| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Adenovirus E1B 19K / BCL 2 interacting protein BNIP 3 contains a BH 3 domain and a mitochondrial targeting sequence . ^^^ Cellular protein BNIP 3 ( previously NIP 3 ) interacts with E1B 19K , BCL 2 , BCL xL , and EBV BHRF 1 . ^^^ BNIP 3 contains a C terminal trans membrane ( TM ) domain similar to other BCL 2 family proteins and BNIP 1 ( previously NIP 1 ) . ^^^ The TM domains of BNIP 3 and BNIP 1 can functionally substitute for the TM domain of a BCL 2 family member EBV BHRF 1 . ^^^ These results suggest that BNIP 3 is a member of the BH 3 contaning BCL 2 family of pro apoptotic proteins and functions in mitochondria . . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| We have identified a C . elegans protein , ceBNIP 3 , homologous to the human BCL 2 / EIB 19K interacting BCL 2 family pro apoptotic protein BNIP 3 . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Cellular protein BNIP 3 is a BCL 2 family proapoptotic protein that interacts with viral antiapoptosis proteins such as adenoviruses E1B 19K and EBV BHRF 1 and cellular antiapoptosis proteins such as BCL 2 and BCL xL . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| BNIP 3 ( formerly NIP 3 ) is a member of the Bcl 2 family that is expressed in mitochondria and induces apoptosis without a functional BH 3 domain . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| At the evolutionary breakpoint junction , a human EST ( GI : 1114654 ) with identity to the human and mouse BCL 2 interacting gene , BNIP 3 , was mapped to mouse Chr 3 . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Sequence analysis reveals that the different domains of BNIP 3 have been conserved throughout evolution . ceBNIP 3 contains a C terminal transmembrane ( TM ) domain , a conserved domain ( CD ) of 19 amino acids , a BCL 2 homology 3 ( BH 3 ) like domain and a PEST sequence . ceBNIP 3 is expressed primarily as a 25 kDa monomer and a 50 kDa homodimer . ^^^ |
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| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Bcl2 / adenovirus EIB 19kD interacting protein 3 ( BNIP 3 ) is a cell death factor that is a member of the Bcl 2 proapoptotic family recently shown to induce necrosis rather than apoptosis . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Nitric oxide suppresses the expression of Bcl 2 binding protein BNIP 3 in hepatocytes . ^^^ Using this analysis , we identified a NO suppressed gene fragment homologous with the pro apoptotic Bcl 2 binding protein BNIP 3 . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| BNIP 3 ( formerly NIP 3 ) is a proapoptotic mitochondrial protein classified in the Bcl 2 family based on limited sequence homology 3 ( BH 3 ) domain and COOH terminal transmembrane domain . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| BNip 3 is a member of Bcl 2 family proteins that displays proapoptotic activity . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Hypoxia and acidosis activate cardiac myocyte death through the Bcl 2 family protein BNIP 3 . ^^^ We now report that hypoxia acidosis associated cell death is mediated by BNIP 3 , a member of the Bcl 2 family of apoptosis regulating proteins . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| BNIP 3 heterodimerizes with Bcl 2 / Bcl 10 ( L ) and induces cell death independent of a Bcl 2 homology 3 ( BH 3 ) domain at both mitochondrial and nonmitochondrial sites . ^^^ BNIP 3 ( formerly NIP 3 ) is a pro apoptotic , mitochondrial protein classified in the Bcl 2 family based on limited sequence homology to the Bcl 2 homology 3 ( BH 3 ) domain and COOH terminal transmembrane ( TM ) domain . ^^^ BNIP 3 expressed in yeast and mammalian cells interacts with survival promoting proteins Bcl 2 , Bcl 10 ( L ) , and CED 9 . ^^^ Deletion mapping of BNIP 3 excluded its BH 3 like domain and identified the NH ( 2 ) terminus ( residues 1 49 ) and TM domain as critical for Bcl 2 heterodimerization , and either region was sufficient for Bcl 10 ( L ) interaction . ^^^ Substitution of the BNIP 3 TM domain with that of cytochrome b ( 5 ) directed protein expression to nonmitochondrial sites and still promoted apoptosis and heterodimerization with Bcl 2 and Bcl 10 ( L ) . ^^^ |
