Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.80120301
N Bak interacts with Bcl XL but not BAX , suggesting an indirect mechanism for promoting Bax translocation to the mitochondria . 0.80120301^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.87181824
Our results show that the ITCs caused phosphorylation of Bcl 2 , induced mitochondrial translocation of Bak , and disrupted the association of Bcl xl with both Bak and Bax in mitochondrial membrane , indicating that ITC induced mitochondrial damage results at least in part from modulation of select Bcl 2 family members . . 0.87181824^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
There was no correlation between the susceptibility to gemcitabine and the endogenous expression of the B cell lymphoma 2 ( BCL 2 ) family proteins BCL 2 , BCL XL , myeloid cell leukemia 1 ( MCL 1 ) , BCL 2 associated 10 protein ( BAX ) , BCL 2 homologous antagonist / killer ( BAK ) and BCL XS . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The viral infection depleted immature B cells ( IgM+SWC3+ ) and favored proapoptotic mRNA expression profiles [ i . e . , suppressed B cell leukemia / lymphoma xl ( Bcl xl ) and stimulated Bcl 2 homologous antagonist / killer ( Bak ) ] in the external inguinal lymph nodes . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 homolog , Bak , promotes apoptosis and binds anti apoptotic family members including Bcl 2 and Bcl xL . ^^^ We have identified a domain in Bak that is both necessary and sufficient for cytotoxic activity and binding to Bcl xL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Specific mutations that disrupt the ability of Bcl XL to interact with Bax or Bak still preserve 70 80 % of the anti death activity of wild type Bcl XL . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Elevated expression of Bcl 10 and reduced Bak in primary colorectal adenocarcinomas . ^^^ Taken together , these results suggest that expression of Bcl XL is increased in undifferentiated primary colorectal cancers , often with accompanying reciprocal decreases in the anti apoptotic proteins Bcl 2 and Mcl 1 and the pro apoptotic protein Bak , whereas Bax expression is relatively constant . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
This protective effect of Bcl 2 occurs in the absence of significant variations , in the stimulated livers , in the level of expression of other proteins also involved in resistance or sensitivity to apoptosis , namely Bcl 10 , Bax , Bad , Bak , and p 53 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Thus , like Bcl 2 and Bcl 10 , the Bcl w protein promotes cell survival , in contrast to other close homologues , Bax and Bak , which facilitate cell death . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The apoptosis regulating proteins Bcl 2 , Bax , Bcl 10 , Bak , and Mcl 1 were examined by immunohistochemical methods in 48 archival specimens of adenocarcinoma of the stomach , and the results were correlated with tumor histology ( intestinal versus diffuse pattern ) and clinical stage ( early versus late stage disease , ie , stages 1 and 2 versus stage 3 ) . ^^^ Tumor cells containing immunostaining for the anti apoptotic proteins Bcl 2 , Bcl 10 , and Mcl 1 were present in 26 ( 54 % ) , 41 ( 85 % ) , and 36 ( 75 % ) of the 48 cases evaluated , respectively , whereas immunopositivity for the pro apoptotic proteins Bax and Bak was found in 44 ( 92 % ) and 42 ( 88 % ) specimens Comparisons of these immunostaining results with tumor histology revealed statistically significant differences for Bax ( P = 0 . 03 ) , Bcl 10 ( P = 0 . 003 ) , and Mcl 1 ( P = 0 . 005 ) , which were all more frequently immunopositive for tumors with an intestinal than a diffuse histological pattern ( chi 2 analysis ) . ^^^ The immunointensity for the Bcl 2 , Bcl 10 , and Mcl 1 proteins was stronger in tumor cells compared with normal foveolar cells in 7 ( 21 % ) , 15 ( 44 % ) , and 8 ( 2 . 1 % ) of 34 cases , respectively , whereas the immunointensity of the proapoptotic proteins Bax and Bak was reduced compared with normal cells in 8 ( 24 % ) and 24 ( 71 % ) cases . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Since the discovery of Bcl 2 a decade ago , several other cellular and viral genes encoding homologous proteins have been identified , some of which suppress cell death akin to Bcl 2 ( Bcl XL , Mcl 1 , A1 / Bfl 1 , Nr 13 , Ced 9 , BHRF 1 ) and others which promote apoptosis ( Bax , Bcl Xs , Bak , Bik , Bad ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bcl xL , Bcl xS , and Bak levels were also unchanged after OA treatment in both cell types . ^^^ Bcl xL , Bcl xS , and Bak levels were also unchanged after OA treatment in both cell types . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Apoptosis resistance in the metastatic cells was associated with higher levels of expression of the cell death suppressor BCL 2 and lower levels of the death promoters BAX and BAK than were detected in the nonmetastatic LNCaP Pro 5 cells , whereas levels of two other BCL 2 family members ( BCL 10 ( L ) and BAD ) were indistinguishable . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The pro apoptotic protein bax was expressed at lower levels in carcinomas than in adenomas , whereas bak and bclx were expressed in the same order of magnitude in all tissues examined . ^^^ In all four cell lines , the amounts of the pro apoptotic proteins bax , bak and bclx were higher than in most tumor tissues . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Structure of Bcl xL Bak peptide complex : recognition between regulators of apoptosis . ^^^ The molecular basis for heterodimer formation was investigated by determination of the solution structure of a complex between the survival protein Bcl xL and the death promoting region of the Bcl 2 related protein Bak . ^^^ The structure and binding affinities of mutant Bak peptides indicate that the Bak peptide adopts an amphipathic alpha helix that interacts with Bcl xL through hydrophobic and electrostatic interactions . ^^^ Mutations in full length Bak that disrupt either type of interaction inhibit the ability of Bak to heterodimerize with Bcl xL . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The human Bcl 2 family member Bak induces apoptosis in mammalian cells which is counteracted by the Bcl 10 ( L ) protein . ^^^ We show that Bak also kills the unicellular fission yeast Schizosaccharomyces pombe and that this is inhibited by coexpression of human Bcl 10 ( L ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The product of harakiri , Hrk , physically interacts with the death repressor proteins Bcl 2 and Bcl 10 ( L ) , but not with death promoting homologs , Bax or Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Western blot and PCR analysis did not show consistent differences between cell lines examined in the expression of Bcl 2 , Bcl 10 ( L ) , Bcl 10 ( S ) , and Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The three pro apoptotic members of the family , Bak , Bad , and Bax , all showed an early decline in mRNA levels when Bcl 10 transcripts increased , followed by later peaks at 12 , 24 , and 48 to 72 hours , respectively . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bax / Bak lethality was suppressed by coexpression of Bcl 2 family members that are anti apoptotic in vertebrates , namely Bcl xL , Bcl 2 , Mcl 1 , and A 1 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Preablation biopsy specimens and prostatectomy specimens were immunohistochemically stained for apoptotic cells and for expression of apoptosis regulatory proteins Bcl 2 , Bax , Bcl 10 , and Bak . ^^^ In all 26 specimens , benign prostatic hyperplasia demonstrated increased expression of the Bcl 2 protein , but no change in the expression of Bax , Bcl 10 , and Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The effects of the expression of the human Bcl 2 family proteins Bax , Bak , Bcl 2 , and Bcl XL were examined in the fission yeast Schizosaccharomyces pombe and compared with Bax induced cell death in mammalian cells . ^^^ Expression of the proapoptotic proteins Bax and Bak conferred a lethal phenotype in this yeast , which was strongly suppressed by coexpression of the anti apoptotic protein Bcl XL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Analysis of bi transgenic K rasVal 12 10 TAgWt mice homozygous for wild type or null p 53 alleles established that the enhancement of apoptosis occurs through a p 53 independent mechanism , is not attributable to augmented proliferation or to an increase in abortive cell cycle reentry ( compared to TAgWt mice ) , and is not associated with detectable changes in the crypt villus patterns of expression of apoptotic regulators ( Bcl 2 , Bcl xL , Bak , and Bax ) or mediators of epithelial cell matrix interactions and survival ( e . g . , alpha5beta1 integrin and its ligand , fibronectin ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 family members analyzed were Bcl 2 , Bcl 10 , Bax , Bad , Bak , A 1 , and Mcl 1 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Expression of the BCL 2 protein family members , BAX , BAK , BAD , BCL xL , BCL xS , and BCL 2 , was measured ( by western blotting using specific antibodies ) in PC 12 cells before and during apoptosis induced by either H2O2 treatment or by serum deprivation and during rescue from apoptosis by nerve growth factor ( NGF ) . ^^^ Our results show that the expression of BAX , BAK , BAD , and BCL xL is altered in a stimulus dependent manner but can not be used to define whether a cell will undergo or survive apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Remarkably , reentry of villus enterocytes to the cell cycle increases the radiosensitivity of the crypt epithelium without changing Bcl 2 , Bcl xL , Bak , or Bax expression . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Other proteins , like bcl xL , A 1 or mcl 1 have the same anti apoptotic function , but several molecules of the same family , like bcl xS , bax alpha or bak can trigger the opposite effect . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
It shares a conserved domain , BH 3 , with other pro apoptotic proteins , Bax , Bak , Bid , and Hrk , and certain anti apoptosis proteins such as Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Protein expression of Fas / APO 1 or bcl 2 , and messenger RNA ( mRNA ) expression of bcl 2 , bcl xL , bax , bak , Fas / APO 1 , Fas ligand ( Fas L ) , c myc , mad , or max were determined . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The expression of several other bcl 2 family members ( bcl 10 , ich 1 , bax , bag , and bak ) and retinoid receptors ( RARalpha , RXRalpha , and RXRbeta ) was not affected by treatment with RAR and / or RXR activating retinoids ; RARbeta RNA was undetectable before and after retinoid treatment . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bak can accelerate chemotherapy induced cell death independently of its heterodimerization with Bcl XL and Bcl 2 . ^^^ Bak has been shown to both promote apoptosis and to inhibit cell death while two other members of the Bcl 2 family of proteins , Bcl XL and Bcl 2 delay apoptosis induced by various stimuli including chemotherapeutic agents . ^^^ We generated clones with stable expression of Bak wild type ( wt ) and Bak with its BH 3 ( delta 78 86 ) domain deleted ( deltaBH 3 ) in FL5 . 12 cells or FL5 . 12 cells expressing either Bcl XL or Bcl 2 to determine if Bak could accelerate apoptosis and antagonize the death repressor activity of Bcl XL and Bcl 2 during chemotherapy induced apoptosis . ^^^ In FL5 . 12 cells expressing Bcl XL and Bak wt or Bak deltaBH 3 , both Bak wt or Bak deltaBH 3 were able to antagonize the protective effect of Bcl XL when treated with etoposide or fluorouracil . ^^^ Immunoprecipitation studies revealed that deletion of BH 3 disrupted heterodimerization between Bak and Bcl XL and that both Bak wt and Bak deltaBH 3 failed to interact with Bcl 2 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
A 26 amino acid peptide within this domain , which showed significant homology to the alpha helical BH 3 domains of related apoptotic proteins like Bak and Bax , was found to be necessary and sufficient to bind Bcl xL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
