| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Delineation of a limit Cdc 42 GTPase activating protein domain . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Cloning and expression of a human CDC 42 GTPase activating protein reveals a functional SH 3 binding domain . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Our data indicate that the insert region of Cdc42Hs is not essential for its interactions with various target / effector molecules or for interactions with the guanine nucleotide exchange factor , Dbl , or the Cdc 42 GTPase activating protein ( GAP ) . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| We have previously identified CdGAP ( for Cdc 42 GTPase activating protein ) as a specific GAP for Rac 1 and Cdc 42 . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Six genes such as beta tubulin , high mobility group ( nonhistone chromosomal ) protein 1 , connective tissue growth factor , insulin like growth factor binding protein 2 , alpha tubulin , and RAS related gene were overexpressed in CAP therapy resistance group , whereas seven genes such as CD 9 antigen , alpha 2 macroglobulin , caveolin 2 , interleukin 1 receptor antagonist , Rho GTPase activating protein 1 , reticulon 3 , cyclin dependent kinase 10 , keratin 7 were underexpressed in CAP therapy resistance group . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Comparison of gene expression during activation of Jurkat and PB T cells revealed a common set of genes that were up regulated , such as Rho GTPase activating protein 1 , SKP 2 , CDC25A , T cell specific transcription factor 7 , cytoskeletal proteins , and signaling molecules . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The catalytic efficiencies ( Kcat / Km ) of the GAP domains of Bcr , 3BP 1 , and p 190 on Cdc 42 are found to be 60 , 160 , and over 500 fold less than that of Cdc42GAP , respectively , and the differences are due , to a large part , to differences in Km . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The Rho related small GTP binding protein Cdc 42 has a low intrinsic GTPase activity that is significantly enhanced by its specific GTPase activating protein , Cdc42GAP . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| BNIP 2 shares a region of homology with the noncatalytic domain of Cdc42GAP , a GTPase activating protein for the small GTP binding molecule , Cdc 42 . ^^^ In all cases , tyrosine phosphorylation of BNIP 2 severely impaired its association with Cdc42GAP and its induced GTPase activating protein like activity toward Cdc 42 . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| This domain was predicted to fold into alpha helical bundles similar to the topology of the catalytic GAP domain of Cdc42GAP . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| On the basis of the structural determinations of the Cdc 42 Cdc42GAP complex , as well as the Ras RasGAP complex , it has been proposed that an arginine residue provided by the GAP ( called the `` arginine finger ' ' ) stabilizes charges developing on the guanine nucleotide during the transition state for GTP hydrolysis and is an important contributor to GAP stimulated catalysis . ^^^ However , the 85 kDa regulatory subunit ( p 85 ) of the phosphoinositide 3 kinase ( PI 3K ) is homologous with the Cdc42GAP and contains the essential arginine residue , but is ineffective as a GAP . ^^^ In the study presented here , we have tested this idea by examining three residues within the Cdc42GAP , which are missing in the GAP homology domain of the 85 kDa regulatory subunit ( p 85 ) of the PI 3 kinase and are involved in specific interactions with switch domain residues of Cdc 42 . ^^^ The cycling of Cdc 42 between its on ( GTP bound ) and off ( GDP bound ) states is essential for its stimulation of cell growth and transformation , with an important aspect of this cycle being the regulation of the GTP hydrolytic activity of Cdc 42 by its GTPase activating protein ( Cdc42GAP ) . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Concerted regulation of cell dynamics by BNIP 2 and Cdc42GAP homology / Sec14p like , proline rich , and GTPase activating protein domains of a novel Rho GTPase activating protein , BPGAP 1 . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The sequence 133 147 is also necessary for its heterophilic interaction with the BCH domain of the Rho GTPase activating protein , p50RhoGAP / Cdc42GAP . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The second approach was to determine whether the transforming activity of the fast cycling Cdc 42 [ F28L ] mutant can be reversed by compensating for its accelerated nucleotide exchange reaction through the expression of the GTPase activating protein ( Cdc42GAP ) and the ensuing stimulation of GTP hydrolytic activity . