| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.54535009 |
| We previously showed that BNIP 2 interacted with Cdc 42 and its cognate inactivator , p50RhoGAP / Cdc42GAP via its BNIP 2 and Cdc42GAP homology ( BCH ) domain , but its cellular and physiological roles still remain unclear . 0.54535009^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of the Bcl 2 associated protein BNIP 2 by fibroblast growth factor receptor 1 prevents its binding to Cdc42GAP and Cdc 42 . ^^^ BNIP 2 shares a region of homology with the noncatalytic domain of Cdc42GAP , a GTPase activating protein for the small GTP binding molecule , Cdc 42 . ^^^ We show here that BNIP 2 and Cdc42GAP could directly bind to each other and they also compete for the binding to the same target , Cdc 42 . ^^^ In all cases , tyrosine phosphorylation of BNIP 2 severely impaired its association with Cdc42GAP and its induced GTPase activating protein like activity toward Cdc 42 . ^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| Evidence for a novel Cdc42GAP domain at the carboxyl terminus of BNIP 2 . ^^^ BNIP 2 contains many arginine residues at the carboxyl terminus , which includes the region of homology to the noncatalytic domain of Cdc42GAP , termed BNIP 2 and Cdc42GAP homology ( BCH ) domain . ^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| The BNIP 2 and Cdc42GAP homology domain of BNIP 2 mediates its homophilic association and heterophilic interaction with Cdc42GAP . ^^^ The carboxyl terminus of BNIP 2 shares high homology to the non catalytic domain of Cdc42GAP , termed BCH ( for BNIP 2 and Cdc42GAP homology ) domain . ^^^ Using glutathione S transferase recombinant proteins , immunoprecipitation studies , and yeast two hybrid assays , it was found that BNIP 2 and Cdc42GAP could form homo and hetero complexes via their conserved BCH domains . ^^^ The results suggest that BCH domains of BNIP 2 and Cdc42GAP represent a novel protein protein interaction domain that could potentially determine and / or modify the physiological roles of these molecules . . ^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| The BNIP 2 and Cdc42GAP homology / Sec14p like domain of BNIP Salpha is a novel apoptosis inducing sequence . ^^^ The BNIP S gene encodes two protein isoforms ; the longer protein ( BNIP Salpha ) contains a complete BNIP 2 and Cdc42GAP Homology ( BCH ) domain , a novel protein domain that we recently identified , whereas its shorter variant ( BNIP Sbeta ) lacks the full BCH domain as a result of an alternative RNA splicing that introduces a nonsense intron . ^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| BNIPL 2 , a novel homologue of BNIP 2 , interacts with Bcl 2 and Cdc42GAP in apoptosis . ^^^ We found that the human BNIPL 2 shares homology to human BNIP 2 and also possesses a BNIP 2 and Cdc42GAP homology ( BCH ) domain . ^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| Concerted regulation of cell dynamics by BNIP 2 and Cdc42GAP homology / Sec14p like , proline rich , and GTPase activating protein domains of a novel Rho GTPase activating protein , BPGAP 1 . ^^^ We have identified a novel RhoGAP , BPGAP 1 ( for BNIP 2 and Cdc42GAP Homology ( BCH ) domain containing , Proline rich and Cdc42GAP like protein subtype 1 ) , that is ubiquitously expressed and shares 54 % sequence identity to Cdc42GAP / p50RhoGAP . ^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| BPGAP 1 is a novel RhoGAP that co ordinately regulates pseudopodia and cell migration through the interplay of its BNIP 2 and Cdc42GAP homology domains serving as a homophilic / heterophilic interaction device , an enzymic RhoGAP domain that inactivates RhoA and a proline rich region that binds the Src homology 3 domain of cortactin . ^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| We recently identified a novel RhoGAP , BPGAP 1 , that uses the BNIP 2 and Cdc42GAP homology ( BCH ) domain , RhoGAP domain and proline rich region to regulate cell morphology and migration . ^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| Bcl 2 / adenovirus E1B 19 kDa interacting protein 2 like 1 ( BNIPL 1 ) is a novel human protein identified in our laboratory , which can interact with Bcl 2 and Cdc42GAP and induce apoptosis via the BNIP 2 and Cdc42GAP homology ( BCH ) domain . ^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| Increased expression of proapoptotic BMCC 1 , a novel gene with the BNIP 2 and Cdc42GAP homology ( BCH ) domain , is associated with favorable prognosis in human neuroblastomas . ^^^ Its 350 kDa protein product possessed a Bcl 2 / adenovirus E1B nineteen kDa interacting protein 2 ( BNIP 2 ) and Cdc42GAP homology domain in the COOH terminus in addition to P loop and a coiled coil region near the NH 2 terminus . ^^^ |
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| Interacting proteins: Q12982 and Q07960 |
Pubmed |
SVM Score :0.0 |
| BNIP Salpha induces cell rounding and apoptosis by displacing p50RhoGAP and facilitating RhoA activation via its unique motifs in the BNIP 2 and Cdc42GAP homology domain . ^^^ We recently showed that BNIP Salpha induced cell rounding that leads to apoptosis via its BNIP 2 and Cdc42GAP Homology ( BCH ) domain , but the underlying mechanism has not been determined . ^^^ |
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