None of the cytokines tested caused a change in the levels of expression of Bcl 2 , Bax , Bcl 10 , or Bak proteins . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Thus , as previously shown for BAX , BAK , BCL 2 , and BCL XL , the BH 3 domain of BAD is required for its dimerization with other BCL 2 family proteins . ^^^ BAD was further analyzed for its ability to bind to various mutants of BCL 2 and BCL XL that have lost the ability to bind BAX and BAK , some of which retain biological activity and some of which do not . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The pattern of endogenous expression levels of Bax , Bcl 2 , Bcl 10 and Bak , which was not modulated by cisplatin treatment , demonstrated that these Bcl 2 family proteins are not involved in drug induced apoptosis in the TGCT cell lines . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Deletion of BH 4 rendered Bcl 2 ( and Bcl xL ) inactive but did not impair either Bcl 2 homodimerization or ability to bind to Bax or five other pro apoptotic relatives ( Bak , Bad , Bik , Bid or Bim ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Immunoblot analysis of primary adenocarcinomas revealed expression of the anti apoptotic proteins Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 , as well as the pro apoptotic proteins Bax , Bak , and CPP 32 , in at least 2 of the 3 tumors examined . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Alteration of proteins regulating apoptosis , Bcl 2 , Bcl 10 , Bax , Bak , Bad , ICH 1 and CPP 32 , in Alzheimer ' s disease . ^^^ Apoptosis is regulated by the B cell leukemia 2 gene product ( Bcl 2 ) family ( Bcl 2 , Bcl 10 , Bax , Bak and Bad ) and the caspase family ( ICH 1 and CPP 32 ) , with apoptosis being prevented by Bcl 2 and Bcl 10 , and promoted by Bax , Bak , Bad , ICH 1 and CPP 32 . ^^^ In the membranous fraction , the levels of Bcl 2 alpha , Bcl xL , Bcl 10 beta , Bak and Bad were increased in AD . ^^^ In the cytosolic fractions , the level of Bcl 10 beta was increased , while Bcl xL , Bax , Bak , and Bad and ICH 1L were unchanged . ^^^ These findings demonstrate a differential involvement of cell death regulatory proteins in AD and suggest that Bak , Bad , Bcl 2 and Bcl 10 are upregulated in AD brains . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The expression of several apoptosis regulating proteins , including the Bcl 2 family proteins Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , and BAD ; the Bcl 2 binding protein BAG 1 ; and the cell death protease Caspase 3 ( CPP 32 ) , was evaluated by immunoblotting using 58 peripheral blood B CLL specimens from previously untreated patients . ^^^ Expression of Bcl 2 , Mcl 1 , BAG 1 , Bax , Bak , and Caspase 3 was commonly found in circulating B CLL cells , whereas the Bcl XL and BAD proteins were not present . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Positive ( ICE , ICErel 2 , ICErel 3 , Ich 1L , CPP 32 , mch 2 , mch 3 , bcl xS , bax and bak ) and negative ( bcl 2 , bcl xL , MCL 1 and Ich 1S ) regulators of apoptosis were successively examined using a semi quantitative technique of reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Also , Bcl 2 , Bcl 10 , Bak , Bad and p 53 were increased in AD brains . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Expression of the death related proteins ( DRPs ) Bcl 2 , Bax , Bcl 10 and Bak that regulate cell survival and death was examined using immuno histochemical methods in a group of 142 T 1 ( < 2 cm ) ductal breast carcinomas . ^^^ Expression of these DRPs was associated significantly with the HG of the tumors : Bcl 2 and Bak expression was predominant in HG I / II tumors , whereas expression of Bcl xL and Bax was commonly observed in HG 3 tumors , as occurs for p 53 over expression . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
There were no changes in levels of Bcl 2 , Bcl XL , or 24 kDa Bax over 72 hr after exposure to cisplatin or paclitaxel , but each agent led to up regulation of Bak and 21 kDa Bax in A 2780 cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Expression of p 53 , p21 / WAF / CIP , Bcl 2 , Bax , Bcl 10 , and Bak in radiation induced apoptosis in testicular germ cell tumor lines . ^^^ Expression of p21 / WAF / CIP was determined by Northern blot analysis and immunoblotting was used to monitor p 53 , Bax , Bcl 2 , Bcl 10 , and Bak protein levels . ^^^ Constitutive expression of Bax , Bcl 2 , Bcl 10 , and Bak was not affected by radiation and showed no correlation with cell susceptibility to radiation induced apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Recent studies have focused on the role that programmed cell death ( i . e . , apoptosis ) plays in both normal and neoplastic growth : certain genes can either suppress ( e . g . , Bcl 2 , Bcl xL ) or promote ( e . g . , Bik , Bax , Bak ) apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Moreover , BI 1 can interact with Bcl 2 and Bcl XL but Bax or Bak , as demonstrated by in vivo cross linking and coimmunoprecipitation studies . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In this study we have investigated by Western blotting the expression pattern of Bcl 2 and its homologues Bax , Bak , Bcl xL , Bcl xS , Mcl 1 and Bad in 12 distant lymph node metastases from patients who have been treated by different regimes , in nine newly established cell lines of these metastases , in three cell lines obtained from other sources and in primary melanocytic cell lines from three neonatal and two adult subjects . ^^^ Taken together , our data suggest that Bax , Bak , Bad , Bcl xL and Mcl 1 are expressed in addition to Bcl 2 in both normal melanocytes and in cell lines established from melanoma metastases . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Quantitative Western blotting was used to examine the protein expression of P 53 and P21WAF 1 , Bcl 2 and Bcl 10 ( L ) ( anti apoptotic proteins ) , and Bax , Bak , and Bad ( proapoptotic proteins ) . ^^^ Upon deprivation , these cancer cells up regulated P 21 and Bcl 2 and / or BclX ( L ) , lost response to withdrawal induced up regulation of Bax / Bad / Bak or decreased or even completely lost Bax expression and expressed some novel proteins such as P 25 and P54 / 55 complex . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
To investigate the molecular mechanism of glandular parenchyma destruction in Sjgren ' s syndrome ( SS ) , Bcl 2 , Bax , Bcl 10 , and Bak expression were studied . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 family proteins are key regulators of apoptosis and function as cell death antagonists ( e . g . , Bcl 2 , Bcl XL , and Mcl 1 ) or agonists ( e . g . , Bax , Bad , and Bak ) . ^^^ Here we report that among the Bcl 2 family of proteins tested ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bad , and Bak ) , Bcl XL was unique in that its protein levels were tightly regulated by hemopoietins in both immortal and primary myeloid progenitors . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Formalin fixed tissue sections were immunohistochemically stained for apoptosis associated proteins ( Bcl 2 , Bcl 10 , Bax , Bak , p 53 , MDM 2 , BHRF ) . ^^^ Most lymphomas were positive for Bcl 10 and Bax , and few expressed Bak . ^^^ The irregular expression of Bcl 2 , Bcl 10 , Bax , and Bak in oral lymphomas indicates dysfunctional apoptotic mechanisms in these tumors . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Similarly , we analyzed the expression of bcl 2 related proteins bcl xL , bax , bad , and bak before and during ex vivo expansion . ^^^ These cells expressed strongly the bcl xL protein ( > 95 % ) but were bax low ( 4 % to 12 % ) , bad low ( 0 % to 0 . 8 % ) , and bak low ( 0 % to 3 % ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In the yeast cell assay , BOD interacts with diverse antiapoptotic Bcl 2 proteins [ Mcl 1 , Bcl 2 , Bcl xL , Bcl w , Bfl 1 , and Epstein Barr virus ( EBV ) BHRF 1 ] but not with different proapoptotic Bcl 2 proteins ( BAD , Bak , Bok , and Bax ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bleomycin induced apoptosis was accompanied by decreases in bcl 2 and bcl xl and increases in p 53 , bak , and bax protein levels . ^^^ Transforming growth factor ( TGF ) beta induced apoptosis was accompanied by decreased bcl xL and increased bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 ( L ) , Bax , Bad , Bak and p 53 protein expression was analysed by Western blotting . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The proteins evaluated were p 53 and six members of the Bax / Bcl 2 family : three proapoptotic proteins ( Bax , Bak , and Bcl xS ) and three survival factors ( Bcl 2 , Bcl xL , and Mcl 1 ) . ^^^ In addition , expression levels of Bcl 2 , Bcl xL , Bcl xS , Bak , or Mcl 1 did not correlate with sensitivity or resistance to the four drugs . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Expression of the Bcl 2 , Mcl 1 , Bcl 10 , Bax , and Bak proteins was analyzed to determine whether the differences in MCF 7 cell sensitivity to apoptosis could be correlated to the differential expression of these proteins . ^^^ Whereas Bak , Bcl 10 , and Mcl 1 levels were identical between variants , the levels of Bcl 2 were 3 . 5 3 . 8 fold higher and the levels of Bax were 1 . 5 1 . 7 fold lower in the resistant variants ( M and L ) as compared with those of the sensitive variant ( N ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We have previously examined the involvement of the B cell leukemia 2 gene product ( Bcl 2 ) family proteins ( Bcl 2 , Bcl 10 , Bax , Bak , and Bad ) in Alzheimer ' s disease ( AD ) and found that Bcl 2 , Bcl 10 , Bak , and Bad were upregulated . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Taxol and estramustine induced modulation of human prostate cancer cell apoptosis via alteration in bcl xL and bak expression . bcl xL is an antiapoptotic protein that shares sequence homology with bcl 2 and seems to convey chemoresistance in many human tumor cell lines . bcl xL protein is expressed at a 3 fold higher level in PC 3 cells than it is in LNCaP cells . ^^^ Treatment of LNCaP cells with 10 nm Taxol led , after 24 h , to relatively specific and almost total down regulation of bcl xL protein in the absence of alteration of bax , bak , or bcl 2 levels . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Apoptosis in the presence of wild type Ras correlated with up regulated expression of Bak that did not occur in TS K Ras clones , whereas survival in these clones correlated with elevated expression of Bcl xL . ^^^ Thus , the Bak : Bcl xL ratio was high in TS and TS pCIneo cells undergoing apoptosis , whereas the Bcl xL : Bak ratio was high in TS K Ras clones exhibiting a survival response . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
To inhibit the effect of intrinsic Bcl xL protein , we overexpressed Bak , which binds Bcl xL and inhibits the anti apoptotic effect of Bcl xL , by transfection into MKN 45 cells . ^^^ In conclusion , we demonstrated that administration of bcl 10 antisense oligonucleotides or overexpression of Bak protein induces sensitization to apoptosis in MKN 45 gastric cancer cells , suggesting that endogenous Bcl xL expression in cancer cells is an important modulator of apoptosis . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Since the role of the Bcl 2 gene family has been only poorly investigated in colorectal cancer , we have examined the expression of the apoptosis blockers Bcl xL and Bcl 2 , as well as the proapoptotic factors Bax and Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Expression of bcl 2 , bcl 10 , bax and bak in renal parenchyma , oncocytomas and renal cell carcinomas . ^^^ Expression of bcl 2 , bcl 10 , bax and bak was investigated by immunohistochemistry and Western blotting of regular and alterated renal parenchyma as well as in 57 renal cell carcinomas . ^^^ Moderate to strong expression for bcl 2 , bcl 10 , bax and bak was found in 24 , 38 , 2 and 13 of 57 carcinomas , respectively . ^^^ Bcl 2 , bcl 10 , bax and bak expression were correlated to tumor type . ^^^ Chromophilic carcinomas stained stronger for bcl 2 , bcl 10 and bax , whereas chromophobic carcinomas stained stronger for bcl 10 , bax and bak compared to clear cell carcinomas . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Modulation of cytokine induced cardiac myocyte apoptosis by nitric oxide , Bak , and Bcl 10 . ^^^ Cytokines also mediated an NO dependent , sustained increase in myocyte expression of the Bcl 2 homologs Bak and Bcl 10 ( L ) . ^^^ The NO donor S nitrosoglutathione also induced apoptosis and cell levels of Bak , but not of Bcl 10 ( L ) . ^^^ The rate and extent of this apoptosis is modulated by alterations in the cellular balance of Bak and Bcl 10 ( L ) , which respond differentially to cytokine induced and exogenous NO and by the availability of oxidant species . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
After androgen withdrawal , there were no significant changes in the levels of clusterin , Bcl xl , Bak , and Bad . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
