| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Adenoviral E1A associated protein p 300 as a functional homologue of the transcriptional co activator CBP . ^^^ |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Adenoviral E1A associated protein p 300 is involved in acute myeloid leukemia with t ( 11 ; 22 ) ( q 23 ; q 13 ) . p 300 , which was originally cloned as a nuclear binding target of the adenovirus E1A oncoprotein , forms a family with cyclic AMP response element binding protein ( CREB ) binding protein ( CBP ) . p300 / CBP are considered to be transcriptional coactivators that connect the basal transcriptional machinery to various DNA binding transcriptional factors . p300 / CBP are implicated in both cell differentiation and regulation of cell cycle . ^^^ |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| One important coactivator complex includes a p 160 coactivator ( e . g . , GRIP 1 , SRC 1 , or ACTR ) that binds directly to activated NR , the histone acetyltransferase p 300 or CBP , and the arginine specific histone methyltransferase CARM 1 . ^^^ |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Both interact with p 300 and CBP ( encoded by Ep 300 and Crebbp , respectively ) , two other histone acetyltransferases that integrate multiple signalling pathways . ^^^ |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| The protein EP 300 and its paralog CREBBP ( CREB binding protein ) are ubiquitously expressed transcriptional co activators and histone acetyl transferases . ^^^ The gene EP 300 is essential for normal cardiac and neural development , whereas CREBBP is essential for neurulation , hematopoietic differentiation , angiogenesis and skeletal and cardiac development . ^^^ The CBP / p300 interacting transactivator with ED rich tail 2 ( CITED 2 ) binds EP 300 and CREBBP with high affinity and regulates gene transcription . ^^^ |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| EP 300 ( p 300 ) and CREBBP ( CBP ) are highly related transcriptional co activators possessing histone acetyltransferase activity . ^^^ Analysis of genetic stability at the EP 300 and CREBBP loci in a panel of cancer cell lines . ^^^ A role for EP 300 and CREBBP as tumor suppressors in cancer has been suggested by the fact that they are targeted by viral oncogenes ; there is an increased incidence of hematologic malignancies in mice monoallelic for CREBBP ; and loss , albeit at a low frequency , of both EP 300 alleles in epithelial cancers has been observed . ^^^ Because the level of EP300 / CREBBP appears to have a critical effect on integrating certain transcriptional processes , we sought to determine whether a loss in the combined gene dosage of EP 300 and CREBBP might play a role in cancer . ^^^ Accordingly , we screened a panel of 103 cell lines for loss of heterozygosity and found 35 and 51 % LOH for the CREBBP and EP 300 loci , respectively . ^^^ |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Genetic heterogeneity in Rubinstein Taybi syndrome : mutations in both the CBP and EP 300 genes cause disease . ^^^ |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Previous studies have identified cytogenetic deletions in the CREBBP gene in eight to 12 % of patients and very recently , Roelfsema et al . reported EP 300 gene mutations in three of 92 ( 3 . 3 % ) patients with either true RSTS or different syndromes resembling RSTS . ^^^ |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Here we report characteristic patterns of expression of 12 members of 3 classes of chromatin modifier genes in 6 different cancer types : histone acetyltransferases ( HATs ) EP 300 , CREBBP , and PCAF ; histone deacetylases ( HDACs ) HDAC 1 , HDAC 2 , HDAC 4 , HDAC 5 , HDAC7A , and SIRT 1 ; and histone methyltransferases ( HMTs ) SUV39H1and SUV39H2 . ^^^ |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q09472 and Q92793 |
Pubmed |
SVM Score :0.0 |
| NA |
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