Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Induction of the CINC promoter by IL 17 in IEC 6 cells was TNF receptor associated factor 6 ( TRAF 6 ) , but not TRAF 2 , dependent . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Mutation of the distinct binding sites for TNF receptor associated factor 6 ( TRAF 6 ) and for TRAF 2 , 3 , and 5 in the CD 40 cytoplasmic domain revealed their independent contributions to DC maturation and activation of NF kappaB . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
The cytoplasmic region of HVEM bound to several members of the TNFR associated factor ( TRAF ) family , namely TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 5 , but not to TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
The site also binds TRAF 2 and TRAF 5 , but not TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
RIP 2 interacted with other members of the TNFR 1 signaling complex , including inhibitor of apoptosis protein cIAP 1 and with members of the TNFR associated factor ( TRAF ) family , specifically TRAF 1 , TRAF 5 , and TRAF 6 , but not with TRAF 2 , TRAF 3 , or TRAF 4 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
From this deletion analysis , we determined that TRAF 2 , TRAF 5 , and TRAF 6 interact with RANK at its C terminal 85 amino acid tail ; the binding affinity appeared to be in the order of TRAF 2 > TRAF 5 > TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
However , plasma membrane proximal elements in these proinflammatory cytokine pathways are apparently not involved since dominant negative mutants of the TRAF 2 and TRAF 6 adaptors , which effectively block signaling through the cytoplasmic tails of the TNF alpha and IL 1 receptors , respectively , do not inhibit Tax induction of NF kappaB . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 6 , but not TRAF 4 or TRAF 5 , bound directly to the CD 40 cytoplasmic domain . ^^^ CD 40 interactions with TRAF 2 and TRAF 3 were stronger than the interactions with TRAF 1 and TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Coimmunoprecipitation experiments suggested potential interactions between the cytoplasmic tail of TRANCE R with TRAF 1 , TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 . ^^^ Dominant negative forms of TRAF 2 , TRAF 5 , and TRAF 6 and an endogenous inhibitor of TRAF 2 , TRAF interacting protein ( TRIP ) , substantially inhibited TRANCE R mediated NF kappaB activation , suggesting a role of TRAFs in regulating DC and osteoclast function . ^^^ TRAF 6 also complexed to the C region in addition to several regions N terminal to the TRAF 2 and TRAF 5 association sites . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Here we show that ASK 1 interacts with members of the TRAF family and is activated by TRAF 2 , TRAF 5 , and TRAF 6 overexpression . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Indeed , TRAF 6 dominant negative mutant abolished NF kappaB activation by PPME photosensitization , and TRAF 2 dominant negative mutant was without any effect , and overexpression of IkappaB kinases increased gene transcription controlled by NF kappaB . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Deletion analysis showed that residues 246 269 of CD 40 which are required for its association with TRAF 2 , TRAF 3 , and TRAF 5 are dispensable for its interaction with TRAF 6 , whereas residues 230 245 were required . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Although four members of the tumor necrosis factor receptor associated factor ( TRAF ) family , including TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 , bind to the CD 40 cyt , how each TRAF protein contributes to the NFkappaB activation by CD 40 is not clear . ^^^ Here we report that TRAF 2 , TRAF 3 , and TRAF 5 bind cyt C , whereas TRAF 6 binds cyt N . cyt N is conserved poorly between human and mouse CD 40 , while cyt C is highly conserved . ^^^ Furthermore , NFkappaB activation by cyt C is inhibited by a kinase negative form of NFkappaB inducing kinase more efficiently than that by cyt N , consistent with the result that NFkappaB activation by TRAF 2 and TRAF 5 is inhibited by a kinase negative form of NFkappaB inducing kinase more efficiently than that by TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Several tumor necrosis factor receptor associated factor ( TRAF ) family proteins including TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 , as well as Jak 3 , have been implicated as potential mediators of CD 40 signaling . ^^^ An extensive in vitro binding study indicated that TRAF 2 and TRAF 3 bind to the CD 40 cytoplasmic tail ( CD40ct ) with much higher affinity than TRAF 5 and TRAF 6 and that TRAF 2 and TRAF 3 bind to different residues of the CD40ct . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
