Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.71655392
We demonstrate the utility of this approach by applying it to clones isolated in a two hybrid screen using Bcl xL as bait , showing that two hybrid derived fragments of Bad and Bax , previously known to interact with Bcl xL , both colocalize and coimmunoprecipitate with Bcl xL . . 0.71655392^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.55331003
To determine the role of dimerization in regulating the death promoting activity of Bad and the death inhibiting activity of Bcl xL , mutations within the hydrophobic BH 3 binding pocket in Bcl xL that eliminated the ability of Bcl xL to form a heterodimer with Bad were tested for the ability to promote cell survival in the presence of Bad . 0.55331003^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.71089217
Surprisingly , all of the mutated BCL 2 and BCL XL proteins analyzed strongly interacted with human BAD . 0.71089217^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :1.0584917
Association of BAD with Bcl xL was observed , and a portion of BAD was dephosphorylated after induction of gp 160 . 1.0584917^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :1.2912272
Proapoptotic BAD ( Bcl 2 associated death protein ) has been shown to dissociate from its sequestered site with the molecular chaperone protein 14 3 3 and displace proapoptotic BAX ( Bcl 2 associated 10 protein ) from antiapoptotic BCL Xl . 1.2912272^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.92802181
These results establish a critical role for a BH 3 domain within BAD and provide evidence that BAD may function as a death ligand whose pro apoptotic activity requires heterodimerization with BCL XL . . 0.92802181^^^ We report here that deletion mapping and site directed mutagenesis identified a BH 3 domain within BAD that proved necessary for both its heterodimerization with BCL XL and its death agonist activity . 0.90969472^^^ BH 3 domain of BAD is required for heterodimerization with BCL XL and pro apoptotic activity . 0.50297215^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bad , Bcl xS , and Ced 9 lacked suppressor activity . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 family members analyzed were Bcl 2 , Bcl 10 , Bax , Bad , Bak , A 1 , and Mcl 1 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Expression of the BCL 2 protein family members , BAX , BAK , BAD , BCL xL , BCL xS , and BCL 2 , was measured ( by western blotting using specific antibodies ) in PC 12 cells before and during apoptosis induced by either H2O2 treatment or by serum deprivation and during rescue from apoptosis by nerve growth factor ( NGF ) . ^^^ Our results show that the expression of BAX , BAK , BAD , and BCL xL is altered in a stimulus dependent manner but can not be used to define whether a cell will undergo or survive apoptosis . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bad , a heterodimeric partner for Bcl XL and Bcl 2 , displaces Bax and promotes cell death . ^^^ Bad selectively dimerized with Bcl xL as well as Bcl 2 , but not with Bax , Bcl xs , Mcl 1 , A 1 , or itself . ^^^ Bad binds more strongly to Bcl xL than Bcl 2 in mammalian cells , and it reversed the death repressor activity of Bcl xL , but not that of Bcl 2 . ^^^ When Bad dimerized with Bcl xL , Bax was displaced and apoptosis was restored . ^^^ The susceptibility of a cell to a death signal is determined by these competing dimerizations in which levels of Bad influence the effectiveness of Bcl 2 versus Bcl xL in repressing death . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
This protective effect of Bcl 2 occurs in the absence of significant variations , in the stimulated livers , in the level of expression of other proteins also involved in resistance or sensitivity to apoptosis , namely Bcl 10 , Bax , Bad , Bak , and p 53 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14 3 3 not BCL 10 ( L ) . ^^^ One distant member , BAD , heterodimerizes with BCL 10 ( L ) or BCL 2 , neutralizing their protective effect and promoting cell death . ^^^ Only the nonphosphorylated BAD heterodimerized with BCL 10 ( L ) at membrane sites to promote cell death . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Since the discovery of Bcl 2 a decade ago , several other cellular and viral genes encoding homologous proteins have been identified , some of which suppress cell death akin to Bcl 2 ( Bcl XL , Mcl 1 , A1 / Bfl 1 , Nr 13 , Ced 9 , BHRF 1 ) and others which promote apoptosis ( Bax , Bcl Xs , Bak , Bik , Bad ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Apoptosis resistance in the metastatic cells was associated with higher levels of expression of the cell death suppressor BCL 2 and lower levels of the death promoters BAX and BAK than were detected in the nonmetastatic LNCaP Pro 5 cells , whereas levels of two other BCL 2 family members ( BCL 10 ( L ) and BAD ) were indistinguishable . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The three pro apoptotic members of the family , Bak , Bad , and Bax , all showed an early decline in mRNA levels when Bcl 10 transcripts increased , followed by later peaks at 12 , 24 , and 48 to 72 hours , respectively . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Induction of anergy resulted in up regulation and persistent expression of moderate amounts of bcl xL and bax and absence of induction of bad . ^^^ Subsequent sensitivity to AICD was associated with down regulation of bcl xL , induction of bad , and the displacement of bax from bcl xL : bax heterodimers . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Interference of BAD ( Bcl xL / Bcl 2 associated death promoter ) induced apoptosis in mammalian cells by 14 3 3 isoforms and P 11 . ^^^ Unlike most other members of the Bcl 2 family , BAD ( Bcl xL / Bcl 2 associated death promoter ) , a death enhancer , has no C terminal transmembrane domain for targeting to the outer mitochondrial membrane and nuclear envelope . ^^^ We hypothesized that BAD , in addition to binding Bcl xL and Bcl 2 , may interact with proteins outside the Bcl 2 family . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
FL cells express the death suppressor proteins bcl 2 , bcl xL , and mcl 1 ; whereas GC B cells express bcl xL and mcl 1 but also the proapoptotic proteins bax alpha and bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The BAD protein is a pro apoptotic member of the Bcl 2 family whose ability to heterodimerize with survival proteins such as Bcl 10 ( L ) and to promote cell death is inhibited by phosphorylation . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Deletion of BH 4 rendered Bcl 2 ( and Bcl xL ) inactive but did not impair either Bcl 2 homodimerization or ability to bind to Bax or five other pro apoptotic relatives ( Bak , Bad , Bik , Bid or Bim ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
We also found that the expression of p 53 , p21waf1 / cip1 , Bcl 2 , Bax , Bcl xL , Bad and cyclins D 1 , E , A and B did not show any significant changes following c Myc induction . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Alteration of proteins regulating apoptosis , Bcl 2 , Bcl 10 , Bax , Bak , Bad , ICH 1 and CPP 32 , in Alzheimer ' s disease . ^^^ Apoptosis is regulated by the B cell leukemia 2 gene product ( Bcl 2 ) family ( Bcl 2 , Bcl 10 , Bax , Bak and Bad ) and the caspase family ( ICH 1 and CPP 32 ) , with apoptosis being prevented by Bcl 2 and Bcl 10 , and promoted by Bax , Bak , Bad , ICH 1 and CPP 32 . ^^^ In the membranous fraction , the levels of Bcl 2 alpha , Bcl xL , Bcl 10 beta , Bak and Bad were increased in AD . ^^^ In the cytosolic fractions , the level of Bcl 10 beta was increased , while Bcl xL , Bax , Bak , and Bad and ICH 1L were unchanged . ^^^ These findings demonstrate a differential involvement of cell death regulatory proteins in AD and suggest that Bak , Bad , Bcl 2 and Bcl 10 are upregulated in AD brains . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Sensitive S 49 cells and resistant variants did not differ in the expression levels of the apoptosis regulating genes bax , bad , bcl 10 and bcl 2 , the status of the p 53 gene nor in a different requirement for the growth factors 2 2 , IL 4 or IL 9 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The effect of TGF beta 1 and DEX on cellular amounts of several apoptosis related proteins , members of the Bcl 2 family , Bcl 2 , Bcl xL , Bcl xS , Bad , and Bax was also examined . ^^^ Bcl 2 and Bcl xS proteins were not detected , and Bax and Bad content did not change by treatment with TGF beta 1 or DEX . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The expression of several apoptosis regulating proteins , including the Bcl 2 family proteins Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , and BAD ; the Bcl 2 binding protein BAG 1 ; and the cell death protease Caspase 3 ( CPP 32 ) , was evaluated by immunoblotting using 58 peripheral blood B CLL specimens from previously untreated patients . ^^^ Expression of Bcl 2 , Mcl 1 , BAG 1 , Bax , Bak , and Caspase 3 was commonly found in circulating B CLL cells , whereas the Bcl XL and BAD proteins were not present . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Also , Bcl 2 , Bcl 10 , Bak , Bad and p 53 were increased in AD brains . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The IL 7 trophic affect correlated with increased intracellular levels of Bcl 2 and decreased levels of Bax , whereas no Bcl 10 ( L ) , Bcl w , or Bad was detectable . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In this study we have investigated by Western blotting the expression pattern of Bcl 2 and its homologues Bax , Bak , Bcl xL , Bcl xS , Mcl 1 and Bad in 12 distant lymph node metastases from patients who have been treated by different regimes , in nine newly established cell lines of these metastases , in three cell lines obtained from other sources and in primary melanocytic cell lines from three neonatal and two adult subjects . ^^^ Taken together , our data suggest that Bax , Bak , Bad , Bcl xL and Mcl 1 are expressed in addition to Bcl 2 in both normal melanocytes and in cell lines established from melanoma metastases . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Quantitative Western blotting was used to examine the protein expression of P 53 and P21WAF 1 , Bcl 2 and Bcl 10 ( L ) ( anti apoptotic proteins ) , and Bax , Bak , and Bad ( proapoptotic proteins ) . ^^^ Upon deprivation , these cancer cells up regulated P 21 and Bcl 2 and / or BclX ( L ) , lost response to withdrawal induced up regulation of Bax / Bad / Bak or decreased or even completely lost Bax expression and expressed some novel proteins such as P 25 and P54 / 55 complex . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 family proteins are key regulators of apoptosis and function as cell death antagonists ( e . g . , Bcl 2 , Bcl XL , and Mcl 1 ) or agonists ( e . g . , Bax , Bad , and Bak ) . ^^^ Here we report that among the Bcl 2 family of proteins tested ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bad , and Bak ) , Bcl XL was unique in that its protein levels were tightly regulated by hemopoietins in both immortal and primary myeloid progenitors . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bcl xS and Bad potentiate the death suppressing activities of Bcl xL , Bcl 2 , and A 1 in yeast . ^^^ Bcl xS and Bad potentiate the death suppressing activities of Bcl xL , Bcl 2 , and A 1 in yeast . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
