| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.74116397 |
| Here we show that TANK synergized with TRAF 2 , TRAF 5 , and TRAF 6 but not with TRAF 3 in SAPK activation . 0.74116397^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Overexpression of 1 TRAF inhibits TRAF 2 mediated NF kappa B activation signaled by CD 40 and both TNF receptors . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| In vitro kinase assays demonstrate that IKK 1 phosphorylates 1 TRAF in the middle portion that associates with TRAF 2 . ^^^ Interestingly , TRAF 2 is freed from the 1 TRAF / TRAF2 complex after 1 TRAF phosphorylation . ^^^ NF kappaB activation by IKK 1 is significantly blocked by coexpression of the N terminal domain of 1 TRAF , dominant negative TRAF 2 , and dominant negative NIK and IKK beta . ^^^ NF kappaB activation by IKK 1 may be mediated through phosphorylation of 1 TRAF by IKK 1 and subsequent liberation of TRAF 2 . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Increased levels of TRAF 1 , TRAF 2 , and TANK / 1 TRAF were expressed in astrocytomas compared with levels in normal brain tissue ( p = 0 . 02 , 0 . 006 , and 0 . 01 , respectively ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Dominant negative forms of TRAF 2 , TRAF 5 , and TRAF 6 and an endogenous inhibitor of TRAF 2 , TRAF interacting protein ( TRIP ) , substantially inhibited TRANCE R mediated NF kappaB activation , suggesting a role of TRAFs in regulating DC and osteoclast function . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The effects of various factors on the efficiency of the Gee minnow trap to sample populations of mosquitofish , Gambusia affinis , in both rice field enclosures and a laboratory tank were assessed . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The processing system is made of latrines with an hydraulic trap and of a classical septic tank with three compartments made of second hand drums around which a jacket of concrete is sunk , so that tightness of the whole is achieved meaning no possible pollution of the surroundings . . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TANK , a co inducer with TRAF 2 of TNF and CD 40L mediated NF kappaB activation . ^^^ In cotransfection experiments , TANK and TRAF 2 activate NF kappaB synergistically , requiring both the amino terminal portion of TANK and the ring finger domain of TRAF 2 . ^^^ TANK has a negatively acting carboxyl terminus and is constitutively inactive , but TRAF 2 binding overcomes the internal inhibitory influence . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The following structures are recommended for incorporation in the overall design ; oil separator and silt trap , spillage containment , settlement pond , vegetative wetland and final settlement tank . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NF kappaB activation by a signaling complex containing TRAF 2 , TANK and TBK 1 , a novel IKK related kinase . ^^^ TBK 1 , TANK and TRAF 2 can form a ternary complex , and complex formation appears to be required for TBK 1 activity . ^^^ The TBK 1 TANK TRAF 2 signaling complex functions upstream of NIK and the IKK complex and represents an alternative to the receptor signaling complex for TRAF mediated activation of NF kappaB . . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| It consists of a tank for intensive fish culture which is equipped with a feeding lock representing also a trap for biomass removal followed by a water recycling system . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| For the tank with dispersant , only 6 % of chrysene initially introduced was detected in the sediment trap whereas 70 % was found in the trap in the tank without dispersant . . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Concentrations of steroids and inorganic ions were measured in waste water of an aerated sand trap as well as in aerosol particles emitted from this tank at the waste water treatment plant ( WWTP ) of Bayreuth , Germany , in January and February 2003 . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The TRAP identified in the present study shares considerable homology with , and may be the human homologue of , a mouse protein , TNF receptor associated factor 2 ( TRAF 2 ) , that binds mouse TNFR 2 . . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Interaction of the p 55 tumor necrosis factor receptor 1 ( TNF R 1 ) associated signal transducer TRADD with FADD signals apoptosis , whereas the TNF receptor associated factor 2 protein ( TRAF 2 ) is required for activation of the nuclear transcription factor nuclear factor kappa B . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The coding region of TNF receptor associated factor 2 ( TRAF 2 ) , which is known to interact with CD 40 for NF kappaB induction , was also found to be normal in B cell lines deficient in NF kappaB induction . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TNF induced activation of the transcription factor NF kappaB and the c jun N terminal kinase ( JNK / SAPK ) requires TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The TNF R 1 associated death domain protein interacts with the p 55 TNF R 1 cytoplasmic domain and recruits the Fas associated death domain protein ( which directly activates the apoptotic proteases ) , the protein kinase receptor interacting protein , and TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| A threonine residue at position 234 , previously shown to be important for CD 40 association with TNF receptor associated factor 2 ( TRAF 2 ) , TRAF 3 , and TRAF 5 , was not required for NF kappa B activation . