| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.57930549 |
| Using microcapillary reverse phase high performance liquid chromatography nano electrospray tandem mass spectrometry , we identified VAMP 3 and VAMP 8 as VAMP isoforms coimmunoprecipitated from platelets with syntaxin 4 . 0.57930549^^^ We conclude that VAMP 3 and VAMP 8 form SNARE complexes with platelet syntaxin 4 and are required for platelet granule secretion . . 0.50979546^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| In order to better understand the molecular mechanisms of platelet granule secretion , we evaluated the effect of activation induced degranulation on three functional platelet SNARE proteins , SNAP 23 , VAMP 3 , and syntaxin 4 . ^^^ In contrast , calpeptin did not prevent SFLLRN induced degradation of VAMP 3 and syntaxin 4 did not undergo substantial proteolysis following platelet activation . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| SNAP 23N can assemble spontaneously with the coiled coil domains from SNAP 23C , syntaxin 4 , and VAMP 3 to form a heterotetrameric complex . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| SNAP 23 interacted with syntaxin 3 , syntaxin 4 , VAMP 2 , VAMP 3 and VAMP 8 . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| Syntaxin 2 , Syntaxin 3 , Syntaxin 4 , vesicle associated membrane protein ( VAMP ) 2 , VAMP 3 , and synaptosome associated protein ( SNAP ) 23 could be readily detected in normal human PC obtained from intestinal lamina propria and blood , as well as in human PC lines . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| Coupled to the recent detection of vesicle associated membrane protein 2 and cellubrevin in skeletal muscle , syntaxin 4 may play a role in membrane traffic in this tissue . . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization using isoform specific oligonucleotide probes to different exocytotic protein messenger RNAs ( mRNAs ) showed strong hybridization signal for synaptotagmin 1 , cysteine string protein ( CSP ) , VAMP 2 ( vesicle associated membrane protein ) , cellubrevin , munc 18 ( mammalian homologue of unc 18 ) , SNAP 25a ( synaptosomal associated protein of 25 kDa ) , syntaxin 1A , syntaxin 4 , syntaxin 5 , and alpha SNAP ( soluble NSF attachment protein ) in the anterior and intermediate , but not in the posterior lobe of the pituitary . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| Recently , several SNARE proteins were found in adipocytes : vesicle associated membrane protein ( VAMP 2 ) , its related homologue cellubrevin , and syntaxin 4 . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| An interaction of SNAP 23 and syntaxin 4 on the plasma membrane with vesicle associated synaptobrevin 2 and / or cellubrevin , known as SNAP ( soluble N ethyl maleimide sensitive factor attachment protein ) receptors or SNAREs , has been proposed to provide the targeting and / or fusion apparatus for insulin stimulated translocation of the GLUT 4 isoform of glucose transporter to the plasma membrane . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| Such analyses suggest that in 3T3 L 1 adipocytes there are approximately 374 , 000 copies of syntaxin 4 , 1 . 15 10 10 ( 6 ) copies of SNAP 23 , 495 , 000 copies of VAMP 2 , 4 . 3 10 10 ( 6 ) copies of cellubrevin and 452 , 000 copies of Munc18c per cell , compared to previous estimates of 280 , 000 copies of Glut 4 . ^^^ Thus , the main SNARE proteins involved in insulin stimulated Glut 4 exocytosis ( syntaxin 4 and VAMP 2 ) are expressed in approximately equimolar amounts in adipocytes , whereas by contrast the endosomal 5 SNARE cellubrevin is present at approximately 10 fold higher levels and the t SNARE SNAP 23 is also present in an approximately 3 fold molar excess . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| SNARE protein expression in models of insulin resistance : normalization of glycemia by rosiglitazone treatment corrects overexpression of cellubrevin , vesicle associated membrane protein 2 , and syntaxin 4 in skeletal muscle of Zucker diabetic fatty rats . ^^^ Studies have suggested an important role for synaptobrevin and syntaxin homologues in this event , particularly the 5 soluble N ethylmaleimide attachment protein receptors ( SNAREs ) cellubrevin and vesicle associated membrane protein 2 ( VAMP 2 ) and the t SNARE syntaxin 4 , but the expression of these proteins has not been studied in insulin resistant tissues . ^^^ In contrast , cellubrevin , VAMP 2 , and syntaxin 4 protein levels were elevated ( 2 . 8 fold , P = 0 . 02 ; 3 . 7 fold , P = 0 . 01 ; and 2 . 2 fold , P < 0 . 05 , respectively ) in skeletal muscle from ZDF rats compared with lean controls . ^^^ Restoration of normoglycemia and normoinsulinemia in ZDF rats with rosiglitazone ( 30 micromol / kg ) normalized cellubrevin , VAMP 2 , and syntaxin 4 protein to levels approaching those observed in lean control animals . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| Levels of the 5 SNARE protein cellubrevin and of the t SNARE protein syntaxin 4 were increased in this process in parallel to GLUT 4 . ^^^ |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q15836 and Q12846 |
Pubmed |
SVM Score :0.0 |
| NA |
|