| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.51306395 |
| Son of sevenless ( Sos 1 ) , a bifunctional guanine nucleotide exchange factor ( GEF ) , activates Ras in vivo and displays Rac GEF activity in vitro , when engaged in a tricomplex with Eps 8 and E3b1 Abi 1 , a RTK substrate and an adaptor protein , respectively . 0.51306395^^^ |
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| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.80165498 |
| Eps 8 has been shown to form a Rac specific guanine nucleotide exchange factor complex with Abi 1 and Sos 1 , which seems essential for ruffling formation induced by oncogenic Ras . 0.80165498^^^ |
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| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.0 |
| We also show that Eps 8 , E3b1 and Sos 1 form a tri complex in vivo that exhibits Rac specific GEF activity in vitro . ^^^ We propose a model in which Eps 8 mediates the transfer of signals between Ras and Rac , by forming a complex with E3b1 and Sos 1 . . ^^^ |
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| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.0 |
| Eps 8 is a substrate of the EGFR , which is held in a complex with Sos 1 by the adaptor protein E3bl ( ref . 2 ) , thereby mediating activation of Rac . ^^^ |
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| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.0 |
| An effector region in Eps 8 is responsible for the activation of the Rac specific GEF activity of Sos 1 and for the proper localization of the Rac based actin polymerizing machine . ^^^ This is achieved through the formation of a tricomplex consisting of Eps 8 E3b1 Sos 1 , which is endowed with Rac guanine nucleotide exchange activity . ^^^ We propose a model whereby the engagement of Eps 8 in a tricomplex with E3b1 and Sos 1 facilitates the interaction of Eps 8 with Sos 1 and the consequent activation of an Sos 1 Rac specific catalytic ability . ^^^ |
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| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.0 |
| Abi 1 scaffolds together Eps 8 and Sos 1 , a dual specificity guanine nucleotide exchange factor for Ras and Rac proteins , thus facilitating the formation of a trimeric complex , in turn required for activation of Rac . ^^^ |
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| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.0 |
| Phosphoinositide 3 kinase activates Rac by entering in a complex with Eps 8 , Abi 1 , and Sos 1 . ^^^ One possible candidate for this function is the Rac activating complex Eps 8 Abi1 Sos 1 , which possesses Rac specific guanine nucleotide exchange factor ( GEF ) activity . ^^^ Here , we show that Abi 1 ( also known as E3b1 ) recruits PI3K , via p 85 , into a multimolecular signaling complex that includes Eps 8 and Sos 1 . ^^^ The recruitment of p 85 to the Eps 8 Abi1 Sos 1 complex and phosphatidylinositol 3 , 4 , 5 phosphate ( PIP 3 ) , the catalytic product of PI3K , concur to unmask its Rac GEF activity in vitro . ^^^ |
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| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.0 |
| Sos 1 , a guanine nucleotide exchange factor ( GEF ) , eps 8 and Abi 1 , two signaling proteins , and the lipid kinase phosphoinositide 3 kinase ( PI 3 K ) , assemble in a multimolecular complex required for Rac activation leading to actin cytoskeletal remodeling . ^^^ Similarly to eps 8 , eps8Ls interact with Abi 1 and Sos 1 ; however , only eps8L1 and eps8L2 activate the Rac GEF activity of Sos 1 , and bind to actin in vivo . ^^^ |
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| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.0 |
| E3b1 is a regulator of Rac because it can form a complex with Sos 1 and eps 8 , and such a Sos 1 e3B1 eps 8 complex serves as a guanine nucleotide exchange factor for Rac . ^^^ |
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| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.0 |
| In addition , we describe a novel interaction between palladin and Eps 8 , a receptor tyrosine kinase ( RTK ) substrate that participates in the activation of the Rac specific guanine nucleotide exchange function of Sos 1 . ^^^ |
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| Interacting proteins: Q12929 and Q07889 |
Pubmed |
SVM Score :0.0 |
| NA |
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