| Interacting proteins: P62937 and Q08881 |
Pubmed |
SVM Score :0.638276 |
| Mutation of a conformationally heterogeneous proline in the SH 2 domain of Itk disrupted interaction with CypA and specifically increased Th 2 cytokine production from wild type CD4+ T cells . 0.638276^^^ |
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| Interacting proteins: P62937 and Q08881 |
Pubmed |
SVM Score :0.0 |
| Regulation of the tyrosine kinase Itk by the peptidyl prolyl isomerase cyclophilin A . ^^^ Our studies indicate that Itk catalytic activity is inhibited by the peptidyl prolyl isomerase activity of cyclophilin A ( CypA ) . ^^^ |
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| Interacting proteins: P62937 and Q08881 |
Pubmed |
SVM Score :0.0 |
| This overview takes a close look at one particular signaling protein , the T cell specific tyrosine kinase Itk , and examines the role of proline isomerization and the peptidyl prolyl isomerase cyclophilin A in mediating Itk function following T cell receptor engagement . . ^^^ |
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