Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.50711412
TRAF 3 forms heterotrimers with TRAF 2 and modulates its ability to mediate NF { kappa } B activation . 0.50711412^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The CAP 1 protein contains a C terminal domain that shares strong amino acid sequence homology with a unique domain found recently in two putative signal transducing proteins that bind to the TNF R 2 cytosolic tail , TRAF 1 and TRAF 2 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
A region of CRAF 1 was similar to the TNF alpha receptor associated factors TRAF 1 and TRAF 2 and so defined a shared TRAF C domain that was necessary and sufficient for CD 40 binding and homodimerization . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
We performed a yeast two hybrid library screen with the cytoplasmic domain of CD 30 and isolated multiple independent cDNAs encoding human tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and CRAF 1 ( TRAF 3 ) . ^^^ The ability of TRAF 1 , TRAF 2 , and CRAF 1 to associate with CD 30 was confirmed using an in vitro coprecipitation assay , further demonstrating that the interaction was specific and direct . ^^^ CRAF 1 bound only a single site , which contained the sequence PEQET , whereas TRAF 1 and TRAF 2 were capable of binding to either the PEQET site or an additional downstream domain . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The up regulated genes include HIAP 1 , CRAF 1 , TRAF 6 , CASP 1 , CASP 2 , CASP 3 , CASP 4 , HPRT , GADD 45 , MCL 1 , NIP 1 , BCL2L2 , TRAP 3 , GSTP 1 , DAXX , PIG 11 , UBC , PIG 3 , PCNA , CDC 10 , JNK 1 and RBP 2 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
LAP 1 is homologous to a murine protein , tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , implicated in growth signaling from the p 80 TNFR . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
LAP 1 may be a torsinA substrate , as expression of the isolated lumenal domain of LAP 1 inhibits the NE localization of `` substrate trap ' ' EQ torsinA and EQ torsinA coimmunoprecipitates with LAP 1 to a greater extent than wild type torsinA . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Overexpression of TRAF 2 , but not TRAF 1 or TRAF 3 , was sufficient to induce NF kappa B activation . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Isolation and characterization of death domain ( TNF RI , Fas , TRADD , FADD / MORT 1 , RIP ) and TRAF domain containing proteins ( TRAF 1 , TRAF 2 , TRAF 3 ) have partially bridged a large molecular gap within one of several signaling pathways which originate at the plasma membrane and terminate in the nucleus . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
TRAF 1 , TRAF 2 , and TRAF 3 share a conserved C terminal TRAF domain . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Deletion analysis showed that residues 246 269 of CD 40 which are required for its association with TRAF 2 , TRAF 3 , and TRAF 5 are dispensable for its interaction with TRAF 6 , whereas residues 230 245 were required . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 interact in vivo with the CD 30 cytoplasmic domain ; TRAF 2 mediates CD 30 induced nuclear factor kappa B activation . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Association of TRAF 1 , TRAF 2 , and TRAF 3 with an Epstein Barr virus LMP 1 domain important for B lymphocyte transformation : role in NF kappaB activation . ^^^ We now show that in EBV transformed B lymphocytes most of TRAF 1 or TRAF 3 and 5 % of TRAF 2 are associated with LMP 1 and that most of LMP 1 is associated with TRAF 1 or TRAF 3 . ^^^ TRAF 1 , TRAF 2 , and TRAF 3 bind to a single site in the LMP 1 CT corresponding to amino acids ( aa ) 199 to 214 , within a domain which is important for B lymphocyte growth transformation ( aa 187 to 231 ) . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Coexpression of CD 30 with TRAF 1 or TRAF 2 but not TRAF 3 augmented NF kappaB activation through domain 2 but not domain 1 . ^^^ NF kappaB induction through domain 2 was inhibited by coexpression of either full length TRAF 3 or dominant negative forms of TRAF 1 or TRAF 2 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Characterization of LMP 1 ' s association with TRAF 1 , TRAF 2 , and TRAF 3 . ^^^ We have characterized and mapped in detail a region of LMP 1 that associates with TRAF 1 , TRAF 2 , and TRAF 3 . ^^^ TRAF 1 , TRAF 2 , and TRAF 3 appear to associate independently with LMP 1 but bind an overlapping target site . ^^^ TRAF 3 associates with LMP 1 most avidly and can compete with TRAF 1 and TRAF 2 for binding to LMP 1 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The cytoplasmic region of HVEM bound to several members of the TNFR associated factor ( TRAF ) family , namely TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 5 , but not to TRAF 6 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Clones corresponding to genes coding for TRAF 1 , TRAF 2 , and TRAF 3 molecules , postulated to be involved in signalling via the TNF and CD 40 receptors , were isolated . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The importance of TRAF interactions in mediating these effects was confirmed using dominant negative TRAF 2 and TRAF 3 mutants which also identified differences in the signalling events mediated by the two NF kappaB activating domains of LMP 1 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Studies with human B cells show that the binding of CD 154 ( gp 39 , CD40L ) to CD 40 recruits TNF receptor associated factor 2 ( TRAF 2 ) and TRAF 3 to the receptor complex , induces the downregulation of the nonreceptor associated TRAFs in the cell and induces an increased expression of Fas on the cell surface . ^^^ Combined signaling through the interluekin 4 receptor and CD 40 induces an increased expression of Fas with a commensurate increase in the level of TRAF 2 , but not TRAF 3 , that is recruited to the receptor complex . ^^^ In contrast , engagement of the membrane immunoglobulin and CD 40 limits Fas upregulation and reduces the recruitment of TRAF 2 , relative to TRAF 3 , to the CD 40 receptor complex . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Mutation of critical residues in the TRAF 3 binding site of LMP 1 that prevents binding of TRAF 2 , TRAF 3 , and TRAF 5 does not affect NF kappaB activating potential . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
A threonine residue at position 234 , previously shown to be important for CD 40 association with TNF receptor associated factor 2 ( TRAF 2 ) , TRAF 3 , and TRAF 5 , was not required for NF kappa B activation . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 interact in vivo with the CD 30 cytoplasmic domain ; TRAF 2 mediates CD 30 induced nuclear factor kappa B activation . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
While 4 1BB bound TRAF 2 and TRAF 1 , Ox 40 interacted with TRAF 3 and TRAF 2 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
We found that tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 , all interacted with the cytoplasmic domain of 4 1BB . ^^^ Mutation analysis showed that TRAF 1 , TRAF 2 , and TRAF 3 were associated with one of two runs of acidic residues found in the cytoplasmic domain of 4 1BB . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
In vitro binding experiments showed that tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , TRAF 3 , and TRAF 5 but not TRAF 4 associated with glutathione S transferase OX 40 fusion protein . ^^^ The cotransfection experiments using human embryo kidney cell derived HEK 293T cells showed that TRAF 2 , TRAF 3 , and TRAF 5 associated with OX 40 in vivo . ^^^ In addition , the introduction of TRAF 3 together with the dominant negative mutants of TRAF 2 or TRAF 5 further reduced NF kappaB activation . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
This report analyzes the gene expression of bcl xs , bcl xl , bax alpha , bax beta , fadd , fas , fas ligand ( fas L ) , ice , TNF alpha , TNF beta , TNFR 1 , TNFR 2 , TRAF 1 , TRAF 2 , TRAF 3 , cIAP 2 , and tradd at the level of mRNA in the single Reed Sternberg cells and their variants . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Stimulation of PBLs with anti CD 3 Ab induced marked increases in the steady state levels of TRAF 3 protein in vitro as determined by immunoblotting , while levels of TRAF 2 were unchanged , implying a dynamic regulation of TRAF 3 expression . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Overexpression of TRAF 2 potently activates NF kappaB , although TRAF 2 did not induce expression of the EGFR either alone or in combination with TRAF 1 and TRAF 3 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