We have previously examined the involvement of the B cell leukemia 2 gene product ( Bcl 2 ) family proteins ( Bcl 2 , Bcl 10 , Bax , Bak , and Bad ) in Alzheimer ' s disease ( AD ) and found that Bcl 2 , Bcl 10 , Bak , and Bad were upregulated . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The expression of Bax was clearly induced only on IL 2 stimulated or PMA plus ionomycin stimulated PBLs and that of other Bcl 2 family proteins such as Bcl 10 and Bad could not be detected on human PBLs , including IL 2 stimulated or PMA plus ionomycin stimulated PBLs . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Importantly , this effect was associated with binding of HA BAD to BCL xL and concomitant disruption of BAX : BCL xL interaction . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Two colour cytometric analysis of permeabilized CD34+ cells stained with antibodies to Bcl 2 , Bcl 10 ( anti apoptotic ) , Bax and Bad ( pro apoptotic ) , demonstrated significantly higher ratios of pro 5 anti apoptotic proteins in early MDS ( 2 . 47 ( 1 . 19 9 . 42 ) compared to advanced disease ( 1 . 14 ( 0 . 06 3 . 32 ) , P=0 . 0001 ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
After androgen withdrawal , there were no significant changes in the levels of clusterin , Bcl xl , Bak , and Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Nonetheless , there were no significant alterations in levels of immunoreactive Bcl 2 , Bcl 10 ( L ) , Bax , Bad , and Bak , nor any evidence of cytochrome c release into cytosol and dissipation of delta ( psi ) m . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Analyses of apoptosis and of the apoptosis regulatory proteins Bcl 2 , Bax , Bcl 10 , and Bad were done in 95 nontumorous and neoplastic pituitary tissues by terminal deoxynucleotide transferase mediated dUTP nick end labeling ( TUNEL ) , immunohistochemistry , and Western blotting . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Similarly , we analyzed the expression of bcl 2 related proteins bcl xL , bax , bad , and bak before and during ex vivo expansion . ^^^ These cells expressed strongly the bcl xL protein ( > 95 % ) but were bax low ( 4 % to 12 % ) , bad low ( 0 % to 0 . 8 % ) , and bak low ( 0 % to 3 % ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In the yeast cell assay , BOD interacts with diverse antiapoptotic Bcl 2 proteins [ Mcl 1 , Bcl 2 , Bcl xL , Bcl w , Bfl 1 , and Epstein Barr virus ( EBV ) BHRF 1 ] but not with different proapoptotic Bcl 2 proteins ( BAD , Bak , Bok , and Bax ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
We did not observe any changes in Bcl 2 or Bcl 2 related proteins ( Bcl 10 , Bax , and Bad ) in control or KCREB transfected cells before or after treatment with Tg . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The expression of genes involved in cell death ( MA 3 , p 53 , Bad , and Bcl xS ) seems to be elevated , whereas the expression of genes involved in cell survival ( Bcl 2 ) is reduced . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 ( L ) , Bax , Bad , Bak and p 53 protein expression was analysed by Western blotting . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Here we demonstrate that inhibition of the epidermal growth factor receptor tyrosine kinase activity with either an epidermal growth factor receptor antagonistic monoclonal antibody ( MoAb 425 ) or an epidermal growth factor receptor selective tyrosine kinase inhibitor ( AG 1478 ) downregulated Bcl 10 ( L ) expression in normal human keratinocytes but had no effect on expression of the pro apoptotic Bcl 2 homologs Bad , Bak , and Bax . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Thus , the pro apoptotic proteins Bax , Bak and Bad , as well as the death suppressors Bcl 10 , Bcl 2 and Bcl w , are synthesised in mouse mammary gland , and dynamic changes in the expression profiles of these proteins occurs during development . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bcl XL , Bcl Xs , BAX , BAD , MCL 1 ) and of Interleukin 1 converting enzyme ( ICE ) related proteins ( ICE , CPP 32 , ICH 1 ) was analyzed in acute leukemia cells by flow cytometry . ^^^ However , BCL Xs and BAK were weakly expressed in K 562 , as were Bcl 10 , BAD and BAK in the VAL line . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
METHODS : Primary bovine glomerular endothelial cells were stimulated with TNF alpha or LPS , and apoptotic cell death was investigated by DNA fragmentation analysis , morphological studies , measurement of cytochrome c efflux and mitochondrial permeability transition , Bak , Bad , Bax , Bcl 2 , Bcl xL protein expression , and caspase 3 like protease activity . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
We found that E 2 treatment of differentiated PCER cells in serum free media increased the levels of Bcl XL mRNA and reduced the levels of BAD mRNA relative to those in vehicle treated PCER cells , and also relative to those in PCCON cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Phosphorylated Bad , an apoptotic member of the Bcl 2 family , can not bind to Bcl xL and results in Bcl xL homodimer formation and subsequent antiapoptotic activity . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
However , there was no difference between the two cell lines in the expression of Bcl 2 family proteins Bcl 2 , Bcl XL , Bcl XS , Bad , and Bax at the whole cell level , as analyzed by Western blotting . ^^^ Although the proapoptotic proteins Bcl XS , Bad , and Bax were mainly located in the cytosol , CEM / VLB100 mitochondria expressed higher levels of these proapoptotic proteins . ^^^ However , after exposure to TNF alpha , Bax , Bad , and Bcl XS translocated from the cytosol to the mitochondria of both cell lines . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Calcineurin was found to dephosphorylate BAD , a pro apoptotic member of the Bcl 2 family , thus enhancing BAD heterodimerization with Bcl xL and promoting apoptosis . ^^^ The Ca2+ induced dephosphorylation of BAD correlated with its dissociation from 14 3 3 in the cytosol and translocation to mitochondria where Bcl xL resides . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
This inactivated BAD is held by the 14 3 3 protein , freeing BCL XL and BCL 2 to promote survival . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Recently , these two growth factors have been shown to activate the PI 3 kinase AKT pathway which leads to the phosphorylation of the pro apoptotic Bcl XL regulator Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Regulation of bad phosphorylation and association with Bcl 10 ( L ) by the MAPK / Erk kinase . ^^^ Serine 112 phosphorylation was shown to be absolutely required for dissociation of Bad from Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In HepG 2 cells that possessed wild type p 53 , CD 437 induced S phase arrest and apoptosis were accompanied by the up regulation of cyclin A , cyclin B , p 53 , p 21 ( CIP1 / Waf1 ) , Bad , and Bcl Xs proteins and by a decrease in Bcl 2 protein levels . ^^^ In Hep3B cells , CD 437 mediated S phase arrest and apoptosis were also associated with a concomitant up regulation of cyclin A , cyclin B , Bad , and Bcl Xs . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
TGF beta dose dependently increased the expression of Bcl 2 and Bad and decreased the expression of Bcl 10 ( L ) in U 937 cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Immature hematopoietic progenitor cells ( CD34+ / 33 / 13 ) did not express Bcl 2 but Bcl XL , the majority of CD 34 cells expressed Bcl 2 , Bcl XL and BAD , and normal promyelocytes ( CD 34 / 33+ ) lacked expression of both Bcl 2 and Bcl XL , while leukemic CD34+progenitors and promyelocytes expressed these anti apoptotic proteins . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Phosphorylation of BAD prevents its interaction with the antiapoptotic protein Bcl XL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Mammary gland tissue , similar to many other tissues , expresses a number of different Bcl 2 relatives including bcl 10 , bax , bak , bad , bcl w , bfl 1 , bcl 2 as well as the bcl 2 binding protein Bag 1 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Here , the expression of bcl 2 family members ( bcl 2 , bax , bad , and bcl 10 ( s / l ) ) and caspases 1 , 2 , 3 , 4 , and 6 was investigated through a range of stages of chick lens development using immunocytochemistry , Western blotting , and affinity labelling for caspases using biotinylated caspase inhibitors . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In this study , we demonstrate that constitutive expression of bcl xl but not bcl 2 , bcl xs , bak , bad , or bax was associated with apoptosis resistance after IL 2 deprivation in CTLL 2 cells that expressed Tax . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The expression of members of the Bcl 2 family of proteins , such as Bcl 2 , Bcl xL , Bax , and Bad , was unchanged by the overexpression of PHGPx in cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
HGF triggers Bad phosphorylation via the PI 3 kinase / Akt pathway , thereby inactivating this pro apoptotic protein , while simultaneously inducing expression of anti apoptotic Bcl xL . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 and its homologues , Bcl xL , Bcl xS , Bax , Bad , Bak and Bag 1 , was detected in all NHL cases , with wide variations between histological subtypes and within each subtype . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
We have found that , in addition to Bcl 2 and Bax , the expression levels of apoptosis inducers ( Bad , Bak ) and inhibitors ( Bcl xL , Mcl 1 ) were highly variable in blasts from 78 children with newly diagnosed acute lymphoblastic leukemia ( ALL ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Analysis of the expression of the Bcl 2 members indicated that phosphorylation of Bad and Bcl 10 expression which are respectively regulated by the PI 3 kinase / Akt pathway and STAT 5 probably explain this cooperation . ^^^ These results indicate that the activations of STAT 5 and the PI 3 kinase by IL 3 in Ba / F3 cells are tightly connected and cooperate to mediate IL 3 dependent suppression of apoptosis by modulating Bad phosphorylation and Bcl 10 expression . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The anti and pro apoptotic proteins Bcl XL and BAD are highly implicated in EPO dependent survival of erythroid cells . ^^^ Apoptosis may also be triggered by inactivation of Bcl XL by BAD . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In the present study , we characterized the regulation of antiapoptotic ( Bcl 2 , Bcl xL ) and proapoptotic ( Bad , Bax ) Bcl 2 family proteins in the rat heart during development and in oxidative stress induced apoptosis . ^^^ In unstimulated neonatal cardiac myocytes , Bcl 2 and Bcl xL were associated with the mitochondria , but Bad and Bax were predominantly present in a crude cytosolic fraction . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In asymptomatic transgenic mSOD 1 mice , expression of Bcl 2 , Bcl XL , Bad , and Bax does not differ from that in nontransgenic mice . ^^^ In contrast , in symptomatic mice , expression of Bcl 2 and Bcl XL , which inhibit apoptosis , is reduced , whereas expression of Bad and Bax , which stimulate apoptosis , is increased . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Phosphorylation at either site results in loss of the ability of BAD to heterodimerize with the survival proteins BCL XL or BCL 2 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bad is a critical regulatory component of the intrinsic cell death machinery that exerts its death promoting effect upon heterodimerization with the antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) . ^^^ Growth factors promote cell survival through phosphorylation of Bad , resulting in its dissociation from Bcl 2 and Bcl 10 ( L ) and its association with 14 3 3tau . ^^^ PAK phosphorylates Bad in vitro and in vivo on Ser 112 and Ser 136 , resulting in a markedly reduced interaction between Bad and Bcl 2 or Bcl 10 ( L ) and the increased association of Bad with 14 3 3tau . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Here , using yeast two hybrid and co immunoprecipitation studies , we show that RAD 9 , a human protein involved in the control of a cell cycle checkpoint , interacts with the anti apoptotic Bcl 2 family proteins BCL 2 and BCL 10 L , but not with the pro apoptotic BAX and BAD . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
