Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
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Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NA
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Furthermore , the dominant negative NESK mutant inhibited the JNK activation induced by TNF alpha or TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) and TNF receptor associated factor 2 protein were moderately down regulated . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The mutated form TNFR 2 ( 196ARG ) shows a reduction of inducible TRAF 2 recruitment upon TNF alpha stimulation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In addition , we show that the activation of Tpl 2 by TNF alpha depends on signals transduced by both TRAF 2 and RIP 1 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In the TNF alpha pathway , Rip 1 interacts with the E 3 ubiquitin ligase Traf 2 and is modified by polyubiquitin chains . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Spin trap protection from tumor necrosis factor cytotoxicity . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
ATAR , a novel tumor necrosis factor receptor family member , signals through TRAF 2 and TRAF 5 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) receptor 1 signaling downstream of TNF receptor associated factor 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Caveolin 1 associates with TRAF 2 to form a complex that is recruited to tumor necrosis factor receptors . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
CD 40 signaling through a newly identified tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) binding site . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF Peer Assistance Program : when Judy fell , she did n ' t know it was into a trap . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TANK , a co inducer with TRAF 2 of TNF and CD 40L mediated NF kappaB activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF receptor associated factor 2 ( TRAF 2 ) was identified as an interacting protein in both screens . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The TNF receptor family member CD 27 signals to Jun N terminal kinase via Traf 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF receptor associated factor 2 binding site is involved in TNFR 75 dependent enhancement of TNFR 55 induced cell death . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
A mammalian homolog of Drosophila schnurri , KRC , regulates TNF receptor driven responses and interacts with TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Role of TNF receptor associated factor 2 in the activation of IgM secretion by CD 40 and CD120b . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Trx induced ASK 1 ubiquitination / degradation could be blocked by ASK 1 activators TNF and TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Cutting edge : profound defect in T cell responses in TNF receptor associated factor 2 dominant negative mice . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Endogenous TAB 3 interacts with TRAF 6 and TRAF 2 in an IL 1 and a TNF dependent manner , respectively . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 mediates activation of the transcription factors NF kappaB and AP 1 by TNF . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The data show that TNF decreased RANKL induced expression of the osteoclast markers , TRAP and cathepsin K . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
A region of CRAF 1 was similar to the TNF alpha receptor associated factors TRAF 1 and TRAF 2 and so defined a shared TRAF C domain that was necessary and sufficient for CD 40 binding and homodimerization . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Starting with methionine 113 of full length TRAP , sTRAP lacks the transmembrane region and a part of the extracellular domain but contains the entire TNF alpha homology region and can , therefore , bind to CD 40 . ^^^ TNF alpha , Fas / APO 1 ligand ) , TRAP thus has the potential to be biologically active not only in a transmembrane form but also as a soluble molecule . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Spontaneous apoptosis of dendritic cells is efficiently inhibited by TRAP ( CD 40 ligand ) and TNF alpha , but strongly enhanced by interleukin 10 . ^^^ IL 10 strongly reduced mLC viability , whereas TRAP and TNF alpha facilitated the survival of mLC . ^^^ IL 10 led to an earlier onset of DNA fragmentation , whereas TRAP and TNF alpha delayed internucleosomal DNA cleavage . ^^^ TNF alpha and TRAP , in contrast , reduced engulfment of mLC by macrophages . ^^^ Interestingly , IL 10 , even at low concentrations , reverted the effects of TNF alpha and TRAP in inhibiting mLC apoptosis . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We have developed a technique to investigate osteocyte gene expression in vivo , using the reverse transcriptase linked polymerase chain reaction ( PCR ) , and have shown that they express mRNA for beta actin ( beta ACT ) , osteocalcin ( OC ) , connexin 43 ( Cx 43 ) , insulin like growth factor 1 ( IGF 1 ) , c fos and c jun , but not tumor necrosis factor alpha ( TNF alpha ) or tartrate resistant acid phosphatase ( TRAP ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Our findings show that : ( 1 ) TNF RII is able to activate two members of the MAP kinase family : extracellular regulated kinase ( ERK ) and c jun N terminal kinase ( JNK ) ; ( 2 ) TRAF 2 , a molecule that binds TNF RII and associates indirectly with TNF RI , is sufficient to activate JNK upon overexpression ; ( 3 ) dominant negative TRAF 2 blocks TNF alpha mediated JNK activation and ( 4 ) TRAF 2 signals the activation of JNK and NF kappaB through different pathways . ^^^ Our findings suggest that TNF alpha mediated JNK activation in fibroblasts is independent of the cell death pathway and that TRAF 2 occupies a key role in TNF receptor signaling to JNK . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
This report analyzes the gene expression of bcl xs , bcl xl , bax alpha , bax beta , fadd , fas , fas ligand ( fas L ) , ice , TNF alpha , TNF beta , TNFR 1 , TNFR 2 , TRAF 1 , TRAF 2 , TRAF 3 , cIAP 2 , and tradd at the level of mRNA in the single Reed Sternberg cells and their variants . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF alpha may also play a role in the recruitment of osteoclasts because TRAP positive osteoclasts appeared after TNF alpha expression . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
However , plasma membrane proximal elements in these proinflammatory cytokine pathways are apparently not involved since dominant negative mutants of the TRAF 2 and TRAF 6 adaptors , which effectively block signaling through the cytoplasmic tails of the TNF alpha and IL 1 receptors , respectively , do not inhibit Tax induction of NF kappaB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF alpha signaling involves the recruitment of at least three proteins ( TRADD , RIP , and TRAF 2 ) to the type 1 TNF alpha receptor tail , leading to the sequential activation of the downstream NF kappaB inducing kinase ( NIK ) and IkappaB specific kinases ( IKKalpha and IKKbeta ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
These findings indicate that the NF kappaB and TRAF 2 pathways activate independent antiapoptotic mechanisms which act in concert to suppress the proapoptotic signals induced by TNF alpha . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF receptor associated factor 2 is involved in both IL 1 beta and TNF alpha signaling cascades leading to NF kappa B activation and IL 8 expression in human intestinal epithelial cells . ^^^ Cytokine signaling involves the participation of many adaptor proteins , including the docking protein TNF receptor associated factor 2 ( TRAF 2 ) , which is believed to transmit the TNF alpha signal through both the 1 kappa B / NF kappa B and c Jun N terminal kinase ( JNK ) / stress related protein kinase ( SAPK ) pathways . ^^^ We characterized the effect of a dominant negative TRAF 2 delivered by an adenoviral vector ( Ad5dnTRAF 2 ) on the cytokine signaling cascade in several IEC and also investigated whether inhibiting the TRAF 2 transmitting signal blocked TNF alpha induced NF kappa B and IL 8 gene expression . ^^^ We concluded that TRAF 2 is partially involved in TNF alpha mediated signaling through 1 kappa B / NF kappa B in IEC . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The TNF alpha and IL 1 signals are transduced through TRAF 2 and TRAF 6 , respectively . ^^^ Oligomerization of the TRAF 2 effector domain results in specific binding to MEKK 1 , a protein kinase capable of JNK , p 38 , and IKK activation , and induction of TNF alpha and IL 1 responsive genes . ^^^ TNF alpha also enhances the binding of native TRAF 2 to MEKK 1 and stimulates the kinase activity of the latter . ^^^ Thus , TNF alpha and IL 1 signaling is based on oligomerization of TRAF 2 and TRAF 6 leading to activation of effector kinases . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Death deflected : IL 15 inhibits TNF alpha mediated apoptosis in fibroblasts by TRAF 2 recruitment to the IL 15Ralpha chain . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NF kappaB was activated after the stimulation of TRAP , bFGF , and TNF alpha in electrophoretic mobility shift assay , and E 5510 suppressed the NF kappaB activation induced by TRAP and bFGF but not the activation by TNF alpha . ^^^ The phosphorylation of ERK1 / 2 was rapidly induced by TRAP and bFGF but not by TNF alpha . ^^^ These results indicate that TRAP and bFGF induced 1 kappaB degradation and NF kappaB activation through a distinct pathway from TNF alpha and that ERK1 / 2 may play an important role in NF kappaB activation induced by TRAP and bFGF . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) receptor ( TNFR ) associated factors 1 and 2 ( TRAF 1 and TRAF 2 ) and inhibitor of apoptosis proteins cIAP 1 ( MIHB ) and cIAP 2 ( MIHC ) were recently identified as proteins that associate with the TNF alpha receptors TNFRI ( p 55 ) and TNFRII ( p 75 ) and inhibit TNF alpha induced programmed cell death or apoptosis . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
This study revealed that TNF alpha directly induced the formation of tartrate resistant acid phosphatase ( TRAP ) positive multinucleated cells ( MNCs ) , which produced resorption pits on bone in vitro in the presence of M CSF . ^^^ The osteoclast progenitors expressed TNF receptors , p 55 and p 75 ; and the induction of TRAP positive MNCs by TNF alpha was inhibited completely by an anti p 55 antibody and partially by an anti p 75 antibody . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In transfected cells , TTRAP inhibits in a dose dependent manner the transcriptional activation of a nuclear factor kappaB ( NF kappaB ) dependent reporter mediated by CD 40 , TNF R 75 or Phorbol 12 myristate 13 acetate ( PMA ) and to a lesser extent by TRAF 2 , TRAF 6 , TNF alpha , or interleukin 1beta ( IL 1beta ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Examination of Stat 1 deficient cells showed an apparent increase in TNF alpha induced TRADD RIP and TRADD TRAF 2 complex formation , while interaction between TRADD and FADD was unaffected . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Moreover , the transducing molecule TRAF 2 co immunoprecipitates with IL 15Ralpha and may be deflected to TNFRI using anti IL 15 blocking mAbs and TNF alpha . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Both signals were partially dependent upon induction of TNF alpha and IL 6 , and the cytoplasmic adaptor molecule TNF receptor associated factor 2 is involved in both R 848 and CD 40 mediated differentiation . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNFR associated factor 2 ( TRAF 2 ) expression was down regulated in CD 30 ( + ) cells , and addition of anti TNF alpha Ab significantly reduced apoptosis in the CD 30 ( + ) but not the CD 30 ( ) population . ^^^ These observations support the hypothesis that increased IL 4 expression in M . tuberculosis activated lymphocytes promotes CD 30 expression , which sensitizes the lymphocytes to TNF alpha mediated apoptosis via TRAF 2 depletion . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 is required for TNF alpha mediated activation of c Jun N terminal kinase ( JNK ) , contributes to activation of NF kappaB , and mediates anti apoptotic signals , . ^^^ Here we show that binding of TNF alpha to TNF RII induces ubiquitination and proteasomal degradation of TRAF 2 . ^^^ Moreover , E 3 defective c IAP 1 prevented TNF alpha induced TRAF 2 degradation and inhibited apoptosis . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The 25 % stretch also caused sustained clustering of tumor necrosis factor alpha ( TNF alpha ) receptor 1 and its association with TNF alpha receptor associated factor 2 ( TRAF 2 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Thus , to investigate the molecular mechanism involved in the unresponsiveness of these cell clones to TNF alpha induced apoptosis , we examined the effect of TNF alpha on the expression of antiapoptotic proteins , including TNF receptor associated factor ( TRAF ) 1 , TRAF 2 , cellular inhibitor of apoptosis protein ( cIAP ) 1 , and cIAP 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Moreover , preincubation of HUVEC with 10 ng / mL TcdB 10463 reduced TNF alpha related expression of interleukin 8 ( IL 8 ) , TNF receptor associated factor 2 ( TRAF 2 ) , and human inhibitor of apoptosis protein 1 ( hIAP 1 ) mRNA . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF alpha ) and actinomycin D treatment results in accelerated TRAF 2 degradation in wild type mouse embryo fibroblasts ( MEFs ) , as compared with Siah 2 ( / ) cells . ^^^ Apoptosis induced by TNF alpha and actinomycin D treatment is increased upon expression of Siah 2 , or attenuated upon expression of TRAF 2 or RING mutant Siah 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
