| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.68968704 |
| Here we present evidence that RhoA associates specifically with the guanine nucleotide exchange factor Lbc in human peripheral blood monocytes stimulated with fMLP and that Lbc specifically catalyzes the guanine nucleotide exchange activity of RhoA in human peripheral blood monocytes . 0.68968704^^^ |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.76463712 |
| Brx interacted with GR , forming a ternary complex with RhoA . 0.76463712^^^ |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| AKAP Lbc is a novel member of the A kinase anchoring protein ( AKAPs ) family , which functions as a cAMP dependent protein kinase ( PKA ) targeting protein as well as a guanine nucleotide exchange factor ( GEF ) for RhoA . ^^^ |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| We have recently identified a novel anchoring protein expressed in cardiomyocytes , called AKAP Lbc , that functions as a PKA targeting protein as well as a guanine nucleotide exchange factor ( GEF ) that activates the GTPase RhoA . ^^^ |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| Moreover , activation of ER by Brx could be specifically inhibited by a dominant negative mutant of Cdc42Hs , but not by dominant negative mutants of RhoA or Rac 1 . ^^^ |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| The Ht 31 cDNA includes the estrogen receptor cofactor Brx and the RhoA GDP / GTP exchange factor proto lymphoid blast crisis ( Lbc ) sequences . ^^^ |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| Point mutations in the switch 2 region of the small G proteins , many of which would affect the interaction with GEF in the case of Ras , or a mutation in the switch 1 region that was identified as a contact site between Rab3A and Rab GEF had little effect on RhoA or Cdc42Hs with regard to the ability to interact with Lbc or Cdc 24 , suggesting that there exists a unique mechanism of regulation of the Rho family proteins by their GEFs . ^^^ |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| Previously , we demonstrated that both Lfc and Lsc , like their closest relative Lbc , can act catalytically in stimulating the guanine nucleotide exchange activity of RhoA in vitro . ^^^ |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| The continuous coupled enzyme system was used for characterization of the interactions between the small GTPase RhoA and its guanine nucleotide exchange factors , Lbc and Dbl . ^^^ |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| Expression of a catalytically inactive proto Lbc mutant in HEK293T cells attenuates Galpha 12 and thrombin induced activation of an SRE transcriptional reporter , and the levels of inhibition observed is similar to that obtained with an analogous p 115 RhoGEF mutant . proto Lbc mutant expression also led to decreased levels of Galpha 12 induced RhoA activation in vivo . ^^^ |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P61586 |
Pubmed |
SVM Score :0.0 |
| NA |
|