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| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Using CD 47 as bait in a yeast two hybrid system , we identified the Bcl 2 homology 3 ( BH 3 ) only protein 19 kDa interacting protein 3 ( BNIP 3 ) , a pro apoptotic member of the Bcl 2 family , as a novel partner . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| BNIP 3 ( Bcl 2 / E1B 19 kDa interacting protein ) is a proapoptotic member of the Bcl 2 family that is expressed in hypoxic regions of tumors . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| The Bcl 2 family pro apoptotic molecule , BNIP 3 regulates activation induced cell death of effector cytotoxic T lymphocytes . ^^^ BNIP 3 is a recently described pro apoptotic member of the Bcl 2 family and in BNIP 3 cDNA transfected cell lines , cell death occurs via a caspase independent pathway with opening of the mitochondrial permeability transition ( PT ) pore and rapid loss of mitochondrial transmembrane potential ( Delta psi m ) . ^^^ Our results using the T cell receptor transgenic mice P 14 , specific for lymphocyte choreomeningitis virus ( LCMV ) glycoprotein , show that in contrast to the other Bcl 2 family pro apoptotic molecules , BNIP 3 is transcriptionally highly up regulated in effector cytotoxic T lymphocytes ( CTL ) . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Experiments with BNIP 3 have implicated the transmembrane ( TM ) domain in its proapoptotic function , homodimerization , and interactions with Bcl 2 and Bcl xL . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that the adenovirus E4orf6 protein inhibits apoptosis mediated by BNIP 3 and Bik , which are BH 3 only proteins of the Bcl 2 family . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| One of the most strongly induced transcripts was identified as the gene encoding the pro apoptotic Bcl 2 family member BNIP 3 . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| BNIP 3 expression was associated significantly with high hypoxia inducible factor 1alpha ( P = 0 . 003 ) , carbonic anhydrase 9 ( P = 0 . 04 ) , and was inversely associated with bcl 2 expression ( P = 0 . 009 ) . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| In this report , we used cDNA microarray analysis to show that SNAP , an NO donor , strongly induces Bcl 2 / adenovirus E1B 19kDa interacting protein 3 ( BNIP 3 ) in macrophages . ^^^ BNIP 3 is a mitochondrial pro apoptotic protein that contains a Bcl 2 homology 3 domain and a COOH terminal transmembrane ( TM ) domain . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Analysis by cDNA microarray , RT PCR , and Western blot showed that cell death members of Bcl 2 family , Bcl 2 / adenovirus E1B 19 kDa interacting protein 3 ( BNIP 3 ) and its homologue BNIP 3 like ( BNIP3L ) , were upregulated in As ( 2 ) O ( 3 ) induced autophagic cell death . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| The BH 3 only proteins , including BNip 3 , are members of the Bcl 2 family of cell death regulating factors . ^^^ A micro array analysis of 20 , 000 genes identified the pro apoptotic Bcl 2 family member BNip 3 as one of the most strongly upregulated of > 100 hypoxia inducible genes in cardiac myocytes . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| BNIP 3 protein is a proapoptotic member of the Bcl 2 family that is expressed in hypoxic regions of tumors . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| BNIP 3 is a proapoptotic member of the Bcl 2 protein family involved in hypoxia induced cell death . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| In addition to this major signaling pathway , Bcl2 / adenovirus E1B 19 kDa protein interacting protein ( BNIP 3 ) , a Bcl 2 family proapoptotic protein , was identified as being expressed at lower levels in drug resistant pancreatic cancer cell lines . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Membrane translocation and oligomerization of hBok are triggered in response to apoptotic stimuli and Bnip 3 . hBok is a human pro apoptotic member of the Bcl 2 family . ^^^ |