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| We report here the crystal structure of Cdc42Hs , with the non hydrolysable GTP analogue GMPPNP , in complex with the GAP domain of p50rhoGAP at 2 . 7A resolution . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| In contrast with Cdc 42 ( for which the GAP domain of p50RhoGAP is 50 fold more efficient than those of p 190 , Bcr , and 3BP 1 ) and with RhoA ( toward which only p50RhoGAP and p 190 displayed high efficiencies ) , the catalytic efficiencies ( Kcat / Km ) of the GAP domains of p50RhoGAP , p 190 , Bcr , and 3BP 1 on Rac 1 are found to be comparable in a range between 0 . 9 and 2 . 6 min 1 microM 1 . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The GTPase activity of TC 10 was lower than that of Cdc 42 , and TC 10 possessed a lower affinity for , but greater responsiveness to , the p50Rho GTPase activating protein ( p50RhoGAP ) than did Cdc 42 . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| This activity could be identified by Western blotting and immunoprecipitation with specific antibody directed against the GAP domain of p50RhoGAP . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| In contrast to Rac 1 and RhoA , nonprenylated Cdc 42 is able to interact with membrane localized GAPs . ( 2 ) Full length p50RhoGAP and p190RhoGAP react less intensely with nonprenylated Rac 1 than with the prenylated protein , whereas no difference was observed in the reaction of isolated GAP domains of either p50RhoGAP or Bcr with the different types of Rac 1 . ( 3 ) Fluoride exerts a significant inhibitory effect only on the interaction of prenylated Rac 1 with the isolated GAP domains of p50RhoGAP or Bcr . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| A eukaryotic GTPase activating protein , p50RhoGAP , showed a similar cooperativity with RhoGDI on actin reorganization , suggesting that ExoS RhoGAP functions as a molecular mimic of eukaryotic RhoGAPs to inactivate Rho GTPases through RhoGDI . . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Interaction of p 50 Rho GTPase activating protein ( p50RhoGAP ) with Rho family small GTPases was investigated in a yeast two hybrid system , by radioactive GAP assay , and in a Rac regulated enzymatic reaction , through superoxide production by the phagocytic NADPH oxidase . ^^^ The yeast two hybrid system revealed an interaction between the C terminal GAP domain and the N terminal part of p50RhoGAP . ^^^ The GAP assay and the NADPH oxidase activity indicate that the GTPase activating effect of full length p50RhoGAP is lower on non prenylated than on prenylated small GTPase . ^^^ Removal of amino acids 1 48 and 169 197 of p50RhoGAP increases the GAP effect on non prenylated Rac , whereas prenylated Rac reacts equally well with the full length and the truncated proteins . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| P50RhoGAP , the first identified GTPase activating protein for Rho GTPases , is composed of a Sec 14 like domain and a Rho GTPase activating protein ( GAP ) domain . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Several fragments of the human and rat GAP ( rGAP ) sequences ( hGAP 25 53 , hGAP 27 40 and rGAP 20 43 ) produced tracer displacement curves that were non parallel with the hGAP 1 56 curve and / or gave only incomplete tracer displacement when all three antisera were tested . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| RhoGAP , the major RasGAP associated protein , binds GTP directly . ^^^ A mutated form of p 190 that fails to bind nucleotide retains its RasGAP binding and RhoGAP activities , indicating that GTP binding by p 190 is not required for these functions . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The product of the breakpoint cluster region gene bcr , rho GTPase accelerating protein ( rhoGAP ) and rasGAP associated p 190 share structurally related rho GAP domains , and possess GAP activity for rho family members in vitro . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Unlike SH 2 domains , whose interactions with tyrosine containing peptides are promoted by phosphorylation of the SH 2 binding site , the regulatory mechanism for SH 3 interactions is unclear . p 120 RasGAP ( GTPase activating protein ) , which contains an SH 3 domain flanked by two SH 2 domains , forms an abundant SH 2 mediated complex with p 190 RhoGAP in cells expressing activated tyrosine kinases . ^^^ Tandem SH 2 binding sites mediate the RasGAP RhoGAP interaction : a conformational mechanism for SH 3 domain regulation . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The GAP domain is active on Rho , Rac , and Cdc 42 in vitro but with a clear preference for Rho ; we refer to the molecule as PTPL 1 associated RhoGAP 1 , PARG 1 . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Expression of dominant negative mutants of Rac or Cdc 42 , the Rho inhibitory molecule C 3 transferase , or the GTPase activating protein RhoGAP p 190 causes a marked reduction in the number of primary dendrites in nonpyramidal ( multipolar ) neurons and in the number of basal dendrites in neurons with pyramidal morphologies . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Consequently , in the transition state complex but not in the ground state , the rhoGAP domain contributes a residue , Arg 85 ( GAP ) directly into the active site of the G protein . ^^^ Their rate of hydrolysis of GTP to GDP by virtue of their intrinsic GTPase activity is slow , but can be accelerated by up to 10 ( 5 ) fold through interaction with rhoGAP , a GTPase activating protein that stimulates Rho family proteins . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Here , we show that this induced invasion involves an increase in tyrosine phosphorylation of a 190 kDa GTPase activating protein for Rho family members ( p 190 ( RhoGAP ) ; p 190 ) and membrane protrusive activities at invadopodia . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The predicted protein sequence of the gene , named ARHGAP 6 , contains homology to the GTPase activating ( GAP ) domain of the rhoGAP family of proteins , which has been implicated in the regulation of actin polymerization at the plasma membrane in several cellular processes . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Domains of rasGAP and rhoGAP are related . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| By enhancing their GTPase activity , GAP proteins inactivate small Rho and Ras proteins , so inactivation of rhoGAP proteins might cause constitutive activation of their GTPase targets . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The complex of a heterotrimeric G protein with its activating protein shows that the latter protein does not participate directly in the hydrolytic reaction and has a different structure of RhoGAP and RasGAP . . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Phosphotyrosine ( p Tyr ) dependent and independent mechanisms of p 190 RhoGAP p 120 RasGAP interaction : Tyr 1105 of p 190 , a substrate for c Src , is the sole p Tyr mediator of complex formation . p 190 RhoGAP is a 190 kDa protein that stably associates with p 120 RasGAP and regulates actin dynamics through members of the Rho family of small GTPases . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| In vitro , both the wild type and S36N mutant HA p 190 proteins showed similar GAP activities toward RhoA , but when expressed in NIH 3T3 fibroblasts only wild type p 190 appeared able to function as a RhoGAP . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Here , we have examined in detail the effects of a temperature dependent 5 Src protein on the regulation of p 190 RhoGAP , a GTPase activating protein ( GAP ) that has been implicated in disruption of the organised actin cytoskeleton , and addressed the dependence of 5 Src induced stress fibre loss on inhibition of Rho activity . ^^^ We found that activation of 5 Src induced association of tyrosine phosphorylated p 190 with p 120 ( RasGAP ) and stimulation of p 120 ( RasGAP ) associated RhoGAP activity , although p 120 ( RasGAP ) itself was not a target for phosphorylation by 5 Src in chicken embryo cells . ^^^ Furthermore , these effects were rapidly reversible since switching off 5 Src led to dissociation of the p190 / p120 ( RasGAP ) complex , inactivation of p 120 ( RasGAP ) associated RhoGAP activity and re induction of actin stress fibres . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Therefore , we suggest a GAP mechanism for rna1p , which constitutes a variation of the arginine finger mechanism found for Ras GAP and RhoGAP . . ^^^ It contains 11 leucine rich repeats that adopt the nonglobular shape of a crescent , bearing no resemblance to RhoGAP or RasGAP . ^^^ In contrast to RasGAP and RhoGAP , Arg 74 could be substituted by lysine and contributed significantly to the binding of Ran . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Therefore , we postulate that the loss of rhoGAP C 1 function is most likely compensated by other members of the GAP family . . ^^^ The C 1 gene at Xq 28 encodes a protein assumed to function as a Rho GTPase activating protein ( rhoGAP ) . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Here , we present evidence that the inactivation of RhoGAP ( GTPase activating protein ) activity is an equally effective means of promoting Rho mediated cellular processes . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Formation of complexes involving RasGAP and p 190 RhoGAP during morphogenetic events of the gastrulation in xenopus . ^^^ The first complex , including RasGAP , p 190 RhoGAP and p 62 , was previously characterized in murine fibroblasts overexpressing c Src or transformed by 5 Src and has been correlated with cytoskeleton remodelling . ^^^ A second complex , not identified in other models includes tyrosine phosphorylated p66SHC , Grb 2 , RasGAP and p 190 RhoGAP . ^^^ The interaction of RasGAP and p 190 RhoGAP in two multiprotein complexes could constitute an additional level of Rho regulation during morphogenetic events of gastrulation . . