| Interacting proteins: Q08050 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Overexpression of two cofactors known to interact with E1A , pRb and CBP failed to overcome inhibition of HNF 3 activity . ^^^ These data suggest that E1A inhibits HNF 3 activity by inactivating a limiting cofactor ( s ) distinct from pRb or CBP . . ^^^ |
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| Interacting proteins: Q08050 and Q92793 |
Pubmed |
SVM Score :0.0 |
| Retention of this FoxM1B 596 Cdk phosphorylation site was found to be essential for recruiting the histone acetyltransferase CREB binding protein ( CBP ) to the FoxM1B transcriptional activation domain . ^^^ Consistent with these findings , dominant negative Cdk 1 protein significantly reduced FoxM1B transcriptional activity and inhibited FoxM1B recruitment of the CBP coactivator protein . ^^^ Likewise , Cdc25B mediated stimulation of Cdk activity together with elevated levels of the CBP coactivator protein provided a 6 . 2 fold synergistic increase in FoxM1B transcriptional activity . ^^^ We demonstrated that FoxM1B transcriptional activity requires binding of either S phase or M phase Cdk cyclin complexes to mediate efficient Cdk phosphorylation of the FoxM1B Thr 596 residue , which is essential for recruitment of p300 / CBP coactivator proteins . . ^^^ |
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