| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The TNF R 1 associated death domain protein interacts with the p 55 TNF R 1 cytoplasmic domain and recruits the Fas associated death domain protein ( which directly activates the apoptotic proteases ) , the protein kinase receptor interacting protein , and TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Although fully capable of transducing apoptotic signals , which depend on the adapter Fas associated death domain protein ( FADD ) and on the subsequent recruitment / activation of the apoptotic proteases , TNF R 1 usually does not kill cells ; this is due to the induction of a complex cytoprotective response that requires TNF receptor associated factor 2 ( TRAF 2 ) , a signal transducer that couples TNF R 1 to both nuclear factor kappaB ( NFkappaB ) dependent and NFkappaB independent transcriptional events implicated in induction of genes protecting from TNF cytotoxicity . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of mRNA for TNF receptors ( TNFR ) , including TNFRI and TNFRII , and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase ( RT ) PCR in bone marrow samples from control , MDS and AML cases . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The constitutive expression of mRNA for TNF alpha receptors ( TNFR 1 and TNFR 2 ) and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) , and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase PCR ( RT PCR ) in PBMCs from control and RA cases . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TRADD TRAF 2 and TRADD FADD interactions define two distinct TNF receptor 1 signal transduction pathways . ^^^ Here we show that TRADD directly interacts with TRAF 2 and FADD , signal transducers that activate NF kappa B and induce apoptosis , respectively . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| DR 3 signal transduction is mediated by a complex of intracellular signaling molecules including TRADD , TRAF 2 , FADD , and FLICE . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Interaction of the p 55 tumor necrosis factor receptor 1 ( TNF R 1 ) associated signal transducer TRADD with FADD signals apoptosis , whereas the TNF receptor associated factor 2 protein ( TRAF 2 ) is required for activation of the nuclear transcription factor nuclear factor kappa B . ^^^ TRAF 2 was both sufficient and necessary for activation of SAPK by TNF R 1 ; conversely , expression of a dominant negative FADD mutant , which blocks apoptosis , did not interfere with SAPK activation . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Casper interacts with FADD , caspase 8 , caspase 3 , TRAF 1 , and TRAF 2 through distinct domains . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| This report analyzes the gene expression of bcl xs , bcl xl , bax alpha , bax beta , fadd , fas , fas ligand ( fas L ) , ice , TNF alpha , TNF beta , TNFR 1 , TNFR 2 , TRAF 1 , TRAF 2 , TRAF 3 , cIAP 2 , and tradd at the level of mRNA in the single Reed Sternberg cells and their variants . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The latter appears to be dependent on TRAF 2 , but independent of FADD or caspases . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| FADD , Casper , and caspase 8 induced NF kappaB activation are inhibited by dominant negative mutants of TRAF 2 , NIK , IkappaB kinase alpha , and IkappaB kinase beta . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TRAIL , anti APO 1 , and FADD ( 80 208 ) initiated gene induction was blocked by a dominant negative mutant of TRAF 2 or the p 38 kinase inhibitor SB 203580 , similar to tumor necrosis factor receptor 1 induced NF kappaB activation . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Examination of Stat 1 deficient cells showed an apparent increase in TNF alpha induced TRADD RIP and TRADD TRAF 2 complex formation , while interaction between TRADD and FADD was unaffected . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The expression of adapter molecules TNF receptor associated death domain ( TRADD ) , Fas associated death domain ( FADD ) and TNF associated factor 2 ( TRAF 2 ) and caspase 3 was analyzed by Western blotting . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| In this study , we further examined the interaction of the core protein with the signaling molecules of TNFR 1 , including FADD , TRADD , and TRAF 2 , in a human embryonic kidney cell line , HEK 293 , that overexpresses the HCV core protein . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| We selectively used constructs expressing dominant negative Fas associated death domain protein ( FADD ) , TNF receptor associated factor 2 ( TRAF 2 ) or IkappaB to inhibit pathways downstream of the TNF receptor . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| These data support the hypothesis that the FACS FadD functions in the vectorial movement of exogenous fatty acids across the plasma membrane by acting as a metabolic trap , which results in the formation of acyl CoA esters . . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The point of bifurcation of this pathway and the decision making molecules FADD , TRAF 2 and RIP are discussed . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| We further demonstrate that the signaling strength induced by a given ligand / receptor interaction is regulated at the level of adaptor protein recruitment , as shown for FADD , caspase 8 , and TRAF 2 . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Analysis of the native TNF signaling complex revealed the recruitment of RIP , TRADD , and TRAF 2 but not FADD or caspase 8 . ^^^ In an in vitro binding assay , the intracellular domain of TNF R 1 bound TRADD , RIP , and TRAF 2 but did not bind FADD or caspase 8 . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The first complex ( complex 1 ) is formed at the membrane by TNF R 1 , TRADD , RIP , TRAF 2 and c IAP 1 , while the second complex ( complex 2 ) , formed in the cytosol , predominantly contains FADD and pro caspases 8 / 10 but lacks TNF R 1 . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| In this study , we utilized gene knockout mouse embryonic fibroblasts cells and found that tumor necrosis factor receptor ( TNFR ) 1 mediates TNF induced necrotic cell death , and that RIP , FADD , and TRAF 2 are critical components of the signaling cascade of this TNF induced necrotic cell death . ^^^ Interestingly , during TNF induced necrotic cell death , the cellular ROS level was significantly elevated in wild type , but not in RIP ( / ) , TRAF 2 ( / ) , and FADD ( / ) cells . ^^^ These results suggest that RIP , TRAF 2 , and FADD are crucial in mediating ROS accumulation in TNF induced necrotic cell death . . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| IL 8 induced NF kappaB activation is for the most part unaltered when cells are transfected with dominant negative TRADD , FADD , or TRAF 2 , but is inhibited with dominant negative TRAF 6 , NIK , IKK , or IkappaBalpha transfected cells . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Several proteins , including FADD , the death domain kinase RIP and the TNF receptor associated factor TRAF 2 have been identified as the key effectors of TNF signaling . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Multiple survival factor genes , including cellular inhibitor of apoptosis protein ( c IAP 1 ) , c IAP 2 , TNF receptor associated factor 1 ( TRAF 1 ) , TRAF 2 , B cell leukemia / lymphoma 2 ( Bcl 2 ) , Bcl 10 , A 1 , and cellular Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme like inhibitory protein ( c FLIP ) , were expressed in basal conditions in both cultured RPE cells and RPE cells in situ , whereas survivin was expressed only by cultured cells . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The secondary complex retained the DISC components FADD and caspase 8 , but recruited several factors involved in kinase activation by TNF , namely , RIP 1 , TRAF 2 , and NEMO / IKKgamma . ^^^ |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13158 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|