| Interacting proteins: Q99638 and Q07817 |
Pubmed |
SVM Score :0.5375484 |
| Human homologue of S . pombe Rad 9 interacts with BCL 2 / BCL xL and promotes apoptosis . 0.5375484^^^ |
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| Interacting proteins: Q99638 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The results also demonstrate that c Abl mediated phosphorylation of Rad 9 induces binding of Rad 9 to the antiapototic Bcl 10 ( L ) protein . ^^^ |
|
| Interacting proteins: Q99638 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Furthermore , analysis of a truncated Rad 9 mutant that corresponds to a putative N terminal cleavage fragment shows that the N terminal portion of Rad 9 localizes in the cytosol , binds to Bcl XL , and induces apoptosis . ^^^ These results support a dual role for cleavage of Rad 9 : ( 1 ) the liberation and translocation of the BH 3 domain containing N terminus of Rad 9 to the cytosol , as a means of promoting apoptosis via antagonism of Bcl XL , and ( 2 ) the disruption of the Rad 9 Rad1 Hus 1 DNA damage checkpoint complex . . ^^^ |
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