We have previously shown that the cytoplasmic domain of receptor activator of NF kappaB ( RANK ) interacts with TRAF 2 , TRAF 5 , and TRAF 6 and that its overexpression activates NF kappaB and JNK pathways . ^^^ Furthermore , transfection experiments with RANK and its deletion mutants in human embryonic 293 cells revealed that the TRAF 6 binding region ( 340 358 ) , but not the TRAF 2 or TRAF 5 binding region , is necessary and sufficient for RANK induced NF kappaB activation . ^^^ Thus , our results indicate that RANK interacts with various TRAFs through distinct motifs and activates NF kappaB via a novel TRAF 6 interaction motif , which then activates NIK , thus leading to NF kappaB activation , whereas RANK most likely activates JNK through a TRAF 2 interacting region in RANK . . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Furthermore , like TRAF 2 and TRAF 3 , TRAF 6 is essential for perinatal and postnatal survival . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Signaling by proinflammatory cytokines : oligomerization of TRAF 2 and TRAF 6 is sufficient for JNK and IKK activation and target gene induction via an amino terminal effector domain . ^^^ The TNF alpha and IL 1 signals are transduced through TRAF 2 and TRAF 6 , respectively . ^^^ Overexpressed TRAF 2 or TRAF 6 activate JNK , p 38 , or IKK in the absence of extracellular stimulation . ^^^ By replacing the carboxy terminal TRAF domain of TRAF 2 and TRAF 6 with repeats of the immunophilin FKBP 12 , we demonstrate that their effector domains are composed of their amino terminal Zn and RING fingers . ^^^ Thus , TNF alpha and IL 1 signaling is based on oligomerization of TRAF 2 and TRAF 6 leading to activation of effector kinases . . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
We report that TRAF 2 , TRAF 5 and TRAF 6 associate with apoptosis signal regulating kinase 1 ( ASK 1 ) , and a catalytically inactive ASK 1 mutant blocks stress activated protein kinase ( SAPK ) / Jun NH 2 terminal kinase ( JNK ) activation by these TRAFs . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Interestingly , overexpression of TRAF 1 in HEK293T completely prevented NF kappaB activation induced by TNF , IL 1 , or overexpression of TRAF 2 or TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Using CD 40 mutants with impairments in their ability to bind selected TNF receptor associated factor ( TRAF ) family proteins , we observed that CD 40 mediated transcriptional induction of the germ line Ig Cgamma 1 and Ig Cepsilon promoters was markedly reduced by mutations that prevent TRAF 2 , TRAF 3 , TRAF 5 or TRAF 6 binding . ^^^ Overexpression of TRAF 2 or TRAF 6 was sufficient to induce transcription of the C ( H ) promoters through an NF kappaB dependent mechanism . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Our data suggest that Abeta stimulation of astrocyte iNOS is mediated in part by IL 1beta and TNFalpha , and involves a TRAF 6 , TRAF 2 , and NIK dependent signaling mechanism . . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Consistent with this we show that p 62 selectively interacts with the TRAF domain of TRAF 6 but not that of TRAF 5 or TRAF 2 in co transfection experiments . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
In contrast to TRAF 2 and TRAF 3 , direct binding of TRAF 1 , TRAF 4 , TRAF 5 , or TRAF 6 to CD 40 was not detected . ^^^ A carboxyl truncation mutant of CD 40 lacking the last 32 amino acids required for TRAF 2 and TRAF 3 binding , CD 40 ( Delta 32 ) , mediated NF kappaB induction through a mechanism that was suppressible by co expression of TRAF 6 ( DeltaN ) , a dominant negative version of TRAF 6 , but not by TRAF 2 ( DeltaN ) , implying that while TRAF 6 does not directly bind CD 40 , it can participate in CD 40 signaling . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Biochemical and biophysical analyses demonstrated that TRAF domains of TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 6 formed homo trimers in solution . ^^^ In surface plasmon resonance studies , a hierarchy of affinity of trimeric TRAFs for trimeric CD 40 was found to be TRAF 2 > TRAF 3 > > TRAF 1 and TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Here we show that TANK synergized with TRAF 2 , TRAF 5 , and TRAF 6 but not with TRAF 3 in SAPK activation . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 p75 ( NTR ) , TRAF 4 p75 ( NTR ) , and TRAF 6 p75 ( NTR ) interactions modulated p 75 ( NTR ) induced cell death and NF kappaB activation with contrasting effects . ^^^ Coexpression of TRAF 2 with p 75 ( NTR ) enhanced cell death , whereas coexpression of TRAF 6 was cytoprotective . ^^^ TRAF 4 also inhibited the NF kappaB response , whereas TRAF 2 and TRAF 6 enhanced p 75 ( NTR ) induced NF kappaB activation . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Together , these results indicate that TRAF 6 , but not TRAF 2 , is a crucial component in the IL 17 signaling pathway leading to proinflammatory responses . . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