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TNF receptor associated factor 2 ( TRAF 2 ) is a signal transducing protein associated with the CD 40 cytoplasmic domain . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Signaling by TRANCE R appears to be dependent on TNF receptor associated factor 2 ( TRAF 2 ) , since JNK induction is impaired in cells from transgenic mice overexpressing a dominant negative TRAF 2 protein . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| A key step by which tumor necrosis factor ( TNF ) signals the activation of nuclear factor kappaB ( NF kappaB ) and the stress activated protein kinase ( SAPK , also called c Jun N terminal kinase or JNK ) is the recruitment to the TNF receptor of TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TNF receptor associated factor 2 ( TRAF 2 ) was identified as an interacting protein in both screens . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The subcellular localization of the TNF receptor associated factor 2 ( TRAF 2 ) adaptor protein in human endothelial cells , which mediates proinflammatory responses of TNF , has been analyzed by confocal immunofluorescence microscopy and by Western blotting of fractionated cell extracts . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor ( TNF ) induced activation of the c jun N terminal kinase ( JNK , also known as SAPK ; stress activated protein kinase ) requires TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Although fully capable of transducing apoptotic signals , which depend on the adapter Fas associated death domain protein ( FADD ) and on the subsequent recruitment / activation of the apoptotic proteases , TNF R 1 usually does not kill cells ; this is due to the induction of a complex cytoprotective response that requires TNF receptor associated factor 2 ( TRAF 2 ) , a signal transducer that couples TNF R 1 to both nuclear factor kappaB ( NFkappaB ) dependent and NFkappaB independent transcriptional events implicated in induction of genes protecting from TNF cytotoxicity . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Either TNF receptor associated factor 2 ( TRAF 2 ) or TRAF 3 binds to the CD 27 molecule from the coimmunoprecipitation experiment . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Cellular resistance to TNF requires TNF receptor associated factor 2 ( TRAF 2 ) , which has been hypothesized to act mainly by mediating activation of the transcription factors nuclear factor kB ( NFkB ) and activator protein 1 ( AP 1 ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Cytokine signaling involves the participation of many adaptor proteins , including the docking protein TNF receptor associated factor 2 ( TRAF 2 ) , which is believed to transmit the TNF alpha signal through both the 1 kappa B / NF kappa B and c Jun N terminal kinase ( JNK ) / stress related protein kinase ( SAPK ) pathways . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| This is the same region of CD 40 required for binding the TNF receptor associated factor 2 ( TRAF 2 ) , TRAF 3 , and TRAF 5 adapter proteins . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| No changes in the levels or molecular weights of the adaptor proteins TRADD ( TNF receptor associated death domain ) , RIP ( receptor interacting protein ) , or TRAF 2 ( TNF receptor associated factor 2 ) were caused by apoptogenic drugs . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Cutting edge : contrasting roles of TNF receptor associated factor 2 ( TRAF 2 ) and TRAF 3 in CD 40 activated B lymphocyte differentiation . ^^^ We examined the contributions of TNF receptor associated factor 2 ( TRAF 2 ) and TRAF 3 to CD 40 activated differentiation in mouse B cells transfected with inducible TRAF and dominant negative TRAF cDNAs . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TNF induced activation of stress activated protein kinases ( SAPKs , Jun NH 2 terminal kinases ) requires TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| In particular , Bcl 2 , TNF receptor associated factor 2 ( TRAF 2 ) , and TRAF 4 were clearly inducible via CD 40 in B cells but not in DCs . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The death domain kinase RIP and the TNF receptor associated factor 2 ( TRAF 2 ) are essential effectors in TNF signaling . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor ( TNF ) alpha or TNF receptor associated factor 2 ( TRAF 2 ) stimulated the NESK activity . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| In addition , we also demonstrated that the TNF receptor associated factor 2 ( TRAF 2 ) plays little role in TRAIL induced IKK activation although it is required for TRAIL mediated JNK activation . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The imprinted gene Peg 3 encodes a zinc finger protein which has been proposed to be involved in tumor necrosis factor alpha ( TNF ) signaling via an interaction with TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| A 20 has been shown to bind to TNF receptor associated factor 2 ( TRAF 2 ) and 14 3 3 chaperone proteins . