| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.63390661 |
| Lithium suppressed Tyr 402 phosphorylation of proline rich tyrosine kinase ( Pyk 2 ) and interactions of Pyk 2 and PSD 95 with NR2A in rat hippocampus following cerebral ischemia . 0.63390661^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.57923761 |
| I / R led to increases of tyrosine phosphorylation of NR2A and interaction of Pyk 2 and Src kinase with NR2A after 6 h of reperfusion . 0.57923761^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Thus , whereas application of glutamate to hippocampal slices from control mice increased fyn protein tyrosine kinase ( PTK ) activity more than 2 . 5 fold , these changes were significantly impaired in LP BM 5 MuLV infected mice . ^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| An important subtype of glutamate receptor , the NMDA receptor , is shown to be regulated by insulin via protein tyrosine kinase ( PTK ) . ^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Here , we show that brain derived neurotrophic factor ( BDNF ) and platelet derived growth factor enhance expression of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid ( AMPA ) type glutamate receptor 1 and 2 / 3 proteins in rodent neocortical neurons via the Src family PTK ( s ) . ^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| We found that the tyrosine kinase related adhesion focal tyrosine kinase ( RAFTK ) is tyrosine phosphorylated in response to glutamate in a time and dose dependent manner . ^^^ RAFTK tyrosine phosphorylation was mediated primarily by class I / II metabotropic glutamate receptors and depends on protein kinase C ( PKC ) activation . ^^^ Like RAFTK phosphorylation , ERK1 / 2 activation is PTX sensitive and can be attenuated by the depletion of intracellular Ca2+ and by PKC inhibition , suggesting that RAFTK might mediate the glutamate dependent activation of ERK1 / 2 . ^^^ Glutamate stimulated DNA synthesis is PTX sensitive and can be inhibited by the MAP kinase kinase inhibitor PD 98059 , suggesting that in primary astrocytes , glutamate might signal via RAFTK and MAP kinase to promote DNA synthesis and cell proliferation . . ^^^ Glutamate stimulated activation of DNA synthesis via mitogen activated protein kinase in primary astrocytes : involvement of protein kinase C and related adhesion focal tyrosine kinase . ^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Selective inhibition of either metabotropic glutamate receptors ( mGluRs ) , protein kinase C ( PKC ) or tyrosine protein kinase ( PTK ) blocked depression at both sites equally effectively . ^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Glutamate induced apoptotic like death ( determined by DAPI staining ) was largely prevented by inhibition of NMDA R , PKC , CaM kinase 2 , PTK and MEK1 / MEK2 ( ERK1 / ERK2 kinase ) , respectively . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| A 1 h incubation of neuronal cultures with tetrodotoxin ( TTX ) , the PI3K inhibitor wortmannin , the NMDA receptor antagonist MK 801 or removal of extracellular calcium significantly reduced basal levels of phospho ( Ser 473 ) PKB , indicating that activity dependent glutamate release maintains PKB activation through an NMDA receptor PI3K pathway . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| The selective src PTK inhibitor PP 1 ( 10 microm intracellularly ) potentiated submaximal mGluR 1 currents evoked by low L glutamate concentrations but had no effect on maximal responses ( 80 or 160 microm L glutamate ) . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Inhibiting Src family tyrosine kinase activity blocks glutamate signalling to ERK1 / 2 and Akt / PKB but not JNK in cultured striatal neurones . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| In EAAT 3 expressing Xenopus oocytes , glutamate induced current was stimulated by coexpression of wild type SGK 1 , constitutively active ( S422D ) SGK 1 , and constitutively active ( T308D , S473D ) PKB , but not by inactive ( K127N ) SGK 1 . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the EAAT 4 glutamate transporter by SGK protein kinase isoforms and PKB . ^^^ The kinase activates glutamate induced current ( 1 ( GLU ) ) in Xenopus oocytes heterologously expressing EAAT 4 , an effect mimicked by its isoforms SGK 2 , 3 and PKB . 1 ( GLU ) was decreased by the ubiquitin ligase Nedd 4 2 , an effect partially but not completely reversed by additional coexpression of the SGK kinase isoforms or PKB . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| The ventilatory responses of peripheral chemoreflex following 0 . 