| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.63674698 |
| Human 90K , also known as Mac 2 binding protein ( Mac 2 BP ) , is a secreted glycoprotein which is widely expressed , binds to the human macrophage associated lectin Mac 2 , and may have a role in host defence . 0.63674698^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Human milk 90K ( Mac 2 BP ) : possible protective effects against acute respiratory infections . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Adhesion to 90K ( Mac 2 BP ) as a mechanism for lymphoma drug resistance in vivo . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Moreover , the data indicate that after the initial activation of L 1 downstream molecules such as the SAP kinase 4 , the met protoonocogene and the galectin 3 binding protein are upregulated . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| After transfection of RA SF with a functional L1 . 2 element , human stress activated protein kinase 2 delta ( SAPK2delta [ or SAPK 4 ] ) , met protooncogene , and galectin 3 binding protein genes were differentially expressed . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Potentially important up regulated genes included gp 96 , lung resistance related protein , galectin 3 binding protein , the M ( r ) 67 , 000 laminin receptor ( on tumor vessels ) , and voltage dependent anion channels . ^^^ |
|
| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To characterize the expression pattern and role of galectin 3 and galectin 3 binding protein ( G3BP ) in rheumatoid arthritis ( RA ) , in comparison with galectin 1 , and to explore whether soluble galectin 3 and G3BP , investigated in serum , synovial fluid , or cell culture supernatant , are associated with disease . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Cloning and characterization of a human Mac 2 binding protein , a new member of the superfamily defined by the macrophage scavenger receptor cysteine rich domain . ^^^ This Mac 2 binding protein ( Mac 2 BP ) has an apparent native molecular mass of several million daltons and contains subunits of 85 97 kDa that are very susceptible to proteolysis at a dibasic cleavage site . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Interactions between galectin 3 and Mac 2 binding protein mediate cell cell adhesion . ^^^ The present study characterizes the interaction between galectin 3 and Mac 2 binding protein in whole cells and measures their relative expression levels . ^^^ Incubation of A 375 cells with affinity purified Mac 2 binding protein resulted in its binding to galectin 3 on the cell surface in a specific carbohydrate dependent manner . ^^^ Mac 2 binding protein also induced homotypic cell aggregation , which was inhibited by lactose or Fab ' fragments of an anti galectin 3 antibody . ^^^ Northern blotting analysis revealed differences in the transcriptional regulation of galectin 3 and Mac 2 binding protein . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Mac 2 binding protein is a cell adhesive protein of the extracellular matrix which self assembles into ring like structures and binds beta 1 integrins , collagens and fibronectin . ^^^ Human Mac 2 binding protein ( M2BP ) was prepared in recombinant form from the culture medium of 293 kidney cells and consisted of a 92 kDa subunit . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Eleven of these genes were constitutively overexpressed in the rheumatoid synoviocyte line , including a chemokine , stromal cell derived factor 1 , and several genes capable of mediating synoviocyte leukocyte interactions , including vascular cell adhesion molecule 1 and Mac 2 binding protein . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| We have determined the crystal structure at 2 . 0 A resolution of the SRCR domain of Mac 2 binding protein ( M2BP ) , a tumor associated antigen and matrix protein . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Mouse cyclophilin C associated protein ( CyCAP ) is a member of the scavenger receptor cysteine rich domain superfamily and is 69 % identical to the human Mac 2 binding protein . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| The multidomain Mac 2 binding protein ( M2BP ) is present in serum and in the extracellular matrix in the form of linear and ring shaped oligomers , which interact with galectin 3 , fibronectin , collagens , integrins and other large glycoproteins . ^^^ Domain organization of Mac 2 binding protein and its oligomerization to linear and ring like structures . