Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.83493012
Also , TNF induced association of FAK with RIP and subsequent association of RIP with TRAF 2 were not observed , resulting in a failure of RIP to recruit the IKK complex in FAK / cells . 0.83493012^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Isolation and characterization of death domain ( TNF RI , Fas , TRADD , FADD / MORT 1 , RIP ) and TRAF domain containing proteins ( TRAF 1 , TRAF 2 , TRAF 3 ) have partially bridged a large molecular gap within one of several signaling pathways which originate at the plasma membrane and terminate in the nucleus . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Interaction of TRAF 2 with TNF R 2 and TRADD requires sequences at the C terminus of the TRAF C domain , whereas interaction with the protein kinase receptor interacting protein 5 ( RIP ) occurs via sequences at the N terminus of the TRAF C domain . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Two other signal transducers , RIP and TRAF 2 , mediate both JNK and NF kappaB activation . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Other TNF R 55 associated proteins like TRAF 2 and RIP , which were reported to mediate TNF R 55 mediated activation of nuclear factor kappaB , did not affect activation of A SMase . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
In contrast , the NF kappaB inducing adapters TRAF 2 and RIP do not signal for A SMase . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
RIP 2 interacted with other members of the TNFR 1 signaling complex , including inhibitor of apoptosis protein cIAP 1 and with members of the TNFR associated factor ( TRAF ) family , specifically TRAF 1 , TRAF 5 , and TRAF 6 , but not with TRAF 2 , TRAF 3 , or TRAF 4 . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
TNFRI has been recently shown to activate NF kappaB through association with TRADD , RIP , and TRAF 2 ; activation of the NF kappaB inducing kinase ( NIK ) ; activation of the IkappaB alpha kinases ( IKKalpha and IKKbeta ) ; and phosphorylation of IkappaB alpha . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Receptor interacting protein ( RIP ) is a second TNFR signal transducer which can bind TRAF 2 . ^^^ We show that RIP activates both p 38 and SAPK ; and that TRAF 2 activation of p 38 requires RIP . ^^^ Thus , TRAF 2 initiates SAPK and p 38 activation by binding two proximal protein kinases : GCK and RIP . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
TNF alpha signaling involves the recruitment of at least three proteins ( TRADD , RIP , and TRAF 2 ) to the type 1 TNF alpha receptor tail , leading to the sequential activation of the downstream NF kappaB inducing kinase ( NIK ) and IkappaB specific kinases ( IKKalpha and IKKbeta ) . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The constitutive expression of TNF receptors ( TNFRI and TNFRII ) and the adapter molecules , including TNFR associated death domain protein ( TRADD ) , TNFR associated factor 2 ( TRAF 2 ) , and receptor interacting protein ( RIP ) , were analyzed both at the protein level by flow cytometry or Western blotting , and at the mRNA level using quantitative PCR or Northern blotting in lymphocytes from aged and young subjects . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
No changes in the levels or molecular weights of the adaptor proteins TRADD ( TNF receptor associated death domain ) , RIP ( receptor interacting protein ) , or TRAF 2 ( TNF receptor associated factor 2 ) were caused by apoptogenic drugs . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
RIP 3 could be co immunoprecipitated with RIP , TRAF 2 and TNFR 1 in mammalian cells . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Here we show that the previously described aPKC binding protein , p 62 , selectively interacts with RIP but not with TRAF 2 in vitro and in vivo . p 62 bridges the aPKCs to RIP , whereas the aPKCs link IKKbeta to p 62 . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The zinc finger protein A 20 inhibits TNF induced NF kappaB dependent gene expression by interfering with an RIP or TRAF 2 mediated transactivation signal and directly binds to a novel NF kappaB inhibiting protein ABIN . ^^^ Moreover , NF kappaB activation induced by overexpression of the TNF receptor associated proteins TNF receptor associated death domain protein ( TRADD ) , receptor interacting protein ( RIP ) , and TNF recep tor associated factor 2 ( TRAF 2 ) was also inhibited by expression of A 20 , whereas NF kappaB activation induced by overexpression of NF kappaB inducing kinase ( NIK ) or the human T cell leukemia virus type 1 ( HTLV 1 ) Tax was unaffected . ^^^ These results demonstrate that A 20 inhibits NF kappaB dependent gene expression by interfering with a novel TNF induced and RIP or TRAF 2 mediated pathway that is different from the NIK IkappaB kinase pathway and that is specifically involved in the transactivation of NF kappaB . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
LMP 1 spontaneously aggregates in the plasma membrane and enables two transformation effector sites ( TES 1 and TES 2 ) within the 200 amino acid cytoplasmic carboxyl terminus to constitutively engage the tumor necrosis factor receptor ( TNFR ) associated factors TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 5 and the TNFR associated death domain proteins TRADD and RIP , thereby activating NF kappaB and c Jun N terminal kinase ( JNK ) . ^^^ Mutant and wt LMP 1 proteins were also similar in their constitutive association with TRAF 1 , TRAF 2 , TRAF 3 , TRADD , and RIP . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The death domain kinase RIP and the TNF receptor associated factor 2 ( TRAF 2 ) are essential effectors in TNF signaling . ^^^ The distinct roles of TRAF 2 and RIP in IKK activation by TNF R 1 : TRAF 2 recruits IKK to TNF R 1 while RIP mediates IKK activation . ^^^ To understand the mechanism by which RIP and TRAF 2 regulate TNF induced activation of the transcription factor NF kappaB , we investigated their respective roles in TNF R 1 mediated IKK activation using both RIP / and TRAF 2 / fibroblasts . ^^^ We found that TNF R 1 mediated IKK activation requires both RIP and TRAF 2 proteins . ^^^ Although TRAF 2 or RIP can be independently recruited to the TNF R 1 complex , neither one of them alone is capable of transducing the TNF signal that leads to IKK activation . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Interaction between Stat 1 and receptor interacting protein ( RIP ) or TNFR associated factor 2 ( TRAF 2 ) was not detected . ^^^ Examination of Stat 1 deficient cells showed an apparent increase in TNF alpha induced TRADD RIP and TRADD TRAF 2 complex formation , while interaction between TRADD and FADD was unaffected . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Using TRAF 2 ( / ) cells , we demonstrated that the TNF induced interaction between IKKgamma and the death domain kinase RIP is TRAF 2 dependent and that one possible function of this interaction is to stabilize the IKK complex when it interacts with TRAF2 . . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Moreover , overexpression of CSN 3 also inhibits NF kappaB activation triggered by proteins involved in TNF signaling , including TNF R 1 , TRAF 2 , RIP , and NIK , but not by TRAF 6 , a protein involved in IL 1 signaling . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Here we provide evidence to conclude that synthetic analogs of the RNAIII inhibiting peptide ( RIP ) and antibodies to its target molecule TRAP function in vitro as efficient suppressors of agr regulated exotoxin production by Staphylococcus aureus . . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Cytoplasmic interaction of TNFRI with TRAF 2 and RIP allows for the activation of JNK and NFkappaB pathways . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
PAN 2 also suppressed NF kappaB induction resulting from overexpression of several adapter proteins and protein kinases involved in the TNF or IL 1 receptor signal transduction , including TRAF 2 , TRAF 6 , RIP , IRAK 2 , and NF kappaB inducing kinase as well as the IkappaB kinases IKKalpha and IKKbeta . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The point of bifurcation of this pathway and the decision making molecules FADD , TRAF 2 and RIP are discussed . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