RIP 2 interacted with other members of the TNFR 1 signaling complex , including inhibitor of apoptosis protein cIAP 1 and with members of the TNFR associated factor ( TRAF ) family , specifically TRAF 1 , TRAF 5 , and TRAF 6 , but not with TRAF 2 , TRAF 3 , or TRAF 4 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Whereas TRAF 2 , 5 , and 6 initiate NF kappaB activation , the outcomes of TRAF 3 initiated signaling are less characterized . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 6 , but not TRAF 4 or TRAF 5 , bound directly to the CD 40 cytoplasmic domain . ^^^ CD 40 interactions with TRAF 2 and TRAF 3 were stronger than the interactions with TRAF 1 and TRAF 6 . ^^^ TRAF 1 , TRAF 2 , and TRAF 3 interacted with the same region . ^^^ Using peptides with progressive deletions , a minimal TRAF 1 , TRAF 2 , and TRAF 3 binding region was mapped to the PVQET sequence in the CD 40 cytoplasmic domain . ^^^ These studies demonstrate that the CD 40 cytoplasmic domain contains two nonoverlapping TRAF binding regions and suggest that TRAF 1 , TRAF 2 , and TRAF 3 could bind competitively to one site . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Coimmunoprecipitation experiments suggested potential interactions between the cytoplasmic tail of TRANCE R with TRAF 1 , TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Either TNF receptor associated factor 2 ( TRAF 2 ) or TRAF 3 binds to the CD 27 molecule from the coimmunoprecipitation experiment . ^^^ This NF kappaB activation signal is inhibited by dominant negative TRAF 2 or intact TRAF 3 , indicating that TRAF 2 and TRAF 3 works as a mediator and an inhibitor , respectively . ^^^ This amino acid alignment contains the EEEG sequence , which is essential for interaction of CD 30 or CD 40 with TRAFs ( TRAF 1 and TRAF 2 , but not TRAF 3 ) , and also contains the PIQED sequence , which is similar to PXQXT that is known to be necessary for interaction of TNF receptor 2 and CD 30 with TRAFs ( TRAF 1 , 2 , and 3 ) . . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Although four members of the tumor necrosis factor receptor associated factor ( TRAF ) family , including TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 , bind to the CD 40 cyt , how each TRAF protein contributes to the NFkappaB activation by CD 40 is not clear . ^^^ Here we report that TRAF 2 , TRAF 3 , and TRAF 5 bind cyt C , whereas TRAF 6 binds cyt N . cyt N is conserved poorly between human and mouse CD 40 , while cyt C is highly conserved . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Several tumor necrosis factor receptor associated factor ( TRAF ) family proteins including TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 , as well as Jak 3 , have been implicated as potential mediators of CD 40 signaling . ^^^ An extensive in vitro binding study indicated that TRAF 2 and TRAF 3 bind to the CD 40 cytoplasmic tail ( CD40ct ) with much higher affinity than TRAF 5 and TRAF 6 and that TRAF 2 and TRAF 3 bind to different residues of the CD40ct . ^^^ Using CD 40 mutants incapable of binding TRAF 2 , TRAF 3 , or Jak 3 , we found that the TRAF 2 binding site of the CD40ct is critical for NF kappaB and stress activated protein kinase activation , as well as the up regulation of the intercellular adhesion molecule 1 ( ICAM 1 ) gene , whereas binding of TRAF 3 and Jak 3 is dispensable for all of these functions . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
AITR associates with TRAF 1 ( TNF receptor associated factor 1 ) , TRAF 2 , and TRAF 3 , and induces nuclear factor ( NF ) kappaB activation via TRAF 2 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
This is the same region of CD 40 required for binding the TNF receptor associated factor 2 ( TRAF 2 ) , TRAF 3 , and TRAF 5 adapter proteins . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Furthermore , like TRAF 2 and TRAF 3 , TRAF 6 is essential for perinatal and postnatal survival . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The core binding site for TRAF 1 , TRAF 2 , and TRAF 3 in CD 40 could be minimally substituted . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Cutting edge : contrasting roles of TNF receptor associated factor 2 ( TRAF 2 ) and TRAF 3 in CD 40 activated B lymphocyte differentiation . ^^^ We examined the contributions of TNF receptor associated factor 2 ( TRAF 2 ) and TRAF 3 to CD 40 activated differentiation in mouse B cells transfected with inducible TRAF and dominant negative TRAF cDNAs . ^^^ We find that binding of TRAF 2 and TRAF 3 to CD 40 is not required for the induction of Ab secretion , but that both TRAF molecules can regulate the activation process . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Here we have defined the oligomeric structure of recombinant TRAF domains that directly interact with CD 40 and quantitated the affinities of TRAF 2 and TRAF 3 for CD 40 . ^^^ Biochemical and biophysical analyses demonstrated that TRAF domains of TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 6 formed homo trimers in solution . ^^^ N terminal deletions of TRAF 2 and TRAF 3 defined minimal amino acid sequences necessary for trimer formation and indicated that the coiled coil TRAF N region is required for trimerization . ^^^ In surface plasmon resonance studies , a hierarchy of affinity of trimeric TRAFs for trimeric CD 40 was found to be TRAF 2 > TRAF 3 > > TRAF 1 and TRAF 6 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Here we show that TANK synergized with TRAF 2 , TRAF 5 , and TRAF 6 but not with TRAF 3 in SAPK activation . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
LMP 1 spontaneously aggregates in the plasma membrane and enables two transformation effector sites ( TES 1 and TES 2 ) within the 200 amino acid cytoplasmic carboxyl terminus to constitutively engage the tumor necrosis factor receptor ( TNFR ) associated factors TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 5 and the TNFR associated death domain proteins TRADD and RIP , thereby activating NF kappaB and c Jun N terminal kinase ( JNK ) . ^^^ Mutant and wt LMP 1 proteins were also similar in their constitutive association with TRAF 1 , TRAF 2 , TRAF 3 , TRADD , and RIP . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Expression of transcripts for TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 5 , as demonstrated by RT PCR , was noted in leukemic blasts that express CD30v . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Using CD 40 mutants with impairments in their ability to bind selected TNF receptor associated factor ( TRAF ) family proteins , we observed that CD 40 mediated transcriptional induction of the germ line Ig Cgamma 1 and Ig Cepsilon promoters was markedly reduced by mutations that prevent TRAF 2 , TRAF 3 , TRAF 5 or TRAF 6 binding . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The tumor necrosis factor receptor associated factor ( TRAF ) pathway also contributed to the activation of the MMP 9 promoter as shown by the use of TRAF 2 and TRAF 3 dominant negative constructs . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Alanine substitution and truncation mutants of the human CD40ct domain were generated , revealing residues critical for binding TRAF 2 , TRAF 3 , or both of these proteins . ^^^ In contrast to TRAF 2 and TRAF 3 , direct binding of TRAF 1 , TRAF 4 , TRAF 5 , or TRAF 6 to CD 40 was not detected . ^^^ CD 40 mutants with impaired binding to TRAF 2 , TRAF 3 , or both of these proteins completely retained the ability to activate NF kappaB and Jun N terminal kinase ( JNK ) , implying that CD 40 can stimulate TRAF 2 and TRAF 3 independent pathways for NF kappaB and JNK activation . ^^^ A carboxyl truncation mutant of CD 40 lacking the last 32 amino acids required for TRAF 2 and TRAF 3 binding , CD 40 ( Delta 32 ) , mediated NF kappaB induction through a mechanism that was suppressible by co expression of TRAF 6 ( DeltaN ) , a dominant negative version of TRAF 6 , but not by TRAF 2 ( DeltaN ) , implying that while TRAF 6 does not directly bind CD 40 , it can participate in CD 40 signaling . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
TRAF 1 was also highly inducible by CD 40 ligand in cultured germinal center B cells , whereas TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 were relatively unchanged . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