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Our laboratory isolated a novel rho GTPase activating protein ( rhoGAP ) gene named ARHGAP 6 from the MLS region . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| RAFTK / Pyk2 tyrosine kinase mediates the association of p 190 RhoGAP with RasGAP and is involved in breast cancer cell invasion . ^^^ Analyses of the members of the HRG stimulated complex revealed that RAFTK is associated with p 190 RhoGAP ( p 190 ) , RasGAP and ErbB 2 , and plays an essential role in mediating the tyrosine phosphorylation of p 190 by Src . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Although Mg ( 2+ ) is not absolutely required for GTP hydrolysis by the Rho GTPases , the divalent ion apparently participates in the GTPase reaction , since the intrinsic GTP hydrolysis rates were enhanced 4 10 fold upon binding to Mg ( 2+ ) , and k ( cat ) values of the Rho GTPase activating protein ( RhoGAP ) catalyzed reactions were significantly increased when Mg ( 2+ ) was present . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The non essential RGD 1 gene from Saccharomyces cerevisiae encodes a protein that has been characterized in vitro as a Rho GTPase activating protein ( RhoGAP ) for the Rho 3 and Rho 4 proteins . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| P 190 RhoGAP ( GTPase activating protein ) is a potent Rho regulator that mediates integrin dependent adhesion signaling in cultured cells . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The GAP domain of ExoS is an all helical protein with no obvious structural homology , and thus no recognizable evolutionary relationship , with the eukaryotic RhoGAP or RasGAP fold . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| We have recently described a new RhoGAP ( GTPase activating protein for RhoGTPases ) gene , MgcRacGAP , primarily expressed in male germ cells , at the spermatocyte stage . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of p 190 on Tyr 1105 by c Src is necessary but not sufficient for EGF induced actin disassembly in C3H10T1 / 2 fibroblasts . p 190 RhoGAP is a tyrosine phosphorylated protein that contains an N terminal GTP binding domain , a middle domain ( MD ) that mediates interaction with p 120 RasGAP and a C terminal GTPase activating protein ( GAP ) domain that is specific for the & Rgr ; family of small GTPases . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of the RhoGAP domain as well as the full length protein interfered with platelet derived growth factor BB induced membrane ruffling , but not with serum induced stress fiber formation , further emphasizing the notion that , in vivo , RICH 1 is a GAP for Cdc 42 and Rac1 . . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Moreover , complex formation between p 190 and p 120 RasGAP occurred in differentiated oligodendrocytes . p 190 RhoGAP activity is known to regulate the RhoGDP : RhoGTP ratio . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Genome wide analyses of Rho GTPase activating protein ( RhoGAP ) function in Drosophila using RNA interference identified p 190 RhoGAP as essential for axon stability in mushroom body neurons , the olfactory learning and memory center . p 190 inactivation leads to axon branch retraction , a phenotype mimicked by activation of GTPase RhoA and its effector kinase Drok and modulated by the level and phosphorylation of myosin regulatory light chain . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Similarly , expression of p120GAP , missing either its pleckstrin homology ( PH ) or its calcium dependent lipid binding ( CaLB ) / C2 domain , restored MAPK down regulation and retained the ability to associate with p 190 RhoGAP and to be phosphorylated by 5 src but exhibited higher saturation densities similar to Gap / cells . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Apart from the fact that it is composed almost entirely of alpha helices , YopE ( GAP ) shows no obvious structural similarity with eukaryotic RhoGAP domains . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Tyrosine phosphorylation of nine cellular proteins was induced or enhanced ; we identified p 120 ( RasGAP ) , p 190 ( RhoGAP ) , p62dok ( downstream of tyrosine kinases ) , and cortactin as H . pylori inducible targets . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| With the aim of isolating the cellular partners of Gem that mediate its biological activity we performed a yeast two hybrid screen and identified a novel protein of 970 amino acids , Gmip , that interacts with Gem through its N terminal half , and presents a cysteine rich domain followed by a Rho GTPase activating protein ( RhoGAP ) domain in its C terminal half . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Proteins containing a RhoGAP ( Rho GTPase activating protein ) domain usually function to catalyze the hydrolysis of GTP that is bound to Rho , Rac and / or Cdc 42 , inactivating these regulators of the actin cytoskeleton . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The RhoGAP domain of p200RhoGAP stimulated the GTPase activities of Rac 1 and RhoA in vitro and in vivo , and the conserved catalytic arginine residue ( Arg 58 ) contributed to the GAP activity . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The CS and DA mutants as well as the wild type reduced the formation of p 190 RhoGAP p 120 RasGAP complexes . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The male germ cell Rac GTPase activating protein gene ( MgcRacGAP ) was initially described as a human RhoGAP gene highly expressed in male germ cells at spermatocyte stage , but exhibits significant levels of expression in most cell types . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| We have previously described a partial cDNA sequence encoding a RhoGAP protein , GAP 25 that is homologous to the recently reported ArhGAP 9 and ArhGAP 12 . ^^^ We now describe a related new member ArhGAP 15 that shares a number of domain similarities , including a pleckstrin homology ( PH ) domain , a RhoGAP domain and a novel motif N terminal to the GAP domain . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Together , these findings indicate that during cytokinesis , MgcRacGAP , previously known as a GAP for Rac / Cdc42 , is functionally converted to a RhoGAP through phosphorylation by Aurora B . . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Here we identify p 190 RhoGAP ( p 190 ) , the most abundant GAP for RhoA in cells , as an interactor with Rnd proteins and show that this interaction is mediated by a p 190 region that is distinct from the GAP domain . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Oligophrenin 1 , a Rho GTPase activating protein ( RhoGAP ) involved in 10 linked mental retardation , is expressed in the enteric nervous system . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The OCRL 1 RhoGAP domain showed low Rac GAP activity in vitro , and when expressed in Swiss 3T3 cells induced specific inhibition of RacGTP dependent ruffles , consistent with OCRL 1 being an active RacGAP . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| To specifically target RhoA , RhoB , or RhoC function , we have generated a set of chimeric molecules by fusing the RhoGAP domain of p 190 , a GTPase activating protein that accelerates the intrinsic GTPase activity of all three Rho GTPases , with the C terminal hypervariable sequences of RhoA , RhoB , or RhoC . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Analyses of the members of the HRG stimulated complex revealed that RAFTK associated with p 190 RhoGAP ( p 190 ) , RasGAP , c Abl as well as with the focal adhesion molecules p130cas and paxillin . c Abl was found to be associated with RAFTK through the region of RAFTK containing amino acids 419 1009 . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| We find that the p 190 RhoGAP , a potent GAP for the Rho and Rac GTPases , is similarly sensitive to phospholipids . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| DLC 1 , a tumour suppressor gene inactivated in liver carcinogenesis and encoding a Rho GTPase activating protein ( RhoGAP ) maps to one of the deleted regions ( 8p21 . 3 22 ) . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| In the present study we characterize a novel RhoGAP protein ( RC GAP 72 ) that interacts with actin stress fibers , focal adhesions , and cell cell adherens junctions via its 185 amino acid C terminal region . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| The corresponding cDNA encodes a predicted 30 kDa subunit containing a Ras homologous GTPase Activating Protein ( RhoGAP ) domain , suggesting a possible involvement in the regulation of actin cytoskeleton changes . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Structurally , DLC 1 protein contains a conserved GTPase activating protein for Rho family protein ( RhoGAP ) domain , which has been thought to regulate the activity of Rho family proteins . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| Here , we report that Ptprz deficient mice exhibit impairments in hippocampus dependent contextual fear memory because of abnormal tyrosine phosphorylation of p 190 RhoGAP , a GTPase activating protein ( GAP ) for Rho GTPase . ^^^ |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P20936 |
Pubmed |
SVM Score :0.0 |
| NA |
|