| Interacting proteins: Q9NQC7 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The inhibition of NF kappaB activation by CYLD is mediated , at least in part , by the deubiquitination and inactivation of TNFR associated factor 2 ( TRAF 2 ) and , to a lesser extent , TRAF 6 . ^^^ |
|
| Interacting proteins: Q9NQC7 and Q12933 |
Pubmed |
SVM Score :0.0 |
| In addition , TRAF 2 and TRAF 6 appear to be differentially involved in NF kappaB dependent induction of CYLD by TNF alpha and NTHi . ^^^ |
|
| Interacting proteins: Q9NQC7 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Recently , it was reported that CYLD directly interacts with NEMO / IKKgamma and TRAF 2 in the NF kappaB signaling pathway . ^^^ |
|
| Interacting proteins: Q9NQC7 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Tumor suppressor CYLD is a deubiquitinating enzyme ( DUB ) that inhibits the ubiquitination of key signaling molecules , including tumor necrosis factor ( TNF ) receptor associated factor 2 ( TRAF 2 ) . ^^^ Under normal conditions , CYLD dominantly suppresses the ubiquitination of TRAF 2 . ^^^ In response to cellular stimuli , CYLD undergoes rapid and transient phosphorylation , which is required for signal induced TRAF 2 ubiquitination and activation of downstream signaling events . ^^^ |
|
| Interacting proteins: Q9NQC7 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The CYLD gene encodes a deubiquitinase that removes lysine 63 linked ubiquitin chains from TRAF 2 and inhibits p65 / p50 NF kappaB activation . ^^^ These data indicate that , depending on the external signals , Cyld can negatively regulate different NF kappaB pathways ; inactivation of TRAF 2 controls survival and inflammation , while inhibition of Bcl 3 controls proliferation and tumor growth . . ^^^ |
|
| Interacting proteins: Q9NQC7 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
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