However , NFkappaB stimulation by AII differs from that of TNF alpha since a TNF receptor associated factor 2 ( TRAF 2 ) dominant negative mutant does not prevent AII mediated NFkappaB activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Furthermore , expression of dn TNF alpha receptor associated factor 2 ( TRAF 2 ) , but not dnTRAF 6 , inhibited TNF alpha signal transduction . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Here we show that the PAR 4 agonist peptide ( PAR4AP , GYPGKF ) , but not the PAR1AP ( TRAP , SFLLRN ) , induced tumor necrosis factor alpha ( TNF alpha ) production not only in cultured murine microglial cells in vitro but also in rat cortex in vivo . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Both TNF alpha and TRAF 2 mediated nuclear factor kappaB ( NF kappaB ) activations were inhibited by NS5A TRAF 2 interaction . ^^^ Using in vitro kinase assay , we have found that NS5A protein synergistically activated both TNF alpha and TRAF 2 mediated JNK in human embryonic kidney 293T cells . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The TNF alpha but not IL 1beta induced Ser 536 phosphorylation was severely impaired in murine embryonic fibroblasts derived from traf 2 / traf 5 / mice . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
PURPOSE : Tumor necrosis factor alpha ( TNF alpha ) exerts apoptosis throughout an intracellular transduction pathway that involves the protein kinases TRAF 2 ( integration point of apoptotic and survival signals ) , signal regulating kinase ( ASK 1 ) ( pro apoptotic protein ) , mitogen activated protein kinase kinase 4 ( MEK 4 ) ( p 38 activator and metastasis suppressor gene ) , Jun N terminal kinase ( JNK ) ( stress mitogen activated protein kinase ) and the transcription factor activator protein 1 ( AP 1 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The cytokine tumor necrosis factor alpha ( TNF alpha ) stimulates the NF kappaB , SAPK / JNK , and p 38 mitogen activated protein ( MAP ) kinase pathways by recruiting RIP 1 and TRAF 2 proteins to the tumor necrosis factor receptor 1 ( TNFR 1 ) . ^^^ In transfection studies , RIP 1 and TRAF 2 stimulate p 38 MAP kinase activation , and dominant negative forms of RIP 1 and TRAF 2 inhibit TNF alpha induced p 38 MAP kinase activation . ^^^ We found TNF alpha induced p 38 MAP kinase activation and interleukin 6 ( IL 6 ) production impaired in rip 1 ( / ) murine embryonic fibroblasts ( MEF ) but unaffected in traf 2 ( / ) MEF . ^^^ These studies suggest that TNF alpha induced activation of p 38 MAP kinase and SAPK / JNK pathways bifurcate at the level of RIP 1 and TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Ebselen inhibited TNF alpha induced TNF receptor associated factor 2 ( TRAF 2 ) ASK 1 complex formation and phosphorylation of stress activated protein kinase ERK kinase 1 ( SEK 1 ) , which is an upstream signaling molecule of JNK . ^^^ These findings suggest that ebselen prevents TNF alpha induced EC activation through the inhibition of TRAF 2 ASK1 SEK 1 signaling pathway , which leads to JNK activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In the absence of Traf 2 , TNF alpha induced ubiquitination of Rip 1 is impaired , suggesting that Traf 2 may be the E 3 ubiquitin ligase responsible for the TNF alpha dependent , ubiquitination of Rip 1 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The NF kappa B induced antiapoptotic proteins , iNOS and TRAF 2 , had decreased message at 9 and 12 hours , respectively , in TNF alpha and AdI kappa B treated cells . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In addition , TRAF 2 and TRAF 6 appear to be differentially involved in NF kappaB dependent induction of CYLD by TNF alpha and NTHi . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
First , reverse transcriptase polymerase chain reactions ( RT PCR ) were carried out to detect the mRNA encoding receptor activator of NF kappaB ( RANK ) , RANK ligand ( RANKL ) , osteoprotegerin ( OPG ) , tumour necrosis factor alpha ( TNF alpha ) , interleukin ( IL ) 1beta , IL 6 and the osteoclast markers tartrate resistant acid phosphatase ( TRAP ) and cathepsin K . ^^^ In real time PCR , the expression levels of TNF alpha , IL 1beta , IL 6 , RANKL , TRAP and cathepsin K mRNA increased , whereas the expression levels of RANK and OPG were unchanged and decreased respectively . ^^^ Quantitative real time PCR showed that TNF alpha , RANK and TRAP mRNA expression did not change significantly with time , and that IL 1beta and cathepsin K changed slightly compared with those in the synovium . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
GGTI 2166 inhibited TRAP activity induced by RANKL or TNF alpha in both cell cultures and prevented the incorporation of [ 3H ] all trans geranylgeraniol into prenylated proteins in RAW cells . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Here we report that eIF4GI , which is a scaffold protein interacting with many translation factors , interacts with TRAF 2 , a signaling molecule that plays a key role in activation of NF kappaB through TNF alpha . ^^^ Moreover , TRAF 2 is absent from TNFR 1 complexes under stress conditions even after TNF alpha treatment . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 is essential for TNF alpha induced osteoclastogenesis . ^^^ Using this system , we showed that TRAF 2 is required for TNF alpha induced osteoclastogenesis . ^^^ Because TRAF 2 deficient mice show embryonic lethality , it has remained unclear whether TRAF 2 is crucial in RANKL or TNF alpha induced osteoclastogenesis . ^^^ To examine the involvement of TRAF 2 in osteoclast differentiation , we cultured osteoclast progenitors from TRAF 2 deficient and wildtype mice with soluble RANKL or TNF alpha in the presence of M CSF , and counted the number of TRACP ( + ) multinucleate cells formed . c jun N terminal kinase ( JNK ) and NF kappaB activation in osteoclast progenitors was examined by Western blot analysis and electrophoretic mobility shift assay , respectively . ^^^ RANKL induced osteoclastogenesis gave a reduction of 20 % in the progenitors from TRAF 2 deficient mice compared with that of the cells from littermate wildtype mice , whereas TNF alpha induced osteoclastogenesis was severely impaired in the cells from the TRAF 2 deficient mice . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF alpha upregulated expression of TRAF 1 , TRAF 2 , c IAP 1 , c IAP 2 , c FLIP , and A 1 . ^^^ TRAF 1 , c FLIP , and to a lesser extent c IAP 2 protein levels were increased by TNF alpha in a time dependent manner , whereas c IAP 1 , survivin , Bcl 10 ( L ) , and TRAF 2 protein levels were not influenced by TNF alpha treatment at any time point tested . ^^^ Overexpression of mutant IkappaB blocked TNF alpha induced TRAF 1 , TRAF 2 , c IAP 1 , c IAP 2 , c FLIP , and A 1 gene expression and downregulated TRAF 1 protein levels . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF alpha induced c IAP1 / TRAF2 complex translocation to a Ubc 6 containing compartment and TRAF 2 ubiquitination . ^^^ Furthermore , Ubc 6 co localized with translocated TRAF2 / c IAP 1 in the ER associated compartment in vivo , and a catalytically inactive Ubc 6 mutant inhibited TNF alpha induced , TNF R 2 dependent TRAF 2 degradation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Plasma nitrotyrosine , plasma malondialdehyde ( MDA ) , oxidised LDL ( oxLDL ) , plasma total radical trapping antioxidant parameter ( TRAP ) , IL 6 , IL 18 , TNF alpha , plasma glucose and insulin were measured . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The analysed factors included TNF alpha , TNFR 1 , TNF receptor associated death domain ( TRADD ) , caspase 3 , caspase 8 , TNF receptor associated factor 2 ( TRAF 2 ) and receptor interactive protein ( RIP ) , all of which are involved in the TNF alpha / TNFR 1 signalling pathway mediated apoptosis . ^^^ The quantitative RT PCR indicated that the infected muscle tissues up regulate the expression of pro apoptosis genes ( TNF alpha , TNFR 1 and TRADD , caspase 3 and caspase 8 ) , and anti apoptosis genes ( TRAF 2 and RIP ) at the beginning of cyst formation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Using a salicylate trap method , we observed that only simultaneous exposure of endothelial cells to iron and TNF alpha accelerated hydroxyl radical production . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF alpha stimulates the JNK , ERK , and p 38 mitogen activated protein kinases and the NF kappaB pathway by recruiting RIP 1 and TRAF 2 to the TNF receptor 1 . ^^^ Here we showed that Tpl 2 activation by TNF alpha signals depends on the integrity of the Tpl 2 interacting proteins RIP 1 and TRAF 2 , which are required for the engagement of the ERK mitogen activated protein kinase pathway . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Our findings indicate that : ( 1 ) EM reduced UHMWPE induced tissue inflammation , including the diminished pouch membrane thickness , reduced inflammatory cellular infiltration , and lowered IL 1beta and TNF alpha expression ( mRNA and protein ) ; ( 2 ) EM inhibited UHMWPE induced osteoclastogenesis , with reduced gene activation of RANK , RANKL , and CPK , and diminished RANKL expression in UHMWPE stimulated pouches , and ( 3 ) EM markedly reduced the number of TRAP ( + ) cells in pouch tissues , and protected against bone collagen depletion . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We recently reported that NS5A protein interacts with TRAF 2 and modulates tumor necrosis factor alpha ( TNF alpha ) induced NF kappaB and Jun N terminal protein kinase ( JNK ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Further studies suggest that ER stress induces down regulation of TRAF 2 expression , which impairs TNF alpha induced activation of NF kappaB and c Jun N terminal kinase and turns TNF alpha from a weak to a powerful apoptosis inducer . ^^^ Thus , ER stress induces two signals , namely TNF alpha induction and TRAF 2 down regulation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Conversely , silencing of GSTP 1 1 expression through RNA interference ( RNAi ) resulted in increase of TNF alpha dependent TRAF 2 ASK1 association followed by hyper activation of ASK 1 and JNK . ^^^ These findings indicate that GSTP 1 1 plays an important regulatory role in TNF alpha induced signaling by forming ligand binding interactions with TRAF 2 , which provides a new insight for analysing the protective effects of GSTP 1 1 in tumor cells . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