However , during the apoptotic process one death repressor , Bcl XL , and two death promoters , Bak and Bad , were expressed . ^^^ The expression levels of Bcl XL and Bak remained unchanged , whereas the level of Bad was down regulated . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In contrast to previous studies , we found no evidence of Bad binding to anti apoptotic Bcl 2 , Bcl XL or McI 1 , or of alterations in Bax heterodimers . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
These results suggest that Akt / AKT1 expressed in these clones can phosphorylate Bad and prevent it from binding to Bcl XL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In contrast , the expression of Bcl 10 ( L ) decreased and that of proapoptotic Bax , Bad , and Bak was unchanged or down regulated after removal of growth factors . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl xL , Bad , Bak , and Bax levels were not altered by either treatment . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Using reverse transcriptase polymerase chain reaction , cloning , and sequencing techniques , we have found that HL 60 cells express bak , bik , bax , bad , bcl 2 , bcl xL , bcl w , bfl 1 , fas , and caspases 1 4 and 7 10 . ^^^ Peripheral blood neutrophils expressed bak , bad , bcl w , bfl 1 , fas , and caspases 1 , 3 , 4 , and 7 10 , but hardly expressed bcl 2 , bcl xL , bik , bax , and caspase 2 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Susceptibility to drug induced apoptosis correlates with differential modulation of Bad , Bcl 2 and Bcl xL protein levels . ^^^ The earliest event induced by drug exposure was increase in Bad protein levels , followed by Bcl 2 down regulation , cytochrome c release , and Bcl xL and Bax up regulation . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 family protein BAD promotes apoptosis by binding through its BH 3 domain to Bcl 10 ( L ) and related cell death suppressors . ^^^ When BAD is phosphorylated on either Ser ( 112 ) or Ser ( 136 ) , it forms a complex with 14 3 3 in the cytosol and no longer interacts with Bcl 10 ( L ) at the mitochondria . ^^^ Here we show that phosphorylation of a distinct site Ser ( 155 ) , which is at the center of the BAD BH 3 domain , directly suppressed the pro apoptotic function of BAD by eliminating its affinity for Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
BAD Ser 155 phosphorylation regulates BAD / Bcl XL interaction and cell survival . ^^^ The BH 3 domain of BAD mediates its death promoting activities via heterodimerization to the Bcl XL family of death regulators . ^^^ Phosphorylation at these sites promotes binding of BAD to 14 3 3 proteins , sequestering BAD away from the mitochondrial membrane where it dimerizes with Bcl XL to exert its killing effects . ^^^ Protein kinase A , RSK 1 , and survival factor signaling stimulate phosphorylation of BAD at Ser 155 , blocking the binding of BAD to Bcl XL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The interaction of BAD ( Bcl 2 / Bcl 10 ( L ) antagonist , causing cell death ) with Bcl 2 / Bcl 10 ( L ) is thought to neutralize the anti apoptotic effects of the latter proteins , and may represent one of the mechanisms by which BAD promotes apoptosis . ^^^ A variety of survival signals are reported to induce the phosphorylation of BAD at Ser ( 112 ) or Ser ( 136 ) , triggering its dissociation from Bcl 2 / Bcl 10 ( L ) . ^^^ The phosphorylation of BAD at Ser ( 155 ) prevents it from binding to Bcl 10 ( L ) and promotes its interaction with 14 3 3 proteins . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The cohort of BCR / ABL expressing cells resistant to apoptosis induced by DM BAD showed only high levels of BCL 2 and BCL 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
However , the proapoptotic protein BAD , whose phosphorylation is induced by NGF , is degraded in NGF deprived neurons expressing hBcl 2 , while the level of Bcl xL remains unaffected . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
To explore the potential involvement of Bcl 2 family members in this process , the expression and localization of some Bcl 2 family proteins ( Bcl 2 , Bcl xL , Bcl w , Bak , Bax , and Bad ) and p 53 were analyzed during testicular development in the rat by Western blotting and immunohistochemistry . ^^^ The dynamic changes in the expression profiles of Bcl 2 family proteins are consistent with a model in which germ cells are primed for apoptosis during the first cycle of spermatogenesis by de novo expression of the death effectors Bax and Bad in a p 53 dependent manner and these proteins are prevented from triggering further apoptosis after the first spermatogenic cycle has been set up by anti apoptotic Bcl 2 family proteins Bcl xL and Bcl w . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Akt inhibits apoptosis by phosphorylating Bad , thus promoting its binding to and blockade of the activity of the cell survival factor Bcl 10 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In studies of apoptosis associated proteins , BMP 2 was seen to down regulate the expression of Bcl 10 ( L ) ; however , BMP 2 had no effects on the expression of Bcl 2 , Bax , or Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Rac 2 stimulates Akt activation affecting BAD / Bcl XL expression while mediating survival and actin function in primary mast cells . ^^^ Rac 2 ( / ) mast cells demonstrated a significant reduction in growth factor induced survival , which correlated with the lack of activation of Akt and significant changes in the expression of the Bcl 2 family members BAD and Bcl XL , in spite of a 3 fold induction of Rac 1 protein . ^^^ These results suggest that Rac 2 plays a unique role in multiple cellular functions and describe an essential role for Rac 2 in growth factor dependent survival and expression of BAD / Bcl XL . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Biochemical characterization indicates that this occurs via mechanisms that may include 1 ) activation of the phosphatidylinositol 3 kinase / protein kinase B pathway , resulting in phosphorylation and blockade of the proapoptotic functions of BAD ; 2 ) up regulation of the antiapoptotic protein Bcl xL ; and 3 ) inhibition of the cleavage of BH 3 interacting domain death agonist ( BID ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The cascade is also anti apoptotic by modulation of Bcl 2 , Bcl xL and BAD function . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis revealed that the content of Bcl 10 ( L ) ( but not of Bcl 2 , BAX , Bad , and Bim ) significantly decreased in thymocytes after CLP . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Impaired BAD phosphorylation resulted in increased binding to Bcl XL instead of 14 3 3 protein , thus sequestering the Bcl XL antiapoptotic protein to promote survival . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Expression of other apoptosis related genes ( bcl 2 , bcl XL , bax , bad , caspase 3 ) was not affected by light exposure or the lack of c Fos in knockout mice . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Adult mice exposed to greater than 95 % oxygen concentrations for 48 to 88 hours had increased whole lung mRNA levels of Bax and Bcl 10 ( L ) , no change in Bak , Bad , or Bcl 2 , and decreased levels of Bcl w and Bfl 1 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Both anti apoptotic ( Bcl W , Bcl 10 ( L ) ) and pro apoptotic ( Bad , Bak , Bax ) members of the Bcl 2 family were expressed in developing skeletal muscle in vivo . ^^^ Loss of Bcl 2 did not affect expression of other family members , because neonatal muscles of wild type and Bcl 2 null mice had similar amounts of Bcl 10 ( L ) , Bcl W , Bad , Bak , and Bax mRNAs . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 10 ( L ) and BAD phosphorylation are critical for the survival of erythroid cells , and orthovanadate in the absence of EPO both maintained expression levels of antiapoptotic Bcl 10 ( L ) and induced BAD phosphorylation at serine 112 . ^^^ Activated JAK2 / STAT5 then likely acts upstream of Bcl 10 ( L ) expression and PI 3 kinase likely promotes BAD phosphorylation to protect from apoptosis . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In FDCP Mix cells , neither IL 3 nor TGF beta 1 induced any change in Bcl 10 ( L ) protein levels or the proapoptotic proteins Bad or Bax . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In MCF 7 , an increase in Bad and Bax protein expression and a decrease in Bcl 10 ( L ) protein and Bcl 2 protein and mRNA were observed . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
BAD , a proapoptotic member of the bcl 2 gene family , is rapidly dephosphorylated after injury , dissociates from 14 3 3 in the cytosol , and translocates to the mitochondria of neurons where it binds to Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Heterodimerization of Bcl 2 and Bcl 10 ( L ) with Bax and Bad in colorectal cancer . ^^^ The rate of cell loss owing to apoptosis is mediated by competitive dimerization with selective pairs of cell death antagonists ( Bcl 2 , Bcl 10 ( L ) ) and agonists ( Bax , Bad ) . ^^^ We analyzed the expression of Bcl 2 , Bcl 10 ( L ) , Bax , and Bad in normal appearing mucosa and colorectal tumor tissues by Western blotting after immunoprecipitation . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Moreover , DEX treatment increased the expression of anti apoptotic Bcl 2 and Bcl xL proteins in human and rat hepatocytes , respectively , whereas the expression of pro apoptotic proteins Bcl xS or Bad was not detected or remained unchanged . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Survival factors activate kinases which , in turn , phosphorylate the proapoptotic Bcl xl / Bcl 2 associated death promoter homolog ( BAD ) protein at key serine residues . ^^^ Although BAD is known to interact with Bcl 2 , Bcl w , and Bcl xL , the exact relationship between BAD and anti or proapoptotic Bcl 2 proteins has not been analyzed systematically . ^^^ Even though wild type BAD only interacted with selected numbers of antiapoptotic proteins , underphosphorylated mutant BAD interacted with all antiapoptotic Bcl 2 proteins tested ( Bcl 2 , Bcl w , Bcl xL , Bfl 1 / A1 , Mcl 1 , Ced 9 , and BHRF 1 ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Mutation analysis indicated that the cell cycle effect of BAD was not dependent on its phosphorylation status or subcellular localization , but strictly co segregated with BCL [ 10 ( L ) ] binding . bclx ( / ) MEFs expressing BAD and bad ( / ) MEFs both arrested in G0 / G1 in low serum similar to wild type controls , suggesting that the ability to overcome the G0 / G1 checkpoint resulted from the presence of BAD / BCL 10 ( L ) heterodimers , rather than the absence of BCL [ 10 ( L ) ] or BAD . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Rationale for Bcl xL / Bad peptide complex formation from structure , mutagenesis , and biophysical studies . ^^^ The three dimensional structure of the anti apoptotic protein Bcl xL complexed to a 25 residue peptide from the death promoting region of Bad was determined using NMR spectroscopy . ^^^ Although the overall structure is similar to Bcl xL bound to a 16 residue peptide from the Bak protein ( Sattler et al . , 1997 ) , the Bad peptide forms additional interactions with Bcl xL . ^^^ However , based upon site directed mutagenesis experiments , these additional contacts do not account for the increased affinity of the Bad 25 mer for Bcl xL compared to the Bad 16 mer . ^^^ Rather , the increased helix propensity of the Bad 25 mer is primarily responsible for its greater affinity for Bcl xL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Since the Bcl 2 family of proteins constitutes a critical checkpoint in apoptosis , acting upstream of the apoptotic machinery , we investigated the expression of six Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