During this process , IL 6 downregulated expression of BCL 2 in 1A9 M cells and stimulated BCL XL expression , but had no effect on p 53 , Bax , or Bak gene expression . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Nonetheless , there were no significant alterations in levels of immunoreactive Bcl 2 , Bcl 10 ( L ) , Bax , Bad , and Bak , nor any evidence of cytochrome c release into cytosol and dissipation of delta ( psi ) m . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Prognostic significance of Bcl 2 , Bcl xL / S , Bax and Bak expressions in colorectal carcinomas . ^^^ The immunohistochemical expressions of the apoptosis related proteins Bcl 2 , Bcl xL / S , Bax and Bak were investigated in tumor specimens selected from 58 consecutive patients undergoing surgery for advanced colorectal carcinoma . ^^^ In the normal colonic mucosa , Bcl 2 positive epithelial cells tended to be located at the base of the crypts , while the Bcl xL / S , Bax and Bak positive epithelial cells tended to be located at the luminal surface . ^^^ The intracellular expression patterns of Bcl 2 and Bax were diffuse cytoplasmic , whereas those of Bcl xL / S and Bak were granular cytoplasmic . ^^^ In the adenocarcinomas , the intracellular expression patterns of all antibodies were diffuse cytoplasmic , and the percentages of Bcl 2 , Bcl xL / S , Bax and Bak positive cases ( > 20 % of cancer cells labeled ) were 29 % , 43 % , 45 % and 69 % , respectively . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
No changes in Bcl 2 , Bak , or Bcl xS were found after p 53 expression . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The fivefold elevation in steady state Bcl 2 concentration is not accompanied by detectable changes in the levels or cellular distributions of the related anti apoptotic regulator Bcl xL or of the proapoptotic regulators Bax and Bak and does not produce detectable effects on basal proliferation , differentiation , or death programs . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Therefore , using anesthetized pigs with documented myocardial hypoperfusion and short term hibernation , we investigated the left ventricular mRNA expression of the inducible heat shock protein Hsp 70 and of the anti apoptotic Bcl XL in comparison with the pro apoptotic Bak and Fas expression . ^^^ For transcriptional analyses , the porcine cDNA sequences of Bcl XL , Bak and Fas were identified by polymerase chain reaction ( PCR ) or by screening of a porcine heart cDNA library and cloned . ^^^ Using reverse transcription polymerase chain reaction ( RT PCR ) , we observed an unchanged mRNA expression of inducible Hsp 70 , Bcl XL , Bak and Fas after 85 min of hypoperfusion in the short term hibernating myocardium , as well as after 30 min of subsequent reperfusion in the stunned myocardium , compared with transcription in a non hypoperfused control area of the same ventricle . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Immunofluorescence showed Bcl xL and Bak were largely associated with mitochondria and in untreated cells they coimmunoprecipitated in the presence of nonioinic detergent . ^^^ This association was significantly decreased after cell perturbation suggesting that Bcl xL dissociation from Bak occurred on exposure of Bak ' s NH 2 terminus . ^^^ Release of proteins , including Bcl xL , from Bak is suggested to be an important event in commitment to death . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Furthermore , we modeled a complex of BCL XL and BID by aligning the BID and BAK BH 3 motifs in the known BCL XL BAK BH 3 complex . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We investigated the expression of apoptosis in these diseases , using TdT mediated dUTP nick end labeling ( TUNEL ) method and immunohistochemistry with Bcl 2 , Bcl 10 , Bak and caspase 3 ( CPP 32 ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
METHODS : Immunohistochemistry was performed on tissue sections using antibodies against bcl 2 , bcl 10 , bax , and bak . ^^^ The bcl 10 and bak proteins both are expressed in the basal and spinous strata but are down regulated in the granular cell layer . ^^^ Both bcl 2 and bax were diffusely cytosolic whereas bcl 10 and bak exhibited a distinct perinuclear distribution . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Developmental expression patterns of Bcl 2 , Bcl 10 , Bax , and Bak in teeth . ^^^ The ontogenic profile of expression of four members of the Bcl 2 family ( Bcl 2 , Bcl 10 , Bax and Bak ) was examined in the mouse by immunohistochemistry using paraffin sections . ^^^ In general , contemporaneous co expression of the Bcl 2 and Bax proteins , and of the Bcl 10 and Bak proteins was noted in various types of cells during the developmental process , with the intensity of Bcl 2 > Bax and of Bak > Bcl 10 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Here we demonstrate that inhibition of the epidermal growth factor receptor tyrosine kinase activity with either an epidermal growth factor receptor antagonistic monoclonal antibody ( MoAb 425 ) or an epidermal growth factor receptor selective tyrosine kinase inhibitor ( AG 1478 ) downregulated Bcl 10 ( L ) expression in normal human keratinocytes but had no effect on expression of the pro apoptotic Bcl 2 homologs Bad , Bak , and Bax . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We examined the expression of the bcl 2 family oncoproteins bax , bak , bcl 2 , bcl xL , and mcl 1 in the course of differentiation of human keratinocytes cultured at low ( 0 . 15 mM ) and high ( 1 . 87 mM ) calcium concentrations . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Ninety archived paraffin embedded specimens from 25 patients ( two or more sequential biopsies each ) and eight control specimens were evaluated in immunohistochemically stained sections for tumor suppressor protein p 53 , p 53 binding protein mdm 2 , and apoptosis regulatory proteins Bcl 2 , Bcl 10 , Bax , and Bak . ^^^ Bcl 10 was expressed in 73 / 90 specimens , with staining displayed earlier in premalignant lesions than either p 53 or Bak . ^^^ These data show that apoptosis associated proteins are altered in variable patterns in both premalignant and malignant oral epithelial lesions . p 53 and especially Bak and Bcl 10 are expressed early ; Bax is largely absent ; and Bcl 2 and mdm 2 show sporadic expression in the development of oral premalignant and malignant disease . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In human PMN freshly isolated from the circulation , expression of bcl Xl , bax alpha , and bak , members of the bcl 2 family of apoptosis associated genes , was found using the reverse transcription polymerase chain reaction technique . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bak BH 3 peptides antagonize Bcl xL function and induce apoptosis through cytochrome c independent activation of caspases . ^^^ Here we report that synthetic peptides corresponding to the BH 3 domain of Bak bind to Bcl xL , antagonize its anti apoptotic function , and rapidly induce apoptosis when delivered into intact cells via fusion to the Antennapedia homeoprotein internalization domain . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Thus , the pro apoptotic proteins Bax , Bak and Bad , as well as the death suppressors Bcl 10 , Bcl 2 and Bcl w , are synthesised in mouse mammary gland , and dynamic changes in the expression profiles of these proteins occurs during development . ^^^ In extracts of mammary tissue in vivo , Bak heterodimerized with Bcl 10 whereas Bax associated with Bcl w , but Bak / Bcl w heterodimers were not detected . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
However , BCL Xs and BAK were weakly expressed in K 562 , as were Bcl 10 , BAD and BAK in the VAL line . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
There was no evidence showing that changes in the expressions of Bcl 2 , Bcl xL , Bak , and Bax lead directly to IFN alpha mediated apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
METHODS : Primary bovine glomerular endothelial cells were stimulated with TNF alpha or LPS , and apoptotic cell death was investigated by DNA fragmentation analysis , morphological studies , measurement of cytochrome c efflux and mitochondrial permeability transition , Bak , Bad , Bax , Bcl 2 , Bcl xL protein expression , and caspase 3 like protease activity . ^^^ Mechanistically , TNF alpha induced cell death was preceded by an efflux of mitochondrial cytochrome c into the cytosol and , subsequently , by a marked increase in the proapoptotic protein Bak and a decrease in the anti apoptotic Bcl xL protein content . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Here we create liposomes that carry the mitochondrial porin channel ( also called the voltage dependent anion channel , or VDAC ) to show that the recombinant pro apoptotic proteins Bax and Bak accelerate the opening of VDAC , whereas the anti apoptotic protein Bcl 10 ( L ) closes VDAC by binding to it directly . ^^^ Bax and Bak allow cytochrome c to pass through VDAC out of liposomes , but passage is prevented by Bcl 10 ( L ) . ^^^ In agreement with this , VDAC 1 deficient mitochondria from a mutant yeast did not exhibit a Bax / Bak induced loss in membrane potential and cytochrome c release , both of which were inhibited by Bcl 10 ( L ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In addition , Bcl 2 also prevented the increase in cellular levels of Bak , Bax and Bcl xL , along with degradation of actin and Bax . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The expression of the pro apoptotic proteins ( Bax , Bak ) and anti apoptotic proteins ( Bcl 2 , Bcl 10 , Mcl 1 ) was studied by immunohistochemistry in 110 invasive ductal breast carcinomas . ^^^ Overall , Bcl 2 , Bcl 10 , Mcl 1 , Bax , Bak , ER , and p 53 were detected in 62 , 75 , 68 , 75 , 60 , 68 and 26 per cent of the cases respectively , but at different levels in each case . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
No significant changes in Bcl 2 , BclX , and Bax protein expression level were observed in the transfected clones as compared with the control H 460 cells whereas a 2 fold increase in Bak protein levels was noticed . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Mammary gland tissue , similar to many other tissues , expresses a number of different Bcl 2 relatives including bcl 10 , bax , bak , bad , bcl w , bfl 1 , bcl 2 as well as the bcl 2 binding protein Bag 1 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
TGF alpha inhibited apoptosis and increased bcl 10 ( L ) and decreased bak protein levels in c myc hepatocytes but not in wild type hepatocytes . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In this study , we demonstrate that constitutive expression of bcl xl but not bcl 2 , bcl xs , bak , bad , or bax was associated with apoptosis resistance after IL 2 deprivation in CTLL 2 cells that expressed Tax . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The antiapoptotic protein bcl 2 was apparently up regulated in A549 / UCN cells , however , bcl xL , another antiapoptotic protein , was down regulated , without changes in bak and bax . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Unlike other proapoptotic Bcl 2 family members , such as Bax and Bak , Bcl 10 ( S ) does not seem to induce cell death in the absence of an additional death signal . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Neither the expression of the anti apoptotic protein Bcl xL nor that of the pro apoptotic proteins Bax and Bak were altered in cells expressing mutated N Ras . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 and its homologues , Bcl xL , Bcl xS , Bax , Bad , Bak and Bag 1 , was detected in all NHL cases , with wide variations between histological subtypes and within each subtype . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We have found that , in addition to Bcl 2 and Bax , the expression levels of apoptosis inducers ( Bad , Bak ) and inhibitors ( Bcl xL , Mcl 1 ) were highly variable in blasts from 78 children with newly diagnosed acute lymphoblastic leukemia ( ALL ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl 10 , Bax , and Bak expression in short and long lived patients with diffuse large B cell lymphomas . ^^^ The expression of the apoptosis regulating proteins , Bcl 2 , Bcl 10 , Bax , and Bak , in the initial biopsy samples was examined with immunohistochemical methods . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
However , during the apoptotic process one death repressor , Bcl XL , and two death promoters , Bak and Bad , were expressed . ^^^ The expression levels of Bcl XL and Bak remained unchanged , whereas the level of Bad was down regulated . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The BCL 2 family includes both proapoptotic ( e . g . , BAX and BAK ) and antiapoptotic ( e . g . , BCL 2 and BCL 10 ( L ) ) molecules . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We have recently shown that some of these proteins , such as Bcl 10 ( L ) , Bax , and Bak , directly modulate the mitochondrial voltage dependent anion channel ( VDAC ) and thus regulate apoptogenic cytochrome c release and potential loss . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