These findings suggest that TRUSS activates JNK in a TRAF 2 dependent fashion and is involved in TNF alpha induced AP 1 activation via JNK kinases . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The generation of the anti apoptotic signal on binding of TNF alpha to the TNF receptor ( TNFR ) 1 has been shown to be associated with the recruitment of TRAF 2 to the TNFR 1 in a process that requires ubiquitination of TRAF 2 with lysine 63 linked polyubiquitin chains . ^^^ We found that TNF alpha stimulation of JAB 1 siRNA transfected RA FLSs failed to stimulate ubiquitination of TRAF 2 . ^^^ Thus , we conclude that JAB 1 regulated ubiquitination of TRAF 2 is a novel mechanism whereby TNF alpha can induce anti apoptosis signaling and production of matrix metalloproteinases through activation of nuclear factor kappaB and JNK in RA FLSs . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The constitutive expression of mRNA for TNF alpha receptors ( TNFR 1 and TNFR 2 ) and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) , and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase PCR ( RT PCR ) in PBMCs from control and RA cases . ^^^ PBMCs of RA patients showed a significant increase in TNF alpha and TNFR 1 expression as compared with that from control subjects along with significantly increased constitutive expression of TRADD , RIP , and TRAF 2 mRNA . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The C terminus possesses substantial homology to the tumor necrosis factor receptor associated factor ( TRAF ) domain that is found in two proteins ( TRAF 1 and TRAF 2 ) that associate with the cytoplasmic domain of the related 75 kDa tumor necrosis factor receptor . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
LAP 1 is homologous to a murine protein , tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , implicated in growth signaling from the p 80 TNFR . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We have identified a novel molecule expressed on the surface of activated T cells , which was designated TRAP ( Tumor necrosis factor Related Activation Protein ) , and could demonstrate that TRAP is a ligand for the CD 40 receptor expressed on B cells . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Baboons were administered the spin trap , 5 , 5 dimethyl 1 pyrroline N oxide ( DMPO ) during infusions of live Escherichia coli ( E . coli ) with or without challenge with tumor necrosis factor ( TNF ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Using the yeast two hybrid system , we have identified that the same region of CD 30 interacts with tumor necrosis factor receptor associated factor ( TRAF ) 1 and TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
As MIHB and MIHC were able to bind to the tumor necrosis factor receptor associated factors TRAF 1 and TRAF 2 in yeast two hybrid assays , these results suggest that IAP proteins that inhibit apoptosis may do so by regulating signals required for activation of ICE like proteases . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We performed a yeast two hybrid library screen with the cytoplasmic domain of CD 30 and isolated multiple independent cDNAs encoding human tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and CRAF 1 ( TRAF 3 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 1 and TRAF 2 form an oligomeric complex that associates with the cytoplasmic domains of various members of the tumor necrosis factor ( TNF ) receptor superfamily . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Computer analysis showed that p 97 is very similar to type 1 tumor necrosis factor ( TNF ) receptor associated protein ( TRAP ) 2 and 55 . 11 , both of which were identified recently as binding proteins of the cytoplasmic domain of type 1 TNF receptor by yeast two hybrid screening . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The tumor necrosis factor receptor 2 signal transducers TRAF 2 and c IAP 1 are components of the tumor necrosis factor receptor 1 signaling complex . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 interact in vivo with the CD 30 cytoplasmic domain ; TRAF 2 mediates CD 30 induced nuclear factor kappa B activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Interaction of the p 55 tumor necrosis factor receptor 1 ( TNF R 1 ) associated signal transducer TRADD with FADD signals apoptosis , whereas the TNF receptor associated factor 2 protein ( TRAF 2 ) is required for activation of the nuclear transcription factor nuclear factor kappa B . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor associated factor ( TRAF ) 5 and TRAF 2 are involved in CD 30 mediated NFkappaB activation . ^^^ The two conserved subdomains , D 1 and D 2 , in the C terminal cytoplasmic region of CD 30 were tested for interaction with two tumor necrosis factor receptor associated factor ( TRAF ) proteins with NFkappaB activating capacity , TRAF 2 and TRAF 5 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor ( TNFR ) associated factor 2 ( TRAF 2 ) and TRAF 1 were found as components of the TNFR 2 signaling complex , which exerts multiple biological effects on cells such as cell proliferation , cytokine production , and cell death . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) mediated kinase cascades : bifurcation of nuclear factor kappaB and c jun N terminal kinase ( JNK / SAPK ) pathways at TNF receptor associated factor 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 is believed to mediate the activation of NF kappaB and JNK induced by the tumor necrosis factor receptor ( TNFR ) superfamily , which elicits pleiotropic responses in lymphocytes . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Activation of stress activated protein kinase / c Jun N terminal kinase , but not NF kappaB , by the tumor necrosis factor ( TNF ) receptor 1 through a TNF receptor associated factor 2 and germinal center kinase related dependent pathway . ^^^ A key step by which tumor necrosis factor ( TNF ) signals the activation of nuclear factor kappaB ( NF kappaB ) and the stress activated protein kinase ( SAPK , also called c Jun N terminal kinase or JNK ) is the recruitment to the TNF receptor of TNF receptor associated factor 2 ( TRAF 2 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 interact in vivo with the CD 30 cytoplasmic domain ; TRAF 2 mediates CD 30 induced nuclear factor kappa B activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Here , we provide biochemical evidence that exposure of keratinocytes to UVB causes rapid association of tumor necrosis factor ( TNF ) receptor 1 with its downstream partner TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor ( TNFR ) associated factor 2A ( TRAF2A ) , a TRAF 2 splice variant with an extended RING finger domain that inhibits TNFR 2 mediated NF kappaB activation . ^^^ We describe here the identification and characterization of tumor necrosis factor receptor ( TNFR ) associated factor 2A ( TRAF2A ) , a splice variant of the TRAF 2 molecule utilized for signal transduction by members of the TNFR family . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We found that tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 , all interacted with the cytoplasmic domain of 4 1BB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In vitro binding experiments showed that tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , TRAF 3 , and TRAF 5 but not TRAF 4 associated with glutathione S transferase OX 40 fusion protein . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
CD 27 , a member of the tumor necrosis factor receptor superfamily , activates NF kappaB and stress activated protein kinase / c Jun N terminal kinase via TRAF 2 , TRAF 5 , and NF kappaB inducing kinase . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
CD 28 independent , TRAF 2 dependent costimulation of resting T cells by 4 1BB ligand . 4 1BB ligand ( 4 1BBL ) is a member of the tumor necrosis factor ( TNF ) family expressed on activated antigen presenting cells . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) induced activation of the c jun N terminal kinase ( JNK , also known as SAPK ; stress activated protein kinase ) requires TNF receptor associated factor 2 ( TRAF 2 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In addition , the presence of CD 4 , CD 8 , CD 20 , IL 6 , tumor necrosis factor alpha , tartrate resistant acid phosphatase ( TRAP ) , matrix metalloproteinase 1 ( MMP 1 ) , and MMP 9 positive cells was confirmed by immunohistochemical staining . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Recent data involving traf 2 knockout mice have suggested a necessity of the protein in viability of skeletal muscle tissue . traf 2 / mice are born with decreased muscle mass that is hypothesized to be due to the increased circulating tumor necrosis factor in these mice . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In order to identify factors that contribute to CDK 9 ' s differentiation specific function , we screened a mouse embryonic library in the yeast two hybrid system and found a tumor necrosis factor signal transducer , TRAF 2 , to be an interacting protein . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The ability of CTAR 1 to activate NF kappaB appears to be attributable to the direct interaction of tumor necrosis factor ( TNF ) receptor associated factor 2 ( TRAF 2 ) , while recent work indicates that CTAR 2 induced NF kappaB is mediated through its association with TNF receptor associated death domain ( TRADD ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Although four members of the tumor necrosis factor receptor associated factor ( TRAF ) family , including TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 , bind to the CD 40 cyt , how each TRAF protein contributes to the NFkappaB activation by CD 40 is not clear . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Several tumor necrosis factor receptor associated factor ( TRAF ) family proteins including TRAF 2 , TRAF 3 , TRAF 5 , and TRAF 6 , as well as Jak 3 , have been implicated as potential mediators of CD 40 signaling . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The tumor necrosis factor receptor associated factor ( TRAF ) pathway also contributed to the activation of the MMP 9 promoter as shown by the use of TRAF 2 and TRAF 3 dominant negative constructs . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) receptor associated factor 2 ( TRAF 2 ) can interact with various members of the TNF receptor family . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Insulin increased the expression of tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) mRNA and protein in Chinese hamster ovary cells overexpressing insulin receptors ( IRs ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Dicoumarol prevented SAPK activation in vivo by chemical cell stressors and also prevented SAPK activation induced by expression of the tumor necrosis factor alpha ( TNFalpha ) receptor associated protein TRAF 2 but not by expression of truncated active MEKK 1 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
LMP 1 spontaneously aggregates in the plasma membrane and enables two transformation effector sites ( TES 1 and TES 2 ) within the 200 amino acid cytoplasmic carboxyl terminus to constitutively engage the tumor necrosis factor receptor ( TNFR ) associated factors TRAF 1 , TRAF 2 , TRAF 3 , and TRAF 5 and the TNFR associated death domain proteins TRADD and RIP , thereby activating NF kappaB and c Jun N terminal kinase ( JNK ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) receptor associated factor 2 ( TRAF 2 ) is an intracellular protein involved in signal transduction from TNF receptor 1 and 2 and related receptors . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Transfection with a dominant negative mutant of the signaling protein TRAF 2 reduced IL 6 release upon exposure to UV , indicating that UV induced IL 6 release is mediated by activation of the tumor necrosis factor receptor 1 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