A novel anti apoptotic mechanism of FLIP in the recruitment of RIP and TRAF 1 and TRAF 2 to activate ERK and NF kappaB has been defined . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The constitutive expression of mRNA for TNF receptors ( TNFR ) , including TNFRI and TNFRII , and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase ( RT ) PCR in bone marrow samples from control , MDS and AML cases . ^^^ An increased constitutive expression of mRNA for TRADD , FADD and RIP and decreased expression of mRNA for TRAF 2 were observed in bone marrow cells from MDS patients , especially from RA patients , as compared with controls , although the differences were not significant . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
TRADD also binds two other adaptors receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) , which are required for TNF induced NF kappaB and c Jun N terminal kinase activation , respectively . ^^^ Analysis of the native TNF signaling complex revealed the recruitment of RIP , TRADD , and TRAF 2 but not FADD or caspase 8 . ^^^ In an in vitro binding assay , the intracellular domain of TNF R 1 bound TRADD , RIP , and TRAF 2 but did not bind FADD or caspase 8 . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Here we show that upon TNFalpha binding , TNFR 1 translocates to cholesterol and sphingolipid enriched membrane microdomains , termed lipid rafts , where it associates with the Ser / Thr kinase RIP and the adaptor proteins TRADD and TRAF 2 , forming a signaling complex . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
TL1A induced the formation of a DR 3 signaling complex containing TRADD , TRAF 2 , and RIP and activated the NF kappaB and the ERK , JNK , and p 38 mitogen activated protein kinase pathways . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The first complex ( complex 1 ) is formed at the membrane by TNF R 1 , TRADD , RIP , TRAF 2 and c IAP 1 , while the second complex ( complex 2 ) , formed in the cytosol , predominantly contains FADD and pro caspases 8 / 10 but lacks TNF R 1 . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
In this study , we utilized gene knockout mouse embryonic fibroblasts cells and found that tumor necrosis factor receptor ( TNFR ) 1 mediates TNF induced necrotic cell death , and that RIP , FADD , and TRAF 2 are critical components of the signaling cascade of this TNF induced necrotic cell death . ^^^ Interestingly , during TNF induced necrotic cell death , the cellular ROS level was significantly elevated in wild type , but not in RIP ( / ) , TRAF 2 ( / ) , and FADD ( / ) cells . ^^^ These results suggest that RIP , TRAF 2 , and FADD are crucial in mediating ROS accumulation in TNF induced necrotic cell death . . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
An important regulatory step in control of antiapoptotic signaling is the assembly of the TNFR 1 TNFR 1 associated death domain protein ( TRADD ) TNFR associated factor 2 ( TRAF 2 ) receptor interacting protein ( RIP ) complex that controls NF kappaB activation . ^^^ Inhibition of either delta PKC or PI 3 kinase decreased TNF mediated recruitment of RIP and TRAF 2 to TNFR 1 . ^^^ Thus delta PKC and PI 3 kinase are positive regulators of TNF mediated association of TRAF 2 and RIP with TNFR 1 . ^^^ These results suggest that delta PKC and PI 3 kinase regulate TNF antiapoptotic signaling at the level of the TNFR 1 through control of assembly of a TNFR 1 TRADD RIP TRAF 2 complex . . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Our in vitro ubiquitination assay revealed that while TRAF 2 had no effect , both c IAP 1 and c IAP 2 mediated RIP ubiquitination with similar efficiency , indicating that c IAPs can function as E 3 toward RIP . . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Data from this study suggest that receptor interacting protein ( RIP ) and tumor necrosis factor receptor ( TNFR ) associated factor 2 ( TRAF 2 ) , two key effector molecules of TNF signaling , are essential for ROS induced cell death . ^^^ We found that RIP ( / ) or TRAF 2 ( / ) mouse embryonic fibroblasts ( MEF ) are resistant to ROS induced cell death when compared to wild type cells , and reconstitution of RIP and TRAF 2 gene expression in their respective deficient MEF cells restored their sensitivity to H ( 2 ) O ( 2 ) induced cell death . ^^^ We also found that RIP and TRAF 2 form a complex upon H ( 2 ) O ( 2 ) exposure , but without the participation of TNFR 1 . ^^^ Finally , our results demonstrate that activation of c Jun NH ( 2 ) terminal kinase 1 is a critical event downstream of RIP and TRAF 2 in mediating ROS induced cell death . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