A number of signal transducers and transcription factors have been associated with the antiapoptotic phenotype of CML cells , some of which lead to the expression and / or activation of members of the Bcl 2 family of apoptosis modulators , such as Bcl xL and Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The expression of proapoptotic ( Bad , Bak , Bax ) and antiapoptotic ( Bcl 2 , Bcl XL ) genes was analyzed by quantitative RT PCR . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The neurons died by a caspase dependent mechanism after inhibition of PI 3 kinase , and were also killed by antisense Bcl xL and antisense Bcl 2 or by overexpression of Bcl xS , Bad , and Bax . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Using mid gestation human jejunum and colon organotypic cultures , we analyzed the impact of growth factors ( namely insulin ; 10 microg / ml ) and pharmacological compounds that inhibit signal transduction molecules / pathways ( namely tyrosine kinases , Fak , P 13 K / Akt , and MEK / Erk ) on cell survival and Bcl 2 homolog expression ( anti apoptotic : Bcl 2 , Bcl 10 ( L ) , Mcl 1 ; pro apoptotic : Bax , Bak , Bad ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Specifically , this report examined expression of apoptotic promoters Bax and Bad and apoptotic inhibitors Bcl 2 and Bcl 10 ( all members of the Bcl 2 protein family ) . ^^^ Expression of Bcl 2 , Bcl 10 , Bax , and Bad and the extent of apoptosis were determined by flow cytometric analysis of freshly isolated cells and cells cultured with TGF beta ( 1 ) and FL effectors . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The increased expressions of Bax and Bad were detected in HAECs incubated for 24 h with gly ox HDL , but gly ox HDL failed to interfere with the expression of Bcl 2 and Bcl 10 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
LY 294002 prevented both BAD phosphorylation at Ser 136 and Bcl 10 ( L ) protein induction , while PD 098 , 059 did not . ^^^ Our data indicated that sublytic C5b 9 rescued Schwann cell from apoptosis via activation of PI 3 kinase Akt , BAD phosphorylation on Ser 136 and increased expression of Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Survival factor induced phosphorylation of Bad results in its dissociation from Bcl 10 ( L ) but not Bcl 2 . ^^^ The pro apoptotic Bcl 2 family protein Bad heterodimerizes with Bcl 2 and Bcl 10 ( L ) in the outer mitochondrial membranes , nullifying their anti apoptotic activities and promoting cell death . ^^^ We report that interleukin 3 ( IL 3 ) stimulation induces Bad phosphorylation and triggers its translocation from mitochondria to cytoplasm in cells expressing Bcl 10 ( L ) but not Bcl 2 . ^^^ Overexpression of Bad sensitized Bcl 10 ( L ) expressing FL5 . 12 cells to apoptosis induced by IL 3 deprivation , but had no effect on the viability of cells expressing Bcl 2 . ^^^ IL 3 stimulation induced Bad phosphorylation at Ser 112 , impairing its binding to Bcl 10 ( L ) and resulting in its association with 14 3 3 proteins in the cytosol . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Expression and redistribution of cellular Bad , Bax , and Bcl 10 ( L ) protein is associated with VCD induced ovotoxicity in rats . ^^^ These data provide evidence that the apoptosis induced by VCD in ovarian small preantral follicles of rats is associated with increased expression of Bad protein , redistribution of Bcl 10 ( L ) protein and cytochrome c from the mitochondria to the cytosolic compartment , and an increase in the Bax / Bcl 10 ( L ) ratio in the mitochondria . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Furthermore , LY 294002 pretreatment blocks TNF alpha and Jo 2 induced Bcl xL levels in hepatocytes , with no effect on the phosphorylation levels of Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bad is a pro apoptotic member of the Bcl 2 family of proteins that is thought to exert a death promoting effect by heterodimerization with Bcl 10 ( L ) , nullifying its anti apoptotic activity . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
To gain insight into the function of alpha synuclein , the present study examined the association between alpha synuclein and the following Bcl 2 family proteins : Bcl 2 ; Bcl XL ; Bcl associated death promoter ( BAD ) ; and Bcl 2 associated 10 protein . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
We examined the effects of cadmium on the bcl 2 family of proteins bcl 2 , bax , bad , and bcl xS / L in cadmium induced cytotoxicity . ^^^ Western blot analyses revealed that cadmium markedly increased endogenous bcl 2 protein ( to 3 4 times the level in wild type cells ) earlier than metallothionein induction , but that the metal did not enhance the induction of bax , bad , or bcl xS proteins . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The aim of our study was to determine whether mRNA levels of Mdm 2 , Bcl 2 , Bcl 10 ( L ) , Bad , and Bax are independent prognostic parameters for outcome . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
However , Bcl 2 , Bcl XL , and Bad all remained unchanged in wogonin and fisetin treated HL 60 cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
This is closely associated with [ 1 ] the down regulation of Bcl 2 and Bcl xL proteins and [ 2 ] upregulation of Bax and Bad , whose gene products are known to be involved the regulation of apoptosis in mammalian cells . ^^^ These findings suggest that modulation of Bax , Bcl xL , Bcl 2 and Bad proteins by ICI may be , in part , responsible for the anti proliferative and apoptotic effect of ICI seen clinically and in animal models . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Here , we show that A 1 , Mcl 1 , Bcl 10 ( L ) , and Bad are major transcripts in human neutrophils and that levels of these transcripts are cytokine regulated . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
BAD induces apoptosis in cells over expressing Bcl 2 or Bcl xL without loss of mitochondrial membrane potential . ^^^ A potential prototype of such a compound is the endogenous Bcl 2 and Bcl xL binding protein BAD . ^^^ Previous reports indicate that BAD can overcome the anti apoptotic effect of Bcl xL but not Bcl 2 . ^^^ We report that transient transfection of BAD induced cell death in cells with and without over expression of Bcl 2 or Bcl xL . ^^^ Forty eight hours after transfection , BAD increased cell death in COS , COS Bcl 2 , and COS Bcl xL cells as demonstrated by decreased GFP expression , and an increase in the number of number of floating cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bad , Bax , Bcl 10 ( S ) ) were reduced 2 4 fold in the resistant cell line , whereas the anti apoptotic proteins Bcl 2 and Bcl 10 ( L ) were expressed at similar levels in both cell lines . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Cellular commitment to apoptosis is partly regulated by the Bcl 2 family proteins , which includes the death antagonists Bcl 2 and Bcl 10 ( L ) , and death agonists Bax and Bad . ^^^ Cellular expression of Bcl 2 , Bcl 10 ( L ) , Bax or Bad in MS patients was independent of the expression of other apoptotic regulatory molecules , such as Fas receptor protein or FLIP . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Furthermore , MAP kinase pathway dependent serine 112 phosphorylation was shown to be required for dissociation of Bad from Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
These findings suggest that modulation of MAP kinase and Akt expression , Bcl xL , Bcl xs , Bcl 2 and Bad proteins by finasteride may be , in part , responsible for the anti proliferative and apoptotic effect of this drug seen clinically and in animal models . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In addition , gene expression analysis revealed that EGCG prevented both the 6 OHDA induced expression of several mRNAs , such as Bax , Bad , and Mdm 2 , and the decrease in Bcl 2 , Bcl w , and Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
SNV infection also induced translocation of endogenous Bad into mitochondria and heterodimerization of Bad with Bcl xL . ^^^ On the other hand , the structurally most similar pro survival members , Bcl 2 , Bcl xL , and Bcl w , suppressed SNV induced apoptosis in the absence of Bad , whereas Mcl 1 and A 1 did not . ^^^ Bcl w could inhibit SNV induced apoptosis in the presence of Bad , but Bcl xL could not . ^^^ Bad could be coimmunoprecipitated with Bcl xL or Bcl 2 , but not with Bcl w . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The Bad ( S112A S136A ) DTTR protein altered the subcellular distribution of Bcl 10 ( L ) , indicating that it enters the cell cytoplasm and binds Bcl 10 ( L ) . ^^^ Bad ( S112D S136A ) DTTR , mutated to mimic phosphorylation of Bad , showed lower toxicity than either Bad ( wild type ) DTTR or Bad ( S112A S136A ) DTTR , additionally indicating that Bad DTTR must bind Bcl 10 ( L ) to stimulate apoptosis . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The loss of Purkinje cells in the BDNF knockouts was accompanied by decreases in anti apoptotic Bcl xl and in phosphorylated ( and hence inactivated ) pro apoptotic Bad , and reduced activity of the antioxidant glutathione reductase , while the antioxidant catalase was increased by ethanol treatment in this genotype . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
There were no significant changes in the levels of Bcl xl , Bad , and Bax after heat exposure . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Furthermore , the known downstream modulators of the Akt / PI3K cell survival pathway , Bcl 10 ( L ) , and BAD proteins showed decreased expression after I3C treatment . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Fluorescent Bad peptide interacts strongly with Bcl 10 ( L ) with a K ( d ) of 21 . 48nM . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Our data demonstrated that Gyp induced apoptotic cell death was accompanied by up regulation of Bax , Bak and Bcl 10 ( L ) , and down regulation of Bcl 2 and Bad , while it had no effect on the level of Bag 1 protein . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In addition , it counteracted the effect of TNP BSA on the expression of the Bcl 2 family , resulting in down regulation of Bax and Bad and up regulation of Bcl XL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