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| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| We observed changes in the expression of vital genes belonging to the cell cycle ( cyclin D 1 and CDK 4 ) and apoptosis ( BNIP 3 , BID , and BCL 2 ) pathway in response to BL 1521 . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| The pro cell death Bcl 2 family member , BNIP 3 , is localized to the nucleus of human glial cells : Implications for glioblastoma multiforme tumor cell survival under hypoxia . ^^^ The Bcl 2 nineteen kilodalton interacting protein 3 ( BNIP 3 ) is a hypoxia inducible proapoptotic member of the Bcl 2 family that induces cell death by associating with the mitochondria . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Bcl 2 / adenovirus E1B 19 kDa interacting protein 3 ( BNIP 3 ) is a mitochondrial pro apoptotic protein that has a single Bcl 2 homology 3 ( BH 3 ) domain and a COOH terminal transmembrane ( TM ) domain . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| Bnip 3 is a pro apoptotic member of the Bcl 2 family that induces cell death by opening the mitochondrial permeability transition pore . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| The E1B 19K / Bcl 2 binding protein Nip 3 is a dimeric mitochondrial protein that activates apoptosis . ^^^ Nip 3 ( nineteen kD interacting protein 3 ) is an E1B 19K and Bcl 2 binding protein of unknown function . ^^^ Bcl 2 overexpression initially delays the onset of apoptosis induced by Nip 3 but the resistance is completely overcome in longer periods of incubation . ^^^ Nip 3 protein levels are much higher and persist longer in Bcl 2 expressing cells . ^^^ In conclusion , Nip 3 is an apoptosis inducing dimeric mitochondrial protein that can overcome Bcl 2 suppression . . ^^^ |
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| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| We have isolated a novel cDNA that encodes a product showing significant sequence homology ( 56 % identity ) to human NIP 3 , a protein thought to interact with adenovirus E1B19kD and human BCL 2 proteins . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| We have identified Nix , a homolog of the E1B 19K / Bcl 2 binding and pro apoptotic protein Nip 3 . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| B 5 binds strongly to Nip 3 and itself , weakly to E1B19K , but not to Bcl 2 and localizes in nuclear envelope , endoplasmic reticulum and mitochondria . ^^^ |
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| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| This study shows that transcription of the gene encoding Nip 3 , a proapoptotic member of the Bcl 2 family of cell death factors , is strongly induced in response to hypoxia . ^^^ This study demonstrates a direct link between HIF 1alpha and a proapoptotic member of the Bcl 2 family and offers a reasonable physiological function for members of the Bcl 2 subfamily , including Nip 3 and its close relative Nix . ^^^ |
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| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| The function of HAX 1 is unknown , although the similarity of its sequence to those of Nip 3 and Bcl 2 infers a role in the regulation of apoptosis . ^^^ |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| The expression of PLAGL 2 in Balb / c3T3 cells led to the mRNA expression of a proapoptotic factor , Nip 3 , which can dimerize with Bcl 2 . ^^^ |
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| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| The predicted amino acid sequence of HAX 1 exhibits similarity to that of another cellular protein Nip 3 which has been shown to interact with cellular and viral anti apoptotic proteins such as Bcl 2 and BHRF 1 , an EBV homolog of Bcl 2 . ^^^ Here we investigated whether HAX 1 , like Nip 3 , interacts with Bcl 2 proteins and report the following . ( 1 ) A purified chimeric protein consisting of gluthathione S transferase ( GST ) fused to BHRF 1 ( GST BHRF 1 ) or Bcl 2 ( GST Bcl 2 ) specifically pulled down HAX 1 transiently expressed in COS 7 cells . ( 2 ) GST BHRF 1 or GST Bcl 2 was not able to pull down EBNA LP transiently expressed in COS 7 cells , whereas each of the GST fusion proteins formed complexes with EBNA LP in the presence of RAX 1 . ^^^ |
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| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12983 and P10415 |
Pubmed |
SVM Score :0.0 |
| NA |
|