TNAP specifically inhibits NF kappaB activation induced by tumor necrosis factor ( TNF ) alpha , TNF receptor 1 , TRADD , RIP , TRAF 2 , and NIK but does not affect IKK 1 and IKK 2 mediated NF kappaB activation . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Since TRAF 2 and TRAF 6 play important roles in CD 40 signaling and TRAF 6 plays an important role in TLR 4 signaling , we examined the role of RIP in signaling via CD 40 and TLR 4 . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
In the normal rat cortex , a portion of TNFR 1 was present in lipid raft microdomains , where it associated with the adaptor proteins TRADD ( TNF receptor associated death domain ) , TNF receptor associated factor 2 ( TRAF 2 ) , the Ser / Thr kinase RIP ( receptor interacting protein ) , TRAF 1 , and cIAP 1 ( cellular inhibitor of apoptosis protein 1 ) , forming a survival signaling complex . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Several proteins , including FADD , the death domain kinase RIP and the TNF receptor associated factor TRAF 2 have been identified as the key effectors of TNF signaling . ^^^ Recently , we found that the effector molecules of TNF signaling , such as RIP and TRAF 2 , are also involved in other cellular responses . ^^^ These finding suggests that RIP and TRAF 2 serve a broader role than as just an effector of TNF signaling . . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Indeed , the TRAF 2 interacting protein RIP can mediate IKK activation when it is modified by K ( 63 ) polyubiquitin chains , but is targeted to degradation by the proteasome when it is K ( 48 ) polyubiquitinted by the NF kappaB inhibitor A 20 . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The analysed factors included TNF alpha , TNFR 1 , TNF receptor associated death domain ( TRADD ) , caspase 3 , caspase 8 , TNF receptor associated factor 2 ( TRAF 2 ) and receptor interactive protein ( RIP ) , all of which are involved in the TNF alpha / TNFR 1 signalling pathway mediated apoptosis . ^^^ The quantitative RT PCR indicated that the infected muscle tissues up regulate the expression of pro apoptosis genes ( TNF alpha , TNFR 1 and TRADD , caspase 3 and caspase 8 ) , and anti apoptosis genes ( TRAF 2 and RIP ) at the beginning of cyst formation . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The constitutive expression of mRNA for TNF alpha receptors ( TNFR 1 and TNFR 2 ) and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) , and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase PCR ( RT PCR ) in PBMCs from control and RA cases . ^^^ PBMCs of RA patients showed a significant increase in TNF alpha and TNFR 1 expression as compared with that from control subjects along with significantly increased constitutive expression of TRADD , RIP , and TRAF 2 mRNA . ^^^ These data suggested enhanced signaling by the TNFR 1 TRADD RIP TRAF 2 pathway and suppressed signaling by the TNFR 1 TRADD FADD pathway in PBMCs of RA patients . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The initial plasma membrane bound complex ( complex 1 ) consists of TNFR 1 , the adaptor TRADD , the kinase RIP 1 , and TRAF 2 and rapidly signals activation of NF kappa B . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The cytokine tumor necrosis factor alpha ( TNF alpha ) stimulates the NF kappaB , SAPK / JNK , and p 38 mitogen activated protein ( MAP ) kinase pathways by recruiting RIP 1 and TRAF 2 proteins to the tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^ Genetic studies have revealed that RIP 1 links the TNFR 1 to the IkappaB kinase ( IKK ) complex , whereas TRAF 2 couples the TNFR 1 to the SAPK / JNK cascade . ^^^ In transfection studies , RIP 1 and TRAF 2 stimulate p 38 MAP kinase activation , and dominant negative forms of RIP 1 and TRAF 2 inhibit TNF alpha induced p 38 MAP kinase activation . ^^^ We found TNF alpha induced p 38 MAP kinase activation and interleukin 6 ( IL 6 ) production impaired in rip 1 ( / ) murine embryonic fibroblasts ( MEF ) but unaffected in traf 2 ( / ) MEF . ^^^ Yet , both rip 1 ( / ) and traf 2 ( / ) MEF exhibit a normal p 38 MAP kinase response to inducers of osmotic shock or IL 1alpha . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Although the general NF kappaB inhibiting protein A 20 inhibits caspase 1 derived activation of NF kappaB , dominant negative forms of TRAF 2 and RIP 1 have no effect . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The kinase activity of Rip 1 is not required for tumor necrosis factor alpha induced IkappaB kinase or p 38 MAP kinase activation or for the ubiquitination of Rip 1 by Traf 2 . ^^^ In the absence of Traf 2 , TNF alpha induced ubiquitination of Rip 1 is impaired , suggesting that Traf 2 may be the E 3 ubiquitin ligase responsible for the TNF alpha dependent , ubiquitination of Rip 1 . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
TNF binding induces release of AIP 1 from TNFR 1 , resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD , RIP 1 , TRAF 2 , and AIPl . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Analyzing cell lines expressing an internalization deficient receptor ( TNF R 1 DeltaTRID ) revealed that recruitment of RIP 1 and TRAF 2 to TNF R 1 occurred at the level of the plasma membrane . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
A novel caspase 2 complex containing TRAF 2 and RIP 1 . ^^^ Caspase 2 interacts with TRAF 1 , TRAF 2 , and RIP 1 . ^^^ Furthermore , we demonstrate that endogenous caspase 2 is recruited into a large and inducible protein complex , together with TRAF 2 and RIP 1 . ^^^ These results demonstrate the inducible assembly of a novel protein complex consisting of caspase 2 , TRAF 2 , and RIP 1 that activates NF kappaB and p 38 MAPK through the caspase recruitment domain of caspase 2 independently of its proteolytic activity . . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
In addition , we show that the activation of Tpl 2 by TNF alpha depends on signals transduced by both TRAF 2 and RIP 1 . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
In the TNF alpha pathway , Rip 1 interacts with the E 3 ubiquitin ligase Traf 2 and is modified by polyubiquitin chains . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
Monarch 1 reduces NFkappaB activation by TLR signaling molecules MyD 88 , IRAK 1 ( type 1 interleukin 1 receptor associated protein kinase ) , and TRAF 6 ( TNF receptor ( TNFR ) associated factor ) as well as TNFR signaling molecules TRAF 2 and RIP 1 but not the downstream NFkappaB subunit p 65 . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
The secondary complex retained the DISC components FADD and caspase 8 , but recruited several factors involved in kinase activation by TNF , namely , RIP 1 , TRAF 2 , and NEMO / IKKgamma . ^^^ Apo2L / TRAIL stimulation of JNK and p 38 further depended on RIP 1 and TRAF 2 , whereas IKK activation required NEMO . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
TNF alpha stimulates the JNK , ERK , and p 38 mitogen activated protein kinases and the NF kappaB pathway by recruiting RIP 1 and TRAF 2 to the TNF receptor 1 . ^^^ Here we showed that Tpl 2 activation by TNF alpha signals depends on the integrity of the Tpl 2 interacting proteins RIP 1 and TRAF 2 , which are required for the engagement of the ERK mitogen activated protein kinase pathway . ^^^ However , neither RIP 1 nor TRAF 2 overexpression was sufficient to activate Tpl 2 and ERK . ^^^ These data therefore dissect the TNF receptor 1 proximal events that regulate Tpl 2 and ERK and highlight a role for RIP 1 , TRAF 2 , and Syk in this pathway . . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
We reveal that receptor interacting protein 1 ( RIP 1 ) and tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , are upstream of JNK in PARP 1 hyperactivated cells , because PARP 1 induced JNK activation was attenuated in RIP 1 / and TRAF 2 / mouse embryonic fibroblast cells . ^^^ Consistently , knockouts of RIP 1 and TRAF 2 caused a resistance to PARP 1 induced cell death . ^^^ Therefore , our study uncovers that RIP 1 , TRAF 2 , and JNK comprise a pathway to mediate the signaling from PARP 1 overactivation to mitochondrial dysfunction . . ^^^
Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q15311 and Q12933	Pubmed	SVM Score :0.0
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