| Interacting proteins: Q12851 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Activation of stress activated protein kinase / c Jun N terminal kinase , but not NF kappaB , by the tumor necrosis factor ( TNF ) receptor 1 through a TNF receptor associated factor 2 and germinal center kinase related dependent pathway . ^^^ |
|
| Interacting proteins: Q12851 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Comparing early and late stage melanoma cells revealed low expression of TRAF 2 and GCK in early stage melanoma , which coincided with poor resistance to UV induced , TNF mediated apoptosis ; forced expression of GCK alone or in combination with TRAF 2 efficiently increased JNK and NF kappaB activities , which coincided with increased protection against apoptosis . ^^^ Conversely , forced expression of the dominant negative form of TRAF 2 or GCK in late stage melanoma cells reduced NF kappaB activity and decreased Fas expression , resulting in a lower degree of UV induced , Fas mediated cell death . ^^^ |
|
| Interacting proteins: Q12851 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Although the TRAF 2 TRAF domain binds ASK 1 , GCK , and the highly related kinase GCKR , the RING finger domain is needed for their activation . ^^^ |
|
| Interacting proteins: Q12851 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Germinal center kinase couples TRAF 2 to mitogen activated protein kinase / ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen activated protein kinase kinase kinase upstream of MKK 6 and p 38 . ^^^ We show that the human SPS 1 homologue germinal center kinase ( GCK ) can interact in vivo with the TNFR 1 signal transducer TNFR associated factor 2 ( TRAF 2 ) and with MAPK / ERK kinase kinase 1 ( MEKK 1 ) , a MAPK kinase kinase ( MAPKKK ) upstream of the SAPKs , thereby coupling TRAF 2 to the SAPKs . ^^^ |
|
| Interacting proteins: Q12851 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TNF mediated activation of the stress activated protein kinase pathway : TNF receptor associated factor 2 recruits and activates germinal center kinase related . ^^^ TRAF 2 is a potent activator of a 95 kDa serine / threonine kinase termed germinal center kinase related ( GCKR , also referred to as KHS 1 ) , which signals activation of the SAPK pathway . ^^^ |
|
| Interacting proteins: Q12851 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TRAF 2 and TANK individually formed weak interactions with germinal center kinase ( GCK ) related kinase ( GCKR ) . ^^^ |
|
| Interacting proteins: Q12851 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Recombinant forms of MAP3K MEK kinase 1 ( MEKK 1 ) interact in vivo and in vitro with the STE 20 protein homologue germinal center kinase ( GCK ) , and both GCK and MEKK 1 associate in vivo with the adapter protein tumor necrosis factor ( TNF ) receptor associated factor 2 ( TRAF 2 ) . ^^^ |
|
| Interacting proteins: Q12851 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Here we describe the cloning and characterization of a novel GCK family kinase , Traf 2 and Nck interacting kinase ( TNIK ) that interacts with both Traf 2 and Nck . ^^^ |
|
| Interacting proteins: Q12851 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|