To elucidate the function of Bcl 10 , recently cloned as an apoptosis associated gene mutated in MALT lymphoma , we identified its binding partner TRAF 2 , which mediates signaling via tumor necrosis factor receptors . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In a signal sequence trap screening of the murine brain , we identified a new member of the tumor necrosis factor receptor superfamily designated TROY . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAIL , anti APO 1 , and FADD ( 80 208 ) initiated gene induction was blocked by a dominant negative mutant of TRAF 2 or the p 38 kinase inhibitor SB 203580 , similar to tumor necrosis factor receptor 1 induced NF kappaB activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
CD 40 engagement also leads to a membrane raft restricted recruitment of tumor necrosis factor ( TNF ) receptor associated factor ( TRAF ) 3 and , to a lesser extent , TRAF 2 , to CD 40 ' s cytoplasmic tail . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Thermodynamic characterization of the interaction between TRAF 2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) plays a role in NF kappaB activation in response to cytokines such as tumor necrosis factor alpha ( TNFalpha ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The imprinted gene Peg 3 encodes a zinc finger protein which has been proposed to be involved in tumor necrosis factor alpha ( TNF ) signaling via an interaction with TNF receptor associated factor 2 ( TRAF 2 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Induction of NF kappaB was partially inhibited by dominant negative tumor necrosis factor receptor associated kinase 6 ( TRAF 6 ) but not TRAF 2 , whereas induction of IL 8 gene was partially inhibited by both TRAF 6 and TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We identified c Jun N terminal inhibitory kinase ( JIK ) as a binding partner of IRE1alpha , and JIK was seen to modulate IRE1alpha TRAF 2 ( tumor necrosis factor receptor associated factor 2 ) complex formation and the resultant alteration to c Jun N terminal kinase signaling from IRE1s in response to ER stress . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The alpha and beta subunits of IkappaB kinase ( IKK ) mediate TRAF 2 dependent IKK recruitment to tumor necrosis factor ( TNF ) receptor 1 in response to TNF . ^^^ In response to the proinflammatory cytokine tumor necrosis factor ( TNF ) , IKK is activated after being recruited to the TNF receptor 1 ( TNF R 1 ) complex via TNF receptor associated factor 2 ( TRAF 2 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Previous evidence indicates that the combined transcriptional activation of TRAF 1 , TRAF 2 , IAP 1 , and IAP 2 is required to suppress cell death by tumor necrosis factor ( TNF ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Critical roles of TRAF 2 and TRAF 5 in tumor necrosis factor induced NF kappa B activation and protection from cell death . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Recombinant forms of MAP3K MEK kinase 1 ( MEKK 1 ) interact in vivo and in vitro with the STE 20 protein homologue germinal center kinase ( GCK ) , and both GCK and MEKK 1 associate in vivo with the adapter protein tumor necrosis factor ( TNF ) receptor associated factor 2 ( TRAF 2 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Regulation of the subcellular localization of tumor necrosis factor receptor associated factor ( TRAF ) 2 by TRAF 1 reveals mechanisms of TRAF 2 signaling . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor ( TNF ) induced germinal center kinase related ( GCKR ) and stress activated protein kinase ( SAPK ) activation depends upon the E2 / E3 complex Ubc 13 Uev1A / TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ Tumor necrosis factor ( TNF ) induced activation of apoptosis signal regulating kinase 1 ( ASK 1 ) and germinal center kinases ( GCKs ) and the subsequent activation of stress activated protein kinases ( SAPKs and c Jun NH ( 2 ) terminal kinases ) requires TNF receptor associated factor 2 ( TRAF 2 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Of note , TNF induced NF kappaB DNA binding activity and activation of IkappaB kinases ( IKKs ) were markedly impaired in FAK / cells , whereas the expression of TNF receptor 1 or other signaling molecules such as receptor interacting protein ( RIP ) , tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , IKKalpha , IKKbeta , and IKKgamma was unchanged . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Since vFLIP physically interacts with tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) and TRAF 2 mediates activation of the jun NH ( 2 ) terminal kinase ( JNK ) / activation protein 1 ( AP 1 ) pathway , we hypothesized that vFLIP might also activate this pathway . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor ( TNFR ) associated factor 2 ( TRAF 2 ) is one of the key factors that mediate TNF signaling . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The region containing the YEEVL motif interacted with tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , and a dominant negative TRAF 2 mutant inhibited the K 15 mediated activation of the Ras / MAPK pathway , suggesting the involvement of TRAF 2 in the initiation of these signaling routes . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) deficient B lymphocytes reveal novel roles for TRAF 2 in CD 40 signaling . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Latent membrane protein 1 , tumor necrosis factor receptor associated factor ( TRAF ) 1 , TRAF 2 , TRAF 3 , and nuclear factor kappa B expression in posttransplantation lymphoproliferative disorders . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
A functional link between ZAS and NF kappaB , two distinct families of kappaB binding proteins , stems from our previous in vitro studies that show that a representative member , ZAS 3 , associates with TRAF 2 , an adaptor molecule in tumor necrosis factor signaling , to inhibit NF kappaB activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor associated factor ( TRAF ) 1 regulates CD 40 induced TRAF 2 mediated NF kappaB activation . ^^^ Overexpression of TRAF 1 , however , had no effect on the interaction of TRADD and TRAF 2 , known to be important for tumor necrosis factor receptor 1 ( TNF R 1 ) mediated NF kappaB activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , an adapter protein that associates with the cytoplasmic tail of OX 40 , may play a critical role in OX 40 mediated signal transduction . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In this study , we utilized gene knockout mouse embryonic fibroblasts cells and found that tumor necrosis factor receptor ( TNFR ) 1 mediates TNF induced necrotic cell death , and that RIP , FADD , and TRAF 2 are critical components of the signaling cascade of this TNF induced necrotic cell death . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In yeast two hybrid screening for PKN 1 binding proteins , we identified tumor necrosis factor alpha ( TNFalpha ) receptor associated factor 2 ( TRAF 2 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
When overexpressed , PIAS 3 inhibits NF kappaB dependent transcription induced by treatment with tumor necrosis factor alpha ( TNF alpha ) or interleukin 1beta or by overexpression of TNF family receptors such as RANK , TNFR 1 , and CD 30 or signal transducers of TNF receptor associated factors ( TRAFs ) , including TRAF 2 , TRAF 5 , and TRAF 6 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Data from this study suggest that receptor interacting protein ( RIP ) and tumor necrosis factor receptor ( TNFR ) associated factor 2 ( TRAF 2 ) , two key effector molecules of TNF signaling , are essential for ROS induced cell death . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNAP specifically inhibits NF kappaB activation induced by tumor necrosis factor ( TNF ) alpha , TNF receptor 1 , TRADD , RIP , TRAF 2 , and NIK but does not affect IKK 1 and IKK 2 mediated NF kappaB activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Role of tumor necrosis factor ( TNF ) receptor associated factor 2 ( TRAF 2 ) in distinct and overlapping CD 40 and TNF receptor 2 / CD120b mediated B lymphocyte activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor suppressor CYLD is a deubiquitinating enzyme ( DUB ) that inhibits the ubiquitination of key signaling molecules , including tumor necrosis factor ( TNF ) receptor associated factor 2 ( TRAF 2 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Recent research suggests that sequestration in stress granules of TRAF 2 , an adaptor protein that is required for tumor necrosis factor receptor 1 signaling , may underlie preconditioning by sublethal stresses . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
This pathway involves NF kappaB inducing kinase ( NIK ) and the tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) and results in IFNalpha / beta induced processing of the p100 / NF kappaB 2 precursor into p 52 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor receptor 2 ( TNFR 2 ) signaling is negatively regulated by a novel , carboxyl terminal TNFR associated factor 2 ( TRAF 2 ) binding site . ^^^ Tumor necrosis factor ( TNF ) superfamily receptors typically induce both NF kappaB and JNK activation by recruiting the TRAF 2 signal transduction protein to their cytoplasmic domain . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Upon H ( 2 ) O ( 2 ) treatment , the ASK 1 signalosome forms a higher molecular mass complex at least in part because of the recruitment of tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) and TRAF 6 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In the present paper we analyzed the role that the adaptor protein tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) plays in regulating cellular responses to apoptotic stimuli from the endoplasmic reticulum . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We reveal that receptor interacting protein 1 ( RIP 1 ) and tumor necrosis factor receptor associated factor 2 ( TRAF 2 ) , are upstream of JNK in PARP 1 hyperactivated cells , because PARP 1 induced JNK activation was attenuated in RIP 1 / and TRAF 2 / mouse embryonic fibroblast cells . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Furthermore , receptor activator of nuclear factor kappaB ( RANK ) induced the recruitment of tumor necrosis factor ( TNF ) associated factors 2 and 6 ( TRAF 2 and 6 , respectively ) to the cytoplasmic tail of RANKL with activated IkappaB kinase and IkappaB phosphorylation , while D PDMP treatment inhibited RANKL and induced IkappaB phosphorylation , and that inhibition was recovered by LacCer . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The suppression of NF kappaB activation correlated with sequential inhibition of the tumor necrosis factor ( TNF ) induced activation of IkappaBalpha kinase , IkappaBalpha phosphorylation , IkappaBalpha degradation , p 65 phosphorylation , p 65 nuclear translocation , and the NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TRAF 2 , NIK , IKK beta , and the p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The activating effect of LPS , IFN gamma , IL 2 , TPA , TNF and Zymosan was assessed by the determination of the activities of alpha naphthyl butyrate esterase ( ANBE ) , tartrate resistant acid phosphatase ( TRAP ) , beta glucuronidase ( BG ) and 5 ' nucleotidase ( 5 ' NT ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF induced expression of CD 4 and CD 71 , increased the intensity of HLA DR , CD 25 , CD11c and CD 13 expression and decreased both the intensity and frequency of sIg and cIg positivity . alpha IFN decreased CD 25 expression , the tartrate resistant acid phosphatase activity ( TRAP ) , reduced the TNF induced CD 4 and CD 71 expression and antagonized the TNF effect on the Ig expression . ^^^ The reduction of CD 25 , TNF induced CD 71 and TRAP caused by alpha IFN seems to represent a deactivation of the activated state of hairy cells ( HCs ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 mediated activation of NF kappa B by TNF receptor 2 and CD 40 . ^^^ A truncated derivative of TRAF 2 lacking an amino terminal RING finger domain was a dominant negative inhibitor of NF kappa B activation mediated by TNF R 2 and CD 40 . ^^^ Thus , TRAF 2 is a common mediator of TNF R 2 and CD 40 signaling . