| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In murine IL 3 dependent cell lines BAF B 03 and 32D , IFN gamma upregulated bag 1 and bcl xL gene expression . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The anti apoptotic proteins Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 were present at immunodetectable levels in 7 , 10 , 10 , and 9 of the 11 lines . ^^^ Comparing these 11 cell lines among themselves revealed that steady state levels of Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 were present at relatively higher levels in 4 , 6 , 5 , and 5 of the lines , respectively . ^^^ Immunoblot analysis of primary adenocarcinomas revealed expression of the anti apoptotic proteins Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 , as well as the pro apoptotic proteins Bax , Bak , and CPP 32 , in at least 2 of the 3 tumors examined . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The expression of several apoptosis regulating proteins , including the Bcl 2 family proteins Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , and BAD ; the Bcl 2 binding protein BAG 1 ; and the cell death protease Caspase 3 ( CPP 32 ) , was evaluated by immunoblotting using 58 peripheral blood B CLL specimens from previously untreated patients . ^^^ Expression of Bcl 2 , Mcl 1 , BAG 1 , Bax , Bak , and Caspase 3 was commonly found in circulating B CLL cells , whereas the Bcl XL and BAD proteins were not present . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| On the other hand , the levels of apoptosis inhibiting proteins bcl 2 , bcl xL and BAG 1 increased progressively after immortalization and transformation . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Here , we report that the expression of bcl 2 , bcl xL , bcl xS , bax and bad mRNA as well as of Bcl 2 , Bax , Bcl XL , Bcl XS and Bag 1 proteins is not modulated in these two paradigms of neuronal cell death . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that the resistance protein ( s ) are not Bcl 2 , Bcl 10 , Fap 1 or Bag 1 . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Overexpression of the anti apoptotic bcl xL transcript and the pro apoptotic bax mRNA was also detected but no alterations in bcl 2 or bag 1 mRNA levels were observed . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Mammary gland tissue , similar to many other tissues , expresses a number of different Bcl 2 relatives including bcl 10 , bax , bak , bad , bcl w , bfl 1 , bcl 2 as well as the bcl 2 binding protein Bag 1 . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The expression of Bcl 2 and Bcl 10 ( L ) correlated with that of BAG 1 in breast normal and carcinoma cell lines but not tissues . ^^^ Our study suggests that BAG 1 isoforms may serve as a molecular marker , independent of Bcl 2 and Bcl 10 ( L ) , for human breast cancer . . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| BAG 1 is an anti apoptotic protein that interacts with Bcl 2 , Bcl XL , Hsp70 / Hsc70 , Raf 1 and numerous hormone or growth factor receptors . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Expression of Bcl 2 and its homologues , Bcl xL , Bcl xS , Bax , Bad , Bak and Bag 1 , was detected in all NHL cases , with wide variations between histological subtypes and within each subtype . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Further , Western blot analysis showed that MDR HEN 16 2 / CDDP cells had significantly higher levels of the apoptosis inhibiting proteins BAG 1 p 50 and p 33 isoforms and Bcl 10 ( L ) . ^^^ This study provided the first evidence that overexpression of antiapoptotic BAG 1 p 50 and p 33 and Bcl 10 ( L ) may cause resistance to apoptosis through reduction of caspase 3 activity in human cervical cells having an MDR phenotype . . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In parallel , only adjunctive treatment triggered intragraft induction of molecules with anti oxidant ( HO 1 ) and anti apoptotic ( Bcl xL / Bag 1 ) but not with pro apoptotic ( CPP 32 ) functions , both in the early and late posttransplant phases . ^^^ Th 2 driven up regulation of protective molecule programs at the graft site , such as of anti oxidant HO 1 and / or anti apoptotic Bcl xL and Bag 1 , may contribute , at least in part , to the maintenance of the infectious tolerance pathway in transplant recipients . . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Other members of the Bcl 2 family ( Bag 1 , Bak , Bax , and Bcl xL ) were not altered in expression . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| We studied the expression of several genes involved in differentiation , apoptosis and chemoresistance : ets 1 , bax , bcl 2 , bag 1 , bcl 10 , mdr 1 and mrp . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The expression of other antiapoptotic proteins ( Bcl 10 ( L ) , Bag 1 , A 1 , and Mcl 1 ) did not prevent Bcl 2 AS induced apoptosis . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Since the Bcl 2 family of proteins constitutes a critical checkpoint in apoptosis , acting upstream of the apoptotic machinery , we investigated the expression of six Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Aloe emodin induced apoptosis of CH 27 cells involved modulation of the expression of Bcl 2 family proteins , such as BclX ( L ) , Bag 1 , and Bak , and was associated with the translocation of Bak and Bax from cytosolic to particulate fractions . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The predictive value of bcl 2 , bax , bcl xL , bag 1 , fas , and fasL for chemotherapy response in advanced breast cancer . ^^^ In 126 patients , histological blocks of primary tumors were available for immunohistochemical analysis of bax , bcl 2 , bcl xL , bag 1 , fas and fasL . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Our data demonstrated that Gyp induced apoptotic cell death was accompanied by up regulation of Bax , Bak and Bcl 10 ( L ) , and down regulation of Bcl 2 and Bad , while it had no effect on the level of Bag 1 protein . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| We report herein that human oocytes and preimplantation embryos possess abundant levels of transcripts encoding cell death suppressors , Mcl 1 , Bcl 10 and Bag 1 , and the cell death inducer genes , Bax and Caspase 2 . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Peripheral immune cells were investigated for apoptosis and for the expression of apoptosis regulatory genes CD 95 , CD 95 ligand , FLIP , Bcl 2 , Bcl 10 ( L ) , Bag 1 , and caspase 3 by quantitative real time PCR . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| It was revealed that LIGHT treatment resulted in down regulation of anti apoptosis Bcl 2 family member : Bcl 2 , Bcl 10 ( L ) , Bag 1 , and Mcl 1 ; up regulation of pro apoptosis Bcl 2 family member : Bak and Ser ( 112 ) phosphor Bad ; down regulation of pro apoptosis Bcl 2 member Bax ; the other pro apoptosis member Bid remains unaltered . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| With a serial of Western blot analysis , it is revealed that gossypol induced cell cycle arrest is involved in P 21 up regulation and cyclin D 1 down regulation ; gossypol induced apoptosis triggers down regulation of anti apoptosis Bcl 2 members : Bcl 10 ( L ) , Bag 1 and Mcl 1 , up regulation of pro apoptosis Bcl 2 member Bak , activation of caspase 3 , 6 , 7 , 8 , and 9 , up regulation of Apaf 1 , release of cytochrome c ( cyto c ) from mitochondria , and activation of both DFF 45 and PARP . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| To further understand such merosin driven survival signaling , we analyzed the expression of five Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) in normal and merosin deficient myotubes , with or without pharmacological inhibitors for Fyn and p 38 . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Expression of the Bcl 2 family proteins , Bcl xL and Bag 1 , was increased in CCL 2 treated myocytes subjected to hypoxia . ^^^ |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q99933 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|