In transfected cells , TTRAP inhibits in a dose dependent manner the transcriptional activation of a nuclear factor kappaB ( NF kappaB ) dependent reporter mediated by CD 40 , TNF R 75 or Phorbol 12 myristate 13 acetate ( PMA ) and to a lesser extent by TRAF 2 , TRAF 6 , TNF alpha , or interleukin 1beta ( IL 1beta ) . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
In fact , activation of nuclear factor kappaB was induced by the overexpression of TROY and inhibited by dominant negative forms of TRAF 2 , TRAF 5 , and TRAF 6 , indicating that TRAFs and nuclear factor kappaB are involved in the signal transduction of TROY . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Mutants of DTRAF 1 lacking the N terminal region inhibited NFkappaB induction by either TRAF 2 or TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
H . pylori activates NF kappaB through a signaling pathway involving IkappaB kinases , NF kappaB inducing kinase , TRAF 2 , and TRAF 6 in gastric cancer cells . ^^^ In transfection experiments , effects of dominant negative IkappaBalpha , IKKalpha , IKKbeta , NF kappaB inducing kinase ( NIK ) , TRAF 2 , and TRAF 6 mutants were investigated . ^^^ NF kappaB activation was also inhibited by transfection of kinase deficient NIK or a dominant negative mutant of upstream adapter protein TRAF 2 or TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Enhanced osteoclastogenesis is associated with high expression of otherwise TNF and RANKL induced mediators , including c Src , TRAF 2 , TRAF 6 , and MEKK 1 , levels of which were notably reduced in TNFr 1 knockouts . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
The in vivo locations of TRAF 1 , TRAF 2 , TRAF 5 , and TRAF 6 were determined in human and mouse tissues by immunohistochemistry . ^^^ Dynamic regulation of TRAFs was observed in cultured PBLs , where anti CD 3 Abs , mitogenic lectins , and ILs induced marked increases in the steady state levels of TRAF 1 , TRAF 2 , TRAF 5 , and TRAF 6 . ^^^ TRAF 1 was also highly inducible by CD 40 ligand in cultured germinal center B cells , whereas TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 were relatively unchanged . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
All three HD cell lines showed strong expression of TRAF 2 protein and moderate , comparatively equal expression of TRAF 4 and TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Induction of NF kappaB was partially inhibited by dominant negative tumor necrosis factor receptor associated kinase 6 ( TRAF 6 ) but not TRAF 2 , whereas induction of IL 8 gene was partially inhibited by both TRAF 6 and TRAF 2 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
VP8 * blocked JNK activation directed by TRAF 2 or TRAF 5 but had no effect on JNK activation directed by TRAF 6 or MEKK 1 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
MUL and USP 7 are capable of binding in vitro via their TDs to all of the previously identified TRAF family proteins ( TRAF 1 , TRAF 2 , TRAF 3 , TRAF 4 , TRAF 5 , and TRAF 6 ) , whereas the TD of SPOP interacts weakly with TRAF 1 and TRAF 6 only . ^^^ Analysis of various MUL and USP 7 mutants by transient transfection assays indicated that the TDs of these proteins are necessary and sufficient for suppressing NF kappaB induction by TRAF 2 and TRAF 6 as well as certain TRAF binding TNF family receptors . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Moreover , overexpression of CSN 3 also inhibits NF kappaB activation triggered by proteins involved in TNF signaling , including TNF R 1 , TRAF 2 , RIP , and NIK , but not by TRAF 6 , a protein involved in IL 1 signaling . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Transiently expressed soluble trimeric CD 40 cytoplasmic domain was isolated as complexes that contained TRAF 2 , TRAF 3 , TRAF 5 , TRAF 6 , and the inhibitor of apoptosis protein ( c IAP 1 ) . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
The data suggest that entry of TRAF 6 into the LMP 1 complex is mediated by TRADD and TRAF 2 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
TRAF proteins are thought to be important regulators of cell death and cellular responses to stress , and TRAF 2 , TRAF 5 and TRAF 6 have been demonstrated to mediate activation of NF kappaB and JNK . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
The data presented here show that the shared binding site for TRAF 2 and TRAF 3 accounts for receptor internalization , and the majority of signaling through CD 40 , but is redundant with the TRAF 6 binding site for activation of p 38 and NFkappaB signaling pathways . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
PAN 2 also suppressed NF kappaB induction resulting from overexpression of several adapter proteins and protein kinases involved in the TNF or IL 1 receptor signal transduction , including TRAF 2 , TRAF 6 , RIP , IRAK 2 , and NF kappaB inducing kinase as well as the IkappaB kinases IKKalpha and IKKbeta . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