While the ras induced downregulation of Bak could be reversed by pharmacological inhibition of phosphatidylinositol 3 kinase ( PI 3 kinase ) , the effect of ras on Bcl 10 ( L ) was PI 3 kinase and mitogen activated protein kinase ( MAP kinase ) independent . ^^^ We conclude that ras induced resistance to anoikis in intestinal epithelial cells is mediated by at least two distinct mechanisms : one that triggers downregulation of Bak and another that stabilizes Bcl 10 ( L ) expression in the absence of the ECM . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In contrast , the expression of Bcl 10 ( L ) decreased and that of proapoptotic Bax , Bad , and Bak was unchanged or down regulated after removal of growth factors . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Tumour necrosis factor alpha ( TNF alpha ) and lipopolysaccharide ( LPS ) induced apoptosis of bovine glomerular endothelial cells is now recognized as an important part in the pathogenesis of glomerulonephritis characterized by early mitochondrial cytochrome c release , mitochondrial permeability transition , Bak protein upregulation , Bcl 10 ( L ) protein downregulation and caspase 3 activation . ^^^ Moreover , TNF alpha and LPS induced Bak upregulation , Bcl 10 ( L ) downregulation , and the activation of caspase 3 like proteases , measured fluorometrically using DEVD AMC and PARP cleavage , were efficiently blocked by dexamethasone . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
To investigate the molecular pathway to apoptosis induction , members of the Bcl 2 family of proteins were examined ( Bcl 2 , Bcl 10 , Bax , and Bak ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We first analyzed mRNA expression of pro apoptotic Bak and Bax along with that of anti apoptotic Bcl 2 and Bcl xL , using breast cancer specimens of 27 patients . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl xL , Bad , Bak , and Bax levels were not altered by either treatment . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Using reverse transcriptase polymerase chain reaction , cloning , and sequencing techniques , we have found that HL 60 cells express bak , bik , bax , bad , bcl 2 , bcl xL , bcl w , bfl 1 , fas , and caspases 1 4 and 7 10 . ^^^ Peripheral blood neutrophils expressed bak , bad , bcl w , bfl 1 , fas , and caspases 1 , 3 , 4 , and 7 10 , but hardly expressed bcl 2 , bcl xL , bik , bax , and caspase 2 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Two drug combinations that increase apoptosis and modulate bak and bcl 10 ( L ) expression in human colon tumor cell lines transduced with herpes simplex virus thymidine kinase . ^^^ Over a 2 4 day treatment period with GCV or the other four drugs , protein levels of the apoptosis agonist Bak increased 1 . 5 to 3 fold , whereas a corresponding decrease in the levels of the apoptosis antagonist , Bcl 10 ( L ) , was observed in butyrate , CPT , and 7 hydroxystaurosporine ( UCN 01 ) treated cells . ^^^ The GCV / UCN 01 and GCV / butyrate combinations resulted in increased Bak and decreased Bcl 10 ( L ) protein levels , while the GCV / CPT and GCV / paclitaxel combinations resulted in increased levels of both proteins . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The family can be divided into two classes : those such as Bcl 2 and Bcl xL that suppress cell death , and others , such as Bak and Bax , that appear to promote apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Changes in the relative expression level of Bcl 2 family proteins , including Bak and Bcl Xs , are also observed during p84N5 induced apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The degree of apoptosis was analyzed in relation to several clinicopathologic parameters , cell proliferative activity , and immunohistochemical expression of apoptosis related proteins , including bcl 2 , bax , bcl 10 , bak , p 53 , p 21 ( WAF1 / CIP1 ) , Fas , and Fas ligand . ^^^ Many synovial sarcomas were diffusely positive for bcl 2 family proteins ( bcl 2 , bax , bcl 10 , and bak ) and were negative or only sporadically positive for Fas , Fas ligand , p 53 , and p 21 ( WAF1 / CIP1 ) proteins . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
To explore the potential involvement of Bcl 2 family members in this process , the expression and localization of some Bcl 2 family proteins ( Bcl 2 , Bcl xL , Bcl w , Bak , Bax , and Bad ) and p 53 were analyzed during testicular development in the rat by Western blotting and immunohistochemistry . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Herein , we showed that inhibition of ERK1 / 2 activities caused ( 1 ) a G 1 arrest ; ( 2 ) a down regulation of the expression levels of the anti apoptotic homologs Bcl 2 , Mcl 1 , and Bcl 10 ( L ) without affecting the pro apoptotic levels of Bax and Bak ; ( 3 ) a promotion of caspases 3 , 6 , 8 , and 9 activities ; ( 4 ) a stimulation of PARP cleavage ; and ( 5 ) a programmed cell death by apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We have previously shown that Bax and Bak open the voltage dependent anion channel ( VDAC ) allowing cytochrome c to pass through the channel , and Bcl xL closes the channel . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
During the leukemic phases , the clonal cells were activated blasts expressing elevated levels of wild type ( wt ) p 53 , Bcl 2 , Bcl 10 ( L ) , and Bax , while Bak expression increased during the decline of lymphocytosis . ^^^ The data suggest that wt p 53 , Bcl 10 ( L ) , and Bcl 2 / Bax heterodimers support the accumulation of activated leukemic cells during the leukemic phases , while Bax and Bak may be involved in their decline during regression . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Attenuation of apoptosis by BLyS correlates with changes in the ratios between Bcl 2 family proteins in favor of cell survival , predominantly by reducing the proapoptotic Bak and increasing its prosurvival partners , Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In contrast , levels of Bax protein remained relatively unchanged in four of the cell lines , and levels of Bcl 10 ( L ) , Bcl 10 ( S ) , and Bak proteins showed little or no cell cycle dependent changes in Jurkat T cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
There was no correlation between expression of members of the Bcl 2 family ( Bcl 2 , Bcl xL , Bax , and Bak ) and TRAIL sensitivity . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
After PDT , expression of Bcl 2 , Bcl 10 ( L ) , Bax , and Bak was also examined in cell lysates by Western blot analysis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Other members of the Bcl 2 family ( Bag 1 , Bak , Bax , and Bcl xL ) were not altered in expression . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
IFN gamma increased BAK protein levels and decreased Bcl 2 and Bcl 10 ( S ) protein levels in TSGH 9201 cells . ^^^ IFN gamma mediated apoptosis was associated with the alteration in protein levels of Bcl 2 , Bcl 10 ( S ) and BAK . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
As bFGF did not affect LPS induced apoptotic cell death , bFGF also left LPS induced Bak upregulation and Bcl 10 ( L ) downregulation unaffected . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The shear stress induced up regulation of Bcl 10 ( L ) and Bak mRNA can be abrogated by inhibition of the endothelial NO synthase . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Furthermore , TPA exposure of U 937 cells is associated with increased levels of the pro apoptotic proteins Bak and Bcl xs , whereas simultaneously a decline in the Bcl 2 expression was noticable . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Adult mice exposed to greater than 95 % oxygen concentrations for 48 to 88 hours had increased whole lung mRNA levels of Bax and Bcl 10 ( L ) , no change in Bak , Bad , or Bcl 2 , and decreased levels of Bcl w and Bfl 1 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Both anti apoptotic ( Bcl W , Bcl 10 ( L ) ) and pro apoptotic ( Bad , Bak , Bax ) members of the Bcl 2 family were expressed in developing skeletal muscle in vivo . ^^^ Loss of Bcl 2 did not affect expression of other family members , because neonatal muscles of wild type and Bcl 2 null mice had similar amounts of Bcl 10 ( L ) , Bcl W , Bad , Bak , and Bax mRNAs . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Although the overall structure is similar to Bcl xL bound to a 16 residue peptide from the Bak protein ( Sattler et al . , 1997 ) , the Bad peptide forms additional interactions with Bcl xL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Since the Bcl 2 family of proteins constitutes a critical checkpoint in apoptosis , acting upstream of the apoptotic machinery , we investigated the expression of six Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The expression of proapoptotic ( Bad , Bak , Bax ) and antiapoptotic ( Bcl 2 , Bcl XL ) genes was analyzed by quantitative RT PCR . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
METHODS AND RESULTS : For immunohistochemistry , tissue sections of 32 patients were treated with an antigen retrieval METHOD : Primary antibodies against the apoptosis related proteins , bcl 2 , bcl 10 , bax , and bak were applied . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Additionally , U 69593 increased the content of the anti apoptotic members of the Bcl 2 family of proteins , the Bcl 2 and Bcl 10 ( L ) , whereas it had no significant effect on the apoptosis promoting homologues Bax , Bcl 10 ( S ) and Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Emodin induced apoptosis of CH 27 cells does not involve modulation of endogenous Bcl 10 ( L ) protein expression , but appears to be associated with the increased expression of cellular Bak and Bax proteins . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Using mid gestation human jejunum and colon organotypic cultures , we analyzed the impact of growth factors ( namely insulin ; 10 microg / ml ) and pharmacological compounds that inhibit signal transduction molecules / pathways ( namely tyrosine kinases , Fak , P 13 K / Akt , and MEK / Erk ) on cell survival and Bcl 2 homolog expression ( anti apoptotic : Bcl 2 , Bcl 10 ( L ) , Mcl 1 ; pro apoptotic : Bax , Bak , Bad ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
These changes are accompanied by a concomitant reduction ( 75 % ) in pro apoptotic Bak and stimulation ( 200 % ) of anti apoptotic Bcl xL levels . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Following AdBax / SB and AdBak / SB , a decrease of the AAP bcl xl was noted in combination with increases in PAP bax and bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
BCL 2 , BCL 10 ( L ) sequester BH 3 domain only molecules preventing BAX and BAK mediated mitochondrial apoptosis . ^^^ Comparison of wild type versus mutant BCL 2 , BCL 10 ( L ) indicates these antiapoptotics sequester BH 3 domain only molecules in stable mitochondrial complexes , preventing the activation of BAX , BAK . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The expression of other members of the Bcl 2 family such as Bax , Bcl 10 ( L ) and Bak were not affected . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
DMS inhibited bcl 10 ( L ) and bak but not bax gene expression , while BSOCOP potentiated bax mRNA synthesis immediately after application . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
After neutrophils were incubated with HPWE , expression of Bcl 2 family [ antiapoptotic ( Bcl 2 , Bcl XL and Mcl 1 ) and proapoptotic ( Bax , Bak and Bcl XS ) ] was determined by RT PCR and Western blotting , respectively . ^^^ The expression of Bax and Bak was upregulated and Bcl 2 , Bcl XL and Mcl 1 downregulated in HL 60 cells during neutrophilic differentiation . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