TUNEL staining detected apoptotic T cells at low frequency corresponding to an increased expression of the anti apoptotic molecules Bcl 2 and Bcl 10 ( L ) and a reduced expression of the pro apoptotic molecules Bad , Bax , and Fas ligand in CD 4 and CD 8 T cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The proteins studied were Bcl 2 , Bcl xL ( anti apoptotic ) , Bax , Bad , Bak , and Bcl xS ( pro apoptotic ) . ^^^ Higher expression of pro apoptotic Bcl 2 family proteins ( Bak , Bad , Bcl xS ) and higher Bcl xS / Bcl xL ratio were associated with longer survival and decreased risk of leukemic transformation in univariate analysis , whereas expression of anti apoptotic proteins was associated with decreased survival . ^^^ Conversely pro apoptotic proteins Bad , Bak , and Bcl xS were detected in a higher percentage of cells in RA and RAS . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Moreover , NCTD treatment also increased the phosphorylation of Bcl 2 and Bcl 10 ( L ) but did not affect the expression of Bax or Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The anti apoptotic molecules Bcl xL and Bcl w target protein phosphatase 1alpha to Bad . ^^^ Bcl xL and Bcl w specifically interact with PP1alpha and Bad . ^^^ A phosphatase activity sensitive to okadaic acid was detected in Bcl xL , Bcl w and Bad immunoprecipitates . ^^^ Depletion of Bcl xL and Bcl w decreases the remaining Bad associated phosphatase activity and association of protein phosphatase 1 ( PP 1 ) alpha to Bad . ^^^ Disruption of Bcl xL / PP1alpha or Bcl w / PP1alpha association strongly decreases Bad associated phosphataseactivity and stability of trimolecular complexes . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The phosphorylation state of antiapoptotic ( Bcl 2 , Bcl 10 ( L ) ) and proapoptotic ( BAD , Bid , Bik ) Bcl 2 proteins regulates their cellular activity and , therefore , cell survival and cell death . ^^^ For example , dephosphorylation of BAD by the protein phosphatases PP 1 , PP2A and PP2B allows BAD to interact with Bcl 10 ( L ) and initiate cell death . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The Bad BH 3 peptide ( 21 amino acids ) was slightly more potent than Bax BH 3 at inhibiting Bax / Bcl 10 ( L ) but failed to disrupt Bax / Bcl 2 . ^^^ By contrast , in Bcl 10 ( L ) overexpressing cells , Bad BH 3 exhibited greater cell killing activity than Bax BH 3 . ^^^ Together , our data suggest that agents based on the Bax BH 3 domain may have therapeutic value in cancers overexpressing Bcl 2 , while agents based on the BH 3 domain of Bad may be more useful for tumors overexpressing Bcl 10 ( L ) . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Furthermore , the activity of the pro apoptotic protein Bad ( Bcl 2 / Bcl 10 ( L ) antagonist , causing cell death ) was completely unaffected . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
DEX increases the expression of anti apoptotic Bcl 2 and Bcl 10 ( L ) proteins , decreases the expression of pro apoptotic Bax and inhibits Bad translocation thereby preventing the release of cytochrome c , the activation of caspases , and cell death . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis revealed that Cl F araA induced a dose and time dependent downregulation of Bcl 10 ( L ) and Mcl 1 proteins , and a dose and time dependent dephosphorylation of Akt and its downstream effectors ( Bad , FKHRL 1 ) , particularly in vivo . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 , Mcl 1 , Bcl xL / S , Bcl w , Bax , Bak , and Bad were shown to be expressed in both malignant and non neoplastic , normal plasma cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
G ( 2 ) M arrest was associated with phosphorylation of Bcl 2 ( but not BAD , Bax , or Bcl XL ) : both of these end points were abrogated by treatment with a calcium chelator . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Recent studies suggest that BAD binds to both Bcl 2 and Bcl 10 ( L ) , however mediates its pro apoptotic functions through inhibition of Bcl 10 ( L ) , but not Bcl 2 . ^^^ However , co precipitation assays indicated that , whereas wild type BAD ( BADwt ) directly interacts with Bcl 2 and Bcl 10 ( L ) , BAD ( D119G ) interacts only with Bcl 10 ( L ) . ^^^ Nevertheless both BADwt and BAD ( D119G ) could introduce apoptosis and diminish the anti apoptotic effect of Bcl 2 and Bcl 10 ( L ) in a similar manner in a co transfection assay . ^^^ These data thus suggest that Asp 119 is a crucial site within the BH 3 domain of BAD for interaction of BAD with Bcl 2 , but is dispensable for the interaction of BAD with Bcl 10 ( L ) , for its targeting to mitochondria , and most importantly , for its pro apoptotic functions . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in emodin treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bad remained unchanged . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Apoptosis was studied by the terminal deoxynucleotidyl transferase ( TdT ) mediated deoxy UTP nick end labeling ( TUNEL ) method , and immunohistochemistry was used to detect p 53 , caspase 3 and 6 , the antiapoptotic proteins Bcl 2 and Bcl 10 , and the proapoptotic proteins Bax and Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 members can either be anti ( Bcl 2 , Bcl 10 ( L ) , Bcl w ) or pro apoptotic ( Bax , Bak , Bid , Bad , Bcl 10 ( S ) ) . ^^^ In contrast , a significant increase was observed in the anti apoptotic member Bcl 2 . mRNA expression of Bcl w , Bad , and Bcl 10 ( L ) was not significantly different between the control and TPN groups . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The expression of anti apoptotic proteins ( Bcl 2 , Bcl 10 ( L ) ) and pro apoptotic proteins ( Bax , Bcl 10 ( S ) , Bad , and Bak ) in response to cryo injury varied in this cell line panel . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
These proteins include the death antagonists Bcl 2 and Bcl 10 ( L ) , and death agonists Bax and Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Effector mechanism of magnolol induced apoptosis in human lung squamous carcinoma CH 27 cells . 1 Magnolol , an active component isolated from the root and stem bark of Magnolia officinalis , has been reported to exhibit antitumour effects , but little is known about its molecular mechanisms of action . 2 Magnolol inhibited proliferation of human lung squamous carcinoma CH 27 cells at low concentrations ( 10 40 microM ) , and induced apoptosis at high concentrations ( 80 100 microM ) . 3 Treatment with 80 microM magnolol significantly increased the expression of Bad and Bcl 10 ( S ) proteins , whereas it decreased the expression of Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Apo2L / TRAIL induced the expression of pro apoptotic proteins , Bad and Bax ; downregulated the anti apoptotic proteins , Bcl 2 and Bcl xL ; and activated caspases 3 , 7 , 8 , 9 and 10 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
After treatment with DADAG 8 micrograms . mL 1 for various times , the Bcl XL protein level decreased in a time dependent manner , while the Bad protein level was upregulated . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Coimmunoprecipitation revealed that the dimerization of Bad progressed with 14 3 3 ( Bad / 14 3 3 ) and with Bcl 10 ( L ) ( Bad / Bcl 10 ( L ) ) after tFCI . ^^^ Bad / Bcl 10 ( L ) was prevented by SOD 1 but promoted by H 89 treatment . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Moreover , TIMP 1 enhances specific phosphorylation of both Akt and Bad ( Bcl 2 / Bcl 10 ( L ) antagonist , causing cell death ) in a PI 3 kinase dependent manner and , besides , controls the level of the anti apoptotic protein Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Similarly , a peptide derived from the BH 3 domain of Bad stimulates Bax activity only in the presence of Bcl xL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Cleavage of 14 3 3 protein by caspase 3 facilitates bad interaction with Bcl 10 ( L ) during apoptosis . ^^^ However , Bad associated with the cellular Bcl 10 ( L ) more effectively in human 293T cells co expressing Bad with the truncated form of the 14 3 3 epsilon protein ( D 238 ) than in control cells co expressing Bad with wild type or the uncleavable mutant 14 3 3 epsilon protein ( D238A ) . ^^^ The present study suggests that the cleavage of 14 3 3 protein during apoptosis promotes cell death by releasing the associated Bad from the 14 3 3 protein and facilitates Bad translocation to the mitochondria and its interaction with Bcl 10 ( L ) . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis of Bcl 2 , Bcl xL , Bad , Caspase 3 , PDK 1 , and phospho Akt also revealed SOD mediated changes in gene expression consistent with protection and decreased apoptosis . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
To examine p 75 ( NTR ) dependent apoptosis in tumor cells , we demonstrated that a dose dependent increase in p 75 ( NTR ) expression was associated with a concomitant increase in the mitochondrial proapoptotic effector proteins Bad , Bax and Bik and a decrease in the mitochondrial prosurvival effector proteins phospho Bad , Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
LPA had no effect on Bcl xl , Bad , and Bak mRNA or protein expression . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
METHODS : Assessments were made of neurotrophic factors nerve growth factor , brain derived neurotrophic factor , neurotrophin 3 , and neurotrophin 4 ; apoptosis related proteins Bcl 2 , Bcl xl , Bax , Bcl xs , Bad , phosphorylated Bad , phosphorylated Akt , and phosphorylated c Jun N terminal kinase ; and the antioxidants superoxide dismutase , glutathione reductase , and catalase . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Since Bcl 2 family proteins are key regulators of apoptosis , we examined the effects of H2O2 on the expression of principal Bcl 2 family proteins ( Bcl 2 , Bcl xL , Bax , Bad ) in neonatal rat cardiac myocytes . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In turn , BAD dimerized with antiapoptotic BCL Xl after seizures . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 expression is markedly increased in TGF beta 1 treated pre B cells , whereas cellular FLICE like inhibitory protein long ( c FLIPL ) , Bcl XL , Bax , and Bad expression remains unchanged . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
