| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Sequences similar to this domain were identified in Bax and Bip 1 , two other proteins that promote apoptosis and interact with Bcl xL , and were likewise critical for their capacity to kill cells and bind Bcl xL . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The proapoptotic BH 3 only protein natural born killer / Bcl 2 interacting killer ( Nbk / Bik ) has been described to inhibit Bcl 2 and Bcl xL , thereby supporting the death promoting ability of Bax . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| We have identified a novel cellular protein , Bik , that interacts with the cellular survival promoting proteins , Bcl 2 and Bcl xL , as well as the viral survival promoting proteins , Epstein Barr virus BHRF 1 and adenovirus E1B 19 kDa . ^^^ This death promoting activity of Bik can be suppressed by coexpression of Bcl 2 , Bcl XL , EBV BHRF 1 and E1B 19 kDa proteins suggesting that Bik may be a common target for both cellular and viral anti apoptotic proteins . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Since the discovery of Bcl 2 a decade ago , several other cellular and viral genes encoding homologous proteins have been identified , some of which suppress cell death akin to Bcl 2 ( Bcl XL , Mcl 1 , A1 / Bfl 1 , Nr 13 , Ced 9 , BHRF 1 ) and others which promote apoptosis ( Bax , Bcl Xs , Bak , Bik , Bad ) . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Bik is a potent pro apoptotic protein , which complexes with various anti apoptotic proteins such as Bcl 2 , Bcl xL , 19 kDa adenovirus E1B , and EBV BHRF 1 . ^^^ This result is consistent with the hypothesis that Bik may promote cell death by complexing with and antagonizing the activity of endogenous cellular anti apoptosis proteins such as Bcl 2 and Bcl xL . ^^^ To elucidate the relationship between protein complex formation and induction of cell death , we have identified the minimal sequences of Bik , from a library of N terminal and C terminal deletion mutants , required for interaction with Bcl 2 and Bcl xL and for inducing efficient cell death . ^^^ Two hybrid analysis in yeast and immunoprecipitation analysis of proteins expressed in mammalian cells indicate that a 52 amino acid region ( amino acids 43 94 ) of Bik , encompassing the BH 3 domain , is sufficient for efficient heterodimerization with Bcl 2 and Bcl xL . ^^^ Functional analysis indicates that a Bik deletion mutant expressing residues 43 120 , which efficiently heterodimerizes with the anti apoptosis proteins Bcl 2 and Bcl xL , is defective in eliciting cell death . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Deletion of BH 4 rendered Bcl 2 ( and Bcl xL ) inactive but did not impair either Bcl 2 homodimerization or ability to bind to Bax or five other pro apoptotic relatives ( Bak , Bad , Bik , Bid or Bim ) . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Recent studies have focused on the role that programmed cell death ( i . e . , apoptosis ) plays in both normal and neoplastic growth : certain genes can either suppress ( e . g . , Bcl 2 , Bcl xL ) or promote ( e . g . , Bik , Bax , Bak ) apoptosis . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| After 24 h of TGF beta treatment , the most significant mRNA changes occurred with Bcl XL ( two fold decrease ) and Bik ( twofold increase ) . ^^^ In addition , TGF beta transcriptionally regulates Bcl 2 family members , Bcl XL and Bik , to further influence the apoptosis process . . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| IRS 2 but not IRS 3 binds to Bcl 2 , and IRS 1 associates with Bcl XL but not with Bax or Bik . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Using reverse transcriptase polymerase chain reaction , cloning , and sequencing techniques , we have found that HL 60 cells express bak , bik , bax , bad , bcl 2 , bcl xL , bcl w , bfl 1 , fas , and caspases 1 4 and 7 10 . ^^^ Peripheral blood neutrophils expressed bak , bad , bcl w , bfl 1 , fas , and caspases 1 , 3 , 4 , and 7 10 , but hardly expressed bcl 2 , bcl xL , bik , bax , and caspase 2 . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation state of antiapoptotic ( Bcl 2 , Bcl 10 ( L ) ) and proapoptotic ( BAD , Bid , Bik ) Bcl 2 proteins regulates their cellular activity and , therefore , cell survival and cell death . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| This report suggests enhanced apoptosis of blood neutrophils during the acute phase of CA resulting from enhanced expression of the pro apoptotic proteins Bax and Bik and from a decrease of the anti apoptotic BCl 10 ( L ) mRNA . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| To examine p 75 ( NTR ) dependent apoptosis in tumor cells , we demonstrated that a dose dependent increase in p 75 ( NTR ) expression was associated with a concomitant increase in the mitochondrial proapoptotic effector proteins Bad , Bax and Bik and a decrease in the mitochondrial prosurvival effector proteins phospho Bad , Bcl 2 and Bcl 10 ( L ) . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Here , we found that Bik mutants , in which threonine 33 and / or serine 35 were changed to aspartic acid to mimic the phosphorylation at these two residues , enhanced their binding affinity with the antiapoptotic proteins Bcl 10 ( L ) and Bcl 2 and were more potent than wild type Bik in inducing apoptosis and inhibiting cell proliferation in various human cancer cells . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Specifically , we observe that Abeta significantly reduces expression of antiapoptotic Bcl w and Bcl 10 ( L ) , mildly affects expression of bim , Bcl 2 , and bax , but does not alter expression of bak , bad , bik , bid , or BNIP3 . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Indeed , bortezomib induced increases of Bik and / or Bim in multiple cell lines but not notably of two other BH 3 only proteins ( Puma and Bid ) nor other family members ( Bax , Bak , Bcl 2 , and Bcl xL ) . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Western blot analysis revealed that these resistant cells overexpressed the proteins Bcl XL , Bcl Xs , and Bik , and further data showed that the cells were resistant to 5 FU induced DNA damage and cell cycle disorder . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Subsequent studies showed that combined treatment with bortezomib or MG 132 resulted in an increase of death receptor ( DR ) 5 and Bik at protein levels but had no effects on protein levels of DR 4 , Bax , Bak , Bcl 2 , Bcl XL or Flice inhibitory protein ( FLIP ) . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| PS 341 activated the BH 3 only proteins Bik and Bim and down regulated Bcl 2 and Bcl xL mRNA and protein expression . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Immunoprecipitation studies revealed that Nbk interacts with Bcl 10 ( L ) and Bcl 2 but not with Bax . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| Further , Ad NBK induced cell death is inhibited by Bcl 2 or Bcl xL gene transfer . ^^^ Interestingly , Bcl 2 and Bcl xL transfected glioma cells , which are partially protected from Ad NBK induced cell death , accumulate much higher levels of NBK than are ever observed in control infected cells . ^^^ This indicates that complex formation with Bcl 2 or Bcl xL sequesters NBK in an inactive form and that free NBK , rather than an NBK mediated depletion of free antiapoptotic Bcl 2 family proteins , is the proximate mediator of Ad NBK induced cell death . ^^^ |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13323 and Q07817 |
Pubmed |
SVM Score :0.0 |
| NA |
|