MUL and USP 7 are capable of binding in vitro via their TDs to all of the previously identified TRAF family proteins ( TRAF 1 , TRAF 2 , TRAF 3 , TRAF 4 , TRAF 5 , and TRAF 6 ) , whereas the TD of SPOP interacts weakly with TRAF 1 and TRAF 6 only . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Transiently expressed soluble trimeric CD 40 cytoplasmic domain was isolated as complexes that contained TRAF 2 , TRAF 3 , TRAF 5 , TRAF 6 , and the inhibitor of apoptosis protein ( c IAP 1 ) . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The data presented here show that the shared binding site for TRAF 2 and TRAF 3 accounts for receptor internalization , and the majority of signaling through CD 40 , but is redundant with the TRAF 6 binding site for activation of p 38 and NFkappaB signaling pathways . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Stable transfectants expressing wild type or mutant forms of the cytoplasmic domain of CD 40 suggested that TRAF 3 , but not TRAF 2 , binding was essential for CD 40 mediated RANTES expression . ^^^ Further studies indicated that exogenous expression of wild type TRAF 3 enhanced activation of the RANTES promoter , whereas exogenous expression of wild type TRAF 2 inhibited this activation ; TRAF 3 mediated enhancement was dependent upon NF kappaB . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
We found that CD 40 engagement also results in its recruitment , together with TRAF 2 and TRAF 3 , to membrane microdomains , regions of the plasma membrane enriched in signaling molecules such as the Src family kinases . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The interaction of p 62 with TRAF 3 was specific , since p 62 failed to interact with TRAF 2 , 4 , 5 , or 6 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
TRAF 3 blocked OX 40 , TRAF 2 induced NF kappaB activation , but not NIK and IKKalpha induced NF kappaB activation , indicating that TRAF 3 blocks the pathway between TRAF 2 and NIK . ^^^ C terminal deletion mutants as well as the N terminal deletion mutant of TRAF 3 inhibited NF kappaB activation induced by OX 40 or TRAF 2 . ^^^ Since TRAF 3 bound to OX 40 through the C terminal TRAF domain , the C terminal domain is likely to work as a dominant negative mutant to compete the recruitment of TRAF 2 to the receptor , which transmits the signal from OX 40 to the downstream , NIK kinase . ^^^ On the other hand , the N terminal domain of TRAF 3 seems to affect the downstream of TRAF 2 binding . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
TNF receptor family member BCMA ( B cell maturation ) associates with TNF receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 and activates NF kappa B , elk 1 , c Jun N terminal kinase , and p 38 mitogen activated protein kinase . ^^^ Coimmunoprecipitation experiments performed in transfected cells showed that BCMA associates with TNFR associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 adaptor proteins . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
We carried out comparative in situ hybridization analysis of five Traf genes Traf 1 , Traf 2 , Traf 3 , Traf 4 and Traf 6 during murine odontogenesis from the formation of the epithelial thickening to the early bell stage . ^^^ Traf 2 , Traf 3 and Traf 6 showed weak expression in the thickened epithelium . ^^^ Expression of Traf 1 , Traf 2 and Traf 6 were observed in the outer edges of the bud epithelium whereas Traf 3 was strongly expressed at the tip of the bud epithelium . ^^^ Traf 2 showed restricted expression in the internal enamel epithelium of the bell stage while expression of Traf 1 , Traf 3 , Traf 4 and Traf 6 were observed in both the internal and the external enamel epithelium . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
We also find that TRAF 2 participates in the degradation of TRAF 3 associated with CD 40 signaling , a role that may limit inhibitory actions of TRAF 3 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Latent membrane protein 1 , tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , TRAF 3 , and nuclear factor kappa B expression in posttransplantation lymphoproliferative disorders . ^^^ Of the 6 members of the TRAF family , TRAF 1 , TRAF 2 , and TRAF 3 are most commonly associated with LMP 1 . ^^^ OBJECTIVE : To characterize the expression patterns of these proteins in PTLDs , we studied a series of well characterized cases for expression of LMP 1 , TRAF 1 , TRAF 2 , TRAF 3 , and NFkappaB by immunohistochemical analysis . ^^^ METHODS : A total of 27 specimens from 25 patients were analyzed for LMP 1 , TRAF 1 , TRAF 2 , TRAF 3 , and NFkappaB ( active form ) by immunohistochemical analysis . ^^^ TRAF 1 , TRAF 2 , and TRAF 3 expression did not correlate with either EBER or LMP 1 expression . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Interestingly , the role of PKD was dependent upon the association of CD 40 with TRAF 2 , and was inhibited by the binding of TRAF 3 , revealing a novel functional link between these two classes of signaling molecules . . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Antisense oligodeoxynucleotide ( ODN ) for TRAF 3 inhibited CD 40 induced activation of MEK 1 ERK pathway by decreasing expression of TRAF 3 protein , but antisense ODNs for TRAF 2 , 5 , and 6 were ineffective . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The binding site for TRAF 2 and TRAF 3 but not for TRAF 6 is essential for CD 40 mediated immunoglobulin class switching . ^^^ To define the role of TRAF proteins in CD 40 dependent isotype switching in B cells , we introduced wild type ( WT ) and mutant CD 40 transgenes that lacked the binding motifs for TRAF 6 ( CD40deltaTRAF6 ) , TRAF 2 and TRAF 3 ( CD40deltaTRAF2 / 3 ) , or both ( CD40deltaTRAFs ) into B cells of CD 40 ( / ) mice . ^^^ These results suggest that binding to TRAF 2 and / or TRAF 3 but not TRAF 6 is essential for CD 40 isotype switching and activation in B cells . . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Endogenous association of TRAF 2 , TRAF 3 , cIAP 1 , and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis . ^^^ Four of five proteins identified , TRAF 2 , TRAF 3 , cIAP 1 , and Smac , are reported here . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The KSHV oncoprotein vFLIP contains a TRAF interacting motif and requires TRAF 2 and TRAF 3 for signalling . ^^^ TRAF 2 and TRAF 3 are required for induction of NF kappaB and associated cell survival , as well as Jun amino terminal kinase phosphorylation by vFLIP , whereas TRAF 1 , TRAF 5 and TRAF 6 are dispensable . ^^^ TRAF 2 , but not TRAF 3 , mediates the association of vFLIP with the IkappaB kinase complex . ^^^ These data indicate that vFLIP uses TRAF 2 and TRAF 3 for signalling to NF kappaB , which is crucial for KSHV associated lymphomagenesis . . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
In the absence of TRAF 1 , an increased amount of TRAF 2 was recruited to lipid rafts , and subsequently , more robust degradation of TRAF 2 and TRAF 3 was induced in response to CD 40 signaling . ^^^ Taken together , our findings indicate that TRAF 1 and TRAF 2 cooperate in CD 40 but not LMP 1 signaling and suggest that cellular levels of TRAF 1 may play an important role in modulating the degradation of TRAF 2 and TRAF 3 in response to signals from the TNFR superfamily . . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Signaling via a CD 40 mutant that does not bind TNFR associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 rescued B cells from CD 95 induced apoptosis . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
In mammalian cells , TNAP physically interacts with NIK , TRAF 2 , and TRAF 3 but not IKK 1 or IKK 2 . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
The CD 40 receptor and the Epstein Barr virus oncoprotein LMP 1 are both members of the TNF receptor family and share several signaling mediators , including TRAF 2 and TRAF 3 . ^^^ Previous publications have suggested that both TRAF 2 and TRAF 3 move into lipid rafts upon LMP 1 expression or CD 40 activation , whereas their proteolysis is only enhanced by CD 40 . ^^^ We therefore investigated TRAF 2 and TRAF 3 modifications induced by CD 40 and LMP 1 signaling in a panel of human cell lines of lymphoid and epithelial origins . ^^^ Upon CD 40 stimulation , a marked redistribution of TRAF 2 into the buoyant raft fraction was observed in all cell lines and was often associated with a similar redistribution of TRAF 3 . ^^^ Moreover parallel changes in subcellular distribution of TRAF 2 and TRAF 3 were recorded by electron microscopy . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Some TRAF proteins , such as TRAF 2 and TRAF 3 , have recently been shown to have a positive role in the canonical pathway that activates nuclear factor kappaB ( NF kappaB ) through IkappaB kinase beta ( IKKbeta ) , but a negative role in the noncanonical pathway that activates NF kappaB through IKKalpha . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
In these cells , LIGHT causes the recruitment of TRAF 2 , TRAF 3 , and IkappaB kinase into the LTbetaR complex . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
Foamy cells positive for the DEC 205 marker also expressed high levels of TNFR associated factor 1 ( TRAF 1 ) , TRAF 2 , and TRAF 3 , markers associated with resistance to apoptosis . ^^^
Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: Q13114 and Q12933	Pubmed	SVM Score :0.0
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