| Interacting proteins: Q12929 and P29353 |
Pubmed |
SVM Score :0.0 |
| Concomitant tyrosine phosphorylation of eps 8 and shc , but not of rasGAP , phospholipase C gamma , and eps 15 , was frequently detected in tumor cells . ^^^ This suggested that eps 8 and shc might be part of a pathway which is preferentially selected in some tumors . ^^^ This association was , at least in part , dependent on recognition of shc by the SH 3 domain of eps 8 . ^^^ |
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| Interacting proteins: Q12929 and P29353 |
Pubmed |
SVM Score :0.0 |
| Conversely , expression of Eps 8 , but not of other EGFR substrates such as Shc or Eps 15 , is virtually extinguished in non proliferating , terminally differentiated murine myogenic cells . ^^^ A non myristylated , transformation defective mutant of 5 Src did not phosphorylate Eps 8 , whereas it phosphorylated Shc . ^^^ |
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| Interacting proteins: Q12929 and P29353 |
Pubmed |
SVM Score :0.0 |
| Further analysis demonstrated that , although TSA reduced the expression of Eps 8 in a dose and time dependent manner , both the protein expression and kinase activity of 5 Src remained constant , and the abundance and phosphotyrosine levels of Src substrates , including cortactin , focal adhesion kinase , p 130 ( Cas ) , paxillin , and Shc , were not altered . ^^^ |
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| Interacting proteins: Q12929 and P29353 |
Pubmed |
SVM Score :0.0 |
| NA |
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