A significant decrease in BCL XL protein expression was noted with BAK , BAX , and BCL 2 unchanged , and this was corroborated at the transcriptional level with selectively decreased bcl xl mRNA production after sodium butyrate exposure . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Importantly , 16 10A1 could retard the growth of lymphomas and favored the up regulation of pro apoptotic molecules caspase 3 , caspase 8 , Fas , FasL , Bak , and Bax and down regulation of anti apoptotic molecule Bcl 10 ( L ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Aloe emodin induced apoptosis of CH 27 cells involved modulation of the expression of Bcl 2 family proteins , such as BclX ( L ) , Bag 1 , and Bak , and was associated with the translocation of Bak and Bax from cytosolic to particulate fractions . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In comparison , strong expression of Bax , Bak and p 21 ( waf1 / cip1 ) and suppressed expression of Bcl 2 , Bcl 10 ( L ) and COX 2 were observed in the Mn SOD antisense group and the expression pattern of these proteins was the inverse in the empty vector group . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Paracrine suppression of apoptosis by cytokine stimulated neutrophils involves divergent regulation of NF kappaB , Bcl 10 ( L ) , and Bak . ^^^ Examination of several Bcl 2 family members revealed a selective regulation by each media : CM IL1beta up regulated Bcl 10 ( L ) , while CM IL 8 down regulated Bak expression . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Dynamics of expression of apoptosis regulatory proteins Bid , Bcl 2 , Bcl 10 , Bax and Bak during development of murine nervous system . ^^^ We have used immunohistochemistry and immunoblotting to examine the expression of Bid and four other Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bax and Bak ) in the developing and adult murine central nervous system ( CNS ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bax , Bak and Bim ) in human lymphocytes . ^^^ We investigated the expression of Bcl 2 , Bcl 10 , Bax , Bak and Bim in human lymphocytes using flow cytometry . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 10 , Bcl 2 , Bax , and Bak in endarterectomy and atherectomy specimens . ^^^ The aim of this study was to determine the expression of Bcl 2 , Bcl 10 , Bax , and Bak in relation to apoptosis in advanced atherosclerotic lesions . ^^^ In all TUNEL positive apoptotic cells , Bax and Bak were present , while Bcl 10 was absent . ^^^ In conclusion , increased Bax and Bak coupled with lack / paucity of Bcl 2 and Bcl xL are associated with SMC apoptosis in advanced lesions . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause . ^^^ To investigate the expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak proteins in human uterine leiomyomas and homologous myometrium during the menstrual cycle and after menopause . ^^^ The expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak in leiomyomas ( n=24 ) and myometrial samples ( n=22 ) from women with leiomyomas was measured by immunohistochemistry and Western blot . ^^^ No significant differences were observed for the Bcl 10 or Bak proteins , whereas the Mcl 1 protein was significantly less abundant in secretory phase leiomyomas than in leiomyomas from menopausal women . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Rat1a cells exposed to hyperoxia underwent apoptosis characterized by the release of cytochrome c , activation of caspase 9 , and nuclear fragmentation that was prevented by the overexpression of Bcl 10 ( L . ) Murine embryonic fibroblasts from bax ( / ) bak ( / ) mice were resistant to hyperoxia induced cell death . ^^^ We conclude that exposure to hyperoxia results in apoptosis that requires Bax or Bak and can be prevented by the overexpression of Bcl 10 ( L ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Hypothermia also increased expression for the anti apoptotic Bcl 2 homologue Bcl 10 relative to 1 but decreased expression for the proapoptotic Bcl 2 homologue bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Erythrocyte survival is promoted by plasma and suppressed by a Bak derived BH 3 peptide that interacts with membrane associated Bcl 10 ( L ) . ^^^ Freshly isolated erythrocytes and cultured erythrocytes were both found to express Bcl 10 ( L ) and , to a lesser extent , Bak in membrane protein extracts . ^^^ Treatment of the cells with a Bak derived BH 3 peptide fused to the internalization sequence of the antennapedia protein , which has previously been shown to enter cells by diffusion and antagonize Bcl 10 ( L ) , resulted in substantial cell death in erythrocyte cultures . ^^^ A BH 3 peptide mutated at amino acid 78 of full length Bak required for heterodimerization with Bcl 10 ( L ) had no effect on cell viability or calcium levels . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Although protein expression of Fas , FADD , Bax , Bak , and Bcl 10 in the whole cell lysates was not changed by H pylori , Bax was decreased from mitochondria free cytosol suggesting that Bax was translocated into mitochondria . ( 3 ) Cell death and the activities of caspases 3 and 8 were promoted in MKN 45 cells stably expressing super repressor Ikappabetaalpha that inhibits NFkappaB activation . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The expression of Bax , Bcl 2 , Bak , and Bcl 10 ( L ) was analyzed by immunoblotting . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Malignant pleural mesothelioma lines and tumors rarely express the antiapoptotic Bcl 2 protein but routinely express the antiapoptotic protein Bcl xl and the proapoptotic proteins Bax and Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Our data demonstrated that Gyp induced apoptotic cell death was accompanied by up regulation of Bax , Bak and Bcl 10 ( L ) , and down regulation of Bcl 2 and Bad , while it had no effect on the level of Bag 1 protein . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Immunoblotting for Bcl 2 family members revealed no significant changes in the expression levels of Bcl 2 , Bcl 10 ( L ) , Bax or Bak following gene or ' chemogene ' therapy with E2F 1 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The proteins studied were Bcl 2 , Bcl xL ( anti apoptotic ) , Bax , Bad , Bak , and Bcl xS ( pro apoptotic ) . ^^^ Higher expression of pro apoptotic Bcl 2 family proteins ( Bak , Bad , Bcl xS ) and higher Bcl xS / Bcl xL ratio were associated with longer survival and decreased risk of leukemic transformation in univariate analysis , whereas expression of anti apoptotic proteins was associated with decreased survival . ^^^ Conversely pro apoptotic proteins Bad , Bak , and Bcl xS were detected in a higher percentage of cells in RA and RAS . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Detailed tissue expression of bcl 2 , bax , bak and bcl 10 in the normal human pancreas and in chronic pancreatitis , ampullary and pancreatic ductal adenocarcinomas . ^^^ METHOD : Expression of bcl 2 , bax , bcl 10 , bak and p 53 was determined in formalin fixed paraffin wax embedded archival specimens of normal pancreatic tissue ( n = 7 ) , chronic pancreatitis ( n = 7 ) , pancreatic ductal adenocarcinoma ( n = 23 ) and ampullary cancer ( n = 7 ) by immunohistochemistry using specific antibodies . ^^^ In pancreatic ductal adenocarcinoma and ampullary cancer , bcl 2 was not detected compared with expression seen in normal acini ( p < 0 . 01 ) , minor ( p < 0 . 001 ) and major ducts ( p < 0 . 01 ) , bax expression was reduced with respect to minor ducts ( p < 0 . 01 ) but no different from normal acini or major ducts . bak and bcl 10 were more strongly expressed in malignant epithelia compared with acini and major ducts but reduced when compared with minor ducts ( p < 0 . 01 ) . ^^^ Differential survival of individual patients was predicted by the relative level of bcl 10 expression but not bax or bak , such that strong expression of bcl 10 was associated with a median postoperative survival of 171 days when compared with 912 days for diminished expression ( p < 0 . 001 ) of bcl 10 . ^^^ CONCLUSION : Pancreatic and ampullary cancer are associated with absent bcl 2 expression . bax , bak and bcl 10 expression was reduced compared with normal minor ducts whilst bak and bcl 10 expression was increased when compared with major ducts . bcl 10 expression correlates with survival following resection and may represent a potential prognosis marker . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Butyrate induced apoptosis correlated with an increase in Bak expression and a decrease in the expression of Bcl XL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
A mutated Bak peptide , which has been shown to be inactive for binding to Bcl 10 ( L ) , did not compete . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
To analyze the mechanisms of the apoptotic activity of Cl F araA , we sought to determine the effects of the drug on the levels of Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak ) and cell survival signals via Akt . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We have investigated whether subsets of indolent B cell non Hodgkin ' s lymphoma ( IB NHL ) differ in the expression of the bcl 2 family members ; 116 cases of IB NHL , composed of chronic lymphocytic leukemia ( CLL , n = 48 ) , follicular lymphoma ( FL , n = 38 ) , marginal zone B cell lymphoma ( MZBCL , n = 15 ) , and mantle cell lymphoma ( MCL , n = 15 ) , were investigated for expression of bcl 2 , bcl 10 , mcl 1 , bax , and bak proteins by immunohistochemistry . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
A survey of molecules involved in TRAIL or Bax mediated apoptotic pathways showed no significant change in expression of death receptors , death decoy receptors ; FLIP ; Bcl 2 ; Bcl xS ; Bax ; Bak ; XIAP or caspase 2 , 7 , 8 , or 9 in either DLD1 / Bax R or DLD1 / TRAIL R cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Induction of apoptosis was assessed by gene expression of apoptosis regulating proteins ( Bcl xL , Bak , and Fas ) according to competitive reverse transcriptase polymerase chain reaction . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Although protein expression of Fas , FADD , Bax , Bak , and Bcl 10 in the whole cell lysates was not changed by H pylori , Bax was decreased from mitochondria free cytosol suggesting that Bax was translocated into mitochondria . ( 3 ) Cell death and the activities of caspases 3 and 8 were promoted in MKN 45 cells stably expressing super repressor IkappaBalpha that inhibits NFkappaB activation . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 , Mcl 1 , Bcl xL / S , Bcl w , Bax , Bak , and Bad were shown to be expressed in both malignant and non neoplastic , normal plasma cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We also detected the expression of Bax , Bak , p 53 , Bcl 2 , Bcl 10 ( L ) , AIF and MRP 1 by Western blots . ^^^ Bcl 2 protein expression was significantly increased in p 50 , p 46 and p 33 transfected cells , while the expression of Bax , Bak , p 53 , Bcl 10 ( L ) and MRP 1 was essentially unchanged . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We hypothesized that apoptosis is a downstream event in erectile dysfunction , and pro apoptotic ( Bak and Bax ) and anti apoptotic ( Bcl 2 and Bcl 10 ) factors are involved in the etiology of aging erectile dysfunction . ^^^ Gene expression of pro apoptotic ( Bak and Bax ) and anti apoptotic ( Bcl 2 and Bcl 10 ) factors were then analyzed by reverse transcription polymerase chain reaction . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In contrast , cytochrome c release from the mitochondria involves dynamic changes in Bcl 2 family proteins ( e . g . up regulation of Bak , Bcl 2 , and Bcl 10 ( L ) ) , opening of permeability transition pore , and loss of mitochondrial membrane potential . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Genistein induced apoptosis in MCF 7 cells involves changes in Bak and Bcl 10 without evidence of anti oestrogenic effects . ^^^ On the other hand , an increased Bak and a reduced Bcl 10 ( L ) was observed at 50 microm genistein by Western analysis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The release of cytochrome c is the central gate in turning on / off apoptosis , and is regulated by the interaction of proapoptotic proteins , including Bid , Bax and Bak , and antiapoptotic proteins including Bcl 2 and Bcl 10 ( L ) , and a specific class of inhibitors of apoptosis proteins ( IAPs ) including Akt , survivin , and heat shock proteins . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 members can either be anti ( Bcl 2 , Bcl 10 ( L ) , Bcl w ) or pro apoptotic ( Bax , Bak , Bid , Bad , Bcl 10 ( S ) ) . ^^^ The expression of the pro apoptotic members Bax , Bak , Bid , and Bcl 10 ( S ) was significantly ( P < 0 . 05 ) decreased after TPN . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The expression of anti apoptotic proteins ( Bcl 2 , Bcl 10 ( L ) ) and pro apoptotic proteins ( Bax , Bcl 10 ( S ) , Bad , and Bak ) in response to cryo injury varied in this cell line panel . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Butyrate induced a clear shift of the mitochondrial bcl rheostat towards a proapoptotic constellation , as demonstrated by upregulation of proapoptotic bak accompanied by reduced antiapoptotic bcl 10 ( L ) levels . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Using cultured prostate cancer ( PC ) cell lines , LN CaP and ALVA 31 , we studied the effects of 1alpha , 25 ( OH ) 2 Vitamin D 3 ( VD 3 ) on expression of several apoptosis regulating proteins including : ( a ) Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , and Bak ) ; ( b ) the heat shock protein 70 binding protein BAG1L ; and ( c ) IAP family proteins ( XIAP , cIAP 1 , and cIAP 2 ) . ^^^ VD 3 induced decreases in levels of antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 , BAG1L , XIAP , cIAP 1 , and cIAP 2 ( without altering proapoptotic Bax and Bak ) in association with increases in apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Hyperplastic pancreatic ductal neoplasms from perillyl alcohol and farnesol treated animals had higher Bak protein expression ( p < 0 . 05 ) , and somewhat higher apoptotic rates , diminished expression of the antiapoptotic protein BCL XL , and lower rates of DNA synthesis than the controls . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
