| Interacting proteins: Q9NQS1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The possibility that Bcl 10 ( L ) inhibits cell death at a late ( postmitochondrial ) step in the death pathway is supported by this report of a novel apoptosis inhibitor , Aven , which binds to both Bcl 10 ( L ) and the caspase regulator , Apaf 1 . ^^^ Only those mutants of Bcl 10 ( L ) that retain their antiapoptotic activity are capable of binding Aven . ^^^ Aven , a novel inhibitor of caspase activation , binds Bcl xL and Apaf 1 . ^^^ |
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| Interacting proteins: Q9NQS1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Aven and Bcl xL enhance protection against apoptosis for mammalian cells exposed to various culture conditions . ^^^ In this study , we evaluate a recently discovered anti apoptotic gene , aven , and examine its effectiveness alone and in combination with a member of the Bcl 2 family , bcl xL . ^^^ The commercially popular cell line , Chinese hamster ovary ( CHO ) , was genetically modified to constitutively express aven , bcl xL , and the two genes in combination . ^^^ After exposure to serum deprivation , 4 and 5 day spent medium , and staurosporine , cells expressing Aven provided limited protection against cell death when compared with the protection afforded by cells expressing Bcl xL alone . ^^^ However , the highest survival levels for all insults were achieved when Aven was expressed in combination with Bcl xL . ^^^ |
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| Interacting proteins: Q9NQS1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Two upstream inhibitors involved in the mitochondrial pathway , Bcl 10 ( L ) and Aven , were expressed in addition to a downstream inhibitor of caspases . ^^^ For all single gene experiments , the Bcl 10 ( L ) containing cell lines provided superior protection to either the Aven or XIAP BIRs containing cell lines following initial exposure to the insults . ^^^ During exposure to spent medium , CHO BIRS + Aven + BclX ( L ) was the best inhibitor of apoptosis ( IAP ) initially , whereas CHO BIRs + BclX ( L ) was particularly effective at later times of the experiment . ^^^ |
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