A 40 degrees difference in the directions of the bound peptides in TRAF 6 and TRAF 2 shows that there are marked structural differences between receptor recognition by TRAF 6 and other TRAFs . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
The AP 1 activation by TRAF 2 , TRAF 5 , and TRAF 6 was also greatly suppressed by the dominant negative TAK 1 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
The binding site for TRAF 2 and TRAF 3 but not for TRAF 6 is essential for CD 40 mediated immunoglobulin class switching . ^^^ To define the role of TRAF proteins in CD 40 dependent isotype switching in B cells , we introduced wild type ( WT ) and mutant CD 40 transgenes that lacked the binding motifs for TRAF 6 ( CD40deltaTRAF6 ) , TRAF 2 and TRAF 3 ( CD40deltaTRAF2 / 3 ) , or both ( CD40deltaTRAFs ) into B cells of CD 40 ( / ) mice . ^^^ These results suggest that binding to TRAF 2 and / or TRAF 3 but not TRAF 6 is essential for CD 40 isotype switching and activation in B cells . . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
To investigate the endothelial signaling cascade activated by anti beta ( 2 ) GPI antibodies , we transiently cotransfected immortalized human microvascular endothelial cells ( HMEC 1 ) with dominant negative constructs of different components of the pathway ( Delta TRAF 2 , Delta TRAF 6 , Delta MyD 88 ) together with reporter genes ( NF kappa B luciferase and pCMV beta galactosidase ) . ^^^ Delta TRAF 6 and Delta MyD 88 significantly abrogate antibody induced as well as IL 1 or LPS induced NF kappa B activation , whereas Delta TRAF 2 ( involved in NF kappa B activation by TNF ) does not affect it . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Here , we analyzed the mechanisms for transcriptional induction of 1 kappa B zeta . 1 kappa B zeta mRNA was induced by overexpression of MyD 88 or TRAF 6 , but not TRAF 2 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
We carried out comparative in situ hybridization analysis of five Traf genes Traf 1 , Traf 2 , Traf 3 , Traf 4 and Traf 6 during murine odontogenesis from the formation of the epithelial thickening to the early bell stage . ^^^ Traf 2 , Traf 3 and Traf 6 showed weak expression in the thickened epithelium . ^^^ Expression of Traf 1 , Traf 2 and Traf 6 were observed in the outer edges of the bud epithelium whereas Traf 3 was strongly expressed at the tip of the bud epithelium . ^^^ Traf 2 showed restricted expression in the internal enamel epithelium of the bell stage while expression of Traf 1 , Traf 3 , Traf 4 and Traf 6 were observed in both the internal and the external enamel epithelium . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Introduction of the dominant negative mutant of IkappaB kinase , of NFkappaB inducing kinase , and of tumour necrosis factor receptor associated factor 6 ( TRAF 6 ) , but not that of TRAF 2 , inhibited gastrin induced activation of NFkappaB . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
The inhibition of NF kappaB activation by CYLD is mediated , at least in part , by the deubiquitination and inactivation of TNFR associated factor 2 ( TRAF 2 ) and , to a lesser extent , TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Finally , we show that TRAF 2 and TRAF 6 have overlapping functions in CD 40 mediated NF kappaB activation and CD 80 up regulation . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
We found that the majority of the ectopically expressed RANK and substantial portion of endogenous TRAF 2 and TRAF 6 were detected in the low density raft fractions . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Endogenous TAB 3 interacts with TRAF 6 and TRAF 2 in an IL 1 and a TNF dependent manner , respectively . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
We now use cells lacking expression of TRAF 2 , TRAF 5 , TRAF 6 , IKKalpha , IKKbeta , IKKgamma , TAB 2 , IL 1 receptor associated kinase ( IRAK ) 1 , or IRAK 4 to assess their roles in LMP 1 mediated NF kappaB activation . ^^^ More surprisingly , NF kappaB responses were near normal in TRAF 2 and TRAF 5 double KO MEFs , IKKgamma KO MEFs , TAB 2 KO MEFs , and IRAK 4 KO MEFs but were highly deficient in TRAF 6 KO MEFs and IRAK 1 KO HEK 293 cells . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
RNAi mediated silencing of MALT 1 , TAK 1 , TRAF 6 , and TRAF 2 suppressed TCR dependent IKK activation and interleukin 2 production in T cells . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
When overexpressed , PIAS 3 inhibits NF kappaB dependent transcription induced by treatment with tumor necrosis factor alpha ( TNF alpha ) or interleukin 1beta or by overexpression of TNF family receptors such as RANK , TNFR 1 , and CD 30 or signal transducers of TNF receptor associated factors ( TRAFs ) , including TRAF 2 , TRAF 5 , and TRAF 6 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
