| Interacting proteins: P63098 and Q08209 |
Pubmed |
SVM Score :0.0 |
| We have used the yeast two hybrid system to show that AID , CnB and calmodulin can only bind to a truncated catalytic subunit of yeast calcineurin ( i . e . , CnA 1 delta ) , devoid of AID , but not to full length CnA 1 . ^^^ Both CsA and FK 506 cause disruption of the CnA 1 delta AID interaction , whereas their presence permits CnA 1 delta to bind more strongly to CnB . ^^^ Significantly , in the absence of its cognate cytosolic receptor , neither CsA nor FK 506 inhibits or stimulates the CnA 1 delta AID , CnA 1 delta CnB interactions . ^^^ |
|
| Interacting proteins: P63098 and Q08209 |
Pubmed |
SVM Score :0.0 |
| As was observed previously for MATa cna 1 cna2 double mutants , MATa cnb 1 mutants were defective in their ability to recover from alpha factor induced growth arrest . ^^^ |
|
| Interacting proteins: P63098 and Q08209 |
Pubmed |
SVM Score :0.0 |
| Simultaneous disruption of the two genes ( CNA 1 and CNA 2 ) encoding the alternative forms of the catalytic A subunit of calcineurin , or of the gene ( CNB 1 ) encoding the regulatory B subunit , is lethal in an fks 1 mutant . ^^^ Overexpression of CNA 1 or CNA 2 , in conjunction with CNB 1 , results in a significant decrease in hypersensitivity to FK 506 and CsA . ^^^ |
|
| Interacting proteins: P63098 and Q08209 |
Pubmed |
SVM Score :0.0 |
| Although deletion of the genes encoding the yeast catalytic subunits of calcineurin ( CNA 1 and CNA 2 ) maintain the interaction , absence of the regulatory subunit Cnb 1 prevents binding . ^^^ |
|
| Interacting proteins: P63098 and Q08209 |
Pubmed |
SVM Score :0.0 |
| Yeast cells lacking functional calcineurin ( cna 1 cna2 or cnb 1 mutants ) display growth defects under specific environmental conditions , for example , in the presence of high concentrations of Na+ , Li+ , Mn2+ , or OH but are indistinguishable from wild type cells under standard culture conditions . ^^^ |
|
| Interacting proteins: P63098 and Q08209 |
Pubmed |
SVM Score :0.0 |
| Here we report the identification and characterization of calcineurin genes in Caenorhabditis elegans ( cna 1 and cnb 1 ) , which share high homology with Drosophila and mammalian calcineurin genes . ^^^ |
|
| Interacting proteins: P63098 and Q08209 |
Pubmed |
SVM Score :0.0 |
| Mutants lacking the calcineurin catalytic ( Cna 1 ) or regulatory ( Cnb 1 ) subunit fail to grow at elevated temperature and are defective in virulence and hyphal elongation . ^^^ |
|
| Interacting proteins: P63098 and Q08209 |
Pubmed |
SVM Score :0.0 |
| Calcineurin A alpha ( PPP3CA ) , calcineurin A beta ( PPP3CB ) and calcineurin B ( PPP3R1 ) are located on human chromosomes 4 , 10q21 > q 22 and 2p16 > p 15 respectively . ^^^ |
|