| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The protein encoded by PUMA was found to be exclusively mitochondrial and to bind to Bcl 2 and Bcl 10 ( L ) through a BH 3 domain . ^^^ |
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| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The PUMA protein interacts with Bcl 10 ( L ) and promotes mitochondrial translocation and multimerization of Bax . ^^^ |
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| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In normal cells , and in precancerous B cells of E micro myc transgenic mice , this apoptotic response is associated with the suppression of the antiapoptotic regulators Bcl 2 and Bcl 10 ( L ) and with the concomitant induction of Puma , a proapoptotic BH 3 only protein . ^^^ |
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| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| A PUMA BH 3 peptide can induce Bax conformational change , cytochrome c release , and reduction in the mitochondrial membrane potential ( DeltaPsi ( m ) ) in isolated K 562 mitochondria and can be inhibited by Bcl XL . ^^^ |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Indeed , bortezomib induced increases of Bik and / or Bim in multiple cell lines but not notably of two other BH 3 only proteins ( Puma and Bid ) nor other family members ( Bax , Bak , Bcl 2 , and Bcl xL ) . ^^^ |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis was used to analyze the expression of p 53 , p 53 phospho Ser 15 , p 21 , Bax , PUMA , and Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| PUMA , a key mediator of p 53 induced apoptosis , is a BH 3 only domain proapoptotic protein that localizes to mitochondria and interacts with antiapoptotic Bcl 2 and Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In adriamycin treated BALB / 3T3 cells , the down shift in temperature from 37 degrees C to 32 degrees C increased the Bcl xL protein level and decreased the mRNA level of Puma and mitochondrial translocation of Bax , suppressing caspase 9 mediated apoptosis . ^^^ |
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| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The enhanced TRAIL effect after pretreatment with HDAC inhibitors was consistent with the upregulation of the proapoptotic Bcl 2 family members ( Bim , Bak , Bax , Noxa , and PUMA ) , the downregulation of the anti apoptotic members of the Bcl 2 family ( Bcl 2 and Bcl 10 ( L ) ) , and IAPs . ^^^ |
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| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that a tripartite nexus between Bcl xL , cytoplasmic p 53 , and PUMA coordinates these distinct p 53 functions . ^^^ Nuclear p 53 caused expression of PUMA , which then displaced p 53 from Bcl xL , allowing p 53 to induce mitochondrial permeabilization . ^^^ Mutant Bcl xL that bound p 53 , but not PUMA , rendered cells resistant to p 53 induced apoptosis irrespective of PUMA expression . ^^^ |
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| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^ |
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| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| PUMA Dissociates Bax and Bcl 10 ( L ) to induce apoptosis in colon cancer cells . ^^^ PUMA interacts with anti apoptotic Bcl 2 and Bcl 10 ( L ) and is dependent on Bax to induce apoptosis . ^^^ We found that Bcl 10 ( L ) was most effective among several antiapoptotic proteins in suppressing PUMA induced apoptosis and PUMA dependent apoptosis induced by the DNA damaging agent adriamycin . ^^^ Mutant Bcl 10 ( L ) that can not interact with Bax was unable to protect cells from PUMA mediated apoptosis . ^^^ Knockdown of Bcl 10 ( L ) by RNA interference significantly enhanced PUMA mediated apoptosis in HCT 116 cells but not in PUMA knockout cells . ^^^ |
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| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^ |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9BXH1 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|