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The TRAP identified in the present study shares considerable homology with , and may be the human homologue of , a mouse protein , TNF receptor associated factor 2 ( TRAF 2 ) , that binds mouse TNFR 2 . . ^^^ The N terminal half of the TNF receptor associated protein ( TRAP ) contains RING finger and zinc finger motifs often found in DNA binding proteins including transcription factors . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF receptor associated factor 1 ( TRAF 1 ) and TRAF 2 are the first two members of a novel protein family containing a novel C terminal homology region , the TRAF domain . ^^^ Our analysis indicates that TRAF 1 and TRAF 2 are associated with the cytoplasmic domain of TNF R 2 in a heterodimeric complex in which TRAF 2 contacts the receptor directly . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Isolation and characterization of death domain ( TNF RI , Fas , TRADD , FADD / MORT 1 , RIP ) and TRAF domain containing proteins ( TRAF 1 , TRAF 2 , TRAF 3 ) have partially bridged a large molecular gap within one of several signaling pathways which originate at the plasma membrane and terminate in the nucleus . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRADD TRAF 2 and TRADD FADD interactions define two distinct TNF receptor 1 signal transduction pathways . ^^^ A TRAF 2 mutant lacking its N terminal RING finger domain is a dominant negative inhibitor of TNF mediated NF kappa B activation , but does not affect TNF induced apoptosis . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We have performed extensive mutational analysis on TRAF 2 , examining the requirements for NF kappaB activation , self association , and interaction with other molecules involved in TNF signaling . ^^^ Interaction of TRAF 2 with TNF R 2 and TRADD requires sequences at the C terminus of the TRAF C domain , whereas interaction with the protein kinase receptor interacting protein 5 ( RIP ) occurs via sequences at the N terminus of the TRAF C domain . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 is required for CD 40 and TNF mediated activation of the transcription factor NF kappa B . ^^^ Overexpression of 1 TRAF inhibits TRAF 2 mediated NF kappa B activation signaled by CD 40 and both TNF receptors . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
By combined use of the yeast interaction trap system and a peptide scanning library , the novel WD repeat protein FAN has been identified , which specifically binds to a cytoplasmic nine amino acid binding motif of TNF R 55 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The TNF R 2 associated factor TRAF 2 has been shown to mediate activation of NF kappa B by TNF R 2 and CD 40 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 , a cytoplasmic protein that binds to the p 75 TNF receptor , as well as to several other receptors of the TNF / NGF family , also binds to TRADD , thus further extending the range of receptors of this family that can share common signaling mechanisms . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Several members of the tumour necrosis / nerve growth factor ( TNF / NGF ) receptor family activate the transcription factor NF kappaB through a common adaptor protein , Traf 2 ( refs 1 5 ) , whereas the interleukin 1 type 1 receptor activates NF kappaB independently of Traf 2 ( ref . 4 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Enhancement of TNF receptor p 60 mediated cytotoxicity by TNF receptor p 80 : requirement of the TNF receptor associated factor 2 binding site . ^^^ The ability of TNFR 80 to cooperate with TNFR 60 could be mapped to the binding site for the TNF receptor associated factor 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The coding region of TNF receptor associated factor 2 ( TRAF 2 ) , which is known to interact with CD 40 for NF kappaB induction , was also found to be normal in B cell lines deficient in NF kappaB induction . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Clones corresponding to genes coding for TRAF 1 , TRAF 2 , and TRAF 3 molecules , postulated to be involved in signalling via the TNF and CD 40 receptors , were isolated . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Studies with human B cells show that the binding of CD 154 ( gp 39 , CD40L ) to CD 40 recruits TNF receptor associated factor 2 ( TRAF 2 ) and TRAF 3 to the receptor complex , induces the downregulation of the nonreceptor associated TRAFs in the cell and induces an increased expression of Fas on the cell surface . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Transient overexpression of the TRAF 2 adaptor protein can activate NF kappaB and endogenous JNK , whereas N terminal truncated TRAF 2 protein blocks TNF induced NF kappa B and JNK activation as well as E selectin promoter reporter gene transcription . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
A threonine residue at position 234 , previously shown to be important for CD 40 association with TNF receptor associated factor 2 ( TRAF 2 ) , TRAF 3 , and TRAF 5 , was not required for NF kappa B activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
CD 40 mediated signals inhibit the binding of TNF receptor associated factor 2 to the CD 40 cytoplasmic domain . ^^^ TNF receptor associated factor 2 ( TRAF 2 ) is a signal transducing protein associated with the CD 40 cytoplasmic domain . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Early lethality , functional NF kappaB activation , and increased sensitivity to TNF induced cell death in TRAF 2 deficient mice . ^^^ TRAF 2 is an intracellular signal transducing protein recruited to the TNFR 1 and TNFR 2 receptors following TNF stimulation . ^^^ Thymocytes and other hematopoietic progenitors were highly sensitive to TNF induced cell death and serum TNF levels were elevated in these TRAF 2 deficient animals . ^^^ Examination of traf 2 / cells revealed a severe reduction in TNF mediated JNK / SAPK activation but a mild effect on NF kappaB activation . ^^^ These results suggest that TRAF 2 independent pathways of NF kappaB activation exist and that TRAF 2 is required for an NF kappaB independent signal that protects against TNF induced apoptosis . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Signaling by TRANCE R appears to be dependent on TNF receptor associated factor 2 ( TRAF 2 ) , since JNK induction is impaired in cells from transgenic mice overexpressing a dominant negative TRAF 2 protein . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Other TNF R 55 associated proteins like TRAF 2 and RIP , which were reported to mediate TNF R 55 mediated activation of nuclear factor kappaB , did not affect activation of A SMase . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF signal transduction is mediated by TRAF 2 which binds the TNF Receptor 2 ( TNFR 2 ) and activates NFkappaB . ^^^ Transfection of a truncated Peg 3 containing the TRAF 2 interaction site , abolishes NFkappaB activation by TRAF 2 and / or TNF . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 plays a dual role in NF kappaB dependent gene activation by mediating the TNF induced activation of p 38 MAPK and IkappaB kinase pathways . ^^^ Remarkably , p 38 MAPK activation by TNF proceeds independently of the TRAF 2 associated NF kappaB inducing kinase NIK , which is known to bind and activate two recently identified IkappaB kinases . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The N terminal domains target TNF receptor associated factor 2 to the nucleus and display transcriptional regulatory activity . ^^^ The subcellular localization of the TNF receptor associated factor 2 ( TRAF 2 ) adaptor protein in human endothelial cells , which mediates proinflammatory responses of TNF , has been analyzed by confocal immunofluorescence microscopy and by Western blotting of fractionated cell extracts . ^^^ TNF treatment does not appear to influence the localization of endogenous or transfected TRAF 2 protein . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Remarkably , TRAF 2 DN overexpression , which was found to inhibit the TNF dependent recruitment of endogenous wild type TRAF 2 to the TNF R 75 signaling complex , could neither block TNF R 55 or TNF R 75 induced NF kappaB activation nor granulocyte / macrophage CSF secretion . ^^^ Possibly , additional factors different from TRAF 2 are involved in TNF mediated NF kappaB activation . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Although fully capable of transducing apoptotic signals , which depend on the adapter Fas associated death domain protein ( FADD ) and on the subsequent recruitment / activation of the apoptotic proteases , TNF R 1 usually does not kill cells ; this is due to the induction of a complex cytoprotective response that requires TNF receptor associated factor 2 ( TRAF 2 ) , a signal transducer that couples TNF R 1 to both nuclear factor kappaB ( NFkappaB ) dependent and NFkappaB independent transcriptional events implicated in induction of genes protecting from TNF cytotoxicity . ^^^ Although absolutely required for cytoprotection , TNF receptor associated factor 2 is not sufficient to protect cells from TNF , thus suggesting that it may act in concert with additional TNF R 1 complex components . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Either TNF receptor associated factor 2 ( TRAF 2 ) or TRAF 3 binds to the CD 27 molecule from the coimmunoprecipitation experiment . ^^^ This amino acid alignment contains the EEEG sequence , which is essential for interaction of CD 30 or CD 40 with TRAFs ( TRAF 1 and TRAF 2 , but not TRAF 3 ) , and also contains the PIQED sequence , which is similar to PXQXT that is known to be necessary for interaction of TNF receptor 2 and CD 30 with TRAFs ( TRAF 1 , 2 , and 3 ) . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Cellular resistance to TNF requires TNF receptor associated factor 2 ( TRAF 2 ) , which has been hypothesized to act mainly by mediating activation of the transcription factors nuclear factor kB ( NFkB ) and activator protein 1 ( AP 1 ) . ^^^ To test the possible existence of NFkB independent cytoprotective pathways , we systematically compared selective trans dominant inhibitors of the NFkB pathway with inhibitors of TRAF 2 signaling for their effect on TNF cytotoxicity . ^^^ Blockade of TRAF 2 function ( s ) by signaling deficient oligomerization partners or by molecules affecting TRAF 2 recruitment to the TNF receptor 1 complex completely abrogated the cytoprotective response . ^^^ Although required for cytoprotection , TRAF 2 is not sufficient to protect cells from TNF + cycloheximide cytotoxicity when overexpressed in transfected cells , thus indicating an essential role of additional TNF receptor 1 complex components in the cytoprotective response . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF treatment released SODD from TNF R 1 , permitting the recruitment of proteins such as TRADD and TRAF 2 to the active TNF R 1 signaling complex . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The constitutive expression of TNF receptors ( TNFRI and TNFRII ) and the adapter molecules , including TNFR associated death domain protein ( TRADD ) , TNFR associated factor 2 ( TRAF 2 ) , and receptor interacting protein ( RIP ) , were analyzed both at the protein level by flow cytometry or Western blotting , and at the mRNA level using quantitative PCR or Northern blotting in lymphocytes from aged and young subjects . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
AITR associates with TRAF 1 ( TNF receptor associated factor 1 ) , TRAF 2 , and TRAF 3 , and induces nuclear factor ( NF ) kappaB activation via TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
LPS induced NF kappaB activation was not inhibited by a dominant negative mutant of TRAF 2 that is involved in TNF signaling . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
