| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| BPGAP 1 is a novel RhoGAP that co ordinately regulates pseudopodia and cell migration through the interplay of its BNIP 2 and Cdc42GAP homology domains serving as a homophilic / heterophilic interaction device , an enzymic RhoGAP domain that inactivates RhoA and a proline rich region that binds the Src homology 3 domain of cortactin . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| Correlating with the ability of c Src variants to potentiate or inhibit EGF dependent DNA synthesis is the phosphotyrosine content of multiple cellular proteins , including p 190 RhoGAP , a protein thought to regulate growth factor induced actin cytoskeleton remodeling by modulating the activity of the small GTP binding protein , Rho . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphotyrosine ( p Tyr ) dependent and independent mechanisms of p 190 RhoGAP p 120 RasGAP interaction : Tyr 1105 of p 190 , a substrate for c Src , is the sole p Tyr mediator of complex formation . p 190 RhoGAP is a 190 kDa protein that stably associates with p 120 RasGAP and regulates actin dynamics through members of the Rho family of small GTPases . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| Here , we have examined in detail the effects of a temperature dependent 5 Src protein on the regulation of p 190 RhoGAP , a GTPase activating protein ( GAP ) that has been implicated in disruption of the organised actin cytoskeleton , and addressed the dependence of 5 Src induced stress fibre loss on inhibition of Rho activity . ^^^ We found that activation of 5 Src induced association of tyrosine phosphorylated p 190 with p 120 ( RasGAP ) and stimulation of p 120 ( RasGAP ) associated RhoGAP activity , although p 120 ( RasGAP ) itself was not a target for phosphorylation by 5 Src in chicken embryo cells . ^^^ Furthermore , these effects were rapidly reversible since switching off 5 Src led to dissociation of the p190 / p120 ( RasGAP ) complex , inactivation of p 120 ( RasGAP ) associated RhoGAP activity and re induction of actin stress fibres . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| The first complex , including RasGAP , p 190 RhoGAP and p 62 , was previously characterized in murine fibroblasts overexpressing c Src or transformed by 5 Src and has been correlated with cytoskeleton remodelling . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| Analyses of the members of the HRG stimulated complex revealed that RAFTK is associated with p 190 RhoGAP ( p 190 ) , RasGAP and ErbB 2 , and plays an essential role in mediating the tyrosine phosphorylation of p 190 by Src . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of the p 190 RhoGAP N terminal domain by c Src results in a loss of GTP binding activity . p 190 RhoGAP is a multi domain protein that is thought to regulate actin cytoskeleton dynamics . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| Regulation of CDC 42 GTPase by proline rich tyrosine kinase 2 interacting with PSGAP , a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| RhoGAP is the principal Src substrate in brain and regulates axon outgrowth , guidance and fasciculation . ^^^ Here we identify the potent Rho regulatory protein , p 190 RhoGAP ( GTPase activating protein ) , as the principal Src substrate detected in the developing and mature nervous system . ^^^ Together with the fact that mice lacking neural adhesion molecules or Src kinases also exhibit defects in axon outgrowth , guidance and fasciculation , our results suggest that p 190 RhoGAP mediates a Src dependent adhesion signal for neuritogenesis to the actin cytoskeleton through the Rho GTPase . . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of p 190 on Tyr 1105 by c Src is necessary but not sufficient for EGF induced actin disassembly in C3H10T1 / 2 fibroblasts . p 190 RhoGAP is a tyrosine phosphorylated protein that contains an N terminal GTP binding domain , a middle domain ( MD ) that mediates interaction with p 120 RasGAP and a C terminal GTPase activating protein ( GAP ) domain that is specific for the & Rgr ; family of small GTPases . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| These results suggest that p200RhoGAP is involved in the regulation of neurite outgrowth by exerting its RhoGAP activity and that its cellular activity may be regulated through interaction with Src like tyrosine kinases . . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| Although p 190 RhoGAP is tyrosine phosphorylated by c Src via the tyrosine kinase Pyk 2 , wild type PTP 20 had little effect on p Tyr 418 of c Src and no effect on p Tyr 402 of Pyk 2 , which are required for full c Src activity and for interacting between Pyk 2 and c Src , respectively . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| Ang 2 induced contraction of the SMC was also attenuated by genistein , antibodies to the pp 60 ( c src ) , p ( 190 ) RhoGTPase activating protein ( p 190 RhoGAP ) , carboxyl terminus of Galpha 13 , carboxyl terminus peptide , and ADP ribosylation factor ( ARF ) antibody . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| CAMGAP 1 is composed of an Src homology 3 ( SH 3 ) domain , multiple WW domains , a proline rich region , a PH domain and a RhoGAP domain , and has the domain architecture similar to ARHGAP 9 and ARHGAP 12 . ^^^ |
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| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07960 and P12931 |
Pubmed |
SVM Score :0.0 |
| NA |
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