| Interacting proteins: Q14318 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The search for the corresponding effector genes revealed that the expression of FKBP 25 , FKBP 38 and FKBP 52 ( analysis by reverse transcription polymerase chain reaction ( RT PCR ) did not change following H ( 2 ) O ( 2 ) or FK 506 , and this was also true for the expression of apoptosis related genes caspase 3 , bax , bcl 2 and bcl xL ( analysis by Multiplex PCR ) . ^^^ |
|
| Interacting proteins: Q14318 and Q07817 |
Pubmed |
SVM Score :0.0 |
| FKBP 38 is associated with Bcl 2 and Bcl 10 ( L ) in immunoprecipitation assays and colocalizes with these proteins in mitochondria ; in addition , the expression of FKBP 38 mutant proteins induces a marked redistribution of Bcl 2 and Bcl 10 ( L ) . ^^^ Thus , FKBP 38 might function to inhibit apoptosis by anchoring Bcl 2 and Bcl 10 ( L ) to mitochondria . . ^^^ |
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| Interacting proteins: Q14318 and Q07817 |
Pubmed |
SVM Score :0.0 |
| We demonstrated that FKBP 38 , a member of the immunophilin family , interacts and targets these anti apoptotic proteins Bcl 2 and Bcl xL , thereby assisting them in their pro survival role . ^^^ FKBP 38 is specifically localized on mitochondria , at which FKBP 38 is colocalized with Bcl 2 and Bcl xL . ^^^ Expression of exogenous FKBP 38 promotes mitochondrial targeting of Bcl 2 and Bcl xL , while dominant negative FKBP 38 or siRNA of FKBP 38 disturbs their localization . ^^^ |
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| Interacting proteins: Q14318 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
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