| Interacting proteins: Q12967 and P10114 |
Pubmed |
SVM Score :0.0 |
| This new GDS , ralGDS , is at least 20 fold more active on the ralA and ralB GTPases than on any other GTPase tested , including other members of the ras family ( H ras , N ras , K ras , R ras , rap1a and rap 2 ) , members of the rho family ( rhoA , rhoB and CDC 42 Hs ) and members of the rab family ( rab3a and ypt 1 ) . ^^^ |
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| Interacting proteins: Q12967 and P10114 |
Pubmed |
SVM Score :0.0 |
| In search for effectors of the Ras related GTPase Rap 2 , we used the yeast two hybrid method and identified the C terminal Ras / Rap interaction domain of the Ral exchange factors ( RalGEFs ) Ral GDP dissociation stimulator ( RalGDS ) , RalGDS like ( RGL ) , and RalGDS like factor ( Rlf ) . ^^^ When co transfected in HeLa cells , an activated Rap 2 mutant ( Rap2Val 12 ) but not an inactive protein ( Rap2Ala 35 ) co immunoprecipitates with RalGDS and Rlf ; moreover , Rap 2 RalGEF complexes can be isolated from the particulate fraction of transfected cells and were localized by confocal microscopy to the resident compartment of Rap 2 , i . e . the endoplasmic reticulum . ^^^ |
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