| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| The retinoid 10 receptor ( RXR ) and the peroxisome proliferator activated receptor ( PPAR ) , which are known to be activated , respectively , by 9 cis RA and long chain fatty acid ( LCFA ) , co operated to bind specifically the peroxisome proliferator responsive element ( PPRE ) found upstream of the L FABP gene . ^^^ Our result suggest that the PPAR RXR complex is the molecular target by which 9 cis RA and LCFA regulate the L FABP gene . . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| The levels of PPAR alpha transcriptionally dependent genes [ cytochrome P4504A1 , acyl CoA oxidase ( AOxase ) , and liver fatty acid binding protein ( L FABP ) ] transcripts were determined as indicators of PPAR alpha activation . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Concomitantly , a 6 . 9 fold induction of liver fatty acid binding protein ( L FABP ) expression is observed in comparison to wild type animals fed standard chow , possibly mediated by the peroxisome proliferator activated receptor alpha ( PPARalpha ) . ^^^ Cytosolic transport of phytanic acid to either peroxisomal membranes or to the nucleus for activation of PPARalpha may be mediated by L FABP , which gives rise to the question whether phytanic acid is a transactivator of this protein . ^^^ Finally to test in vitro whether this induction is conferred by phytanic acid , we cotransfected HepG 2 cells with an expression plasmid for murine PPARalpha and a CAT reporter gene with 176 bp of the murine L FABP promoter , containing the peroxisome proliferator responsive element ( PPRE ) . ^^^ These findings , both in vivo and in vitro , demonstrate that phytanic acid is a transcriptional activator of L FABP expression and that this effect is mediated via PPARalpha . . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Deletion and mutation analyses of the mouse L FABP gene suggested that , in addition to the binding site for PPARalpha , a far upstream sequence is required for PPAR dependent transactivation in the liver . ^^^ In contrast to the cultured cell systems , our in vivo DNA electroporation method showed that PPARalpha binding to the promoter is necessary but not sufficient for PPARalpha ligand dependent transcriptional activation of the L FABP gene in vivo . . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Fatty acid oxidation , as inferred from serum beta hydroxybutyrate levels , was increased in response to fasting , although the increase in L Fabp / mice was significantly reduced in comparison to wild type controls , despite comparable induction of PPAR alpha target genes . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Liver fatty acid binding protein ( L FABP ) has been proposed to limit the availability of long chain fatty acids ( LCFA ) for oxidation and for peroxisome proliferator activated receptor alpha ( PPAR alpha ) , a fatty acid binding transcription factor that determines the capacity of hepatic fatty acid oxidation . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Progressive 5 ' deletion analysis revealed that the peroxisome proliferator activated receptor ( PPAR ) responsive element located at position 67 / 55 was responsible for the statin mediated transactivation of the rat L FABP promoter . ^^^ Moreover , treatment with simvastatin and the PPARalpha agonist Wy 14 , 649 resulted in a synergistic induction of L FABP expression ( mRNA and protein ) in rat Fao hepatoma cells . ^^^ This effect was also observed in vivo in wild type mice but not in PPARalpha null animals demonstrating the direct implication of PPARalpha in L FABP regulation by statin treatment . ^^^ Altogether , these data demonstrate that L FABP expression is up regulated by statins through a mechanism involving PPARalpha . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| We also wanted to verify whether the presence of the PPARalpha L162V mutation interacts with genetic variants in LFABP gene . ^^^ Moreover , PPARalpha L162V and LFABP T94A showed to have a synergistic effect on BMI ( p interaction = 0 . 03 ) . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| Liver fatty acid binding protein ( LFABP ) is an abundant protein in liver cytosol whose expression is regulated by PPAR alpha . ^^^ The aim of this study was to investigate the expression of PPAR alpha and LFABP during liver regeneration . ^^^ METHODS : Male Sprague Dawley rats and male C 57 Bl / 6 mice were subjected to 2 / 3 hepatectomy and LFABP and PPAR alpha mRNA and protein levels were measured at different time points after surgery . ^^^ The LFABP mRNA and protein levels paralleled those of PPAR alpha and were also decreased 26 h after hepatectomy . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| The aim of this study was to investigate the interaction between long chain fatty acids ( LCFA ) and growth hormone ( GH ) in the regulation of liver fatty acid binding protein ( LFABP ) and peroxisome proliferator activated receptor alpha ( PPARalpha ) . ^^^ Dietary triglycerides ( 10 % corn oil ) increased LFABP mRNA and cytosolic LFABP about twofold but had no effect on PPARalpha mRNA in Hx rats . ^^^ In summary , these studies show that GH regulates LFABP expression independently of PPARalpha . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| PPAR alpha agonists increased the expression and biosynthesis of liver fatty acid binding protein ( LFABP ) . ^^^ Increased expression of LFABP by transfection of McA RH 7777 cells increased the secretion of apoB 100 , decreased triglyceride biosynthesis and secretion , and increased PPAR alpha mRNA levels . ^^^ These findings suggest that PPAR alpha and LFABP could interact to amplify the effect of endogenous PPAR alpha agonists on the assembly of VLDL . . ^^^ |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P07148 and Q07869 |
Pubmed |
SVM Score :0.0 |
| NA |
|