| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| VP8 * blocked JNK activation directed by TRAF 2 or TRAF 5 but had no effect on JNK activation directed by TRAF 6 or MEKK 1 . ^^^ |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| We show that the human SPS 1 homologue germinal center kinase ( GCK ) can interact in vivo with the TNFR 1 signal transducer TNFR associated factor 2 ( TRAF 2 ) and with MAPK / ERK kinase kinase 1 ( MEKK 1 ) , a MAPK kinase kinase ( MAPKKK ) upstream of the SAPKs , thereby coupling TRAF 2 to the SAPKs . ^^^ |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Oligomerization of the TRAF 2 effector domain results in specific binding to MEKK 1 , a protein kinase capable of JNK , p 38 , and IKK activation , and induction of TNF alpha and IL 1 responsive genes . ^^^ TNF alpha also enhances the binding of native TRAF 2 to MEKK 1 and stimulates the kinase activity of the latter . ^^^ |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Dicoumarol prevented SAPK activation in vivo by chemical cell stressors and also prevented SAPK activation induced by expression of the tumor necrosis factor alpha ( TNFalpha ) receptor associated protein TRAF 2 but not by expression of truncated active MEKK 1 . ^^^ |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| These results suggest that NESK , a novel activator of the JNK pathway , functions in coupling TRAF 2 to the MEKK 1 > MKK 4 > JNK kinase cascade during the late stages of mammalian embryogenesis . . ^^^ |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Enhanced osteoclastogenesis is associated with high expression of otherwise TNF and RANKL induced mediators , including c Src , TRAF 2 , TRAF 6 , and MEKK 1 , levels of which were notably reduced in TNFr 1 knockouts . ^^^ |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Direct activation of mitogen activated protein kinase kinase kinase MEKK 1 by the Ste20p homologue GCK and the adapter protein TRAF 2 . ^^^ Recombinant forms of MAP3K MEK kinase 1 ( MEKK 1 ) interact in vivo and in vitro with the STE 20 protein homologue germinal center kinase ( GCK ) , and both GCK and MEKK 1 associate in vivo with the adapter protein tumor necrosis factor ( TNF ) receptor associated factor 2 ( TRAF 2 ) . ^^^ In addition , we have developed an in vitro assay system with which we demonstrate that purified , active GCK and TRAF 2 activate MEKK 1 . ^^^ The RING domain of TRAF 2 is necessary for optimal in vitro activation of MEKK 1 , but the kinase domain of GCK is not . ^^^ |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NF kappaB activation by TNF receptor associated death domain and TRAF 2 was inhibited by NS5A , whereas MEKK 1 and IKKbeta dependent NF kappaB activation was not affected , suggesting that NS5A may inhibit NF kappaB activation signaled by TRAF 2 . ^^^ |
|
| Interacting proteins: Q13233 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Moreover , FAF 1 suppressed NF kappaB activation induced by transducers of diverse NF kappaB activating signals such as TNF receptor associated factor 2 and 6 , MEKK 1 , and IkappaB kinase beta as well as NF kappaB p 65 , one of the end point molecules in the NF kappaB activation pathway , suggesting that NF kappaB p 65 might be a target molecule upon which FAF 1 acts . ^^^ |
|