This is the same region of CD 40 required for binding the TNF receptor associated factor 2 ( TRAF 2 ) , TRAF 3 , and TRAF 5 adapter proteins . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Here we report the crystal structure of the TRAF domain of human TRAF 2 , both alone and in complex with a peptide from TNF receptor 2 ( TNF R 2 ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
No changes in the levels or molecular weights of the adaptor proteins TRADD ( TNF receptor associated death domain ) , RIP ( receptor interacting protein ) , or TRAF 2 ( TNF receptor associated factor 2 ) were caused by apoptogenic drugs . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Induction of the CINC promoter by IL 17 in IEC 6 cells was TNF receptor associated factor 6 ( TRAF 6 ) , but not TRAF 2 , dependent . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
LMP 1 signal transduction differs substantially from TNF receptor 1 signaling in the molecular functions of TRADD and TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Cutting edge : contrasting roles of TNF receptor associated factor 2 ( TRAF 2 ) and TRAF 3 in CD 40 activated B lymphocyte differentiation . ^^^ We examined the contributions of TNF receptor associated factor 2 ( TRAF 2 ) and TRAF 3 to CD 40 activated differentiation in mouse B cells transfected with inducible TRAF and dominant negative TRAF cDNAs . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The zinc finger protein A 20 inhibits TNF induced NF kappaB dependent gene expression by interfering with an RIP or TRAF 2 mediated transactivation signal and directly binds to a novel NF kappaB inhibiting protein ABIN . ^^^ Moreover , NF kappaB activation induced by overexpression of the TNF receptor associated proteins TNF receptor associated death domain protein ( TRADD ) , receptor interacting protein ( RIP ) , and TNF recep tor associated factor 2 ( TRAF 2 ) was also inhibited by expression of A 20 , whereas NF kappaB activation induced by overexpression of NF kappaB inducing kinase ( NIK ) or the human T cell leukemia virus type 1 ( HTLV 1 ) Tax was unaffected . ^^^ These results demonstrate that A 20 inhibits NF kappaB dependent gene expression by interfering with a novel TNF induced and RIP or TRAF 2 mediated pathway that is different from the NIK IkappaB kinase pathway and that is specifically involved in the transactivation of NF kappaB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF mediated activation of the stress activated protein kinase pathway : TNF receptor associated factor 2 recruits and activates germinal center kinase related . ^^^ TNF induced activation of stress activated protein kinases ( SAPKs , Jun NH 2 terminal kinases ) requires TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ Consistent with a role for GCKR in TNF induced SAPK activation , a kinase inactive mutant of GCKR is a dominant negative inhibitor of TRAF 2 induced SAPK activation . ^^^ TNF treatment of a T cell line , Jurkat , increased both GCRK and SAPK activity and enhanced the coimmunoprecipitation of GCKR with TRAF 2 . ^^^ These findings are consistent with a model whereby TNF signaling results in the recruitment and activation of GCKR by TRAF 2 , which leads to SAPK activation . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
A truncated derivative of TRAF 2 , which inhibits SAPK activation by TNF , blocks TNF induced ASK 1 activation . ^^^ Furthermore , protection from TNF induced cell death conferred by an ASK 1 mutant is dependent upon TRAF 2 . ^^^ Hence , ASK 1 is a common mediator of TRAF regulated SAPK and apoptosis signaling , and the TRAF 2 ASK 1 connection completes the signaling cascade from TNF to SAPK / JNK activation . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Interestingly , overexpression of TRAF 1 in HEK293T completely prevented NF kappaB activation induced by TNF , IL 1 , or overexpression of TRAF 2 or TRAF 6 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In particular , Bcl 2 , TNF receptor associated factor 2 ( TRAF 2 ) , and TRAF 4 were clearly inducible via CD 40 in B cells but not in DCs . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Using CD 40 mutants with impairments in their ability to bind selected TNF receptor associated factor ( TRAF ) family proteins , we observed that CD 40 mediated transcriptional induction of the germ line Ig Cgamma 1 and Ig Cepsilon promoters was markedly reduced by mutations that prevent TRAF 2 , TRAF 3 , TRAF 5 or TRAF 6 binding . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Here we show that TNF receptor ( TNFR ) associated factor 2 ( TRAF 2 ) , an adapter protein that couples TNFRs to the SAPKs and p38s , can activate ASK 1 in vivo and can interact in vivo with the amino and carboxyl terminal noncatalytic domains of the ASK 1 polypeptide . ^^^ Expression of the amino terminal noncatalytic domain of ASK 1 can inhibit TNF and TRAF 2 activation of SAPK . ^^^ Thus , activation of ASK 1 by TNF requires the ROS mediated dissociation of Trx possibly followed by the binding of TRAF 2 and consequent ASK 1 homo oligomerization . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Comparing early and late stage melanoma cells revealed low expression of TRAF 2 and GCK in early stage melanoma , which coincided with poor resistance to UV induced , TNF mediated apoptosis ; forced expression of GCK alone or in combination with TRAF 2 efficiently increased JNK and NF kappaB activities , which coincided with increased protection against apoptosis . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Because hCG also blocked TNF receptor associated factor 2 and NF kappaB inducing kinase reporter gene expression , hCG must act at a step that causes phosphorylation of IkappaBalpha . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We found that NAC suppressed NF kappaB activation triggered by TNF or by overexpression of either the TNF receptor associated death domain protein , TNF receptor associated factor 2 , NF kappaB inducing kinase ( NIK ) , or IkappaB kinases ( IKKalpha and IKKbeta ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The death domain kinase RIP and the TNF receptor associated factor 2 ( TRAF 2 ) are essential effectors in TNF signaling . ^^^ The distinct roles of TRAF 2 and RIP in IKK activation by TNF R 1 : TRAF 2 recruits IKK to TNF R 1 while RIP mediates IKK activation . ^^^ To understand the mechanism by which RIP and TRAF 2 regulate TNF induced activation of the transcription factor NF kappaB , we investigated their respective roles in TNF R 1 mediated IKK activation using both RIP / and TRAF 2 / fibroblasts . ^^^ We found that TNF R 1 mediated IKK activation requires both RIP and TRAF 2 proteins . ^^^ Although TRAF 2 or RIP can be independently recruited to the TNF R 1 complex , neither one of them alone is capable of transducing the TNF signal that leads to IKK activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The TNF induced NF kappa B activation cascade involving TNF receptor 1 TNF receptor associated death domain TNF receptor associated factor 2 NF kappa B inducing kinase IKK was interrupted at the TNF receptor associated factor 2 and NF kappa B inducing kinase sites by vesnarinone , thus suppressing NF kappa B reporter gene expression . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The ratio between soluble and insoluble TRAF 2 determines the sensitivity of cells to TNF alpha induced apoptosis and may play an important role in limiting further TRAF dependent signal transduction . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Overexpression of a dominant negative TNF receptor associated factor 2 construct , lacking the NH ( 2 ) terminal RING finger , completely abrogated both TNFalpha and htr 9 mediated increases in NF kappaB reporter activity . ^^^ These data suggest that TNFR 1 , through a TNF receptor associated factor 2 NF kappaB signaling pathway , mediates TNFalpha induced expression of ICAM 1 on ASM cells by involving a thapsigargin sensitive signaling pathway . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF receptor family member BCMA ( B cell maturation ) associates with TNF receptor associated factor ( TRAF ) 1 , TRAF 2 , and TRAF 3 and activates NF kappa B , elk 1 , c Jun N terminal kinase , and p 38 mitogen activated protein kinase . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
A combination of NMR , BIAcore , and mutagenesis experiments was used to help identify the site of interaction of N TRADD with C TRAF 2 , providing a framework for future attempts to selectively inhibit the TNF signaling pathways . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The TNF induced NF kappaB activation cascade involving TNF receptor 1 / TNF receptor associated death domain / TNF receptor associated factor 2 / NF kappaB inducing kinase / IkappaBalpha kinase was interrupted at the TNF receptor associated factor 2 and NF kappaB inducing kinase sites by oleandrin , thus suppressing NF kappaB reporter gene expression . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In addition , we also demonstrated that the TNF receptor associated factor 2 ( TRAF 2 ) plays little role in TRAIL induced IKK activation although it is required for TRAIL mediated JNK activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Enhanced osteoclastogenesis is associated with high expression of otherwise TNF and RANKL induced mediators , including c Src , TRAF 2 , TRAF 6 , and MEKK 1 , levels of which were notably reduced in TNFr 1 knockouts . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TNF receptor associated factor 2 , and NF kappaB inducing kinase was also abrogated by IFN alpha pretreatment . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Role of TNF receptor associated factor 2 and p 38 mitogen activated protein kinase activation during 4 1BB dependent immune response . 4 1BB is a costimulatory member of the TNFR family , expressed on activated CD 4 ( + ) and CD 8 ( + ) T cells . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 is currently the best characterized TRAF family member , having a key role in mediating TNF R 1 induced activation of NF kappaB and JNK . ^^^ This review focuses on the molecular mechanisms that underlay signal initiation by TNF R 1 and TNF R 2 , with particular consideration of the role of TRAF 2 , and highlights the importance of this molecule for the integration of such antagonizing pathways as death induction and NF kappaB mediated surviving signals . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Caspase cleaved TRAF 1 negatively regulates the antiapoptotic signals of TRAF 2 during TNF induced cell death . ^^^ However , it is unclear how the antiapoptotic signals via TRAF 2 in TNF R 1 signaling is regulated . ^^^ Importantly , we demonstrate that the cleavage product of TRAF 1 coimmunoprecipitates with TRAF 2 that is released from the TNF R 1 complex in response to prolonged TNF treatment . ^^^ These results indicate that caspase dependent cleavage of TRAF 1 generates TRAF 1 c fragments that are able to bind TRAF 2 , and then sequester TRAF 2 from the TNF R 1 complex , rendering cells , at least in part , sensitive to TNF . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The expression of adapter molecules TNF receptor associated death domain ( TRADD ) , Fas associated death domain ( FADD ) and TNF associated factor 2 ( TRAF 2 ) and caspase 3 was analyzed by Western blotting . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Analysis of various MUL and USP 7 mutants by transient transfection assays indicated that the TDs of these proteins are necessary and sufficient for suppressing NF kappaB induction by TRAF 2 and TRAF 6 as well as certain TRAF binding TNF family receptors . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Overexpression of the icp75TNFR cDNA results in TNF induced activation of NFkappaB in a TNF receptor associated factor 2 ( TRAF 2 ) dependent manner . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
A 20 has been shown to bind to TNF receptor associated factor 2 ( TRAF 2 ) and 14 3 3 chaperone proteins . ^^^ A 20 zinc finger protein inhibits TNF induced apoptosis and stress response early in the signaling cascades and independently of binding to TRAF 2 or 14 3 3 proteins . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
