| Interacting proteins: Q08881 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Studies on LAT , SLP 76 , Itk and Vav have revealed their role in the activation of Ras and phospholipase Cgamma 1 Ca2+ signalling pathways . ^^^ |
|
| Interacting proteins: Q08881 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Third , the Itk Src homology ( SH 3 ) 3 and SH 2 domains interact cooperatively with Syk phosphorylated SLP 76 . ^^^ Notably , SLP 76 contains a predicted binding motif for the Itk SH 2 domain and binds to full length Itk in vitro . ^^^ Finally , we show that kinase inactive Itk can antagonize the SLP 76 dependent activation of NF AT . ^^^ |
|
| Interacting proteins: Q08881 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of LAT creates binding sites for the Src homology 2 ( SH 2 ) domains of other proteins , including PLC gamma 1 , Grb 2 , Gads , Grap , 3BP2 , and Shb , and indirectly binds SOS , c Cbl , Vav , SLP 76 , and Itk . ^^^ |
|
| Interacting proteins: Q08881 and Q13094 |
Pubmed |
SVM Score :0.0 |
| The studies on LAT , SLP 76 , ItK and Vav have shown their roles in the signal transduction of Ras and phospholipase Cx 1 to Ca2+ . ^^^ |
|
| Interacting proteins: Q08881 and Q13094 |
Pubmed |
SVM Score :0.0 |
| Loss of Itk expression did not alter gross patterns of Vav tyrosine phosphorylation but appeared to disrupt the interactions of Vav with SLP 76 . ^^^ |
|
| Interacting proteins: Q08881 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08881 and Q13094 |
Pubmed |
SVM Score :0.0 |
| NA |
|