| Interacting proteins: Q08050 and P06493 |
Pubmed |
SVM Score :0.0 |
| Furthermore , restoring FoxM1B expression in old aged mice caused elevated levels of Cyclin B 1 , Cyclin B 2 , Cdc25B , Cdk 1 , and p55CDC mRNA as well as stimulating Cdc25B nuclear localization during liver regeneration , all of which are required for mitosis . ^^^ |
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| Interacting proteins: Q08050 and P06493 |
Pubmed |
SVM Score :0.0 |
| Previous liver regeneration studies demonstrated that the mouse forkhead box M1B ( FoxM1B ) transcription factor regulates hepatocyte proliferation through expression of cell cycle genes that stimulate cyclin dependent kinase 2 ( Cdk 2 ) and Cdk 1 activity . ^^^ Consistent with these findings , dominant negative Cdk 1 protein significantly reduced FoxM1B transcriptional activity and inhibited FoxM1B recruitment of the CBP coactivator protein . ^^^ |
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| Interacting proteins: Q08050 and P06493 |
Pubmed |
SVM Score :0.0 |
| Moreover , cDNA array analysis showed that PC SPES caused up regulation of p 21 ( WAF1 / CIP1 ) and decreased expression of cyclin B , Nedd 8 , cdc 2 , skp 1 , PCNA , MAD2L1 , cyclin H , CKS 2 , E2F , Rbx 1 , MCM 2 , MCM 5 , Mpp 2 , Cullin Cul4A , Cks1p9 and McM 7 , which are involved in cell cycle progression . ^^^ |
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| Interacting proteins: Q08050 and P06493 |
Pubmed |
SVM Score :0.0 |
| Here , we show that both early passage Foxm 1 ( ) ( / ) ( ) mouse embryonic fibroblasts ( MEFs ) and human osteosarcoma U2OS cells depleted of FoxM 1 protein by small interfering RNA fail to grow in culture due to a mitotic block and accumulate nuclear levels of cyclin dependent kinase inhibitor ( CDKI ) proteins p 21 ( Cip 1 ) and p 27 ( Kip 1 ) . ^^^ We also identify the mechanism by which FoxM 1 deficiency causes elevated nuclear levels of the CDKI proteins p 21 ( Cip 1 ) and p 27 ( Kip 1 ) . ^^^ We provide evidence that FoxM 1 is essential for transcription of Skp 2 and Cks 1 , which are specificity subunits of the Skp 1 Cullin 1 F box ( SCF ) ubiquitin ligase complex that targets these CDKI proteins for degradation during the G ( 1 ) / S transition . ^^^ |
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| Interacting proteins: Q08050 and P06493 |
Pubmed |
SVM Score :0.0 |
| Deletion of FoxM 1 in endothelial cells induced decreased expression of cyclins , Cdc 2 , and Cdc25C , increased p 27 ( Kip 1 ) expression , and decreased Cdk activities . ^^^ |
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| Interacting proteins: Q08050 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08050 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08050 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q08050 and P06493 |
Pubmed |
SVM Score :0.0 |
| NA |
|