| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of BCL 10 ( L ) prevented processing of caspase 8 in LN 18 cells but not in LN 229 cells . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Western blot assessed caspase 3 , caspase 8 , Bcl 2 , and Bcl XL protein expression . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| No changes were noted in the expression of mRNAs encoding Bcl 2 , Bcl xL , Bax , caspase 8 , caspase 3 , or GAPDH . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Curcumin induced activation of caspase 8 was blocked by Ku 70 but not by Bcl XL . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| TCDD did not cause significant changes in the relative gene expression of caspase 8 , Bcl 2 and Bcl xL . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| After Doxo treatment , enhanced CD95 / CD95 L expression and caspase 8 activation were not blocked by Bcl 2 or Bcl 10 ( L ) and were found in cells with a mitochondrial transmembrane potential ( delta psi ( m ) ) that was still normal ( delta psi ( m ) high cells ) . ^^^ In marked contrast , after Bet A treatment , caspase 8 activation occurred in a Bcl 2 or Bcl 10 ( L ) inhibitable fashion and was confined to cells that had lost their delta psi ( m ) ( delta psi ( m ) low cells ) . ^^^ In contrast to caspase 8 , cleavage of caspase 3 or poly ( ADP ribose ) polymerase was always restricted to delta psi ( m ) low cells , downstream of the Bcl 2 or Bcl 10 ( L ) controlled checkpoint of apoptosis . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Detachment induced caspase 8 activation did not require the function of downstream caspases but was blocked by overexpression of the anti apoptotic proteins Bcl 2 or Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| HIP 1 activity was found to be independent of the DED containing caspase 8 but was significantly inhibited by the antiapoptotic protein Bcl 10 ( L ) , implicating the intrinsic pathway of apoptosis in HIP 1 induced cell death . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Overexpression of Bcl 10 ( L ) prevented the processing of caspase 8 as well as caspase 9 , 6 and Bid in response to drugs , but was less effective in CD 95 induced apoptosis . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 activation and apoptosis were independent of CD 95 ligation and evidenced only for concentrations inducing Bcl 10 ( L ) phosphorylation and a decrease in mitochondria permeability . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Furthermore we observed cleavage of both caspase 9 and caspase 8 after overexpression of p 53 and found that p 53 dependent apoptosis was inhibited by either cellular ( c Flip s , Bcl 10 ( L ) ) or pharmacological inhibitors of caspase 8 or caspase 9 respectively . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Importantly , 16 10A1 could retard the growth of lymphomas and favored the up regulation of pro apoptotic molecules caspase 3 , caspase 8 , Fas , FasL , Bak , and Bax and down regulation of anti apoptotic molecule Bcl 10 ( L ) . ^^^ In contrast , GL 1 augmented the level of anti apoptotic molecules Bcl w and Bcl 10 ( L ) and decreased the levels of pro apoptotic molecule caspase 8 , thereby providing a novel insight into the mechanism whereby triggering through CD 80 and CD 86 could deliver regulatory signals . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , activation of caspase 8 in control ( vector ) and Bcl 10 ( L ) transfectants of MCF 7 Fas cells proceeds with similar kinetics , resulting in a complete processing of cellular caspase 8 . ^^^ Most of the cytosolic caspase 8 substrates are not cleaved in the Bcl 10 ( L ) protected cells , raising the question of how Bcl 10 ( L ) expressing MCF 7 Fas cells survive large amounts of potentially cytotoxic caspase 8 . ^^^ We now demonstrate that active caspase 8 is initially generated at the DISC of both MCF 7 Fas Vec and MCF 7 Fas Bcl 10 ( L ) cells and that the early steps of CD 95 signaling such as caspase 8 dependent cleavage of DISC bound c FLIP ( L ) , caspase 8 dependent clustering , and internalization of CD 95 , as well as processing of pro caspase 8 bound to mitochondria are very similar in both transfectants . ^^^ However , events downstream of mitochondria , such as release of cytochrome c , only occur in the vector transfected MCF 7 Fas cells , and no in vivo caspase 8 activity can be detected in the Bcl 10 ( L ) expressing cells . ^^^ Our data suggest that , in Bcl 10 ( L ) expressing MCF 7 Fas cells , active caspase 8 is sequestered on the outer mitochondrial surface presumably by association with the protein `` bifunctional apoptosis regulator ' ' in a way that does not allow substrates to be cleaved , identifying a novel mechanism of regulation of apoptosis sensitivity by mitochondrial Bcl 10 ( L ) . . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Expression of apoptosis related genes such as Bax , Bcl 10 ( L ) , Bcl 2 or caspase 8 were reduced by p27Kip1 transduction compared with that of beta actin , whereas p27Kip1 transduction did not affect the expression level of Fas or the Fas ligand . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Indeed , DC activation effectively inhibited DC apoptosis , which was predominantly accompanied by the upregulation of Bcl 10 ( L ) and to a lesser extent Bcl 2 , while Bax and FLICE inhibitory protein ( FLIP ) remained unchanged . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Blood and liver were analyzed for plasma aminotransferase activity , liver histology , liver apoptotic nuclei , mRNA of several cytokines ( tumor necrosis factor [ TNF ] alpha , interleukin [ IL ] 1beta , IL 6 , and IL 10 ) , apoptotic ligands ( TRAIL ) , cytokine receptors ( TNFRp 55 ) , pro and antiapoptotic regulators / adaptors ( Fas receptor , FasL , FADD , TRADD , RIP , Bak , Bax , Bcl 10 , Bcl 2 and Bcl w ) , and caspase 8 . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Similarities between preparations included : an enhanced ability for both Apo2L / TRAIL preparations to kill a greater relative percentage of HaCaT cells compared with keratinocytes ; enhanced cytotoxicity towards keratinocytes that had their NF B activity inhibited ; a dependence of both Apo2L / TRAIL preparations on FADD and caspase activation ; triggering of the same caspase cascades including caspase 8 and 3 ; and an ability to induce apoptosis even when HaCaT cells and keratinocytes were transduced to overexpress either Bcl 2 or Bcl 10 ( L ) ( survival factors that reduce susceptibility to UV light induced apoptosis ) . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| DES induced the expression of 12 genes ( bad , bax , bcl 10 , caspase 1 , p 53 , cyclin D 3 , GADD 45 , p 21 , p 15 , p 27 , p 57 and Skp 1 ) and down regulated the expression of eight genes ( bcl 2 , caspase 2 , caspase 7 , caspase 8 , E 124 , iNOS , mdm 2 and NFkappab 1 ) at twofold or greater levels . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , SK BR 3 breast tumour cells exhibiting increased expression level of Bcl 10 ( L ) were resistant to TRAIL , though upon exposure to TRAIL , caspase 8 and Bid were activated . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This review focuses on novel strategies to induce apoptosis in glioma cells by transduction with adenoviral vectors carrying a variety of apoptosis related genes , including Fas ligand , Fas , FADD , caspase 8 , p 53 , p33ING1 , p73alpha , Bax , Apaf 1 , caspase 9 , IkappaBdN , caspase 3 , Bcl 2 , and Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| LPS stimulation induced the expression of Fas , caspase 8 , cellular FLIP Bfl 1 / A1 , and Bcl 10 , but not FasL , TNFR p 55 , Bak , Bax , and Bad at the transcriptional level . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Lethal effects were significantly diminished in U 937 cells ectopically expressing dominant negative caspase 8 , dominant negative Fas associated death domain , CrmA ( receptor pathway ) , or Bcl 2 or Bcl 10 ( L ) ( mitochondrial pathway ) . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Furthermore , this apoptosis is coincident with a loss of mitochondrial membrane potential and is inhibited by either overexpression of bcl 10 ( L ) or the presence of inhibitors of caspase 8 , 9 , or 3 activity . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Bcl 2 and Bcl 10 ( L ) overexpression but not lack of caspase 8 protects the Jurkat cells from the anticancer drug induced cytolysis . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Coadministration of TRAIL markedly increased FP induced apoptosis in leukemic cells ectopically expressing Bcl 2 , Bcl 10 ( L ) , or a phosphorylation loop deleted form of Bcl 2 ( DeltaBcl 2 ) , whereas lethality was substantially attenuated in cells ectopically expressing CrmA , dominant negative FADD , or dominant negative caspase 8 . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Infection of these cells with an adenoviral vector transducing the Fhit gene ( Ad Fhit ) revealed that complete protection from apoptosis was conferred by the inhibitor of caspases Cytokine response modifier A ( CrmA ) and by a dominant negative form of the adapter protein Fas associated death domain ( FADD ) and partial protection by a dominant negative form of caspase 8 , while cells over expressing mitochondrial mediators of the apoptotic response such as Bcl 2 or Bcl 10 ( L ) that are resistant to treatment with cisplatin , remained highly susceptible to cell death triggered by Fhit gene transfer . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Our results demonstrated that 16 genes ; bad , bax , bcl 2 , bcl w , bcl 10 , caspase 3 , caspase 7 , caspase 8 , c myc , E 124 , GADD 45 , mdm 2 , NKkappab 1 , p 53 , p 21 , Rb and trail were up regulated and six genes ; caspase 1 , caspase 2 , DR 5 , E2F1 , FasL and iNOS did not changed in response to DES treatment in wild type mice compared to p53+ / knockout mice . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Bcl 10 ( L ) expression inhibited caspase 8 cleavage and death inducing signal complex ( DISC ) formation in plasma membrane . ^^^ GRASP 65 , a Golgi associated protein , physically associated with Fas and caspase 8 ; Bcl 10 ( L ) expression decreased these associations . ^^^ Bcl 10 ( L ) expression also up regulated FLIP , a caspase 8 inhibitor . ^^^ In conclusion , Bcl 10 ( L ) may inactivate caspase 8 by decreasing DISC formation in the plasma membrane , nucleus , and Golgi complex while diverting DISC formation to the mitochondria . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Here we showed that , besides the specific cleavage and activation of Bid by caspase 8 and caspase 3 , TRAIL induced apoptosis in Jurkat T cells required the specific cleavage of Mcl 1 at Asp 127 and Asp 157 by caspase 3 , while other prototypic antiapoptotic factors such as Bcl 2 or Bcl 10 ( L ) seemed not to be affected . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In these models , both SAHA and m carboxycinnamic acid bis hydroxamide induced growth arrest and caspase mediated apoptosis and increased p 21 protein levels , retinoblastoma hypophosphorylation , BH 3 interacting domain death agonist cleavage , Bax up regulation , down regulation of Bcl 2 , A 1 , and Bcl 10 ( L ) expression , and cleavage of poly ( ADP ribose ) polymerase and caspase 8 , 9 , 3 , 7 , and 2 . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Combining the Bcl 10 ( L ) siRNA with TRAIL protein treatment resulted in an increase in the percentage of apoptotic cells and increased cleavage of caspase 8 , caspase 9 , caspase 3 and PARP . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analysis for major antiapoptotic proteins showed considerable up regulation of the short form of cellular FLIP ( cFLIP ) and Bcl 10 ( L ) in BD activated T cells , while levels of Bcl 2 , caspase 3 , and caspase 8 in activated T cells from patients with BD were comparable with those in activated T cells from normal donors . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Similarly , immunoreactivity for the apoptotic signals Fas , Fas ligand , Bax , Bcl 10 , caspase 8 , caspase 9 and caspase 3 was absent from the NBM of AD and control brains . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| As discussed in this Review , insight gained from these studies indicates that cFLIP and caspase 8 form a heterodimer that ultimately links T cell receptor signalling to activation of nuclear factor kappaB through a complex that includes B cell lymphoma 10 ( BCL 10 ) , mucosa associated lymphoid tissue lymphoma translocation gene 1 ( MALT 1 ) and receptor interacting protein 1 ( RIP 1 ) . . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Further analysis of mRNA and protein expression levels of apoptosis signaling molecules FADD , receptor interacting protein , hematopoietic cell protein tyrosine phosphatase , Fas associated phosphatase 1 , FLICE , bel 2 , bcl xL , and , bax alpha showed that only the expression level of bcl xL correlated with T cell resistance to CD 95 mediated apoptosis ( day 1 T cells : bcl xhiL ; day 6 T cells : bcl XloL ) . