| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| Five strains ( MCF 7 , Br 10 , R 27 , ZR 75 1 , and T 61 ) used for the experiments possessed cytosol estrogen receptor ( ER ) , and their growth was estradiol dependent . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| We have investigated the experimental combined chemo and endocrine therapy of UFT and tamoxifen ( TAM ) on two human breast carcinoma xenografts , R 27 and Br 10 with estrogen receptors ( ER ) serially transplanted into nude mice . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| We examined the effect of chemotherapeutic agents on the estrogen receptors ( ER ) of breast carcinomas in vivo using human breast carcinoma strains ( Br 10 , T 61 ) serially transplanted into nude mice . ^^^ Four days after the MMC administration at above doses , the binding sites of ER in Br 10 were not reduced and binding affinity was not affected . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| The tumor growth was significantly stimulated by E 2 in 3 out of the 4 ER positive tumors , the Td of the E 2 treated groups being 17 . 6 days for MCF 7 ( control : 17 . 8 days ) , 12 . 8 days for R 27 ( control : 12 . 5 days approximately 14 . 5 days ) and 10 . 4 days for Br 10 ( control : 14 . 5 days ) , however , in the T 61 tumor , the growth was inhibited by E 2 in a dose dependent manner . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| Whereas three of these strains ( MCF 7 , Br 10 , TM 61 ) possessed cytosol estrogen receptor ( ERc ) and were dependent on estradiol for the tumor growth , the other strain ( MX 1 ) without ERc was hormone independent . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| Estrogen receptor of BX 1 was negative and no estrogen dependency was observed while Br 10 was the receptor positive and the growth of Br 10 was dependent on estrogen . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| Although the growth of Br 10 was enhanced by EP and arrested by TAM , ER processing which was observed by E and EP was also observed temporarily by TAM in the early stage , however it was suppressed subsequently . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| DROL was more effective than TAM against ER positive Br 10 breast carcinoma in nude mice , but neither drug had effects on ER negative MX 1 breast carcinoma . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| The effect of experimental cancer chemotherapy with mitomycin C ( MMC ) was studied using three estrogen receptor ( ER ) positive ( MCF 7 , R 27 , and Br 10 ) and one ER negative ( MX 1 ) human breast carcinoma xenograft serially transplanted into nude mice , and the effect of estradiol ( E 2 ) priming on the antitumor activity of MMC was investigated . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| Here we report the cloning and initial characterization of a novel protein , Brx , that contains a region of identity to the oncogenic Rho guanine nucleotide exchange ( Rho GEF ) protein Lbc , and a unique region capable of binding to nuclear hormone receptors , including the ER . ^^^ Brx bound specifically to the ER via an interaction that required distinct regions of ER and Brx . ^^^ Furthermore , overexpression of Brx in transfection experiments using an estrogen responsive reporter revealed that Brx augmented gene activation by the ER in an element specific and ligand dependent manner . ^^^ Moreover , activation of ER by Brx could be specifically inhibited by a dominant negative mutant of Cdc42Hs , but not by dominant negative mutants of RhoA or Rac 1 . ^^^ Characterization of Brx , a novel Dbl family member that modulates estrogen receptor action . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : We previously identified a protein , Brx , that interacted with estrogen receptor alpha . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| We showed that the novel Dbl family proto oncoprotein Brx enhances ligand dependent activity of ERalpha via a Cdc 42 dependent pathway . ^^^ The proto oncoprotein Brx activates estrogen receptor beta by a p 38 mitogen activated protein kinase pathway . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| The Ht 31 cDNA includes the estrogen receptor cofactor Brx and the RhoA GDP / GTP exchange factor proto lymphoid blast crisis ( Lbc ) sequences . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To evaluate the expression of estrogen receptor alpha ( ERalpha ) , estrogen receptor beta ( ERbeta ) , and breast cancer nuclear receptor auxiliary factor ( Brx ) in eutopic endometrium of normal women and women with endometriosis . ^^^ MAIN OUTCOME MEASURE ( S ) : Expression of immunohistochemical staining intensity and localization of ERalpha , ERbeta , and Brx proteins in eutopic endometrium during the menstrual cycle . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| This novel protein , designated Brx , contains an estrogen receptor binding motif and is highly expressed in hormone responsive breast tissue . ^^^ The anatomical studies support a role for Brx in its association with the estrogen receptor and that Brx may be involved in neuronal and pituitary function in a sexually dimorphic manner . . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| The effects of erythrocyte infusion on 3 . 2 km ( 2 mile ) run performance were evaluated during 3 days ( HA 3 ) and 14 days ( HA 14 ) exposure to high altitude ( 4300 m ) in erythrocyte infused ( ER ) and control ( CON ) subjects that were initially matched ( P > 0 . 05 ; n = 8 in each group ) for age , body size and aerobic fitness . ^^^ The 3 . 2 km run times ( min : s ) did not differ ( P > 0 . 05 ) between groups at SL [ mean ( SEM ) ER , 13 : 14 ( 00 : 19 ) ; CON , 13 : 39 ( 00 : 32 ) ] or during HA 3 [ ER , 19 : 02 ( 00 : 18 ) ; CON , 19 : 44 ( 00 : 43 ) ] and HA 14 [ ER , 17 : 44 ( 00 : 27 ) ; CON , 18 : 45 ( 00 : 55 ) ] but times were slower ( P < 0 . 05 ) when comparing HA 3 or HA 14 to SL . ^^^ Heart rates ( HR ) did not differ between groups at SL [ ER , 188 ( 3 ) beats 10 min ( 1 ) ; CON , 191 ( 3 ) beats 10 min ( 1 ) ] , or during HA 3 [ ER , 170 ( 4 ) beats 10 min ( 1 ) ; CON , 178 ( 4 ) beats 10 min ( 1 ) ] and HA 14 [ ER , 162 ( 6 ) beats 10 min ( 1 ) ; CON , 169 ( 5 ) beats 10 min ( 1 ) ] , but HR were lower ( P < 0 . 05 ) when comparing HA 3 or HA 14 to SL . ^^^ Analysis of covariance ( adjusted for SL group run times ) revealed ( min : s ) 00 : 14 ( HA 3 ) and 00 : 28 ( HA 14 ) mean improvement tendencies ( P > 0 . 05 ) for ER compared to CON . ^^^ |
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| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12802 and P03372 |
Pubmed |
SVM Score :0.0 |
| NA |
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