In addition , TRAF 2 and TRAF 6 appear to be differentially involved in NF kappaB dependent induction of CYLD by TNF alpha and NTHi . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Since TRAF 2 and TRAF 6 play important roles in CD 40 signaling and TRAF 6 plays an important role in TLR 4 signaling , we examined the role of RIP in signaling via CD 40 and TLR 4 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
IL 8 induced NF kappaB activation is for the most part unaltered when cells are transfected with dominant negative TRADD , FADD , or TRAF 2 , but is inhibited with dominant negative TRAF 6 , NIK , IKK , or IkappaBalpha transfected cells . ^^^ The data suggest that IL 8 induced NF kappaB activation proceeds through a TRAF 2 independent but TRAF 6 dependent pathway , followed by recruitment of IRAK and activation of IKK . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
RT PCR was used to measure the expression of RANK , matrix metalloproteinase 9 , TRAF 6 , TRAP , integrin alpha 5 , integrin beta 3 , cathepsin K , and carbonic anhydrase 2 ( CA 2 ) . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
The up regulated genes include HIAP 1 , CRAF 1 , TRAF 6 , CASP 1 , CASP 2 , CASP 3 , CASP 4 , HPRT , GADD 45 , MCL 1 , NIP 1 , BCL2L2 , TRAP 3 , GSTP 1 , DAXX , PIG 11 , UBC , PIG 3 , PCNA , CDC 10 , JNK 1 and RBP 2 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Upon H ( 2 ) O ( 2 ) treatment , the ASK 1 signalosome forms a higher molecular mass complex at least in part because of the recruitment of tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) and TRAF 6 . ^^^ Consistent with our previous findings that TRAF 2 and TRAF 6 activate ASK 1 , H ( 2 ) O ( 2 ) induced ASK 1 activation and cell death were strongly reduced in the cells derived from Traf 2 / and Traf 6 / mice . ^^^ A novel signaling complex including TRAF 2 , TRAF 6 , and ASK 1 may thus be the key component in oxidative stress induced cell death . . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Monarch 1 reduces NFkappaB activation by TLR signaling molecules MyD 88 , IRAK 1 ( type 1 interleukin 1 receptor associated protein kinase ) , and TRAF 6 ( TNF receptor ( TNFR ) associated factor ) as well as TNFR signaling molecules TRAF 2 and RIP 1 but not the downstream NFkappaB subunit p 65 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Overexpression of USP 31 in HEK 293T cells inhibited TNFalpha , CD 40 , LMP 1 , TRAF 2 , TRAF 6 and IKKbeta mediated NF kappaB activation , but did not inhibit Smad mediated transcription activation . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
TRAF 6 is required for TRAF 2 dependent CD 40 signal transduction in nonhemopoietic cells . ^^^ In this study we present evidence that the CD 40 interacting proteins TRAF 2 and TRAF 6 play an important physiological role in CD 40 signaling in nonhemopoietic cells . ^^^ Furthermore , we provide evidence that TRAF 6 regulates CD 40 signal transduction not only through its direct binding to CD 40 but also indirectly via its association with TRAF 2 . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Here , we show that YopJ is a promiscuous deubiquitinating enzyme that negatively regulates signaling by removing ubiquitin moieties from critical proteins , such as TRAF 2 , TRAF 6 , and IkappaBalpha . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 and TRAF 3 are required for induction of NF kappaB and associated cell survival , as well as Jun amino terminal kinase phosphorylation by vFLIP , whereas TRAF 1 , TRAF 5 and TRAF 6 are dispensable . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
We also found that IL 25R mediated NF kappaB activation was inhibited by the expression of dominant negative TRAF 6 but not of dominant negative TRAF 2 . ^^^ In addition , coimmunoprecipitation assay revealed that TRAF 6 , but not TRAF 2 , associated with IL 25R even in the absence of ligand binding . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
In addition , RANK , TRAF 2 , TRAF 6 , and LacCer were found localized in lipid rafts on the cell surfaces . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
We found that siRNA targeting the TRAF 6 C terminal ( siTRAF6C ) receptor interaction domain specifically reduced only TRAF 6 protein expression , without affecting TRAF 2 or 5 levels , and substantially interfered with IL 1 induced NF kappaB and c Jun / AP 1 activation . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
Lys ( 63 ) linked polyubiquitination of TRAF 2 or TRAF 6 is an essential step within the signal transduction cascade responsible for activation of p 38 , c Jun N terminal kinase , and the transcription factor NF kappaB . ^^^
Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q9Y4K3 and Q12933	Pubmed	SVM Score :0.0
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