This increased apoptosis was accompanied by decreased antiapoptotic bcl 2 mRNA expression among bcl 2 related genes ( bcl 2 , bax , bak , mcl 1 , and bcl 10 ( L / S ) ) , and the effect was also more prominent in the cagA ( + ) strains . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Nonetheless , there were no significant alterations in the level of Bcl 2 , Bcl 10 ( L ) , Bax and Bak by the proteasome inhibitor , nor any evidence of cytochrome ( cyt ) c release into cytosol from dying cells , suggesting that cyt c is not involved . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
However , loss of Bax , Bak and Bcl Xs did not compromise sensitivity to TRAIL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis was performed with anti ERK1 / 2 , Mcl 1 , Bak , Bcl 10 and Bax antibodies . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
These two mutants still retained the ability to interact with wild type Bcl 2 and Bcl xL , and abrogated the inhibitory effect of wild type Bcl 2 or Bcl xL on Bax or Bak induced apoptosis . ^^^ Taken together , our results demonstrate that Bcl 2 / DeltaBH1 or Bcl 2 / G145A acts as a dominant negative of endogenous anti apoptotic proteins such as Bcl 2 and Bcl xL , thereby enhancing antitumor drug induced apoptosis , and that this dominant negative activity requires both a failure of interaction with Bax and Bak through the BH 1 domain of Bcl 2 and retention of the ability to interact with Bcl 2 and Bcl xL . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In SPMC CM incubated PMN the antiapoptotic gene Bcl xL mRNA and protein expression was up regulated ; Bak mRNA and protein expression was down regulated compared to control PMN . ^^^ These findings suggest that S . aureus activated PMC extend PMN life span by modulating Bcl xL and Bak gene expression and active caspases activity during acute inflammation and empyema . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
LPA had no effect on Bcl xl , Bad , and Bak mRNA or protein expression . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The objective was to evaluate the immunohistochemical expression of p 53 , p 21 , bax , bak , fas , bcl 2 and bcl 10 proteins in 10 endometriomas , 20 benign ovarian tumours ( 10 mucinous , 10 serous ) and 30 malignant ovarian tumours ( 9 mucinous , 19 serous ; 2 endometrioids ) . p 53 positive cells ( mean+ / SD ) in endometriomas , and benign and malignant tumours were 1 . 9+ / 3 . 2 , 0 and 16 . 2+ / 33 . 0 , respectively . ^^^ No difference in bak , fas , bcl 2 or bcl 10 expression was observed among the groups . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
It was revealed that LIGHT treatment resulted in down regulation of anti apoptosis Bcl 2 family member : Bcl 2 , Bcl 10 ( L ) , Bag 1 , and Mcl 1 ; up regulation of pro apoptosis Bcl 2 family member : Bak and Ser ( 112 ) phosphor Bad ; down regulation of pro apoptosis Bcl 2 member Bax ; the other pro apoptosis member Bid remains unaltered . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We also analyzed the relationship between TCF 4 gene splicing isoforms , proliferation ( proliferating cell nuclear antigen labeling index ) , and apoptosis [ antiapoptotic factors ( Bcl 2 and Bcl 10 ( L ) ) , proapoptotic factors ( Bak and Bax ) , and caspase 3 ] in RCC samples . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
PURPOSE : We hypothesized that apoptosis is a downstream event in erectile dysfunction , and pro apoptotic ( Bak and Bax ) and anti apoptotic ( Bcl 2 and Bcl 10 ) factors are involved in the etiology of diabetes induced erectile dysfunction . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
With a serial of Western blot analysis , it is revealed that gossypol induced cell cycle arrest is involved in P 21 up regulation and cyclin D 1 down regulation ; gossypol induced apoptosis triggers down regulation of anti apoptosis Bcl 2 members : Bcl 10 ( L ) , Bag 1 and Mcl 1 , up regulation of pro apoptosis Bcl 2 member Bak , activation of caspase 3 , 6 , 7 , 8 , and 9 , up regulation of Apaf 1 , release of cytochrome c ( cyto c ) from mitochondria , and activation of both DFF 45 and PARP . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Unlike Bcl 2 , Bak stimulates several apoptosis pathways , and by interacting with Bcl 2 or Bcl XL , it counteracts the anti cell death effect . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Furthermore , Bcl 2 family members Bad , Bak , and Bcl xS protein levels were increased in FHIT transfected clones when compared with Panc 1 cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
To further understand such merosin driven survival signaling , we analyzed the expression of five Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) in normal and merosin deficient myotubes , with or without pharmacological inhibitors for Fyn and p 38 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
LPS stimulation induced the expression of Fas , caspase 8 , cellular FLIP Bfl 1 / A1 , and Bcl 10 , but not FasL , TNFR p 55 , Bak , Bax , and Bad at the transcriptional level . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
However , whereas combination treatment applied to in vitro cell culture was characterized by a significant up regulation and activation of Bax and down regulation of Bcl xL , the treatment applied to tumors induced Bak and Bcl xS , whereas Bcl omega and Bcl xL were down regulated . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In contrast , Bcl 10 ( L ) protein bound and suppressed apoptosis induction by Bax , Bak and both BH 3 domain chimeras . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Analysis of the expression of the members of the Bcl 2 family indicated that the synthetic glucocorticoid increased Bax protein levels without affecting the levels of Bcl 2 , Bcl XL , Bcl XS , or Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
These events were associated with Bcl 2 cleavage , Bax , Bak , and Bad accumulation , mitochondrial translocation of Bax , abrogation of Mcl 1 , Bcl xL , and XIAP upregulation , and a marked induction of JNK and p 53 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic family proteins such as Bcl 2 and Bcl 10 ( L ) function , at least in part , by binding proapoptotic members such as Bax and Bak and thereby preventing release of apoptotic proteins , including cytochrome c , from the mitochondria . `` BH 3 only ' ' members of the family disrupt this interaction by binding , via their BH 3 domain , to a hydrophobic pocket on the surface of the antiapoptotic members . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
To investigate the mechanisms responsible for survival and apoptosis / anoikis in normal human intestinal epithelial crypt cells , we analyzed the roles of various signaling pathways and cell adhesion on the expression of six Bcl 2 homologs ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , Bad ) in the well established HIEC 6 cell model . ^^^ For example , the inhibition of the PI 3 K / Akt 1 pathway down regulated Bcl XL , Mcl 1 , and Bad , while at the same time up regulating Bax , whereas the inhibition of Fak up regulated both Bax and Bak , down regulated Bad , and did not affect the other Bcl 2 homologs analyzed . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
This family of proteins now includes both anti apoptotic molecules such as Bcl 2 and Bcl 10 ( L ) , and pro apoptotic molecules such as Bax , Bak , Bid , and Bad . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Ether lipid resistant S49ar cells were cross resistant to extracellular stress factors ( cold shock , heat shock , H2O2 , dimethylsulfoxide ) and to radiation induced apoptosis but not to physiological apoptotic signals ( dexamethasone , growth factor deprivation , thapsigargin , C 2 ceramide ) and expressed similar levels of the apoptosis regulating proteins Bcl 2 , Bcl 10 , Bax , Bad and Bak as did the parent S49wt cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Expression of thymidylate synthase , thymidine phosphorylase , dihydropyrimidine dehydrogenase , E2F 1 , Bak , Bcl 10 , and Bcl 2 , and clinical outcomes for gastric cancer patients treated with bolus 5 fluorouracil . ^^^ We investigated the relationship between the expression of thymidylate synthase ( TS ) , thymidine phosphorylase ( TP ) , dihydropyrimidine dehydrogenase ( DPD ) , E2F 1 , Bcl 2 , Bak , and Bcl 10 , and the chemotherapeutic effects of sequential MTX / 5FU . ^^^ Immunohistochemical reactivity was defined as positive when over 25 % of cancer cells showed strong staining in the cytoplasm for TS , TP , DPD , Bak , Bcl 2 , and Bcl 10 , and in the nucleus for E2F 1 . ^^^ Furthermore , patients negative for both Bak and Bcl 10 had significantly better prognoses than other patients ( MST , 373 days ; p < 0 . 0001 ) . ^^^ Within the limits of the small patient population , multivariate analysis using the Cox proportional hazards model showed that Bak , Bcl 10 , and histological type were independent variables predicting survival ( p=0 . 0008 , 0 . 0081 , and 0 . 0082 , respectively ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The aim of this study was to evaluate odontogenic myxomas for the expression of cell cycle protein Ki 67 , apoptosis regulating proteins Bcl 2 , Bcl XL , Bak , and Bax , and matrix metalloproteinases MMP 2 , MMP 3 , and MMP 9 . ^^^ Twenty six paraffin embedded tissue sections were used in a standard immunohistochemistry protocol and incubated with one of the following antibodies : Bcl 2 , Bcl XL , Bak , Bax , or Ki 67 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
An illustrative example is presented on the use of FCS to assay binding of Alexa 488 labeled Bak peptide with Bcl 10 ( L ) , which is an intracellular protein that acts to protect against programmed cell death . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
METHODS : We performed semi quantitative RT PCR to examine the expression level of bak , bax , bcl 2 and bcl xL in 70 % hepatectomized rat livers during the whole regeneration process and compared to that of the sham and normal groups . ^^^ RESULTS : The expression of bak and bax was decreased whereas that of bcl 2 and bcl xL was increased in hepatectomized animals compared to normal liver at most time points . ^^^ CONCLUSION : The expression changes of bak , bax , bcl 2 and bcl xL genes are altered not only due to regeneration , but also due to effects of surgical operations . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The ability of RB + AR to induce mitochondria damage was dependent on the proapoptotic proteins Bax and Bak and could be blocked by the antiapoptotic protein Bcl 10 ( L ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In addition , other proteins of the BCL family are overexpressed in MCL like BCLX , whereas the expression of BAX and BAK was not elevated in MCL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L , ) Bax , and Bak were expressed at similar levels in cardiac , dermal , and lung fibroblasts . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Antisense transfected cells expressed high levels of Bax and Bak , but low levels of Bcl 2 and Bcl XL when treated with CDDP , peplomycin , 5 fluorouracil or gamma rays . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In contrast to reported observations in acute promyelocytic leukemia , myeloma cell apoptosis was not associated with either the downregulation of Bcl 2 protein or with alterations in the expression of other Bcl 2 family members , Bax , Bak , Bag , and Bcl xl . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Consistent with these findings , apoptosis induced by phenylurea based compounds was not altered by genetic alterations in the expression of Bcl 2 family proteins that control mitochondria dependent cell death pathways , including over expression of anti apoptotic proteins Bcl 2 or Bcl 10 ( L ) and genetic ablation of pro apoptotic proteins Bax and Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In the hippocampus , an increase in pro apoptotic Bcl 2 family proteins Bcl XS and Bak was detected , concomitant with proteolysis of Bcl XL and Bcl 2 , following ischemia reperfusion injury . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