First , the Bcl xL / BAD ratio in PC 3 cells is at least an order of magnitude greater than that of LNCaP cells . ^^^ In contrast to Bcl xL , Bcl 2 expression levels are similar in both cells lines , and do not respond to serum stimulation , suggesting that Bcl 2 may not play a physiological role in antagonizing apoptosis signals pertinent to BAD activation in prostate cancer cells . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The Bcl 10 , Mcl 1 , Bad , and Bax proteins were also expressed in all CTCL skin lesions tested . ^^^ This study examined cutaneous T cell lymphoma ( CTCL ) cell lines and cutaneous lesions for the presence of Bcl 2 gene family members and found that the two apoptosis inhibiting members Bcl xL and Mcl 1 and the two apoptosis supporting members Bad and Bax were expressed . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Whether conventional hypothermic CPB induces myocyte apoptosis in dog hearts and modulation of bcl 2 , bcl xl , bax , bad , and caspase 3 pathways in this setting was investigated . ^^^ Immunohistochemistry and flow cytometry were employed for detection of expressions of bcl 2 , bcl xl , bax and bad proteins . ^^^ The results of immunohistochemistry demonstrated that bcl 2 , bcl xl , bax and bad proteins were constitutionally present on the sarcolemma of the LV myocytes . ^^^ FACS results showed that , after CPB , expressions of bax and bad in CPB group were significantly upregulated , while the expressions of bcl 2 and bcl xl were not significantly changed in both groups . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Oxidative stress induced early apoptosis was linked to its ability to inhibit not only the expression of Bcl 2 and Bcl XL but the production of antioxidant enzymes as well and to stimulate Bad expression . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Here , we found that HDB induced apoptotic cell death was accompanied by upregulation of cyclin D 3 , Bax , and p 21 and down regulation of Bcl 10 ( L ) , while HDB had no effect on the levels of Bcl 2 and Bad protein . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bad and Bcl 10 mRNA transcription increased significantly . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
CD44v7 deficiency was characterized by an increase in the percentage of apoptotic cells after stimulation , increased numbers of CD95L and CD 152 positive cells , low levels of the anti apoptotic proteins Bcl 2 and Bcl Xl , and decreased phosphorylation of the pro apoptotic protein BAD . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Remarkably , these events occurred in the absence of any reduction in the expression of the Bcl 2 family members Bcl 2 , Mcl 1 , and Bcl xL or any change in the proapoptotic molecules Bad or Bax . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In a murine myeloid cell line , 32D , interleukin 3 ( IL 3 ) deprivation induced apoptosis following the down regulation of Bcl XL and the dephosphorylation of Bad . ^^^ In WtFLT 3 transfected 32D ( WtFLT 3 32D ) cells , FLT 3 ligand ( FL ) stimulation did not restore the down regulation of Bcl XL but maintained the phosphorylation of Bad . ^^^ Furthermore , the dephosphorylation of Bad using LY 294002 and PD 98059 was insufficient for apoptosis , and the down regulation of Bcl XL using antisense treatment was needed to induce apoptosis . ^^^ FLT 3 kinase inhibitor , AG 1296 , alone not only dephosphorylated Bad but also down regulated Bcl XL , leading FLT3 / ITD 32D cells into apoptosis . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
One proposed pathway by which this has been hypothesized to occur is the Ca ( 2+ ) mediated activation of calmodulin and subsequent activation of the phosphatase calcineurin with dephosphorylation of a protein known as BAD , leading to a proapoptotic interaction between BAD and the mitochondrial protein Bcl xL . ^^^ While this pathway is an intriguing route for traumatic axonal pathogenesis , neither conventional immunocytochemical / histochemical nor ultrastructural approaches have had the capacity to shed insight on whether BAD and Bcl xL interact in TAI in vivo . ^^^ We describe the implementation of confocal and two photon excitation fluorescence resonance energy transfer ( FRET ) microscopy techniques through which we demonstrate interaction between the proapoptotic protein BAD and the prosurvival protein Bcl xL within TAI following TBI . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Furthermore , Bcl 2 family members Bad , Bak , and Bcl xS protein levels were increased in FHIT transfected clones when compared with Panc 1 cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
To further understand such merosin driven survival signaling , we analyzed the expression of five Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) in normal and merosin deficient myotubes , with or without pharmacological inhibitors for Fyn and p 38 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Whereas an upregulation of Bcl xL and a downregulation of Bax seemed to contribute to decreased apoptosis in burn rat neutrophils at 2 h of incubation , the decreased apoptosis at 8 h appeared to be associated with a decrease in Bax and increased phosphorylated Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
To explain this intriguing differential sensitivity between unstimulated CD34+ cells versus those stimulated by Epo + KL , we examined the expression of apoptosis regulating genes ( FLIP , BCL 2 , BCL XL , BAD and BAX ) in these cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
These events were associated with Bcl 2 cleavage , Bax , Bak , and Bad accumulation , mitochondrial translocation of Bax , abrogation of Mcl 1 , Bcl xL , and XIAP upregulation , and a marked induction of JNK and p 53 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
It is hypothesized that the balance of proapoptotic ( Bad , Bax ) and antiapoptotic ( Bcl 2 , Bcl Xl ) proteins determines apoptosis . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The cell cycle effects of Bcl 2 and Bcl 10 ( L ) were reversed by Bad , a molecule that counters the survival function of Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Silibinin also caused a strong decrease in Bad heterodimerization with Bclx ( L ) , which was consistent with an increased translocation of Bclx ( L ) to the mitochondria from the cytosol . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
This led , in turn , to the activation of the BCL 2 homology 3 domain only proteins BIM and BAD and down regulation of the anti apoptotic multi BCL homology domain protein BCL xL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
To investigate the mechanisms responsible for survival and apoptosis / anoikis in normal human intestinal epithelial crypt cells , we analyzed the roles of various signaling pathways and cell adhesion on the expression of six Bcl 2 homologs ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , Bad ) in the well established HIEC 6 cell model . ^^^ For example , the inhibition of the PI 3 K / Akt 1 pathway down regulated Bcl XL , Mcl 1 , and Bad , while at the same time up regulating Bax , whereas the inhibition of Fak up regulated both Bax and Bak , down regulated Bad , and did not affect the other Bcl 2 homologs analyzed . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
LPS stimulation induced the expression of Fas , caspase 8 , cellular FLIP Bfl 1 / A1 , and Bcl 10 , but not FasL , TNFR p 55 , Bak , Bax , and Bad at the transcriptional level . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In the present study , we investigated whether inhibition of DEX induced apoptosis by PRL in Nb 2 T cells was accompanied by altered expression of Bcl 2 family members , mcl 1 , bad or bcl 10 ( L ) determined by Northern and immunoblot analysis . ^^^ Prolactin regulation of Bcl 2 family members : increased expression of bcl xL but not mcl 1 or bad in Nb 2 T cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
During survival , BAD is sequestered by 14 3 3 through serine 136 phosphorylation and is dissociated from BCL 10 ( L ) through serine 155 phosphorylation . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Expression levels of p 53 , Bcl 2 , Bcl xL , Bad , Bax , survivin , Caspase 3 and poly ( ADP ribose ) polymerase ( PARP ) were evaluated by immunoblot analysis . ^^^ During the induction of apoptosis , expression of Bcl 2 , Bcl xL and survivin was decreased , and that of p 53 , Bad and Bax was increased . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
JNK phosphorylates BAD at threonine 201 , thereby inhibiting BAD association with the antiapoptotic molecule BCL 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bcl XL / Bcl 2 associated death promoter ( Bad ) , a proapoptotic member of Bcl 2 family , plays an important role in the intrinsic apoptosis pathway . ^^^ Co immunoprecipitation assay revealed that binding of one of the tumor derived Bad mutants with Bcl 2 and Bcl XL is reduced . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Here , we report that rasagiline ( 0 . 1 10 microM ) decreased apoptosis via multiple protection mechanisms , including the stimulation of PKC phosphorylation ; up regulation of PKCalpha and PKC mRNAs , induction of Bcl xL , Bcl w , and brain derived neurotrophic factor ( BDNF ) mRNAs ; and down regulation of Bad and Bax mRNAs . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In general agreement with activation of the intrinsic caspase pathway , cell death correlated with reduced BCL XL expression and with increased levels of the pro apoptotic proteins BAD and BAX . ^^^ Inhibition of caspase 9 after combination treatment blunted neither JNK1 / 2 / 3 activation nor the enhanced expression of BAD and BAX , but did block caspase 3 cleavage , reduced expression of BCL XL and inhibition of ERK1 / 2 activity . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
This family of proteins now includes both anti apoptotic molecules such as Bcl 2 and Bcl 10 ( L ) , and pro apoptotic molecules such as Bax , Bak , Bid , and Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Paclitaxel down regulated the expression of Bcl xL and inhibitor of apoptosis proteins ( c IAP 1 ) and up regulated the expression of Bad and Apaf 1 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Ether lipid resistant S49ar cells were cross resistant to extracellular stress factors ( cold shock , heat shock , H2O2 , dimethylsulfoxide ) and to radiation induced apoptosis but not to physiological apoptotic signals ( dexamethasone , growth factor deprivation , thapsigargin , C 2 ceramide ) and expressed similar levels of the apoptosis regulating proteins Bcl 2 , Bcl 10 , Bax , Bad and Bak as did the parent S49wt cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
On the basis that Bax and Bad were augmented in B 1a cells , and Bcl 2 and Bcl xL reduced , we conclude that the disappearance of B 1a cells , but not B 1b , in IL 10 / mice results from their enhanced susceptibility to apoptosis . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Fibrotic liver also showed downregulation of Bcl 2 and Bcl 10 ( L ) expression and upregulation of Bad expression . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Furthermore , the interaction of p 53 with Bcl 10 ( L ) is blocked by the binding of a 25 residue peptide derived from the BH 3 region of the pro apoptotic protein referred to as Bad . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Upon ATO exposure , both NB 4 and NB 4 As ( R ) cell lines doubled protein levels of the death antagonist Bcl xL , but the amount of free Bcl xL that did not heterodimerize with Bad was 1 . 8 fold greater in NB 4 As ( R ) than in the parental line . ^^^ MEK 1 inhibitors dephosphorylated Bad and inhibited the ATO induced increase of Bcl xL , overcoming ATO resistance in NB 4 As ( R ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Western blot analyses were performed on cultured seminiferous tubule segments for Bcl 2 family proteins ( Bax , Bad , Bcl w , Bcl xL ) and fas ligand . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Although mutations in Mcl 1 had little impact on binding , a single mutation in the BH 3 only ligand Bad enabled it to bind both Mcl 1 and A 1 while retaining its binding to Bcl 2 , Bcl xL , and Bcl w . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In parallel cultures , there was a significant increase in Bad and Bax expression , concomitant with an increase in DNA fragmentation , and a significant decrease in Bcl 2 and Bcl XL expression . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