1 microl microinjection within the NTS of either PTK inhibitor genistein ( 10 mol / L ) , AMPA glutamate receptor inhibitor CNQX ( 10 mol / L ) , or inactive PTK inhibitor daidzein ( 10 mol / L ) were recorded . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Expression studies in Xenopus oocytes demonstrated that glutamate induced inward current ( IGLU ) was stimulated by co expression of SGK 1 , SGK 2 , SGK 3 or PKB . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NMDA receptor activation results in tyrosine phosphorylation of NMDA receptor subunit 2A ( NR2A ) and interaction of Pyk 2 and Src with NR2A after transient cerebral ischemia and reperfusion . ^^^ In this study , effect of ischemia and reperfusion ( I / R ) on tyrosine phosphorylation of NMDA receptor subunit 2A ( NR2A ) and the interaction of two tyrosine kinases , Src and Pyk 2 , with NR2A was investigated . ^^^ Src and Pyk 2 co immunoprecipitated with NR2A and the binding increased after I / R , which also reached a peak at 6 h of reperfusion . ^^^ These data show that NR2A , Src and Pyk 2 might form a protein complex in vivo and the interaction suggests a possible mechanism of signal transduction in the postischemic hippocampus . . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Activation of Pyk 2 and Src / Fyn kinases led to increased tyrosine phosphorylation of NMDA receptor subunits 2A and B ( NR2A / B ) and was blocked by a selective mGluR 1 antagonist , 7 ( hydroxyamino ) cyclopropa [ b ] chromen 1a carboxylate ethyl ester , but not an mGluR 5 antagonist , 2 methyl 6 ( phenylethynyl ) pyridine . ^^^ Functional linkage between mGluR 1 activation and NR2A tyrosine phosphorylation through Pyk 2 and Src was also demonstrated after expression of these elements in human embryonic kidney 293 cells . ^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated the effects of protein tyrosine kinase ( PTK ) and protein tyrosine phosphatase ( PTP ) on the tyrosine phosphorylation of N methyl D aspartate receptor subunit 2A ( NR2A ) and the interactions among NR2A , postsynaptic density protein 95 ( PSD 95 ) , Fyn / Src after brain ischemia / reperfusion ( I / R ) . ^^^ The following results were observed : ( 1 ) the increase in tyrosine phosphorylation of NR2A induced by I / R was suppressed by genistein , an inhibitor of PTK , but was further enhanced by sodium orthovanadate , an inhibitor of PTP , which were administered to the SD rats 20 min before ischemia . ( 2 ) Importantly , genistein and sodium orthovanadate increased and decreased the interactions involving NR2A , PSD 95 , Fyn and Src , respectively . ^^^ These results demonstrated that PTK and PTP were involved in regulating tyrosine phosphorylation of NR2A through changing the interaction among NR2A , PSD 95 , Fyn / Src . . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of NR2A and interaction of NR2A with Src and Pyk 2 in hippocampus induced by brain ischemia and reperfusion ( I / R ) were determined by immunoprecipitation and immunoblot ( ting ) . ^^^ Interaction of NR2A with Src and Pyk 2 , tyrosine phosphorylation and kinase activity of Src and Pyk 2 also increased after I / R . ^^^ Src and Pyk 2 interacting with NR2A might also be involved in this regulation of the tyrosine phosphorylation of NR2A induced by I / R . . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Following ischemia , tyrosine phosphorylation of NR2A and NR2B and activated Src family kinases ( SFKs ) and Pyk 2 were increased in post synaptic densities ( PSDs ) . ^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Mutating both these sites eliminated insulin potentiation of NR2A containing receptors , while co expression of dominant negative Pyk 2 had no effect . ^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| Two different models of brain ischemia were used to examine the evoked changes in the tyrosine phosphorylation of NMDA receptor subunits 2A and 2B ( NR2A and NR2B ) , as well as their interactions with non receptor tyrosine kinases ( NRTKs : FAK , PYK 2 Src ) , and PSD 95 protein . ^^^ |
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| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| To further investigate the mechanisms underlying the neuroprotection of PSD 95 deficiency , the interaction of proline rich tyrosine kinase 2 ( Pyk 2 ) with NR2A as well as autophosphorylation ( Tyr 402 ) of Pyk 2 were detected . ^^^ Immunoprecipitation and immunoblot analysis showed that preischemic treatment with AS , but not MS or vehicle , attenuated the I / R6h induced increases in Pyk 2 NR2A association and Pyk 2 autophosphorylation . ^^^ The protein levels of NR2A and Pyk 2 had no differences under the above conditions . ^^^ |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q14289 |
Pubmed |
SVM Score :0.0 |
| NA |
|