However , NF kappa B activation by TNF was not significantly altered by the HCV core protein , suggesting the existence of TRAF 2 independent pathways for NF kappa B activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The latter also inhibits NF kappaB activation induced by overexpression of receptor interacting protein or TNF receptor associated factor 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We selectively used constructs expressing dominant negative Fas associated death domain protein ( FADD ) , TNF receptor associated factor 2 ( TRAF 2 ) or IkappaB to inhibit pathways downstream of the TNF receptor . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Moreover , overexpression of CSN 3 also inhibits NF kappaB activation triggered by proteins involved in TNF signaling , including TNF R 1 , TRAF 2 , RIP , and NIK , but not by TRAF 6 , a protein involved in IL 1 signaling . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
IL 1 induces the interaction of TNFR associated factor ( TRAF ) 6 with IL 1R associated kinase , which is rapidly recruited to the IL 1R after IL 1 induction , whereas TRAF 2 participates in TNF alpha signaling . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Previously , we have demonstrated that Bcl 10 potentially interacts with the other apoptosis regulator , TNF receptor associated factor 2 ( TRAF 2 ) and inhibitor of apoptosis proteins ( cIAPs ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
At least four different mechanisms of regulation can be distinguished : ( 1 ) NF kappaB mediated induction of proteins of the TNF R complex ; ( 2 ) NF kappaB independent protection against apoptosis by the TNF R associating factor 2 ( TRAF 2 ) mediated recruitment of antiapoptotic proteins ; ( 3 ) dual activation of apoptosis and NF kappaB by a single molecule ; and ( 4 ) amplification of the death signal by proteolytic inactivation of signaling proteins that are involved in NF kappaB activation or cell survival . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Activation of CD 30 led to the induction of apoptotic death of ALCL cells , along with the selective reduction of TNF receptor associated factor 2 and impairment in the ability of these cells to activate the pro survival transcription factor nuclear factor kappa B ( NF kappa B ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Alternative splicing variants of c FLIP transduce the differential signal through the Raf or TRAF 2 in TNF induced cell proliferation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Tumor necrosis factor alpha ( TNF ) receptor associated factor 2 ( TRAF 2 ) is one of the major mediators of TNF receptor superfamily transducing TNF signaling to various functional targets , including activation of NF kappa B , JNK , and antiapoptosis . ^^^ In addition , by using a kinase inactive dominant negative SphK and a mutant SphK that lacks TRAF 2 binding motif we show that the interaction of TRAF 2 with SphK and subsequent activation of SphK are critical for prevention of apoptosis during TNF stimulation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
T2BP , a novel TRAF 2 binding protein , can activate NF kappaB and AP 1 without TNF stimulation . ^^^ TRAF 2 is a key molecule involved in TNF signaling , which is crucial for the regulation of inflammatory processes . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
When overexpressed , NS5A can not inhibit the recruitment of TNF receptor associated factor 2 ( TRAF 2 ) and IkappaB kinase ( IKK ) beta into the TNF receptor 1 TNF receptor associated death domain complex . ^^^ NF kappaB activation by TNF receptor associated death domain and TRAF 2 was inhibited by NS5A , whereas MEKK 1 and IKKbeta dependent NF kappaB activation was not affected , suggesting that NS5A may inhibit NF kappaB activation signaled by TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We previously showed that murine embryonic fibroblasts ( MEFs ) from TNF receptor associated factor 2 ( Traf 2 ) and Traf 5 double deficient ( double knockout ( DKO ) ) mice were highly susceptible to TNF induced cell death . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Dominant negative TNF receptor associated factor 2 ( TRAF 2 ) inhibited activation of NF kappa B , which was also inhibited in embryonic fibroblasts derived from TRAF 2 ( / ) mice , respect to their normal counterpart . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Apoptotic crosstalk of TNF receptors : TNF R 2 induces depletion of TRAF 2 and IAP proteins and accelerates TNF R 1 dependent activation of caspase 8 . ^^^ Life cell imaging and confocal microscopy revealed that both TNF R 1 and TNF R 2 recruited the anti apoptotic factor cIAP 1 in a TRAF 2 dependent manner . ^^^ Thus , TNF R 2 may compete with TNF R 1 for the recruitment of newly synthesized TRAF 2 bound anti apoptotic factors , thereby promoting the formation of a caspase 8 activating TNF R 1 complex . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
PAN 2 also suppressed NF kappaB induction resulting from overexpression of several adapter proteins and protein kinases involved in the TNF or IL 1 receptor signal transduction , including TRAF 2 , TRAF 6 , RIP , IRAK 2 , and NF kappaB inducing kinase as well as the IkappaB kinases IKKalpha and IKKbeta . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Cutting edge : molecular mechanisms of synergy between CD 40 and the B cell antigen receptor : role for TNF receptor associated factor 2 in receptor interaction . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The suppression of CSC activated NF kappaB dependent reporter gene expression by dominant negative form of IkappaB ( alpha ) , TRAF 2 , NIK and IKK suggests a similarity to the TNF induced pathway for NF kappaB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Thus , TRAF 2 is not involved in TNF induced Etk activation , suggesting a novel mechanism for Etk activation by cytokine receptors . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Delta TRAF 6 and Delta MyD 88 significantly abrogate antibody induced as well as IL 1 or LPS induced NF kappa B activation , whereas Delta TRAF 2 ( involved in NF kappa B activation by TNF ) does not affect it . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The TNF induced NF kappaB activation cascade involving TNFR 1 TNF receptor associated death domain TNF receptor associated factor 2 ( TRAF 2 ) NF kappaB inducing kinase ( NIK ) IkappaBalpha kinase was interrupted at the TRAF 2 and NIK sites by calagualine , which would account for its suppression of NF kappaB reporter gene expression . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Adenosine also suppressed NF kappaB dependent reporter gene expression activated by TNF or by overexpression of TNFR 1 , TRAF 2 , NIK , and p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Mutation of the distinct binding sites for TNF receptor associated factor 6 ( TRAF 6 ) and for TRAF 2 , 3 , and 5 in the CD 40 cytoplasmic domain revealed their independent contributions to DC maturation and activation of NF kappaB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Western blot analysis further demonstrated that OIP 1 significantly decreased TNF receptor associated factor 2 ( TRAF 2 ) expression in RAW 264 . 7 cells . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The constitutive expression of mRNA for TNF receptors ( TNFR ) , including TNFRI and TNFRII , and the adapter molecules , such as the TNF receptor associated death domain protein ( TRADD ) , Fas associated death domain protein ( FADD ) , receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) were analyzed by reverse transcriptase ( RT ) PCR in bone marrow samples from control , MDS and AML cases . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Here , we show that TRAF 1 differentially affects TRAF 2 recruitment and activation of NF kappaB by members of the TNF receptor family . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRADD also binds two other adaptors receptor interacting protein ( RIP ) and TNF receptor associated factor 2 ( TRAF 2 ) , which are required for TNF induced NF kappaB and c Jun N terminal kinase activation , respectively . ^^^ Analysis of the native TNF signaling complex revealed the recruitment of RIP , TRADD , and TRAF 2 but not FADD or caspase 8 . ^^^ In an in vitro binding assay , the intracellular domain of TNF R 1 bound TRADD , RIP , and TRAF 2 but did not bind FADD or caspase 8 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The fusion of the transmembrane domain of LMP 1 to signaling domains of CD 40 , TNF R 1 and Fas activates their signaling ; we demonstrate that a fusion of LMP 1 with CD 40 recruits TRAF 2 intracellularly . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Finally , we show that fibroblast growth factor inducible 14 with a mutation at its TNF receptor associated factor ( TRAF ) binding site can not activate NF kappaB and that TWEAK fails to induce the p 100 processing and IkappaBalpha phosphorylation in cells deficient for TRAF 2 and TRAF 5 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We also describe the isolation and characterization of a novel Drosophila member of the TNF receptor family , designated Wengen , which is a type 1 membrane protein that can physically interact with the recently described TRAF 2 homolog dTRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The first complex ( complex 1 ) is formed at the membrane by TNF R 1 , TRADD , RIP , TRAF 2 and c IAP 1 , while the second complex ( complex 2 ) , formed in the cytosol , predominantly contains FADD and pro caspases 8 / 10 but lacks TNF R 1 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Moreover , FAF 1 suppressed NF kappaB activation induced by transducers of diverse NF kappaB activating signals such as TNF receptor associated factor 2 and 6 , MEKK 1 , and IkappaB kinase beta as well as NF kappaB p 65 , one of the end point molecules in the NF kappaB activation pathway , suggesting that NF kappaB p 65 might be a target molecule upon which FAF 1 acts . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NF kappaB reporter activity induced by TNF receptor 1 , TNF receptor associated death domain , TNF receptor associated factor 2 , NF kappaB inducing kinase , and IkappaBalpha kinase , were all blocked by flavopiridol but not that activated by p 65 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
We have previously reported that TROY induces the activation of nuclear factor kappaB via TNF receptor associated factor 2 , 5 , and 6 , and is strongly expressed in the developing central nervous system , including the olfactory bulb . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Cellular inhibitor of apoptosis protein 1 ( c IAP 1 ) can regulate apoptosis through its interaction with downstream TNF receptor effectors ( TRAF 1 and TRAF 2 ) , by binding to and inhibiting certain caspases , and by controlling the levels of specific proapoptotic stimuli ( e . g . , Smac / DIABLO ) within the cell . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
This appears to involve the ubiquitin ligase TNF receptor activation factor 2 ( TRAF 2 ) and acts indirectly by causing cell cycle arrest at a stage where there is high degradation of the FLIP TRAF 2 complex . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