OBJECTIVE : To clarify the in vitro effects of inhibin A ( 1 ) on apoptotic cell death and its mechanisms in ovarian granulosa cells the immunoexpression patterns of the apoptosis markers caspase 3 and pro and anti apoptotic proteins ( Bcl 2 , Bcl xl , Bak ) were evaluated in ovarian granulosa cells collected from women with different hormonal status . ^^^ The expression of caspase 3 , Bak , Bcl 2 , Bcl xl was investigated immunohistochemically . ^^^ Inhibin A exposition enhanced the immunoexpression of prooncogenes ( Bcl 2 , Bcl xl ) and reduced the expression of caspase 3 and pro apoptotic protein Bak in ovarian granulosa cells from the three experimental groups . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 , Bcl xl , Bak and Bax proteins in axons of the optic nerve in closed angle glaucoma ] . ^^^ PURPOSE : The aim of our study was the evaluation of Bcl 2 , Bcl xl , Bak and Bax immunoexpression in axons of the optic nerve with absolute glaucoma . ^^^ The samples were immuno stained with antibodies for Bcl 2 , Bak , Bax and Bcl xl protein . ^^^ RESULTS : In our study proapoptotic Bak and Bax protein expression was stronger than antiapoptotic Bcl 2 , Bcl xl protein expression ; Bak / Bcl 2 ( p = 0 . 008 ) , Bax / Bcl 2 ( p = 0 . 0007 ) , Bak / Bcl xl ( p = 0 . 0356 ) , Bax / Bcl xl ( p = 0 . 0077 ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
MATERIALS AND METHODS : The combined immunohistochemical expression levels of the proteins bax , bak , bad , bid , bcl 2 and bcl xl were evaluated by cluster and discriminant analysis . ^^^ RESULTS : Cluster analysis produced : a ) a low expression ( 69 / 79 cases ) and a high expression pro apoptotic cluster ( 10 / 79 cases ) for the combined expression levels of the pro apoptotic proteins bax , bak , bad and bid and b ) a low expression ( 37 / 76 cases ) and a high expression antiapoptotic cluster ( 39 / 76 cases ) for the combined expression levels of anti apoptotic proteins bcl 2 and bcl xl . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In addition , Bcl 2 , Bcl xL , Bax , and Bak localized in the mitochondria were detected . ^^^ In these rats , mitochondrial wt p 53 was significantly inhibited through decreased mitochondrial localization of wt p 53 and increased cytosolic p 53 , resulting in the upregulation of Bcl 2 and Bcl xL and the downregulation of Bak in the mitochondria . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Overexpression of Bcl 2 or Bcl 10 ( L ) , loss of Bax or Bak function , high expression of inhibitor of apoptosis proteins , and reduced release of second mitochondria derived activator of caspases ( Smac / Diablo ) from the mitochondria to the cytosol have all been reported to result in TRAIL resistance in mitochondria dependent type 2 cancer cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Induction of apoptosis was confirmed by the appearance of sub G 1 populations , and apoptosis cascade involved upregulation of the apoptosis enhancing proteins ( Bak and Bcl xS ) and downregulation of the apoptosis suppressing proteins ( Bcl xL and Bcl 2 ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Cotreatment with 17 AAG and SAHA also induced down regulation of Mcl 1 , Bcl xL , and B Raf ; up regulation of Bak ; cleavage of 14 3 3 proteins ; and a profound conformational change in Bax accompanied by translocation to the membrane fraction . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The major antiapoptotic family members , Bcl 10 ( L ) and Bcl 2 , and the major proapoptotic proteins , Bax and Bak , show distinct temporal and spatial patterns of expression in the developing brain . ^^^ Targeted deletions of Bcl 10 ( L ) and Bcl 2 as well as Bax and Bak have proven to be important tools in delineating the process of cell death in the nervous system . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bcl xl and Bak protein expression in human optic nerve axons in eyeballs post trauma and in the eyes with absolute glaucoma . ^^^ The aim of our study was an evaluation of Bcl xl and Bak protein expressions in optic nerve axons in eyeballs after severe injury and absolute glaucoma . ^^^ The immunohistochemical reaction was performed , using antibodies against human Bcl xl and Bak protein with LSAB and DAB . ^^^ In the injured eyeballs in Group 1 , Bcl xl protein expression was observed in 53 . 8 % , Bak in 38 . 5 % , in Group 2 , Bcl xl in 40 % , Bak 55 % ; in Group 3 , Bcl xl in 62 . 5 % , Bak in 62 . 5 % . ^^^ Nine ( 9 ) , out of 19 ( 47 . 4 % ) cases showed Bcl xl protein positivity , Bak 15 , out of 19 ( 78 . 9 % ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
As expected ( ) gossypol induced complete cytochrome c release from mitochondria , increased caspases 3 and 9 activity , and caused apoptotic death without affecting protein levels of Bcl 2 , Bcl 10 ( L ) , Bax , and Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Additionally , ( ) gossypol was more efficient than etoposide at inducing caspase 3 activation and phosphatidylserine externalization in the setting of Bcl 2 or Bcl 10 ( L ) overexpression . ( ) Gossypol induced apoptosis was associated with Bak activation and release of cytochrome c from mitochondria , suggesting a mitochondrial mediated apoptotic mechanism . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Pathologic assay was performed with terminal deoxynucleotidyl transferase mediated dUTP in situ nick end labeling ( TUNEL ) and hematoxylin and eosin ( HE ) staining . mRNA of Bcl xL and Bak were measured . ^^^ There were more TUNEL positive cells in the LVAD group than in the control group . mRNA of Bcl xL and Bak in LVAD group were high . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In the SCP group , p 53 protein expression was observed in 30 cases ( 66 . 6 % ) , Ki 67 in 14 ( 31 . 1 % ) , PCNA in 44 ( 97 . 8 % ) , Bcl 2 in 24 ( 53 . 3 % ) , Bak in 28 ( 62 . 2 % ) , Bax in 31 ( 68 . 9 % ) , and Bcl xl in 11 ( 100 % ) . ^^^ In the SCC group , p 53 protein expression was evaluated in 8 cases ( 72 . 8 % ) , Ki 67 in 2 ( 18 . 2 % ) , PCNA in 8 ( 72 . 7 % ) , Bcl 2 in 5 ( 45 . 4 % ) , Bax and Bak both in 10 ( 90 . 9 % ) , and Bcl xl in 100 % . ^^^ In the BCC group , p 53 protein expression was estimated in 23 cases ( 85 . 1 % ) , Ki 67 in 13 ( 48 . 1 % ) , PCNA in 26 ( 96 . 2 % ) , Bcl 2 in 13 ( 48 . 1 % ) , Bak in 21 ( 77 . 8 % ) , Bax in 22 ( 81 . 5 % ) , and Bcl xl in 23 ( 85 . 2 % ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The present study demonstrates the role of Bax but not Bak as a critical regulator of curcumin induced apoptosis and implies the potential of targeting antiapoptotic proteins like Bcl XL or overexpression of proapoptotic proteins like Smac as interventional approaches to deal with Bax deficient chemo resistant cancers for curcumin based therapy . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Specifically , we observe that Abeta significantly reduces expression of antiapoptotic Bcl w and Bcl 10 ( L ) , mildly affects expression of bim , Bcl 2 , and bax , but does not alter expression of bak , bad , bik , bid , or BNIP3 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Real time reverse transcription polymerase chain reaction revealed that IGF 1 significantly decreased the mRNA expression ( pro apoptotic gene Fas or Bak and anti apoptotic gene Bcl xL ) ratios of both Fas / Bcl xL ( P < 0 . 01 ) and Bak / Bcl xL ( P < 0 . 01 ) in the presence of 0 . 4 % BSA . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) specifically activates Bak to induce swelling and restructuring of the endoplasmic reticulum . ^^^ Coexpression of Bak and Bcl 10 ( L ) provokes extensive swelling and vacuolization of reticular cisternae . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Treatment of PC 3 cells with troglitazone or Delta 2 TG led to reduced association of Bcl 2 and Bcl xL with Bak , leading to caspase dependent apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Western blot analyses revealed that CT induced an elevation of bcl xL but not bcl 2 or proapoptotic factors bax , bak , and bad . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In contrast , inhibition of MCT 1 expression had no effect on the ability of butyrate to modulate expression of either bcl XL or bak , and this was reflected in a corresponding lack of effect on butyrate induction of apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Indeed , bortezomib induced increases of Bik and / or Bim in multiple cell lines but not notably of two other BH 3 only proteins ( Puma and Bid ) nor other family members ( Bax , Bak , Bcl 2 , and Bcl xL ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In the heart , this cytosolic HSP 60 complexes with Bax , Bak and Bcl XL , but not with Bcl 2 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The PEITC induced apoptosis in TRAMP derived cells was associated with a marked increase in the level of proapoptotic protein Bak and / or a decrease in the levels of antiapoptotic protein Mcl 1 or Bcl xL and disruption of mitochondrial membrane potential . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
To characterize the mechanisms of apoptosis induction by proteasome inhibitors , we examined levels of Bcl 2 protein family members ( Bik / NBK , Bax , Bak , Bcl 2 , and Bcl XL ) , release of cytochrome c , and activation of caspase 9 and 3 in human colon cancer cell lines DLD 1 , LOVO , SW 620 , and HCT 116 ; human lung cancer cell line H 1299 ; and human ovarian cancer cell line SKOV 3 after they were treated with bortezomib . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Terephthalamide derivatives as mimetics of helical peptides : disruption of the Bcl 10 ( L ) / Bak interaction . ^^^ A series of Bcl 10 ( L ) / Bak antagonists , based on a terephthalamide scaffold , was designed to mimic the alpha helical region of the Bak peptide . ^^^ These molecules showed favorable in vitro activities in disrupting the Bcl 10 ( L ) / Bak BH 3 domain complex ( terephthalamides 9 and 26 , K ( 1 ) = 0 . 78 + / 0 . 07 and 1 . 85 + / 0 . 32 microM , respectively ) . ^^^ Extensive structure affinity studies demonstrated a correlation between the ability of terephthalamide derivatives to disrupt Bcl 10 ( L ) / Bak complex formation and the size of variable side chains on these molecules . ^^^ Computational docking simulations and NMR experiments suggested that the binding cleft for the BH 3 domain of the Bak peptide on the surface of Bcl 10 ( L ) is the target area for these synthetic inhibitors . . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Here we used embryonic fibroblasts derived from mice deficient in the multidomain proapoptotic members of the Bcl 2 family ( Bax and Bak ) and the apoptotic components of the apoptosome ( Apaf 1 and caspase 9 ) to unravel the cascade of events by which Bcl 10 ( S ) promotes apoptosis . ^^^ Our results show that Bak but not Bax is essential for Bcl 10 ( S ) induced apoptosis . ^^^ Bcl 10 ( S ) induced activation of Bak , which in turn promoted apoptosis by apoptosome dependent and independent pathways . ^^^ Bak but not Bax is essential for Bcl xS induced apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We have investigated the regulation of Bak and find that , in healthy cells , Bak associates with Mcl 1 and Bcl 10 ( L ) but surprisingly not Bcl 2 , Bcl w , or A 1 . ^^^ When cytotoxic signals activate BH 3 only proteins that can engage both Mcl 1 and Bcl 10 ( L ) ( such as Noxa plus Bad ) , Bak is displaced and induces cell death . ^^^ Accordingly , the BH 3 only protein Noxa could bind to Mcl 1 , displace Bak , and promote Mcl 1 degradation , but Bak mediated cell death also required neutralization of Bcl 10 ( L ) by other BH 3 only proteins . ^^^ The results indicate that Bak is held in check solely by Mcl 1 and Bcl 10 ( L ) and induces apoptosis only if freed from both . ^^^ Proapoptotic Bak is sequestered by Mcl 1 and Bcl xL , but not Bcl 2 , until displaced by BH 3 only proteins . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The overexpression of Bcl xL enhances autophagic cell death when apoptotic cell death is inhibited in Bax ( / ) / Bak ( / ) double knockout cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Using immunohistochemistry the groups were compared for expression of apoptotic proteins : bcl 2 , bcl 10 ( L ) , bax , bak and survivin . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Haploidy influences Bak and Bcl xL mRNA expression and increases incidence of apoptosis in porcine embryos . ^^^ The relative abundance of Bcl xL and Bak mRNA in the diploid blastocysts was similar to that of in vivo fertilized embryos . ^^^ However , Bcl xL was significantly decreased , and Bak mRNA was significantly increased ( p < 0 . 05 ) in haploid parthenotes compared with the diploid parthenotes . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The expression levels of Mcl 1 and Bcl XL but not those of Bcl 2 , Bax , and Bak were suppressed by TSA or SK 7041 treatment . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