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Bcl xL acts downstream of caspase 8 activation by the CD 95 death inducing signaling complex . ^^^ We have shown recently that in peripheral human T cells resistance to CD 95 mediated apoptosis is characterized by a lack of caspase 8 recruitment to the CD 95 death inducing signaling complex ( DISC ) and by increased expression of Bcl xL ( Peter , M . ^^^ This raises the possibility that Bcl xL directly prevents caspase 8 activation by the DISC . ^^^ In these MCF 7 Fas bcl xL cells Bcl xL had no effect on the recruitment of caspase 8 to the DISC . ^^^ To test whether Bcl xL would inhibit active caspase 8 subunits in the cytoplasm , a number of immunoprecipitation experiments were performed . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Bcl xL functions downstream of caspase 8 to inhibit Fas and tumor necrosis factor receptor 1 induced apoptosis of MCF 7 breast carcinoma cells . ^^^ To address the effect of Bcl xL on caspase 8 processing , Fas and TNFR 1 mediated apoptosis were studied in the MCF 7 breast carcinoma cell line stably transfected with human Fas cDNA ( MCF7 / F ) or double transfected with Fas and human Bcl xL cDNAs ( MCF7 / FB ) . ^^^ Moreover , apoptosis induced by direct microinjection of recombinant , active caspase 8 was completely inhibited by Bcl xL . ^^^ These data demonstrate that Bcl xL can exert an anti apoptotic function in cells in which caspase 8 is activated . ^^^ Thus , at least in some cells , caspase 8 signaling in response to Fas or TNFR 1 stimulation is regulated by a Bcl xL inhibitable step . . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , in type 2 but not type 1 cells , overexpression of Bcl 2 or Bcl xL blocked caspase 8 and caspase 3 activation as well as apoptosis . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We demonstrate here that E1B 19K and Bcl xL are able to inhibit apoptosis induced by FADD , but not FLICE . ^^^ Surprisingly , apoptosis was abrogated by E1B 19K and Bcl xL when FADD and FLICE were coexpressed . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| CED 4 directly interacts with the Bcl 2 homologue CED 9 ( or the mammalian Bcl 2 family member Bcl xL ) and the caspase CED 3 ( or the mammalian caspases ICE and FLICE ) . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Coexpression of Q 79 with the caspase inhibitor CrmA , a dominant negative mutant of FADD ( FADD DN ) , Bcl 2 , or Bcl xL , but not an N terminally tagged Bcl xL , prevented the recruitment of caspase 8 and inhibited polyglutamine induced cell death . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Act D treatment of AIDS KS cells markedly and selectively down regulated Bcl xL expression , while the expressions of decoy receptors 1 and 2 , Bax , cellular FLICE ( Fas associated death domain protein like IL 1 converting enzyme ) inhibitory protein , FADD ( Fas associated death domain protein ) , procaspase 8 , and p 53 were not affected . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| We also show by Western blot that Bcl xL , caspase 9 , caspase 8 , and Bid are processed by caspase 3 in injected wild type mice but that this processing does not occur in caspase 3 / mice . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| To analyse the relative position of caspase 8 within the apoptotic cascade we studied caspase activation and apoptosis in Jurkat cells overexpressing Bcl 2 or Bcl xL . ^^^ In parallel , the breakdown of the mitochondrial transmembrane potential ( DeltaPsim ) in response to radiation was inhibited by overexpression of Bcl 2 / Bcl xL Jurkat cells genetically deficient for caspase 8 were found to be completely resistant towards CD 95 . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Neither Bcl XL nor Bcl 2 , which play important roles in antiapoptotic mechanisms in gliomas , protected glioma cells from apoptosis induced by overexpression of caspase 8 . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In Colo 357 cells retrovirally transduced with Bcl XL , caspase 8 activation in response to treatment with TRAIL or anti CD 95 antibody was not different from parental cells and EGFP transfected controls , however , apoptosis was completely suppressed as measured by the mitochondrial transmembrane potential deltapsim , caspase 3 activity ( PARP cleavage ) and DNA fragmentation . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Geranylgeraniol , an intermediate product in mevalonate pathway , induces apoptotic cell death in human hepatoma cells : death receptor independent activation of caspase 8 with down regulation of Bcl xL expression . ^^^ Our results indicate that activation of the caspase cascade initiating from caspase 8 , which could be accelerated by down regulation of Bcl xL expression , plays a key role in an apoptotic process induced by GGOH in human hepatoma cells . . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| RESULTS : HPWE suppressed the activation of caspase 8 and 3 , and upregulated the expression of Bcl XL mRNA and proteins in neutrophils . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Curcumin ( diferuloylmethane ) induces apoptosis through activation of caspase 8 , BID cleavage and cytochrome c release : its suppression by ectopic expression of Bcl 2 and Bcl xl . ^^^ Curcumin activated caspase 8 and caspase 3 in HL 60 neo cells but not in Bcl 2 and Bcl xl transfected cells . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Overexpression of bcl xL strongly blocked the activation of caspase 8 and induction of apoptosis , suggesting that adenovirally transduced caspase 8 was activated at a point downstream of mitochondria . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Treatment of HL 60 cells with TRAIL induced caspase 8 activation within 2 4 h , but no activation could be seen in Bcl 2 expressing or Bcl xL expressing cells . ^^^ Overall , these results indicate that TRAIL induced apoptosis involves activation of caspase 8 , caspase 7 , caspase 3 , and BID cleavage , and Bcl 2 and Bcl xL prevents TRAIL induced apoptosis by abrogating caspase activation and BID cleavage . . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The administration of agonistic anti Fas antibody ( CH 11 ) or cycloheximide alone did not induce apoptosis , whereas the co administration of CH 11 with cycloheximide induced apoptosis in WI 38 cells , in which caspase 8 and 3 , but not 9 , were activated , and 10 chromosome linked inhibitor of apoptosis ( ILP ) and FLICE like inhibitor protein ( FLIP ( L ) ) , but not bcl xL and bcl 2 , were remarkably down regulated . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Hypoxia induced cell cycle arrest at the G0 / G1 phases and massive cell apoptosis after 24 hours through a reduction in the Bcl 2 to Bax ratio , downregulation of Bcl XL and Mcl 1 , and upregulation of caspase 3 and caspase 8 . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Bcl xL did not inhibit the early activation of caspase 8 ( < 4 h ) but inhibited cleavage of Bid , suggesting that Bid is cleaved downstream of the mitochondria , independent of caspase 8 . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Here we show that codelivery of DNA encoding inhibitors of apoptosis ( BCL xL , BCL 2 , XIAP , dominant negative caspase 9 , or dominant negative caspase 8 ) with DNA encoding model antigens prolongs the survival of transduced DCs . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In comparison , cell death using TRAIL ligand caused caspase 8 processing prior to cytochrome c release and executioner caspases and cell death was only partially rescued by Bcl 2 and Bcl xL overexpression . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| GEC on plastic exhibited increased caspase 8 and 9 activities , increased expression of the proapoptotic protein , Bax , and decreased the antiapoptotic protein , Bcl XL , compared with collagen . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| PD184352 / UCN 01 induced mitochondrial dysfunction and apoptosis were both substantially attenuated in cells ectopically expressing Bcl 2 , an N terminal phosphorylation loop deleted mutant Bcl 2 , or Bcl xL , but not in cells expressing dominant negative ( DN ) caspase 8 , cytokine response modifier A ( cowpox virus encoded antiapoptotic protein ) , or DN Fas associated death domain . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 and Bid were cleaved in Colo 357 cells exposed to gemcitabine , and there was no correlation with either Bcl xL or with Bax expression . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Stat 3 C upregulated expression of FLICE inhibitor protein ( FLIP ) , Bcl xL , and Bcl 2 , and accordingly downregulated activities of FLICE and caspase 3 that were redox independent . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Apoptotic pathway analysis detected reduced antiapoptotic B cell leukemia XL ( Bcl xL ) expression and increased activation of caspase 8 and caspase 3 . ^^^ Time course experiments showed that in wild type ( WT ) thymocytes GILZ up regulation was followed by sequential Bcl xL decreased expression and activation of caspase 8 and of caspase 3 . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Adenoviral infection of wild type brown adipocytes with constitutively active Foxol ( ADA ) increased the expression of antiapoptotic genes , decreased Bcl xL and induced caspase 8 and 3 activities , with the final outcome of DNA fragmentation . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Increased apoptosis was a result of enhanced caspase 8 activity , while Bcl 2 and Bcl XL transgene expression had little effect on this phenotype . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Ectopic expression of Bcl 2 or Bcl xL but not dominant negative caspase 8 blocked UCN 01 / L744832 mediated mitochondrial dysfunction and apoptosis but did not prevent activation of p 34 ( cdc 2 ) and JNK or inactivation of MEK / ERK and Akt . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In conclusion , treatment of human endothelial cells with BaP 1 induces apoptosis / anoikis , independently of Bcl 2 family members Bax and Bcl xL and associated with caspase 8 activation and cFLIP ( L ) up regulation . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Apoptosis by gemcitabine in non small cell lung cancer cell line KNS 62 is induced downstream of caspase 8 and is profoundly blocked by Bcl xL over expression . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| In order to understand the molecular alterations leading to heterogeneous cisplatin sensitivity and apoptosis inducibility in NSCLC cells , we analyzed various apoptotic pathways , including the activation of caspase 8 , 9 and 3 , the release of cytochrome c from mitochondria and the expression levels of pro and anti apoptotic proteins such as Bax , Bad , Bcl 2 , Bcl xL , Fas and p 53 using heterogeneously apoptosis sensitive cells ( Ma 10 , Ma 31 and Ma 46 ) . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Antiapoptotic protein levels of FLICE inhibitory protein , Bcl xL , and Bcl 2 in the liver were significantly lower in sympathectomised mice at one and two hours following Jo 2 treatment than in sham operated animals . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Proteins for Western blot analysis included Fas associated death domain ( FADD ) and caspase 8 for extrinsic pathway , as well as Bcl 2 , Bcl XL , Bax , Bad , Bid , Akt , p Akt , and caspase 9 for intrinsic pathway . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| TRAIL induced caspase 8 activation , Bid processing , drop of DeltaPsi ( m ) , and poly ADP ribose polymerase ( PARP ) cleavage but not in caspase 9 activation , and these events were inhibited in HER2 / PI3K / Akt suppressed BT 474 cells , which on the other hand exhibited downregulation of Bcl xL and increased response to mitomycin C . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Caspase 8 and 9 activities were measured in cells overexpressing Bcl xL or c FLIP exposed to docetaxel and paclitaxel using fluorescent substrate cleavage assay . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Treatment with arsenic trioxide ( ATO ; 2 200 microM ) inhibited NF kappaB activity in normal marrow , primary MDS , and ML 1 cells , even in the presence of exogenous TNF alpha ( 20 ng / mL ) , and down regulated NF kappaB dependent antiapoptotic proteins , B cell leukemia XL ( Bcl XL ) , Bcl 2 , 10 linked inhibitor of apoptosis ( XIAP ) , and Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme ( FLICE ) inhibitory protein ( FLIP ) , leading to apoptosis . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| MATERIALS AND METHODS : The growth of the colo 201 human colon cancer cell line was examined by colorimetric 3 ( 4 , 5 dimethylthiazol 2 yl ) 5 ( 3 carboxymethoxyphenyl ) 2 ( 4 sulphophenyl ) 2H tetrazolium ( MTS ) assay , while the expression of apoptosis and proliferation related proteins ( p 53 , Bax , Bcl xL and S , Bcl 2 , Caspase 8 , Caspase 3 and proliferating cell nuclear antigen ( PCNA ) ) were examined by Western blotting . ^^^ The expression of an apoptosis suppressing protein ( Bcl 2 ) was down regulated , an apoptosis enhancing protein ( cleaved form of Caspase 3 ) was up regulated , proliferation related PCNA protein was down regulated and p 53 , Bax , Bcl xL and S and Caspase 8 levels were unchanged . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| DEX treatment upregulated cellular FLICE inhibitory protein ( cFLIP ) expression , but did not alter the protein levels of Bcl 2 , Bcl xL , Mcl 1 , and cIAP as well as Akt activation . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| BAY 11 7082 and curcumin induced cell death was associated with downregulation of Bcl xL , cyclin D 1 , XIAP and c FLIP , followed by caspase 8 , poly ( ADP ribose ) polymerase cleavage and activation . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The number of apoptotic cells in lung sections was determined by a TUNEL method . mRNAs for Fas , FasL and caspase 8 , and for Bad , Bax , Bcl w , Bcl xL and caspase 9 , for the FasL and the mitochondrial cytochrome c pathways of apoptosis , respectively , and mRNA for the effector caspase 3 were quantified in lung tissues by RT PCR . ^^^ RESULTS : After 3 hours of allogeneic perfusion , we observed a significant increase in : 1 ) the number of apoptotic cells in lung sections , 2 ) mRNA levels of FasL , Bcl xL , caspase 8 and caspase 3 , and 3 ) PTP activity ( P < 0 . 05 compared with isogeneic perfusion ) . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Moreover , berberine induced the activation of caspase 8 and 3 , and caused the cleavage of poly ADP ribose polymerase ( PARP ) and the cytochrome c release , whereas the expression of Bid and anti apoptosis factor Bcl XL were decreased markedly . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| EphB 4 knockdown using specific siRNA and antisense oligodeoxynucleotides molecules led to a profound inhibition in cell viability associated with apoptosis via activation of caspase 8 pathway and downregulation of antiapoptotic factor , bcl xl . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis indicated that the induction of apoptosis by GA and ursolic acid was accompanied with an activation of caspase 8 and a reduction in the anti apoptotic proteins , Bcl 2 and Bcl xL , although the pro apoptotic proteins , Bax and Bak , remained unaffected . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Apoptosis induced by each TM was associated with a significant ( approximately 400 % ) increase in caspase 8 activity , but no change in caspase 9 activity , and Western analyses revealed a marked up regulation of Fas ( approximately 500 % ) and FADD ( approximately 300 % ) with no change in expression of Bax , Bcl 2 , or Bcl xL . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The combined treatment of TNF alpha / DOX also resulted in a significant decrease of mRNA levels of anti apoptotic genes , such as the cellular inhibitor of apoptosis 1 ( c IAP 1 ) , and the long isoform of B cell leukemia / lymphoma 10 gene ( Bcl xL ) , leading to efficient induction of caspase 8 cleavage and cell death . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| The authors tried to determine the responsible molecules ; however , expression of TRAIL receptors ; pro caspase 3 / 8 / 9 ; Fas associated death domain protein ( FADD ) ; tumor necrosis factor receptor 1 associated death domain protein ( TRADD ) ; silencer of death domain ( SODD ) ; FLICE inhibitory protein ( FLIP ) ; and Bcl 2 , Bcl xL , and Bax in FLS was not modulated by IFN gamma . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| However , activation of this protease was post mitochondrial since ( 1 ) a pan caspase inhibitor as well as a selective caspase 8 inhibitor were unable to prevent Delta 9 tetrahydrocannabinol induced loss of mitochondrial membrane transmembrane potential , and ( 2 ) cannabinoid induced caspase 8 activation was not observed in Bcl xL over expressing cells . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| Furthermore , PAF inhibited etoposide induced increases in caspase 3 , caspase 8 , and caspase 9 activities , as well as cell death . p50 / p65 heterodimer increased the mRNA expression of Bcl 2 and Bcl xL and decreased etoposide induced caspase activities and cell death . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| TSA reduced FLICE inhibitory protein ( FLIP ) expression but not Bcl 2 , Bcl XL , and Fas expression , indicating that the synergistic effect may be through downregulation of FLIP . ^^^ |
|
| Interacting proteins: Q07817 and Q14790 |
Pubmed |
SVM Score :0.0 |
| This effect markedly elevated the expression of p 21 , p 53 and Bcl xS protein , while the Mcl 1 and Caspase 8 proteins were down regulated . ^^^ |
|