We report here that type 5 collagen is able to determine an increase in the percentage of Apoptag positive cells , to up regulate Bcl xS , Bad , Dap kinase , hsf 1 , mthsp 75 , caspase 1 , 5 , 8 , 9 , and 14 , whilst down regulating Bcl 2 , Bcl xbeta , and hsp 60 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Here , we found that shikonin induced apoptotic cell death was accompanied by upregulation of p 27 , p 53 , and Bad and down regulation of Bcl 2 and Bcl 10 ( L ) , while shikonin had little effect on the levels of Bax protein . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Furthermore , a marked down regulation of the expression of the Bcl 2 , Bcl XL and XIAP , and up regulation of the Bax and Bad proteins were noted . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Downstream cellular pathways include FOXO3a , GSK 3beta , Bad , Bcl xL , NF kappaB , mitochondrial membrane permeability , APAF 1 and caspases . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Whereas TSA treatment increased the expression level of Bad , it decreased the level of Bcl 2 , Bcl xL , and 10 linked inhibitor of apoptosis protein . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : The combined immunohistochemical expression levels of the proteins bax , bak , bad , bid , bcl 2 and bcl xl were evaluated by cluster and discriminant analysis . ^^^ RESULTS : Cluster analysis produced : a ) a low expression ( 69 / 79 cases ) and a high expression pro apoptotic cluster ( 10 / 79 cases ) for the combined expression levels of the pro apoptotic proteins bax , bak , bad and bid and b ) a low expression ( 37 / 76 cases ) and a high expression antiapoptotic cluster ( 39 / 76 cases ) for the combined expression levels of anti apoptotic proteins bcl 2 and bcl xl . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In the present paper , we demonstrate that the absence of apoptosis in HIV 1 infected primary human monocyte differentiated macrophages ( MDM ) correlates with an increase in anti apoptotic ( Bcl 2 and Bcl 10 ( L ) ) and a decrease in pro apoptotic ( Bax and Bad ) proteins . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
B [ a ] P , B [ a ] P 7 , 8 DHD and BPDE 1 induced an accumulation and phosphorylation of p 53 , while the Bcl 2 proteins Bcl xl , Bad and Bid were down regulated . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Statistically significant differences in expression between adenocarcinoma samples and squamous cell carcinoma samples were observed for Bcl 10 ( L ) ( overexpression in 11 of 19 adenocarcinomas [ 58 % ] vs . 0 of 22 squamous cell carcinomas [ 0 % ] ; P < 0 . 001 ) and for Bad ( loss of expression in 5 of 19 adenocarcinomas [ 26 % ] vs . 16 of 22 squamous cell carcinomas [ 73 % ] ; P = 0 . 004 ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Purified , active PKCiota can directly phosphorylate both endogenous and recombinant Bad at these three sites and disrupt Bad / Bcl XL binding in vitro . ^^^ Mechanistically , NNK induced Bad phosphorylation prevents its interaction with Bcl XL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
An up regulated expression of Bcl 2 and Bcl 10 ( L ) proteins was observed in ECSC in comparison with ESCwE and NESC , whereas the levels of Bax , Bad , Fas and Fas ligand proteins in ECSC were similar to those in ESCwE and NESC . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Although most studies focus on phosphorylation of pro and antiapoptotic proteins ( BAD , Bax , Bcl 2 , Bcl xL ) , kinase mediated regulation of complex 1 activity , anion and cation channels , metabolic enzymes , and Mn SOD mRNA has also been reported . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The mechanism of neuroprotective activity has been attributed to the ability of propargylamines inducing the antiapoptotic family proteins Bcl 2 and Bcl xl , while decreasing Bad and Bax and preventing opening of mitochondrial permeability transition pore . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Expression levels of inhibitory apoptosis proteins ( IAPs ) , including cellular IAP 1 ( cIAP 1 ) , cIAP 2 , 10 linked IAP ( XIAP ) , and survivin , and Bcl 2 family members such as Bcl xl and Bad , were determined by Western blot analysis and / or RT PCR , real time PCR . ^^^ These data suggest that the delay in neutrophil apoptosis with thermal injury is partly caused by activation of PI 3 kinase / PKB signaling and NF kappaB , which appeared to be related to the increased Bcl xl expression and phosphorylation of Bad , but not IAP expression . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Inhibition of apoptosis closely correlated with sequestration of Bax , Bid and BAD in the mitochondrial inner membrane , increased Bcl 2 and Bcl 10 ( L ) , and inability to process p 21 Bid . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic ( Bcl 2 and Bcl 10 ( L ) ) and proapoptotic ( Bax and Bad ) proteins were expressed in neonatal rat hearts of both groups . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Specifically , we observe that Abeta significantly reduces expression of antiapoptotic Bcl w and Bcl 10 ( L ) , mildly affects expression of bim , Bcl 2 , and bax , but does not alter expression of bak , bad , bik , bid , or BNIP3 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bad , however , bound tightly to Bcl 2 , Bcl xL , and Bcl w but only weakly to A 1 and not to Mcl 1 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The cleavage of the proapoptotic Bcl 2 proteins , such as Bad and Bax to produce their truncated forms , and the cleavage of the antiapoptotic Bcl 2 proteins , such as Bcl 2 and Bcl XL , into their potent pro apoptotic fragments were detected in our study . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Interestingly , apoptotic +SA cells showed a paradoxical decrease in mitochondrial levels of pro apoptotic proteins Bid , Bax , and Bad , and a corresponding increase in mitochondrial levels of anti apoptotic proteins , Bcl 2 and Bcl xL , suggesting that mitochondrial membrane stability and integrity might actually be enhanced for a limited period of time following acute tocotrienol exposure . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Even a single injection of paraquat + maneb in the non transgenic treated group modulated several key pro and anti apoptotic proteins , including Bax , Bad , Bcl xL , and upstream stress induced cascade . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
These apoptotic pathways are likely regulated by the concurrent expression of prosurvival molecules , including Bcl 2 and Bcl 10 ( L ) ; phosphorylation of Bad ; and high expression of inhibitor of apoptosis proteins chicken IAP 1 , IAP 3 , and survivin . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
DNA fragmentation was accompanied by the following phenomena : elevation in the level of hemeoxygenase 1 protein and thioredoxin reductase mRNA ; repression of Mn superoxide dismutase and catalase mRNAs ; release of cytochrome c from mitochondria into the cytosol ; activation of caspases 8 , 9 and 3 ; decrease in the level of Bcl 2 , Bcl XL and Bid protein ; increase in the level of Bad protein . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The present study investigates the expression of apoptotic proteins Bax , Bad , Bcl 2 , and Bcl xl following hypoxia in the cerebral cortex of the guinea pig fetus as a function of gestational age . ^^^ Hypoxia resulted in increased expression of the proapoptotic proteins Bax and Bad by 20 % and 30 % in the preterm as compared to 24 % and 38 % at term , without altering the expression of anti apoptotic proteins Bcl 2 and Bcl xl . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In order to understand the molecular alterations leading to heterogeneous cisplatin sensitivity and apoptosis inducibility in NSCLC cells , we analyzed various apoptotic pathways , including the activation of caspase 8 , 9 and 3 , the release of cytochrome c from mitochondria and the expression levels of pro and anti apoptotic proteins such as Bax , Bad , Bcl 2 , Bcl xL , Fas and p 53 using heterogeneously apoptosis sensitive cells ( Ma 10 , Ma 31 and Ma 46 ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Current work has identified exciting pathways , such as the Wnt pathway and the serine threonine kinase Akt , as central modulators that oversee cellular apoptosis and their downstream substrates that include Forkhead transcription factors , glycogen synthase kinase 3beta , mitochondrial dysfunction , Bad , and Bcl 10 ( L ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
When cytotoxic signals activate BH 3 only proteins that can engage both Mcl 1 and Bcl 10 ( L ) ( such as Noxa plus Bad ) , Bak is displaced and induces cell death . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The present study examined the effects of progesterone on mRNA and protein levels of the Bcl 2 apoptosis regulatory genes , bax , bad , bcl 2 , and bcl 10 ( L ) , in cerebral cortex after TBI . ^^^ Our results indicate that bax and bad mRNA levels and Bax and Bad protein expression in the ipsilateral , injured cerebral cortex were significantly elevated post TBI , while mRNA levels of bcl 2 and bcl 10 ( L ) or Bcl 2 and Bcl 10 ( L ) protein expression were not changed . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Recent work has identified novel pathways , such as the Wnt pathway and the serine threonine kinase Akt , as central modulators that oversee cellular apoptosis and the formation of neurofibrillary tangles through their downstream substrates that include glycogen synthase kinase 3beta , Bad , and Bcl xL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Incubation of C 6 glioma cells with thallium acetate upregulated the expression of proapoptotic proteins Bad and Apaf and downregulated the expression of anti apoptotic proteins Bcl xL and Bcl 2 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The purpose of the present study was to explore the seizure induced changes in Bad ( Bcl 2 associated death protein ) , 14 3 3 , phosphoBad , Bcl 2 and Bcl XL expression in the rat model of focal limbic seizure . ^^^ The apoptotic and surviving neurons in the hippocampus were observed by terminal deoxynucleotidyl transferrase mediated dUTP nick end labeling ( TUNEL ) and cresyl violet staining , the expression of Bad , 14 3 3 , phosphoBad , Bcl 2 and Bcl XL were detected with immunofluorescence , Western blot and immunoprecipitation . ^^^ Seizure induced the dephosphorylation of Bad and the dissociation of Bad from its chaperone protein 14 3 3 and subsequent dimerization of Bad with Bcl XL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Proteins for Western blot analysis included Fas associated death domain ( FADD ) and caspase 8 for extrinsic pathway , as well as Bcl 2 , Bcl XL , Bax , Bad , Bid , Akt , p Akt , and caspase 9 for intrinsic pathway . ^^^ Levels of FADD , Bax , Bad , and Bid were substantially increased in the TA induced myopathy group , whereas Bcl 2 , Bcl XL , Akt , p Akt , and caspase 9 did not change between control and myopathy groups . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Genomic profiling of acquired resistance to apoptosis in cells derived from human atherosclerotic lesions : potential role of STATs , cyclinD 1 , BAD , and Bcl XL . ^^^ Microarray profiling of fas resistant versus sensitive cells identified a set of genes including STATs , caspase 1 , cyclin D 1 , Bcl xL , VDAC 2 , and BAD . ^^^ Western blot analysis of sensitive and resistant LDC clonal lines confirmed increases in cyclin D 1 , STAT 6 , Bcl xL , and BAD , with decreased expression of caspase 1 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
