| Interacting proteins: Q9HD36 and Q07817 |
Pubmed |
SVM Score :0.64658076 |
| The cell death antagonist Bcl XL interacts with Boo , but is unable to protect 293 cells from Boo / Diva induced cell death . 0.64658076^^^ |
|
| Interacting proteins: Q9HD36 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Like Ced 9 , the mammalian homologues Boo and Bcl xL interact with the human counterpart of Ced 4 , Apaf 1 , and thereby regulate apoptosis . . ^^^ |
|
| Interacting proteins: Q9HD36 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Apaf 1 did not bind , however , to any of the six known mammalian prosurvival family members ( Bcl 2 , Bcl 10 ( L ) , Bcl w , A 1 , Mcl 1 , or Boo ) , or their viral homologs adenovirus E1B 19K and Epstein Barr virus BHRF 1 . ^^^ |
|
| Interacting proteins: Q9HD36 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Consistent with this , Diva did not bind to cellular Bcl 2 family members including Bcl 2 , Bcl XL , Bcl w , Mcl 1 , and A1 / Bfl 1 . ^^^ Consistent with these associations , apoptosis induced by Diva was inhibited by vBcl 2 but not by Bcl XL . ^^^ The expression of Diva inhibited the binding of Bcl XL to Apaf 1 , as determined by immunoprecipitation assays . ^^^ Thus , Diva represents a novel type of proapoptotic Bcl 2 homologue that promotes apoptosis independently of the BH 3 region through direct binding to Apaf 1 , thus preventing Bcl XL from binding to the caspase 9 regulator Apaf 1 . . ^^^ |
|
| Interacting proteins: Q9HD36 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|