| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| When cytotoxic signals activate BH 3 only proteins that can engage both Mcl 1 and Bcl 10 ( L ) ( such as Noxa plus Bad ) , Bak is displaced and induces cell death . ^^^ Accordingly , the BH 3 only protein Noxa could bind to Mcl 1 , displace Bak , and promote Mcl 1 degradation , but Bak mediated cell death also required neutralization of Bcl 10 ( L ) by other BH 3 only proteins . ^^^ |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The enhanced TRAIL effect after pretreatment with HDAC inhibitors was consistent with the upregulation of the proapoptotic Bcl 2 family members ( Bim , Bak , Bax , Noxa , and PUMA ) , the downregulation of the anti apoptotic members of the Bcl 2 family ( Bcl 2 and Bcl 10 ( L ) ) , and IAPs . ^^^ |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^ |
|
| Interacting proteins: Q13794 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^ |
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