This pathway is regulated by bcl 2 family of anti apoptotic ( bcl 2 , bcl xl , mcl 1 ) and pro apoptotic proteins ( bax , bad , bak ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The number of apoptotic cells in lung sections was determined by a TUNEL method . mRNAs for Fas , FasL and caspase 8 , and for Bad , Bax , Bcl w , Bcl xL and caspase 9 , for the FasL and the mitochondrial cytochrome c pathways of apoptosis , respectively , and mRNA for the effector caspase 3 were quantified in lung tissues by RT PCR . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NPD 1 is synthesized in RPE cells undergoing oxidative stress , potently counteracts oxidative stress triggered apoptotic DNA damage in RPE , upregulates antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) , and decreases proapoptotic Bax and Bad expression . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Tregs had high susceptibility to apoptosis that was reversed by IL 2 , which correlated with activation of Erk1 / 2 , up regulation of Bcl 10 ( L ) ( B cell CLL / lymphoma 2 like nuclear gene encoding mitochondrial protein , transcript variant 2 ) , and phosphorylation of Bad ( Bcl 2 antagonist of cell death ) at Ser 112 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
T 3 inhibited the apoptotic process induced by streptozocin , S Nitroso N Acetylpenicylamine ( SNAP ) , and H2O2 via regulation of the pro and anti apoptotic factors Bcl 2 , Bcl XL , Bad , Bax , and Caspase 3 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Pro survival factor Bcl 10 ( L ) can antagonize the pro apoptotic functions of Bax and Bad via two distinct mechanisms . ^^^ On the other hand , Bcl 10 ( L ) can neutralize Bad by sequestering it to mitochondria . ^^^ In order to map the domains of Bcl 10 ( L ) involved in inhibiting Bax and Bad , we have carried out mutational analyses of this protein . ^^^ The resulting Bcl 10 ( L ) mutant constructs were then co transfected with either GFP Bax or GFP Bad . ^^^ In addition , by immunoprecipitation analyses , we found that these deletions differentially affected the ability of the Bcl 10 ( L ) mutant proteins to bind Bax and Bad . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NPD 1 also upregulates the anti apoptotic proteins Bcl 2 and Bcl xL and decreases pro apoptotic Bax and Bad expression . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
MEK activation led to increased expression of COX 2 , Bcl 10 ( L ) , Mcl 1 , and phosphorylated Bad and decreased expression of Bak . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
This study investigated whether estradiol modulates the anti apoptotic signal through the activation of Akt and its downstream targets , including Bad , Bcl 10 ( L ) , and 14 3 3 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The amount of antiapoptotic Bcl xL bound to nonphosporylated Bad in the colonic mucosa is found to be substantially lower in aged than in young rats , resulting in a marked rise in the unbound / free form of Bcl xL in the aging colon . ^^^ Increased levels of Bcl xL and phosphorylated forms of Akt and Bad and reduction in caspase 3 activity were observed throughout the entire length of the colonic crypt of aged rats . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Cytotrophoblasts also expressed a 2 fold higher level of p 53 , a 2 fold lower level of 60 kDa Mdm 2 protein , a 2 fold higher level of Bak , but no differences in the expression of 90 kDa Mdm 2 , Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bad , and Bad phosphorylated at the serine ( 112 ) , serine ( 136 ) , or serine ( 155 ) sites , compared to the syncytiotrophoblasts . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Pim kinases phosphorylate multiple sites on Bad and promote 14 3 3 binding and dissociation from Bcl XL . ^^^ Pim phosphorylation of Bad was also found to promote the 14 3 3 binding of Bad and block its association with Bcl XL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In a model of serum withdrawal induced apoptosis of rat pheochromocytoma PC 12 cells , rasagiline and its propargyl moiety , N propargylamine , decreased cell death via multiple neuroprotective pathways that include the stimulation of PKC phosphorylation ; upregulation of PKCepsilon mRNA ; induction of Bcl 10 ( L ) , Bcl w , and brain derived neurotrophic factor ( BDNF ) mRNAs ; and downregulation of PKCgamma , Bad , and Bax mRNAs . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 and Bcl xL expressions were down regulated after paclitaxel treatment in FHIT expressing cells , whereas Bax and Bad expressions were up regulated . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Levels of other Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Bad , Bak , Bax ) were unaffected by simultaneous ATRA and TGF beta 1 treatment , when compared to ATRA alone . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Upregulation of caspase 1 , 2 , 3 , 6 , 7 , 8 , 11 and 12 and upregulation for the transcripts of apoptosis inhibitors bcl 2 , bcl w and bcl 10 and apoptosis promoters ' bax , bak and bad was detected in spleens of sPCV and mPCV mice , but not control mice . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Up regulation of Bad and p 21 ; down regulation of Bcl 2 , Bcl XL , Bid , p 53 , and fatty acid synthase ; and cleavage of Bax were found in HMDB treated A 431 cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
This BEA induced apoptosis in human NSCLC A 549 cells was also accompanied by the up regulation of Bax , Bak , and p Bad and down regulation of p Bcl 2 , but no effect on the levels of Bcl 10 ( L ) or Bad proteins . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In addition , inhibition of PI 3 kinase did not alter levels of Bax , Bcl 2 , Bcl 10 ( L ) or Bim proteins in mitochondria but caused translocation of the pro apoptotic protein Bad to mitochondria . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis revealed the down regulation of Bcl 2 and Bcl xL and the up regulation of Bax and Bad by cerebral I / R insult . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Chi square analysis revealed no association between expression of Bcl 2 , Bcl XL , Bad , Bak , Bid or p 53 proteins and response to vinorelbine therapy . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Here , we show that tuberin triggers apoptosis , accompanied by downregulation of p70S6K activity and of phosphorylation of BAD on residue Ser 136 , and by upregulation of the interaction of BAD / BCL 2 and BAD / BCL XL . ^^^ Our work proposes a model in which tuberin mediated inhibition of p70S6K activates BAD to heterodimerize with BCL 2 and BCL XL to promote apoptosis . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
The purpose of the present study was to analyse the effects of naltrexone on the expression levels of proteins regulating the extrinsic ( FasL and Fas ) and the mitochondrial ( Bcl 2 , Bcl xL , Bad and Bax ) apoptotic pathways , as well as the active fragment of the executioner caspase 3 in the mouse brain . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In the study of the molecular mechanism of this phenomenon , it was found that GnTV AS reduced the expressions of anti apoptotic proteins , such as phosphorylated protein kinase B and phosphorylated Bad as well as Bcl 2 and Bcl 10 ( L ) , and elevated those of pro apoptotic proteins , including Bax , full length caspase 3 and its activated fragments as well as anti oncoprotein p 53 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Hepatic mRNA levels were measured for several pro apoptotic adaptors / regulators , including FasL , Fas receptor , FADD , TRADD , Bad , Bak , Bax , and Bcl 10 ( S ) , and anti apoptotic regulators , including Bcl w , Bcl 10 ( L ) , Bcl 2 , and Bfl 1 . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
However , Bad was translocated from the cytosol into the mitochondria , where it bound to Bcl xL , and Bak was dissociated from Bcl xL and conformationally changed . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In addition , the results showed that FME induced apoptosis was accompanied by up regulation of Bax and Bad , and down regulation of Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl 2 and Bcl XL and the proapoptotic proteins Bad , Bak , Bax , Bid , Bim , and p 53 in 21 cases of gastric cancer . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
BAD facilitates membrane translocation of Bcl XL in a process that requires LBD 2 . ^^^ The dynamic interaction of BAD with membranes is tied to activation and membrane translocation of Bcl XL . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
PFE pretreatment of NHEK was found to increase the cell cycle arrest induced by UVA in the G 1 phase of the cell cycle and the expression of Bax and Bad ( proapoptotic proteins ) , with downregulation of Bcl 10 ( L ) expression ( antiapoptotic protein ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
There was no evidence that calpain cleaved Bcl 2 family member proteins that regulate mitochondrial membrane permeability including Bcl 2 , Bcl xl , Bad , Bak , Bid , or Bim . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Bad promotes apoptosis by disassociating from 14 3 3 and sequestering Bcl xL through heterodimerization . ^^^ Ethanol effects on interactions between Bad and 14 3 3 or Bcl xL at the more vulnerable and less vulnerable ages were determined using an enzyme linked immunosorbent assay based technique to detect native protein protein interactions . ^^^ RESULTS : At P 4 , EtOH increased mitochondrial localization of Bad , expression of a 15 kDa fragment recognized by Bad antibody , and formation of Bad : Bcl xL complexes . ^^^ At P 7 , EtOH increased Bad : 14 3 3 complexes and reduced Bad : Bcl xL complexes . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Statistically significant differences between epithelial and sarcomatoid tumours were observed for Bid ( p < 0 . 001 ) , Bad ( p = 0 . 012 ) and Bcl XL ( p = 0 . 03 ) . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
BAD antagonizes both the cell cycle and antiapoptotic functions of BCL 2 and BCL 10 ( L ) through BH 3 binding . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In cultures treated with cruzipain , cleavage of caspase 3 was considerably diminished after serum starvation ; Bcl 2 overexpression was inhibited by PD 098059 but not by Ly 294002 , whereas Bad phosphorylation and Bcl xL expression were increased and differentially modulated by both inhibitors . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Phosphorylation of Bad and the expression of an antiapoptotic molecule , Bcl 10 ( L ) , were reduced by the ablation of endogenous Pim 3 . ^^^ Thus , we provide the first evidence that Pim 3 can inactivate Bad and maintain the expression of Bcl 10 ( L ) and thus prevent apoptosis of human pancreatic cancer cells . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
In addition to the impact on Bad phosphorylation , doxorubicin treatment caused p 38 MAPK dependent downregulation of Bcl xL protein . . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
EGF increased the expression of the Bcl 10 ( L ) protein , an antiapoptotic member of the Bcl 2 family , but not that of other anti ( Bcl 2 ) or proapoptotic ( Bad and Bax ) protein members . ^^^
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q92934 and Q07817	Pubmed	SVM Score :0.0
NA