| In transfected cells , TTRAP inhibits in a dose dependent manner the transcriptional activation of a nuclear factor kappaB ( NF kappaB ) dependent reporter mediated by CD 40 , TNF R 75 or Phorbol 12 myristate 13 acetate ( PMA ) and to a lesser extent by TRAF 2 , TRAF 6 , TNF alpha , or interleukin 1beta ( IL 1beta ) . ^^^ |