were expressed in basal conditions in both cultured RPE cells and RPE cells in situ , whereas survivin was expressed only by cultured cells . ^^^ TNF alpha upregulated expression of TRAF 1 , TRAF 2 , c IAP 1 , c IAP 2 , c FLIP , and A 1 . ^^^ TRAF 1 , c FLIP , and to a lesser extent c IAP 2 protein levels were increased by TNF alpha in a time dependent manner , whereas c IAP 1 , survivin , Bcl 10 ( L ) , and TRAF 2 protein levels were not influenced by TNF alpha treatment at any time point tested . ^^^ Overexpression of mutant IkappaB blocked TNF alpha induced TRAF 1 , TRAF 2 , c IAP 1 , c IAP 2 , c FLIP , and A 1 gene expression and downregulated TRAF 1 protein levels . ^^^ |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In the present study , we tested the sensitivity of MCF 7 breast cancer cells overexpressing anti apoptotic genes TRAF 1 , c FLIP , Bcl xL , clAP 2 or Mn SOD to paclitaxel and docetaxel . ^^^ |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Alteration of the transcription of anti apoptotic proteins , including inhibitor of apoptosis protein 1 , 2 ( cIAP 1 , 2 ) , TNF receptor associated factor 1 ( TRAF 1 ) , nuclear factor kappa B 1 protein ( NFkappaB 1 ) , and FLICE inhibitory protein ( FLIP ) was assessed by real time reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| A novel anti apoptotic mechanism of FLIP in the recruitment of RIP and TRAF 1 and TRAF 2 to activate ERK and NF kappaB has been defined . ^^^ |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| The TNF induced NF kappaB regulated gene products cyclin D 1 , COX 2 , MMP 9 , survivin , IAP 1 , IAP 2 , XIAP , Bcl 2 , Bfl 1 / A1 , TRAF 1 , and FLIP were all down regulated by SCH 66336 , which potentiated apoptosis induced by TNF and doxorubicin . ^^^ |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| TNF induced expression of the NF kappaB regulated gene products cyclin D 1 , COX 2 , MMP 9 , survivin , IAP 1 , IAP 2 , Bcl 10 ( L ) , Bfl 1 / A1 , TRAF 1 , and FLIP in wild type mouse embryonic fibroblasts but not in GSK 3beta ( / ) cells , and this correlated with potentiation of TNF induced apoptosis as indicated by cell viability , annexin 5 staining , and caspase activation . ^^^ |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| The NF kappaB regulated gene products cyclin D 1 , cyclooxygenase 2 ( COX 2 ) , matrix metalloproteinase 9 ( MMP 9 ) , survivin , inhibitor of apoptosis protein 1 ( IAP 1 ) , IAP 2 , 10 chromosome linked IAP ( XIAP ) , Bcl 2 , Bfl 1 / A1 , TNF receptor associated factor 1 ( TRAF 1 ) , and Fas associated death domain protein like interleukin 1beta converting enzyme inhibitory protein ( FLIP ) were all down regulated by indole 3 carbinol . ^^^ |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NF kappaB regulated gene products , such as cyclin D 1 , COX 2 , MMP 9 , ICAM 1 , c Myc , survivin , IAP 1 , IAP 2 , XIAP , Bcl 2 , Bcl xL , Bfl 1 / A1 , TRAF 1 and FLIP , were all downregulated by zerumbone . ^^^ |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| These observations corresponded with the down regulation of the expression of anti apoptotic ( IAP 1 , IAP 2 , 10 chromosome linked IAP , Bcl 2 , Bcl 10 ( L ) , TRAF 1 , FLIP , and survivin ) , proliferative ( cyclin D 1 , cyclooxygenase 2 , and c Myc ) , and angiogenic ( ICAM 1 , matrix metalloproteinase 9 , and vascular endothelial growth factor ) gene products . ^^^ |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O15519 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|