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Previously , we have demonstrated that Bcl 10 potentially interacts with the other apoptosis regulator , TNF receptor associated factor 2 ( TRAF 2 ) and inhibitor of apoptosis proteins ( cIAPs ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| When overexpressed , NS5A can not inhibit the recruitment of TNF receptor associated factor 2 ( TRAF 2 ) and IkappaB kinase ( IKK ) beta into the TNF receptor 1 TNF receptor associated death domain complex . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| We previously showed that murine embryonic fibroblasts ( MEFs ) from TNF receptor associated factor 2 ( Traf 2 ) and Traf 5 double deficient ( double knockout ( DKO ) ) mice were highly susceptible to TNF induced cell death . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Dominant negative TNF receptor associated factor 2 ( TRAF 2 ) inhibited activation of NF kappa B , which was also inhibited in embryonic fibroblasts derived from TRAF 2 ( / ) mice , respect to their normal counterpart . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Moreover , preincubation of HUVEC with 10 ng / mL TcdB 10463 reduced TNF alpha related expression of interleukin 8 ( IL 8 ) , TNF receptor associated factor 2 ( TRAF 2 ) , and human inhibitor of apoptosis protein 1 ( hIAP 1 ) mRNA . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor ( TNF ) induced germinal center kinase related ( GCKR ) and stress activated protein kinase ( SAPK ) activation depends upon the E2 / E3 complex Ubc 13 Uev1A / TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ Tumor necrosis factor ( TNF ) induced activation of apoptosis signal regulating kinase 1 ( ASK 1 ) and germinal center kinases ( GCKs ) and the subsequent activation of stress activated protein kinases ( SAPKs and c Jun NH ( 2 ) terminal kinases ) requires TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis further demonstrated that OIP 1 significantly decreased TNF receptor associated factor 2 ( TRAF 2 ) expression in RAW 264 . 7 cells . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of mRNA for TNF receptors ( TNFR ) , including TNFRI and TNFRII , and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase ( RT ) PCR in bone marrow samples from control , MDS and AML cases . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| However , NFkappaB stimulation by AII differs from that of TNF alpha since a TNF receptor associated factor 2 ( TRAF 2 ) dominant negative mutant does not prevent AII mediated NFkappaB activation . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TRADD also binds two other adaptors receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) , which are required for TNF induced NF kappaB and c Jun N terminal kinase activation , respectively . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Ebselen inhibited TNF alpha induced TNF receptor associated factor 2 ( TRAF 2 ) ASK 1 complex formation and phosphorylation of stress activated protein kinase ERK kinase 1 ( SEK 1 ) , which is an upstream signaling molecule of JNK . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Moreover , violacein directly activated TNF receptor 1 signaling , because a violacein dependent association of TNF receptor associated factor 2 ( TRAF 2 ) to this TNF receptor was observed in coimmunoprecipitation experiments . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Both CD 40 and CD120b bind TNF receptor associated factor 2 ( TRAF 2 ) upon ligand stimulation . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| In the normal rat cortex , a portion of TNFR 1 was present in lipid raft microdomains , where it associated with the adaptor proteins TRADD ( TNF receptor associated death domain ) , TNF receptor associated factor 2 ( TRAF 2 ) , the Ser / Thr kinase RIP ( receptor interacting protein ) , TRAF 1 , and cIAP 1 ( cellular inhibitor of apoptosis protein 1 ) , forming a survival signaling complex . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| HGF / SF induced the expression of several known NF kappaB target genes ( cIAP 1 ( cellular inhibitor of apoptosis 1 ) , cIAP 2 , and TRAF 2 ( TNF receptor associated factor 2 ) ) in an NF kappaB dependent manner ; HGF / SF blocked the inhibition of expression of these genes by ADR . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| INTRODUCTION : TNF receptor associated factor 2 ( TRAF 2 ) is a signal transducer for RANK and for two TNF receptor isotypes , TNFR 1 and TNFR 2 . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The analysed factors included TNF alpha , TNFR 1 , TNF receptor associated death domain ( TRADD ) , caspase 3 , caspase 8 , TNF receptor associated factor 2 ( TRAF 2 ) and receptor interactive protein ( RIP ) , all of which are involved in the TNF alpha / TNFR 1 signalling pathway mediated apoptosis . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The C terminal region of TRUSS interacted with TNF receptor associated factor 2 ( TRAF 2 ) and co expression of dominant inhibitory TRAF 2 with TRUSS inhibited AP 1 activation , suggesting that TRUSS signaling occurs upstream of TRAF 2 . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Analysis of the interactions of JAB 1 by reciprocal co immunoprecipitations and confocal microscopy revealed that JAB 1 interacts with TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of mRNA for TNF alpha receptors ( TNFR 1 and TNFR 2 ) and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) , and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase PCR ( RT PCR ) in PBMCs from control and RA cases . ^^^ |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92844 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|