| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| Two closely related mammalian RB binding proteins , RbAp 48 and RbAp 46 , share sequence homology with the Msi 1 protein of yeast . ^^^ |
|
| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| Here , we identify SAP 30 as a novel component of the human histone deacetylase complex that includes Sin 3 , the histone deacetylases HDAC 1 and HDAC 2 , histone binding proteins RbAp 46 and RbAp 48 , as well as other polypeptides . ^^^ The human SAP 30 complex is active in deacetylating core histone octamers , but inactive in deacetylating nucleosomal histones due to the inability of the histone binding proteins RbAp 46 and RbAp 48 to gain access to nucleosomal histones . ^^^ |
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| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| Here we report that BRCA 1 interacts in vivo and in vitro with the Rb binding proteins , RbAp 46 and RbAp 48 , as well as with Rb . ^^^ |
|
| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| They consisted of a protein exhibiting a novel amino acid sequence ; of nuclear lamin B 2 , RbAp 46 , and RbAp 48 ; and of four as yet unknown proteins . ^^^ |
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| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| The histone deacetylases HDAC 1 and HDAC 2 and the histone binding proteins RbAp 48 and RbAp 46 form a core complex shared between NuRD and Sin 3 histone deacetylase complexes . ^^^ |
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| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| CBP ( or its homologue p 300 ) from HeLa cell nuclear extracts coimmunoprecipitated with RbAp 48 and its homologue RbAp 46 and bound to a glutathione S transferase RbAp 48 fusion protein . ^^^ These data indicate that the association of phosphorylated CREB with CBP promotes the binding of RbAp 48 and its homologue RbAp 46 , allowing the formation of a complex that facilitates histone acetylation during transcriptional activation . . ^^^ |
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| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| Interestingly , we do not observe RbAp 46 and RbAp 48 in this complex , although these proteins have been observed in all previously identified complexes and are thought to be part of an HDAC1 / 2 core . ^^^ |
|
| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| We have previously found that a human Sin 3 HDAC complex includes HDAC 1 and HDAC 2 , the histone binding proteins RbAp 46 and RbAp 48 , and two novel polypeptides SAP 30 and SAP 18 . ^^^ |
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| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| Consistent with this interpretation , the N terminal transcriptional repression domain of Suv39H1 bound the so called ' core histone deacetylase complex ' , composed of HDAC 1 , HDAC 2 and the Rb associated proteins RbAp 48 and RbAp 46 . ^^^ |
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| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| In contrast , Mis 15 , Mis 16 ( strong similarity with human RbAp 48 and RbAp 46 ) , Mis 17 , and Mis 18 are all part of the CENP A recruitment pathway . ^^^ RNAi knockdown in human cells shows that Mis 16 function is conserved as RbAp 48 and RbAp 46 are both required for localization of human CENP A . . ^^^ |
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| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| NuRD complex , including HDAC 1 , HDAC 2 , MTA 2 , MBD 2 , RbAp 46 , and RbAp 48 , but MBD 3 is not found in the MBD3L1 bound fraction . ^^^ |
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| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| The results indicate that the mechanisms of RBF regulation at these two types of E2F targets are different and suggest that p 55 , and perhaps p 55 ' s mammalian orthologs RbAp 46 and RbAp 48 , have a conserved function in repression by pRB related proteins . . ^^^ |
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| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| In glutathione S transferase pull down assays , MBD3L2 is found associated with several known components of the Mi 2 NuRD complex , including HDAC 1 , HDAC 2 , MTA 1 , MBD 3 , p 66 , RbAp 46 , and RbAp 48 . ^^^ |
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| Interacting proteins: Q16576 and Q09028 |
Pubmed |
SVM Score :0.0 |
| The Mi 2 / NuRD components MBD 3 , RbAp 46 , RbAp 48 , and HDAC 1 were found to bind to both p66alpha and p66beta in vivo . ^^^ |
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