| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.51298685 |
| Taken together , our results indicate that TRAF 2 and TRAF 5 directly interact with CD 30 and are involved in NFkappaB activation by CD 30 signaling . . 0.51298685^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.60510063 |
| In this study , using isothermal titration calorimetry ( ITC ) , we report thermodynamic characterization of the interaction between TRAF 2 and monomeric peptide sequences from TNFR members , including TNFR 2 , CD 40 , CD 30 , Ox 40 , and 4 1BB , and the Epstein Barr virus ( EBV ) transforming protein , latent infection membrane protein 1 ( LMP 1 ) . 0.60510063^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Using the yeast two hybrid system , we have identified that the same region of CD 30 interacts with tumor necrosis factor receptor associated factor ( TRAF ) 1 and TRAF 2 . ^^^ |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| We performed a yeast two hybrid library screen with the cytoplasmic domain of CD 30 and isolated multiple independent cDNAs encoding human tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and CRAF 1 ( TRAF 3 ) . ^^^ The ability of TRAF 1 , TRAF 2 , and CRAF 1 to associate with CD 30 was confirmed using an in vitro coprecipitation assay , further demonstrating that the interaction was specific and direct . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that TRAF 2 also plays an important role in CD 30 induced NF kappa B activation . ^^^ We also show that TRAF 2 mediated activation of NF kappa B plays a role in the activation of HIV transcription induced by CD 30 cross linking . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 interact in vivo with the CD 30 cytoplasmic domain ; TRAF 2 mediates CD 30 induced nuclear factor kappa B activation . ^^^ |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Induction of nuclear factor kappaB by the CD 30 receptor is mediated by TRAF 1 and TRAF 2 . ^^^ Coexpression of CD 30 with TRAF 1 or TRAF 2 but not TRAF 3 augmented NF kappaB activation through domain 2 but not domain 1 . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| CD 30 induction of human immunodeficiency virus gene transcription is mediated by TRAF 2 . ^^^ In this study , we report that two members of the TNFR associated factor ( TRAF ) family of proteins , TRAF 1 and TRAF 2 , independently bind to the intracellular domain of CD 30 ( CD30IC ) . ^^^ Moreover , dominant negative mutants consisting of the TRAF domain of TRAF 1 and TRAF 2 inhibited CD 30 induction of NF kappaB activation and HIV 1 transcription . ^^^ These results suggest that CD 30 ligation may enhance the expression of HIV via TRAF 2 mediated activation of NF kappaB . . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| CD 30 dependent degradation of TRAF 2 : implications for negative regulation of TRAF signaling and the control of cell survival . ^^^ During CD 30 signal transduction , we found that binding of TRAF 2 to the cytoplasmic domain of CD 30 results in the rapid depletion of TRAF 2 and the associated protein TRAF 1 by proteolysis . ^^^ These data suggest a model in which CD 30 limits its own ability to transduce cell survival signals through signal coupled depletion of TRAF 2 . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 interact in vivo with the CD 30 cytoplasmic domain ; TRAF 2 mediates CD 30 induced nuclear factor kappa B activation . ^^^ TRAF 2 has been previously shown to have a unique role in TRAF mediated NF kappa B activation , and NF kappa B activation following CD 30 cross linking was blocked by a dominant negative TRAF 2 mutant . ^^^ These data indicate that CD 30 cross linking induced NF kappa B activation is predominantly TRAF 2 mediated . . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Reporter gene assays using deletion and mutant constructs of CD 30 revealed that the D 1 subdomain is sufficient for NFkappaB activation , without interaction with TRAF 2 or 5 , and that each subdomain alone can activate NFkappaB . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| This amino acid alignment contains the EEEG sequence , which is essential for interaction of CD 30 or CD 40 with TRAFs ( TRAF 1 and TRAF 2 , but not TRAF 3 ) , and also contains the PIQED sequence , which is similar to PXQXT that is known to be necessary for interaction of TNF receptor 2 and CD 30 with TRAFs ( TRAF 1 , 2 , and 3 ) . . ^^^ |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| The intracellular tail of IL 15Ralpha shows sequence homologies to the TRAF 2 binding motifs of CD 30 and CD 40 . ^^^ |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Crystal structures of the TRAF domain of human TRAF 2 in complex with peptides from the TNFR family members CD 40 , CD 30 , Ox 40 , 4 1BB , and the EBV oncoprotein LMP 1 revealed a conserved binding mode . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TNFR associated factor 2 ( TRAF 2 ) expression was down regulated in CD 30 ( + ) cells , and addition of anti TNF alpha Ab significantly reduced apoptosis in the CD 30 ( + ) but not the CD 30 ( ) population . ^^^ These observations support the hypothesis that increased IL 4 expression in M . tuberculosis activated lymphocytes promotes CD 30 expression , which sensitizes the lymphocytes to TNF alpha mediated apoptosis via TRAF 2 depletion . ^^^ |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Activation of CD 30 led to the induction of apoptotic death of ALCL cells , along with the selective reduction of TNF receptor associated factor 2 and impairment in the ability of these cells to activate the pro survival transcription factor nuclear factor kappa B ( NF kappa B ) . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| We report that in H RS cells overexpression of CD 30 leads to self aggregation , recruitment of TRAF 2 and TRAF 5 , and NF kappaB activation , independent of CD 30 ligand . ^^^ |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| TCR independent CD 30 mediated IL 13 release correlated with activation of c Jun N terminal kinase , p 38 mitogen activated protein kinase ( MAPK ) , and NF kappaB , and was completely inhibited by the expression of a TNFR associated factor 2 ( TRAF 2 ) dominant negative transgene ( TRAF2 . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| Hence , like CD 30 , the CD 40 cytoplasmic tail contains two distinct and functionally important TRAF 2 binding sites . . ^^^ |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| When overexpressed , PIAS 3 inhibits NF kappaB dependent transcription induced by treatment with tumor necrosis factor alpha ( TNF alpha ) or interleukin 1beta or by overexpression of TNF family receptors such as RANK , TNFR 1 , and CD 30 or signal transducers of TNF receptor associated factors ( TRAFs ) , including TRAF 2 , TRAF 5 , and TRAF 6 . ^^^ |
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| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| T cell prolymphocytes did not express cytotoxic granule proteins or NK cell markers , were CD5+ , CD45RO+ like normal spleen T cells , were CD2+ , CD3+ , CD45+ , CD43+ , TCRbeta+ , but CD 25 , CD 30 , ALK 1 , TRAP , DBA 44 , and TdT . ^^^ |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P28908 and Q12933 |
Pubmed |
SVM Score :0.0 |
| NA |
|