| Interacting proteins: Q07837 and Q9UHI5 |
Pubmed |
SVM Score :0.0 |
| LAT 2 does not interact with rBAT , a protein with a significant structural similarity to 4F2hc . ^^^ |
|
| Interacting proteins: Q07837 and Q9UHI5 |
Pubmed |
SVM Score :0.0 |
| Na ( + ) independent glutamine transporter genes encoding for System L ( LAT 1 , LAT 2 ) and System b ( 0 , + ) ( b ( 0 , + ) AT ) have also been recently isolated , and similar to y ( + ) L , have been shown to function as disulfide linked heterodimers with the 4F2 heavy chain ( CD 98 ) or rBAT ( related to b ( 0 , + ) amino acid transporter ) . ^^^ |
|
| Interacting proteins: Q07837 and Q9UHI5 |
Pubmed |
SVM Score :0.0 |
| The heavy chain rbAT ( related to b ( 0 , + ) amino acid transporter ) associates with the light chain b ( 0 , + ) AT ( b ( 0 , + ) amino acid transporter ) to form the amino acid transport system b ( 0 , + ) , whereas the homologous heavy chain 4F2hc interacts with several light chains to form system L ( with LAT 1 and LAT 2 ) , system y ( + ) L ( with y ( + ) LAT 1 and y ( + ) LAT 2 ) , system 10 ( with xAT ) , or system asc ( with asc 1 ) . ^^^ The association of light chains with the two heavy chains is not unambiguous . rbAT may interact with LAT 2 and y ( + ) LAT 1 and vice versa ; 4F2hc may interact with b ( 0 , + ) AT when overexpressed . 4F2hc is necessary for trafficking of the light chain to the plasma membrane , whereas the light chains are thought to determine the transport characteristics of the respective heterodimer . ^^^ |
|
| Interacting proteins: Q07837 and Q9UHI5 |
Pubmed |
SVM Score :0.0 |
| The dopamine precursor L dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT 2 in renal cortex . ^^^ Complementary RNA from two amino acid transporters yielded l DOPA uptake significantly above water injected controls the rBAT / b ( 0 , + ) AT dimer ( rBAT ) and the LAT2 / 4F2 dimer ( LAT 2 ) . ^^^ In contradistinction to renal cortical poly A ( + ) , l DOPA kinetics of rBAT and LAT 2 showed classic Michaelis Menton kinetics with K ( m ) s in the micromolar and millimolar range , respectively . ^^^ Sequence specific antisense oligonucleotides to rBAT or LAT 2 ( AS ) caused inhibition of rBAT and LAT 2 cRNA induced l DOPA transport and cortical poly A ( + ) induced arginine and phenylalanine transport . ^^^ We conclude that rBAT and LAT 2 can mediate apical and basolateral l DOPA uptake into the proximal tubule , respectively . ^^^ |
|
| Interacting proteins: Q07837 and Q9UHI5 |
Pubmed |
SVM Score :0.0 |
| Uptake data correlate to expression of the genes encoding for CAT 1 , CAT 2B , 4F2hc , y ( + ) LAT 1 , y ( + ) LAT 2 , rBAT , and b ( 0 , + ) AT , an expression profile that is also shown by the rat thyroid gland . ^^^ |
|
| Interacting proteins: Q07837 and Q9UHI5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07837 and Q9UHI5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07837 and Q9UHI5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07837 and Q9UHI5 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UHI5 and Q07837 |
Pubmed |
SVM Score :0.0 |
| The heavy chain rbAT ( related to b ( 0 , + ) amino acid transporter ) associates with the light chain b ( 0 , + ) AT ( b ( 0 , + ) amino acid transporter ) to form the amino acid transport system b ( 0 , + ) , whereas the homologous heavy chain 4F2hc interacts with several light chains to form system L ( with LAT 1 and LAT 2 ) , system y ( + ) L ( with y ( + ) LAT 1 and y ( + ) LAT 2 ) , system 10 ( with xAT ) , or system asc ( with asc 1 ) . ^^^ The association of light chains with the two heavy chains is not unambiguous . rbAT may interact with LAT 2 and y ( + ) LAT 1 and vice versa ; 4F2hc may interact with b ( 0 , + ) AT when overexpressed . 4F2hc is necessary for trafficking of the light chain to the plasma membrane , whereas the light chains are thought to determine the transport characteristics of the respective heterodimer . ^^^ |
|
| Interacting proteins: Q9UHI5 and Q07837 |
Pubmed |
SVM Score :0.0 |
| The dopamine precursor L dihydroxyphenylalanine is transported by the amino acid transporters rBAT and LAT 2 in renal cortex . ^^^ Complementary RNA from two amino acid transporters yielded l DOPA uptake significantly above water injected controls the rBAT / b ( 0 , + ) AT dimer ( rBAT ) and the LAT2 / 4F2 dimer ( LAT 2 ) . ^^^ In contradistinction to renal cortical poly A ( + ) , l DOPA kinetics of rBAT and LAT 2 showed classic Michaelis Menton kinetics with K ( m ) s in the micromolar and millimolar range , respectively . ^^^ Sequence specific antisense oligonucleotides to rBAT or LAT 2 ( AS ) caused inhibition of rBAT and LAT 2 cRNA induced l DOPA transport and cortical poly A ( + ) induced arginine and phenylalanine transport . ^^^ We conclude that rBAT and LAT 2 can mediate apical and basolateral l DOPA uptake into the proximal tubule , respectively . ^^^ |
|
| Interacting proteins: Q9UHI5 and Q07837 |
Pubmed |
SVM Score :0.0 |
| Uptake data correlate to expression of the genes encoding for CAT 1 , CAT 2B , 4F2hc , y ( + ) LAT 1 , y ( + ) LAT 2 , rBAT , and b ( 0 , + ) AT , an expression profile that is also shown by the rat thyroid gland . ^^^ |
|
| Interacting proteins: Q9UHI5 and Q07837 |
Pubmed |
SVM Score :0.0 |
| LAT 2 does not interact with rBAT , a protein with a significant structural similarity to 4F2hc . ^^^ |
|
| Interacting proteins: Q9UHI5 and Q07837 |
Pubmed |
SVM Score :0.0 |
| Na ( + ) independent glutamine transporter genes encoding for System L ( LAT 1 , LAT 2 ) and System b ( 0 , + ) ( b ( 0 , + ) AT ) have also been recently isolated , and similar to y ( + ) L , have been shown to function as disulfide linked heterodimers with the 4F2 heavy chain ( CD 98 ) or rBAT ( related to b ( 0 , + ) amino acid transporter ) . ^^^ |
|
| Interacting proteins: Q9UHI5 and Q07837 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UHI5 and Q07837 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UHI5 and Q07837 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UHI5 and Q07837 |
Pubmed |
SVM Score :0.0 |
| NA |
|