SCH 66336 also inhibited the NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TRADD , TRAF 2 , NIK , and IKK but not that activated by the p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Inhibition of either delta PKC or PI 3 kinase decreased TNF mediated recruitment of RIP and TRAF 2 to TNFR 1 . ^^^ Thus delta PKC and PI 3 kinase are positive regulators of TNF mediated association of TRAF 2 and RIP with TNFR 1 . ^^^ These results suggest that delta PKC and PI 3 kinase regulate TNF antiapoptotic signaling at the level of the TNFR 1 through control of assembly of a TNFR 1 TRADD RIP TRAF 2 complex . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Moreover , violacein directly activated TNF receptor 1 signaling , because a violacein dependent association of TNF receptor associated factor 2 ( TRAF 2 ) to this TNF receptor was observed in coimmunoprecipitation experiments . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNF binding induces release of AIP 1 from TNFR 1 , resulting in cytoplasmic translocation and concomitant formation of an intracellular signaling complex comprised of TRADD , RIP 1 , TRAF 2 , and AIPl . ^^^ At the same time , the binding of AIP 1 to TRAF 2 inhibits TNF induced IKK NF kappaB signaling . ^^^ Taken together , our data suggest that AIP 1 is a novel transducer in TNF induced TRAF 2 dependent activation of ASK 1 that mediates a balance between JNK versus NF kappaB signaling . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NF kappaB dependent reporter gene transcription induced by TNF , TNFR 1 , TRADD , TRAF 2 , NIK , and IKK was also blocked by guggulsterone but without affecting p 65 mediated gene transcription . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Analyzing cell lines expressing an internalization deficient receptor ( TNF R 1 DeltaTRID ) revealed that recruitment of RIP 1 and TRAF 2 to TNF R 1 occurred at the level of the plasma membrane . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The release of cytochrome c from mitochrondria , the activation of caspase 3 , 8 , and 9 , the cleavage of nuclear poly ( ADP ribose ) polymerase ( PARP ) , and the expression of TNF receptors ( TNF R1 / p55 and TNF R2 / p75 ) , TNF R associated factor 2 ( TRAF 2 ) , and cellular inhibitor of apoptosis 1 ( c IAP 1 ) were determined by immunoblotting . ^^^ BLM exposure had no marked effect on AM expression of TNF R 1 or caspase 8 activation , but significantly increased the expression of TNF R 2 that was accompanied by a rise in c IAP 1 and a decrease in TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Mda 7 transfection also potentiated NF kappaB reporter activation induced by TNF receptor associated death domain and TNF receptor associated factor 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRAF 2 , cIAP 1 and cIAP 2 all have RING finger domains known to possess E 3 ubiquitin ligase activity , implying that ubiquitination may play an important role in the TNF signaling pathway . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In the normal rat cortex , a portion of TNFR 1 was present in lipid raft microdomains , where it associated with the adaptor proteins TRADD ( TNF receptor associated death domain ) , TNF receptor associated factor 2 ( TRAF 2 ) , the Ser / Thr kinase RIP ( receptor interacting protein ) , TRAF 1 , and cIAP 1 ( cellular inhibitor of apoptosis protein 1 ) , forming a survival signaling complex . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
To reveal signaling events mediated by TNF receptors ( TNF Rs ) in tendinocytes , we focused on four signaling factors , TNF R 1 , TNF R 2 , TNF R associated factor 2 ( TRAF 2 ) and nuclear factor kappa B ( NF kappaB ) , and investigated the distribution and production of these factors . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TRIP 6 also interacts with TRAF 2 , a protein that is crucially involved in TNF signaling , as well as the IL 1 receptor , TLR 2 and Nod 1 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Several proteins , including FADD , the death domain kinase RIP and the TNF receptor associated factor TRAF 2 have been identified as the key effectors of TNF signaling . ^^^ Recently , we found that the effector molecules of TNF signaling , such as RIP and TRAF 2 , are also involved in other cellular responses . ^^^ These finding suggests that RIP and TRAF 2 serve a broader role than as just an effector of TNF signaling . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
HGF / SF induced the expression of several known NF kappaB target genes ( cIAP 1 ( cellular inhibitor of apoptosis 1 ) , cIAP 2 , and TRAF 2 ( TNF receptor associated factor 2 ) ) in an NF kappaB dependent manner ; HGF / SF blocked the inhibition of expression of these genes by ADR . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Evodiamine also inhibited the NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TRADD , TRAF 2 , NIK , and IKK but not that activated by the p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Taken together , our data demonstrate that TRAF 2 , an important effector molecule of TNF signaling , plays a critical , nonredundant role in LIGHT LTbetaR signaling . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Mice deficient in p 55 receptor only showed reduced seizures ; and both p 75 and TNF receptor associated factor 2 protein levels were upregulated in their hippocampi . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Searching available databases by using these nucleotide sequences revealed that 23 genes are immune related , including known acute phase reactants , and four novel genes encoding proteins such as source of immunodominant MHC associated peptides ( SIMP ) , TNF receptor associated factor 2 binding protein ( T2BP ) , poliovirus receptor related protein 1 precursor , glycoprotein A repetitions predominant ( GARP ) . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Glucocorticoid induced TNF receptor , a costimulatory receptor on naive and activated T cells , uses TNF receptor associated factor 2 in a novel fashion as an inhibitor of NF kappa B activation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Zerumbone also inhibited the NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TRADD , TRAF 2 , NIK , and IKK but not that activated by the p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Microscopical analyses of TNFR 2 clustering and TNF receptor associated factor 2 recruitment at contact sites to adjacent cells revealed the formation of stable TNFR complexes by target bound , processed prodrug , resembling the increased signal capacity of natural , membrane expressed TNF . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Monarch 1 reduces NFkappaB activation by TLR signaling molecules MyD 88 , IRAK 1 ( type 1 interleukin 1 receptor associated protein kinase ) , and TRAF 6 ( TNF receptor ( TNFR ) associated factor ) as well as TNFR signaling molecules TRAF 2 and RIP 1 but not the downstream NFkappaB subunit p 65 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The secondary complex retained the DISC components FADD and caspase 8 , but recruited several factors involved in kinase activation by TNF , namely , RIP 1 , TRAF 2 , and NEMO / IKKgamma . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
In this study , we focused on four signaling factors , TNFalpha , TNF R 1 , TNFR associated factor 2 ( TRAF 2 ) and caspase 3 , in order to elucidate the signaling events in tendinocytes . ^^^ In the normal tendon , large amounts of TRAF 2 were found in tendinocytes , but the amounts of TNF R 1 were small . ^^^ TNF R 1 , which was only faintly detected in the normal tendon , was detected at a high level in the inflamed tendon , and the amounts of TRAF 2 and caspase 3 also increased . ^^^ TNFalpha mRNA was also expressed in the scar formed tendon , though it showed weak signals , and the expression levels of TNF R 1 , TRAF 2 and caspase 3 proteins were very low . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Furthermore , SAHA inhibited the NF kappaB dependent reporter gene expression activated by TNF , TNFR 1 , TRADD , TRAF 2 , NF kappaB inducing kinase , IkappaBalpha kinase , and the p 65 subunit of NF kappaB . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Since we observed that MC 160 decreased other NF kappaB activation pathways , namely those activated by receptor interacting protein , TNF receptor associated factor 2 , NF kappaB inducing kinase , or MyD 88 , we hypothesized that the MC 160 product interfered with 1 kappa kinase ( IKK ) activation , an event common to multiple signal transduction pathways . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
The cytoprotective effects of both C peptide and insulin were related to increased expression of TNF receptor associated factor 2 , the product of an NF kappaB dependent survival gene . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Furthermore , mTNF alpha upregulated the expression of TNF receptor associated factor ( TRAF ) 1 and failed to induce TRAF 1 and TRAF 2 membrane translocation , but led to cytoplasmic colocalization . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
NF kappaB reporter activity induced by TNFR 1 , TNF receptor associated death domain , TRAF 2 , TAK 1 , NF kappaB inducing kinase , and IKKbeta was inhibited by indirubin but not that induced by p 65 transfection . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Many cells are resistant , however , to the cytotoxic effects of TNFalpha due to the concurrent activation of pro survival pathways involving the transcription factor NFkappaB and TRAF 2 . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Likewise , dominant negative mutants of tumor necrosis factor alpha receptor associated factor ( TRAF ) 6 , TRAF 2 , and NFkappaB inducing kinase ( NIK ) , intracellular proteins involved in IL 1 and TNFalpha receptor signaling cascades , inhibit Abeta stimulated iNOS promoter activity . ^^^ Our data suggest that Abeta stimulation of astrocyte iNOS is mediated in part by IL 1beta and TNFalpha , and involves a TRAF 6 , TRAF 2 , and NIK dependent signaling mechanism . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Expression of ring finger deleted TRAF 2 sensitizes metastatic melanoma cells to apoptosis via up regulation of p 38 , TNFalpha and suppression of NF kappaB activities . ^^^ Altered TRAF 2 signaling by a form of TRAF 2 , which lacks the ring finger domain ( TRAF2DeltaN ) , increases activities of p 38 MAPK , ATF 2 , and the level of TNFalpha expression . ^^^ Our finding identifies p 38 , TNFalpha and NF kappaB among key players that efficiently sensitizes melanoma cells to UV , ribotoxic ( anisomycin ) and radiomimetic chemicals induced programmed cell death in response to aberrant TRAF 2 signaling . . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
This suggestion was supported by the finding that differentiation of PC 12 per se went along with the increased expression of the proapoptotic TNFalpha receptor 1 ( p 55 ) and its adapter protein Traf 2 , whereas expression and phosphorylation of the antiapoptotic Akt ( PKB ) declined . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNFalpha induced the formation of multinucleated cells ( MNCs ) which were positive for TRAP , VNR and cathepsin K and showed evidence of resorption pit formation . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
RESULTS : The addition of TNFalpha ( + / IL 1alpha ) resulted in differentiation of CD 14 ( + ) macrophages into TRAP ( + ) and VNR ( + ) multinucleated cells capable of extensive lacunar resorption . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
When TNFalpha bound TNFR 2 interacts with TNFR associated factor 2 ( TRAF 2 ) , expression of survival / antiapoptotic genes is up regulated . ^^^ In the present study we determined the changes in localization of TNFalpha and TRAF 2 and their mRNAs and the expression of TNFR 2 in granulosa cells during follicular atresia in pig ovaries . ^^^ In healthy follicles , intense signals for TNFalpha and TRAF 2 and their mRNAs were demonstrated in the outer zone of the granulosa layer , where many proliferating cells and no apoptotic cells were observed . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
TNFalpha activation of the NF kappaB pathway is associated with the inducible binding of TAK 1 to TRAF 2 and both IKKalpha and IKKbeta . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Here we show that upon TNFalpha binding , TNFR 1 translocates to cholesterol and sphingolipid enriched membrane microdomains , termed lipid rafts , where it associates with the Ser / Thr kinase RIP and the adaptor proteins TRADD and TRAF 2 , forming a signaling complex . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Gene levels of RANK , RANKL , TNFalpha , IL 1beta , and cathepsin K ( CK ) were quantified by real time RT PCR , and TRAP staining of pouch membrane was used to evaluate osteoclastogenesis . ^^^
Interacting proteins: P01375 and Q12933	Pubmed	SVM Score :0.0
Seven proteins were identified , including TRADD , TRAP 2 , and TRAF 2 , which are three proteins known to be recruited to TNFalpha receptors . ^^^