This pathway is regulated by bcl 2 family of anti apoptotic ( bcl 2 , bcl xl , mcl 1 ) and pro apoptotic proteins ( bax , bad , bak ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The results showed that Bcl 2 family molecules , such as Bid , Bak , and Bax , are involved in the parthenolide induced apoptosis and that the defective expression of Bcl 10 ( L ) might contribute to the higher parthenolide sensitivity in the SCK cells than in the other adenomatous cholangiocarcinoma cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The enhanced TRAIL effect after pretreatment with HDAC inhibitors was consistent with the upregulation of the proapoptotic Bcl 2 family members ( Bim , Bak , Bax , Noxa , and PUMA ) , the downregulation of the anti apoptotic members of the Bcl 2 family ( Bcl 2 and Bcl 10 ( L ) ) , and IAPs . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Using a sequential synthetic strategy , we have prepared a library of terphenyl derivatives to mimic the helical region of the Bak BH 3 domain that binds Bcl 10 ( L ) . ^^^ Fluorescence polarization assays were carried out to evaluate the ability of terphenyl derivatives to displace the Bcl 10 ( L ) bound Bak peptide . ^^^ These terphenyl derivatives were more selective at disrupting the Bcl 10 ( L ) / Bak over the HDM2 / p53 interaction , which involves binding of the N terminal alpha helix of p 53 to HDM 2 . ^^^ Terphenyl Based Bak BH 3 alpha helical proteomimetics as low molecular weight antagonists of Bcl xL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In addition , antiapoptotic Bcl 2 and Bcl 10 ( L ) levels were increased and pro apoptotic Bax and Bak levels were decreased in the HIF 1alpha overexpressing OSCC line . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic family proteins such as Bcl 2 and Bcl XL function , at least in part , by binding proapoptotic members such as Bax and Bak and thereby prevent release of the apoptotic cascade of events . `` BH 3 only ' ' members of the family disrupt this interaction by binding , via their BH 3 domain , to a hydrophobic pocket on the surface of the antiapoptotic members . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Similarly , although etoposide induced apoptosis was inhibited in Bax ( / ) / Bak ( / ) mouse embryonic fibroblasts , autophagy was not inhibited , which was regulated by Bcl xL . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Subsequent studies showed that combined treatment with bortezomib or MG 132 resulted in an increase of death receptor ( DR ) 5 and Bik at protein levels but had no effects on protein levels of DR 4 , Bax , Bak , Bcl 2 , Bcl XL or Flice inhibitory protein ( FLIP ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
MEK activation led to increased expression of COX 2 , Bcl 10 ( L ) , Mcl 1 , and phosphorylated Bad and decreased expression of Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
This was associated with up regulation of the pro death Bak and Bim , as well as with attenuation of the levels of Her 2 and XIAP , survivin , Bcl 2 , and Bcl 10 ( L ) proteins . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Immunoblot analysis revealed that PFE treatment of PC 3 cells resulted in ( 1 ) induction of Bax and Bak ( proapoptotic ) ; ( 2 ) down regulation of Bcl 10 ( L ) and Bcl 2 ( antiapoptotic ) ; ( 3 ) induction of WAF1 / p21 and KIP1 / p27 ; ( 4 ) a decrease in cyclins D 1 , D 2 , and E ; and ( 5 ) a decrease in cyclin dependent kinase ( cdk ) 2 , cdk 4 , and cdk 6 expression . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Levels of other Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Bad , Bak , Bax ) were unaffected by simultaneous ATRA and TGF beta 1 treatment , when compared to ATRA alone . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Upregulation of caspase 1 , 2 , 3 , 6 , 7 , 8 , 11 and 12 and upregulation for the transcripts of apoptosis inhibitors bcl 2 , bcl w and bcl 10 and apoptosis promoters ' bax , bak and bad was detected in spleens of sPCV and mPCV mice , but not control mice . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
This BEA induced apoptosis in human NSCLC A 549 cells was also accompanied by the up regulation of Bax , Bak , and p Bad and down regulation of p Bcl 2 , but no effect on the levels of Bcl 10 ( L ) or Bad proteins . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Expression of pro apoptotic ( p 53 , p 21 , bax , bak and fas ) and anti apoptotic ( bcl 2 and bcl 10 ) proteins in serous versus mucinous borderline ovarian tumours . ^^^ MATERIALS AND METHODS : Immunohistochemical expression of pro apoptotic ( p 53 , p 21 , bax , bak , fas ) and anti apoptotic proteins ( bcl 2 , bcl 10 ) was determined in 34 borderline ( 19 mucinous , 15 serous ) , 20 benign ( 10 mucinous , 10 serous ) and 28 malignant ovarian tumours ( 9 mucinous , 19 serous ) . ^^^ No difference in bax , bak , fas or bcl 10 expression was observed among the three tumour types . ^^^ No difference in p 53 , bax , bak , fas or bcl 10 expression was observed between serous and mucinous borderline ovarian tumours . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In addition , chalcone also triggered the mitochondrial apoptotic signaling by increasing the amount of Bax and Bak and reducing the level of Bcl 2 and Bcl 10 ( L ) , and subsequently activated caspase 9 in MCF 7 and MDA MB 231 cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis indicated that the induction of apoptosis by GA and ursolic acid was accompanied with an activation of caspase 8 and a reduction in the anti apoptotic proteins , Bcl 2 and Bcl xL , although the pro apoptotic proteins , Bax and Bak , remained unaffected . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
While the expression of Bax , Bak , and Bcl 2 was comparable to the wild type cells , the selected clones showed specific up regulation of Bcl XL , an anti apoptotic protein . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Chi square analysis revealed no association between expression of Bcl 2 , Bcl XL , Bad , Bak , Bid or p 53 proteins and response to vinorelbine therapy . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
A preparation of mitochondria heated at 43 degrees C released cytochrome c in association with Bak oligomerization , and Bcl xL prevented these events . ^^^ Cytosol from untreated cells inhibited heat activated Bax or Bak ; however , depletion of cytosolic Bcl xL ablated this protection . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Cytotrophoblasts also expressed a 2 fold higher level of p 53 , a 2 fold lower level of 60 kDa Mdm 2 protein , a 2 fold higher level of Bak , but no differences in the expression of 90 kDa Mdm 2 , Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bad , and Bad phosphorylated at the serine ( 112 ) , serine ( 136 ) , or serine ( 155 ) sites , compared to the syncytiotrophoblasts . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The pro apoptotic Bcl 2 family proteins , Bak , Bax , and Bim have been shown to be required for disruption of mitochondria and intrinsic cell death of self reactive B cells whereas the anti apoptotic Bcl 2 , Bcl xL , and Mcl 1 can prevent cell death by interfering with the action of Bax and Bak . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bak expression in S . pombe is lethal and this lethality is rescued by co expression of bcl 2 or bcl 10 ( L ) . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Following cisplatin treatment , the expression of Bcl xL , an antiapoptotic molecule , was suppressed , while the expression of Bak , a proapoptotic molecule , increased slightly . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Hepatic mRNA levels were measured for several pro apoptotic adaptors / regulators , including FasL , Fas receptor , FADD , TRADD , Bad , Bak , Bax , and Bcl 10 ( S ) , and anti apoptotic regulators , including Bcl w , Bcl 10 ( L ) , Bcl 2 , and Bfl 1 . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
We detected time and concentration dependent changes in protein expression of anti apoptotic Bcl 10 ( L ) as well as pro apoptotic Bax and Bak proteins . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
These responses on UVB and / or sanguinarine treatments were associated with ( a ) decrease in Bcl 2 and Bcl 10 ( L ) and ( b ) increase in Bax , Bid , and Bak protein levels . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
In vitro data indicate that alpha tocopheryl succinate was able to disrupt the binding of Bak BH 3 peptide to Bcl xL and Bcl 2 with IC 50 of 26 microm , in line with its potency in antiproliferation . ^^^ Treatment of PC 3 cells with this agent led to reduced association of Bcl 2 and Bcl xL with Bak , leading to caspase dependent apoptosis . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
However , Bad was translocated from the cytosol into the mitochondria , where it bound to Bcl xL , and Bak was dissociated from Bcl xL and conformationally changed . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemistry was employed to examine the expression of the antiapoptotic proteins Bcl 2 and Bcl XL and the proapoptotic proteins Bad , Bak , Bax , Bid , Bim , and p 53 in 21 cases of gastric cancer . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
There was no evidence that calpain cleaved Bcl 2 family member proteins that regulate mitochondrial membrane permeability including Bcl 2 , Bcl xl , Bad , Bak , Bid , or Bim . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
RESULTS : Etoposide treatment ( 1 ) induced apoptosis in one clone , ES , but not in another clone , ER , ( 2 ) had no effect on the expression of the antiapoptotic proteins Bcl 2 and Bcl 10 ( L ) in both cell clones , whereas the proapoptotic proteins Bak and Bax were dramatically upregulated in ES , but not ER cells , and ( 3 ) induced more extensive processing of procaspase 8 , procaspase 9 , and the caspase 3 targeted substrates , topoisomerase 1 and PARP , in ES cells . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Justicidin A also reduced Bcl 10 ( L ) and increased Bax and Bak in mitochondria . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
The proapoptotic proteins Bax and Bak are required for MOMP , while the antiapoptotic Bcl 2 proteins , including Bcl 2 , Bcl xL , Mcl 1 , and others , prevent MOMP . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Three groups of the Bcl 2 family proteins can be distinguished : the antiapoptotic proteins , like Bcl 2 and Bcl 10 L , the pro apoptotic members e . g . , Bax , Bak and the BH 3 only proteins . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Bcl xL is overexpressed in hormone resistant prostate cancer and promotes survival of LNCaP cells via interaction with proapoptotic Bak . ^^^ We investigated the role of antiapoptotic Bcl xL in the progression of prostate cancer as well as the interactions of Bcl xL with proapoptotic Bax and Bak in androgen dependent and independent prostate cancer cells . ^^^ In vivo interactions of Bcl xL with Bax or Bak in untreated and camptothecin treated LNCaP and PC 3 cells were investigated by means of coimmunoprecipitation . ^^^ In the absence of any stimuli , Bcl xL interacts with Bax and Bak in androgen independent PC 3 cells but only with Bak in androgen dependent LNCaP cells . ^^^ Interactions of Bcl xL with Bax and Bak were also evidenced in lysates from high grade prostate cancer tissues . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^ Furthermore , Mcl 1 and Bcl 10 ( L ) , but not Bcl 2 , directly sequester Bak in healthy cells , and Bak is freed only when BH 3 only proteins neutralize both its guards . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
Furthermore , we observed an increase in antiapoptotic Bcl 10 and a concurrent decrease in proapoptotic Bak solely in HLRCC leiomyomas . ^^^
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
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Interacting proteins: Q16611 and Q07817	Pubmed	SVM Score :0.0
NA