| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Receptor interacting protein 140 interacts with and inhibits transactivation by , peroxisome proliferator activated receptor alpha and liver 10 receptor alpha . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Finally , peroxisome proliferator activated receptor alpha and delta and liver 10 receptor alpha and beta mRNAs were detected in fetal epidermis by reverse transcriptase polymerase chain reaction and northern analyses . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Activation of PKA also inhibited the TIF 2 mediated coactivation of other nuclear receptors such as PPAR alpha / gamma and liver 10 receptor alpha . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Peroxisome proliferator activated receptor alpha ( PPARalpha ; NR1C1 ) and liver 10 receptor alpha ( LXRalpha ; NR1H3 ) are two nuclear receptors that stimulate the murine Cyp7a1 gene . ^^^ The atypical interaction of peroxisome proliferator activated receptor alpha with liver 10 receptor alpha antagonizes the stimulatory effect of their respective ligands on the murine cholesterol 7alpha hydroxylase gene promoter . ^^^ Peroxisome proliferator activated receptor alpha ( PPARalpha ; NR1C1 ) and liver 10 receptor alpha ( LXRalpha ; NR1H3 ) are two nuclear receptors that stimulate the murine Cyp7a1 gene . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Effects of fatty acids on gene expression : role of peroxisome proliferator activated receptor alpha , liver 10 receptor alpha and sterol regulatory element binding protein 1c . ^^^ The present paper reviews recent data on the mechanisms by which fatty acids influence DNA transcription , and focus specifically on the importance of three transcription factors : peroxisome proliferator activated receptor alpha ; liver 10 receptor alpha ; sterol regulatory element binding protein 1c . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Expression of Pparalpha , farnesoid 10 receptor , and liver 10 receptor alpha genes encoding nuclear receptors that control hepatic bile salt and sterol metabolism was induced on fasting in wild type mice only . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| The levels of mRNAs for liver 10 receptor alpha ( LXRalpha ) , ATP binding cassette A 1 ( ABCA 1 ) , PPARalpha and cholesterol 7alpha hydroxylase ( CYP7A ) in the liver were analyzed by northern blotting . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| The inhibition of the human cholesterol 7alpha hydroxylase gene ( CYP7A1 ) promoter by fibrates in cultured cells is mediated via the liver 10 receptor alpha and peroxisome proliferator activated receptor alpha heterodimer . ^^^ In previous work , we showed that the binding of the liver 10 receptor alpha : peroxisome proliferator activated receptor alpha ( LXRalpha : PPARalpha ) heterodimer to the murine Cyp7a1 gene promoter antagonizes the stimulatory effect of their respective ligands . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Studies investigating the mechanisms by which CLA operates at the cellular level show that the primary targets for CLA are members of the nuclear receptor family , particularly the lipostat transcription factors peroxisome proliferator activated receptor alpha ( PPARalpha ) , PPARgamma , sterol regulatory element binding protein 1c , and liver 10 receptor alpha . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| However , mRNA levels peaked close to that of adult rats ( > 6 wk old rats ) by 4 wk of age for farnesoid 10 receptor ( FXR ) , pregnane 10 receptor ( PXR ) , liver 10 receptor alpha ( LXRalpha ) , peroxisome proliferator activated receptor alpha ( PPARalpha ) , retinoid acid receptor alpha ( RARalpha ) , LRH 1 , and SHP , whereas RXRalpha mRNA lagged behind . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| CONCLUSIONS : These features disclose a marked sexual dimorphism in lipid metabolism associated to old age in rats that can be partially attributed not only to an age related decrease in liver PPARalpha expression , but also to changes in other hepatic transcription factors and enzymes , such as liver 10 receptor alpha ( LXRalpha ) and diacylglycerol acyltransferases ( DGAT ) . . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| We detected RNA expression of PPARalpha , PPARbeta , PPARgamma , retinoid 10 receptor alpha , liver 10 receptor alpha ( LXRalpha ) and pregnane 10 receptor but not FXR in freshly isolated and 7 day maintained sebaceous glands . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| CAP 350 also interacts with PPAR ( delta ) , PPAR ( gamma ) and liver 10 receptor alpha , but not with the 9 cis retinoic acid receptor , RXR ( alpha ) . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| The adipogenic marker genes PPAR gamma and CCAAT / enhancer binding protein alpha ( C / EBP alpha ) are both down regulated after treatment within the period from D 0 6 , while additional treatment also down regulates the expression of sterol regulatory element binding protein 1c ( SREBP 1c ) , liver 10 receptor alpha ( LXR alpha ) , fatty acid binding protein ( aP 2 ) , fatty acid translocase ( CD 36 ) and insulin sensitive glucose transporter 4 ( GLUT 4 ) . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| It also increased cholesterol efflux from HMCs by increasing peroxisome proliferator activated receptor alpha ( PPARalpha ) , PPARgamma , liver 10 receptor alpha , and ATP binding cassette A 1 ( ABCA 1 ) gene expression . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| We determined the activity and expression of Liver 10 receptor alpha ( LXRalpha ) and PPARalpha in the liver of 18 month old rats treated with 10 mg kg ( 1 ) of ATV for 21 days . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| We determined in 18 month old female Sprague Dawley rats treated for 21 days with a daily dose of 3mg gemfibrozil / kg or 3mg rosiglitazone / kg : ( 1 ) plasma concentrations of total cholesterol ( TC ) , triglycerides ( TG ) , nonesterified fatty acids ( NEFA ) , glucose , insulin and leptin , ( 2 ) hepatic concentrations of TG , NEFA and cholesteryl esters ( CE ) , and ( 3 ) the liver expression and binding activity of peroxisome proliferator activated receptor alpha ( PPARalpha ) , and several of its target genes , hepatic nuclear factor 4 ( HNF 4 ) , and liver 10 receptor alpha ( LXRalpha ) . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| LXRalpha bound directly to PPARalpha , as well as to the common heterodimerization partner 9 cis retinoic acid receptor ( RXRalpha ) . ^^^ LXRalpha did not form a DNA binding complex with PPARalpha on synthetic hormone response elements composed of direct repeats of the TGACCT consensus half site or on naturally occurring peroxisome proliferator response elements ( PPREs ) or LXRalpha response elements . ^^^ However , LXRalpha inhibited binding of PPARalpha / RXRalpha heterodimers to PPREs , and coexpression of LXRalpha in mammalian cells antagonized peroxisome proliferator signaling mediated by PPARalpha / RXRalpha in vivo . ^^^ These findings identify a novel partner for PPARalpha and suggest that LXRalpha plays a role in modulating PPAR signaling pathways in the cell . . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| RXR repression was associated with decreased LXRalpha and PPARalpha mRNA levels and reduced RXR 10 RXR , RXR 10 PPAR and RXR 10 LXR binding activities in nuclear extracts . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Phenotype analyses of knock out or transgenic mice pointed out the respective role of the `` enterohepatic ' ' orphan nuclear receptors LXRalpha , LXRB , FXR , LRH 1 , the nuclear receptor PPARalpha , and their heterodimeric partner RXR , as well as the peculiar receptor SHP . ^^^ At last it seems that polyunsaturated fatty acids could activate LXRalpha transcription through its activation by PPARalpha . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Using full length and Gal 4 LBD chimeric receptors in functional assays , 20 : 4 , n 6 induced PPARalpha activity approximately 2 . 2 fold and suppressed LXRalpha activity by 80 % ( ED 50 approximately 25 50 microm ) in HEK 293 E ( early passage ) cells but had no effect on PPARalpha or LXRalpha receptor activity in HEK 293 L ( late passage ) cells . ^^^ Taken together , these findings demonstrate that the rate of assimilation of exogenously added fatty acids and their metabolites into complex lipids plays an important role in regulating PPARalpha and LXRalpha activity . . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| To ascertain the molecular mechanisms involved , expression of peroxisome proliferator activated receptors ( PPAR ) and liver 10 receptoralpha ( LXRalpha ) were examined . ^^^ A natural ligand of LXRalpha , 25 hydroxycholesterol ( 25 OHC ) , had similar effects ; when used together with PPAR agonists , an additive effect was observed , indicating co operation between PPAR and LXRalpha in regulating ABCA 1 gene expression . ^^^ This was supported by the observation that overexpression of either PPARalpha or PPARgamma by transfection enhanced LXRalpha and ABCA 1 gene induction by PPAR agonists . ^^^ Taken together with previous data , it appears that , in addition to increasing lipid uptake , inflammatory cytokines promote intracellular lipid accumulation by inhibiting cholesterol efflux through the PPAR LXRalpha ABCA 1 pathway . ^^^ IL 1beta ( 5 ng / ml ) reduced PPARalpha , PPARgamma , and LXRalpha mRNA expression . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| In luciferase reporter gene assays , overexpression of LXRalpha or beta suppressed PPARalpha induced peroxisome proliferator response element luciferase activity in a dose dependent manner . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| ApoE HSD 1 transgenic mice exhibited fatty liver and dyslipidemia with increased hepatic lipid synthesis / flux associated with elevated hepatic LXRalpha and PPARalpha mRNA levels as well as impaired hepatic lipid clearance . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR alpha , HNF 4alpha , and LXRalpha in mediating the nuclear effects of PUFAs are addressed . . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| The expression of lipogenic transcription factors ( SREBP 1c , PPARgamma , LXRalpha ) was increased , whereas that of a lipolytic nuclear factor PPARalpha was reduced in SH . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| In vitro binding and cell culture studies have identified many transcription factors as prospective targets for fatty acid regulation , including peroxisome proliferator activated receptors ( PPARalpha , beta , gamma 1 , and gamma 2 ) , sterol regulatory element binding protein 1c ( SREBP 1c ) , hepatic nuclear factors ( HNF 4alpha and gamma ) , retinoid 10 receptor ( RXRalpha ) , liver 10 receptor ( LXRalpha ) , and others . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Although RXR agonists activate many heterodimer partners , these modulators selectively activate RXR : PPARalpha and RXR : PPARgamma , but not RXR : RARalpha , RXR : LXRalpha , RXR : LXRbeta , or RXR : FXRalpha . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| The nuclear receptors peroxisome proliferator activated receptor alpha ( PPARalpha ) and liver 10 receptors ( LXRalpha and LXRbeta ) are major regulators of cholesterol homeostasis and their activation results in a reduced absorption of intestinal cholesterol . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| LXRalpha and PPARalpha regulate genes involved in cholesterol metabolism and the inflammatory response in macrophages . ^^^ |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13133 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|