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| An additional characterization of HCV glycoprotein aggregates , with the help of MAb H 14 , indicates that they share an epitope with a cellular protein called Mac 2 binding protein . ^^^ The presence of such an epitope on HCV glycoprotein aggregates could potentially lead to the production of autoantibodies recognizing Mac 2 binding protein in HCV infected patients . . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Monoclonal antibodies specific for human tumor associated antigen 90K / Mac 2 binding protein : tools to examine protein conformation and function . ^^^ We report on the basis of partial protein and cDNA sequence information , that the 100 kDa glycoprotein detected by MAb 1H9 is identical to the 90 kDa glycoprotein variably known as tumor associated antigen 90K ( TAA90K ) , Mac 2 binding protein , and cyclophilin C associated protein . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Distinct ligand binding properties of Mac 2 binding protein and mouse cyclophilin [ correction of mousephilin ] C associated protein . ^^^ Human Mac 2 binding protein ( Mac 2 BP ) is a secreted glycoprotein that is widely expressed . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Influences of the lysosomal associated membrane proteins ( Lamp 1 , Lamp 2 ) and Mac 2 binding protein ( Mac 2 BP ) on the prognosis of pancreatic carcinoma . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| RESULTS : In colon cancer sera , the major galectin 3 ligand was a 40 kilodalton band distinct from mucin , carcinoembryonic antigen , and Mac 2 binding protein . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : The 90K protein ( mac 2 binding protein ) is a member of the macrophage scavenger receptor cysteine rich domain superfamily . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| In addition , L 1 , Mac 2 binding protein ( Mac 2 BP ) , activated leukocyte cell adhesion molecule / CD166 ( ALCAM ) and melanotransferrin were shown to react with PHA L . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Among them , fibronectin , Mac 2 binding protein ( Mac 2 BP ) , and plasminogen activator inhibitor 1 ( PAI 1 ) were further confirmed by Western blot analysis . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Tumor associated antigen 90K / Mac 2 binding protein : possible role in colon cancer . ^^^ The tumor associated antigen 90K ( TAA90K ) / Mac 2 binding protein implicated in cancer progression and metastasis is modified by beta 1 6 branched N linked oligosaccharides in colon cancer cells , glycans shown to contribute to cancer metastasis . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| K ( MAC 2 BP ) gene expression in breast cancer and evidence for the production of 90K by peripheral blood mononuclear cells . ^^^ The tumor derived antigen 90K ( Mac 2 BP ) is a widely expressed , secreted glycoprotein found in the serum of healthy individuals and at elevated levels in the serum of patients with breast cancer and other types of cancer . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| K ( Mac 2 BP ) predicts CD 4 decline in human immunodeficiency virus infected patients with CD 4 counts above 200 10 10 ( 6 ) cells / L . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Elevated plasma levels of 90K ( Mac 2 BP ) immunostimulatory glycoprotein in HIV 1 infected children . 90K is a secreted serum glycoprotein with immune stimulatory activity . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Variations in serum IL 7 and 90K / Mac 2 binding protein ( Mac 2 BP ) levels analysed in cohorts of HIV 1 patients and correlated with clinical changes following antiretroviral therapy . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| Mac 2 BP , also known as 90K , is a highly glycosylated , secreted protein extensively studied in human cancer , which binds galectin 1 , galectin 3 and galectin 7 . ^^^ K ( Mac 2 BP ) and galectins in tumor progression and metastasis . ^^^ |
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| Interacting proteins: Q08380 and P17931 |
Pubmed |
SVM Score :0.0 |
| The authors evaluated the performance of Mac 2BP and its ligand , galectin 3 , as diagnostic markers for patients with biliary carcinoma . ^^^ METHODS : Levels of Mac 2BP , galectin 3 , and CA 19 9 were measured using an enzyme linked immunosorbent assay ( ELISA ) in bile samples from patients with biliary tract carcinoma ( n = 26 ) , benign biliary conditions ( n = 32 ) , and primary sclerosing cholangitis ( n = 20 ) . ^^^ Serum levels of Mac 2BP and galectin 3 also were determined using ELISA . ^^^ |
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