| The additional molecular targets considered here include the type 1 insulin like growth factor receptor , the epidermal growth factor receptor , mammalian target of rapamycin , NF kappaB , hypoxia inducible factor 1alpha , hsp 90 , cyclooxygenase 2 , protein kinase A type 1 , vascular endothelial growth factor , 5 lipoxygenase , 12 lipoxygenase , angiotensin 2 receptor type 1 , bradykinin receptor type 1 , c Src , interleukin 6 , ras , MDM 2 , bcl 2 / bclxL , vitamin D receptor , estrogen receptor beta , and PPAR . ^^^ |