| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.64843397 |
| Inhibiting endogenous Cdk 5 , or perturbing interactions between Cdk 5 and NR2A subunits , abolished NR2A phosphorylation at Ser 1232 and protected CA 1 pyramidal neurons from ischemic insult . 0.64843397^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| Here we report that both Cdk 5 and CK 1 are regulated by metabotropic glutamate receptors ( mGluRs ) in neostriatal neurons . ( S ) 3 , 5 dihydroxyphenylglycine ( DHPG ) , an agonist for group 1 mGluRs , increased Cdk 5 and CK 1 activities in neostriatal slices , leading to the enhanced phosphorylation of Thr 75 and Ser 137 of DARPP 32 , respectively . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| Previously , we reported that ( S ) 3 , 5 dihydroxypenylglycine ( DHPG ) , an agonist for group 1 metabotropic glutamate receptors ( mGluRs ) , stimulates CK 1 and Cdk 5 kinase activities in neostriatal neurons , leading to enhanced phosphorylation , respectively , of Ser 137 and Thr 75 of DARPP 32 ( dopamine and cAMP regulated phosphoprotein , 32 kDa ) . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| The glutamate mediated increase in association of p 35 and CaMKIIalpha is mediated in large part by NMDA receptors , suggesting that cross talk between the Cdk 5 and CaMKII signal transduction pathways may be a component of the complex molecular mechanisms contributing to synaptic plasticity , memory , and learning . . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| In glutamate treated cells p 35 was cleaved to p 25 and this was associated with elevated cdk 5 activity . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| However , expression of Deltac Jun in adult mice blocked the ability of chronic cocaine administration to induce three known targets for AP 1 in the NAc : the AMPA glutamate receptor subunit GluR 2 , the cyclin dependent protein kinase Cdk 5 , and the transcription factor nuclear factor kappaB ( NFkappaB ) , without affecting several other proteins examined for comparison . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| Tissues from the accumbens and ventral tegmental area ( VTA ) were assayed for candidate molecular neuroadaptations , including enzyme activities of cAMP dependent protein kinase ( PKA ) and adenylate cyclase ( AC ) , and protein expression of cyclin dependent kinase 5 ( cdk 5 ) , tyrosine hydroxylase ( TH ) and glutamate receptor subunits ( GluR 1 , GluR 2 and NMDAR 1 ) . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| Autophosphorylation of p 35 by Cdk 5 is a signal for ubiquitination / degradation , and the degradation of p 35 is triggered by glutamate treatment in cultured neurons . p 35 is cleaved to p 25 by calpain at the time of neuronal cell death , and this limited cleavage is suggested to be the cause of neurodegenerative diseases such as Alzheimer ' s disease . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| Both N methyl D aspartate ( NMDA ) and non NMDA receptors mediate glutamate induced cleavage of the cyclin dependent kinase 5 ( cdk 5 ) activator p 35 in cultured rat hippocampal neurons . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| We report here that glutamate , acting via NMDA or kainate receptors , can induce a transient Ca ( 2+ ) / calmodulin dependent activation of Cdk 5 that results in enhanced autophosphorylation and proteasome dependent degradation of a Cdk 5 activator p 35 , and thus ultimately down regulation of Cdk 5 activity . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| In contrast to MEF2A and MEF2D , MEF2C is not phosphorylated by Cdk 5 after glutamate exposure and , therefore , resistant to neurotoxin induced caspase dependent degradation . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| Glutamate treatment and p 25 transfection increase Cdk 5 mediated tau phosphorylation in SH SY5Y cells . ^^^ We show that glutamate increased tau phosphorylation , concomitant with an increased Cdk 5 activity achieved by upregulation of Cdk 5 and p 35 protein levels . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that cyclin dependent kinase 5 ( Cdk 5 ) associates with and phosphorylates NR2A subunits at Ser 1232 in vitro and in intact cells . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| Furthermore , it has been shown that after transient forebrain ischemia , cdk 5 causes specific death of CA 1 neurons in the rat hippocampus by direct phosphorylation of the NR2A subunit of the NMDA receptor and subsequent excitotoxicity . ^^^ |
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| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12879 and Q00535 |
Pubmed |
SVM Score :0.0 |
| NA |
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