Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Bax also heterodimerizes with Bcl xL , Mcl 1 , and A 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Bad selectively dimerized with Bcl xL as well as Bcl 2 , but not with Bax , Bcl xs , Mcl 1 , A 1 , or itself . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Interactions of the Bcl 2 protein with itself and other members of the Bcl 2 family , including Bcl 10 L , Bcl 10 S , Mcl 1 , and Bax , were explored with a yeast two hybrid system . ^^^ Bcl 2 also interacted with Bcl 10 L and Mcl 1 and with the dominant inhibitors Bax and Bcl 10 S . ^^^ This cytotoxicity could be abrogated by B 42 fusion proteins containing Bcl 2 , Bcl 10 L , or Mcl 1 but not those containing Bcl 10 S ( an alternatively spliced form of Bcl 10 that lacks a well conserved 63 amino acid region ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Here , we have investigated the possibility that the three recently identified Bcl 2 homologues , Bax , Bcl 10 , and Mcl 1 , could be involved instead . ^^^ Freshly isolated cells expressed both Bax and Mcl 1 protein , but only low levels of Bcl xL and no detectable Bcl xS , as determined by Western blot analysis . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Immunoblot analysis of cellular expression of Bcl 2 family proteins , Bcl 2 , Bax , Bcl 10 and Mcl 1 , in human peripheral blood and lymphoid tissues . ^^^ Several homologues of the bcl 2 gene , such as bax , bcl 10 or mcl 1 , have recently been identified . ^^^ Like Bcl 2 , both Bcl XL and Mcl 1 appear to function as repressors of apoptotic cell death , whereas Bax facilitates it , indicating possible interactions among them in the control of cellular survival . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Phylogenies were inferred from both the nucleic acid and amino acid sequences of the human , murine , rat , and chicken sequences for BCL 2 and BCL 10 , human MCL 1 , murine A 1 , the nematode Caenorhabditis elegans and Caenorhabditis briggsiae ced 9 proteins , and the sequences BHRF 1 from Epstein Barr and LMW 5 HL from African swine fever viruses . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical analysis of bcl 2 , bax , bcl 10 , and mcl 1 expression in prostate cancers . ^^^ Using antibodies specific for the Bcl 2 , Bax , Bcl 10 , and Mcl 1 proteins in combination with immunohistochemical methods , we examined for the first time the expression of these bcl 2 family genes in 64 cases of adenocarcinoma of the prostate , including 10 Gleason grade 2 to 4 tumors , 21 grade 5 to 7 tumors , 17 grade 8 to 10 tumors , 8 lymph node metastases , and 8 bone metastases . ^^^ The findings suggest that expression of several anti apoptotic members of the bcl 2 gene family , including bcl 2 , bcl 10 , and mcl 1 increases during progression of prostate cancers , a finding that may be relevant to the hormone insensitive , metastatic phenotype of most advanced adenocarcinomas of the prostate . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Taken together , these results suggest that expression of Bcl XL is increased in undifferentiated primary colorectal cancers , often with accompanying reciprocal decreases in the anti apoptotic proteins Bcl 2 and Mcl 1 and the pro apoptotic protein Bak , whereas Bax expression is relatively constant . ^^^ Thus , a shift from expression of the anti apoptotic proteins Bcl 2 and Mcl 1 to the Bcl XL protein may occur during progression of colorectal tumors . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of a cell death inducing gene , Bax , was investigated in 52 cases of Hodgkin ' s disease in parallel with Epstein Barr virus and was compared with the immunodetection of other apoptosis regulating proteins , Mcl 1 , Bcl 2 , and Bcl 10 . ^^^ Mcl 1 was positive in 80 % of the cases , whereas Bcl 2 and Bcl 10 were found in 53 % and 88 % of the cases , respectively . ^^^ With the exception of 1 case , all Bax positive tumors also expressed either Bcl 2 , Bcl 10 , Mcl 1 , or combinations of these anti apoptotic proteins . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Recent work also has revealed the existence of several bcl 2 related genes that also can inhibit ( e . g . , bcl 10 ( L ) and Mcl 1 ) or activate ( e . g . , bax , bcl 10 ( s ) , bag , and bad ) apoptosis in several systems . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of apoptosis regulating proteins , Bcl 2 , Bax , Mcl 1 , and Bcl 10 , was evaluated by immunohistochemical methods in 39 cases of thyroid carcinomas . ^^^ Normal thyroid tissues showed a consistent expression of Bcl 2 and Mcl 1 whereas Bax and Bcl 10 proteins were essentially absent from most follicular thyroid cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of the apoptosis regulating genes Bcl 2 , Bcl 10 , Bax , Mcl 1 , and p 53 analyzed in 4 cases of human immunodeficiency virus ( HIV ) associated Hodgkin ' s disease , in 36 cases of HIV related non Hodgkin ' s lymphomas ( NHLs ) , and in 109 cases of non HIV related NHLs by using immunohistochemistry . ^^^ For the HIV related NHL samples , 36 , 66 , 88 , 100 , and 94 % of the cases were Bcl 2 , Bcl 10 , Bax , Mcl 1 , and p 53 were found to be expressed in 69 , 65 , 82 , 83 , and 42 % , respectively . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We examined the expression of Fas and bcl 2 family gene products , such as Bcl 2 , Bcl 10 , Bax , and Mcl 1 , in human tonsillar B cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The apoptosis regulating proteins Bcl 2 , Bax , Bcl 10 , Bak , and Mcl 1 were examined by immunohistochemical methods in 48 archival specimens of adenocarcinoma of the stomach , and the results were correlated with tumor histology ( intestinal versus diffuse pattern ) and clinical stage ( early versus late stage disease , ie , stages 1 and 2 versus stage 3 ) . ^^^ Tumor cells containing immunostaining for the anti apoptotic proteins Bcl 2 , Bcl 10 , and Mcl 1 were present in 26 ( 54 % ) , 41 ( 85 % ) , and 36 ( 75 % ) of the 48 cases evaluated , respectively , whereas immunopositivity for the pro apoptotic proteins Bax and Bak was found in 44 ( 92 % ) and 42 ( 88 % ) specimens Comparisons of these immunostaining results with tumor histology revealed statistically significant differences for Bax ( P = 0 . 03 ) , Bcl 10 ( P = 0 . 003 ) , and Mcl 1 ( P = 0 . 005 ) , which were all more frequently immunopositive for tumors with an intestinal than a diffuse histological pattern ( chi 2 analysis ) . ^^^ In addition , the percentage of immunopositive tumor cells was significantly higher for Bcl 10 ( 62 + / 6 % versus 45 + / 6 % , mean + / SE , P = 0 . 01 ) and for Mcl 1 ( 48 + / 6 % versus 30 + / 6 % ; P = 0 . 04 ) in tumors with intestinal versus diffuse histology ( unpaired t test ) . ^^^ The immunointensity for the Bcl 2 , Bcl 10 , and Mcl 1 proteins was stronger in tumor cells compared with normal foveolar cells in 7 ( 21 % ) , 15 ( 44 % ) , and 8 ( 2 . 1 % ) of 34 cases , respectively , whereas the immunointensity of the proapoptotic proteins Bax and Bak was reduced compared with normal cells in 8 ( 24 % ) and 24 ( 71 % ) cases . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
This multigene family of cell death regulators includes members which enhance rates of apoptosis , including bcl xs and bax , and those which inhibit apoptosis , including MCL 1 and bcl xL . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Since the discovery of Bcl 2 a decade ago , several other cellular and viral genes encoding homologous proteins have been identified , some of which suppress cell death akin to Bcl 2 ( Bcl XL , Mcl 1 , A1 / Bfl 1 , Nr 13 , Ced 9 , BHRF 1 ) and others which promote apoptosis ( Bax , Bcl Xs , Bak , Bik , Bad ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical analysis of Bcl 2 , Bcl 10 , Mcl 1 , and Bax in tumors of central and peripheral nervous system origin . ^^^ The expression of Bcl 2 , Bcl 10 , Mcl 1 , and Bax was examined by immunohistochemical methods in 93 tumors of nervous system origin , including 49 gliomas ( 30 astrocytomas and 19 glioblastoma multiforme ( GMs ) ) , 16 medulloblastomas ( MBs ) , 19 neuroblastomas ( NBs ; 9 undifferentiated and 10 differentiated ) , and 9 miscellaneous neuroectodermal neoplasms . ^^^ Among the 49 gliomas , immunopositivity ( defined as > or = 10 % ) was observed for Bcl 2 in 45 ( 92 % ) , Bcl 10 in 48 ( 98 % ) , Mcl 1 in 49 ( 100 % ) , and Bax in 48 ( 98 % ) of 49 specimens . ^^^ Of the 16 MBs , immunopositivity was found for Bcl 2 in 4 ( 25 % ) , Bcl 10 in 9 ( 56 % ) , Mcl 1 in 8 ( 50 % ) , and Bax in 16 ( 100 % ) of the cases . ^^^ The intensity of immunostaining was strong for Bcl 2 in only 1 ( 6 % ) specimen , for Bcl 10 in 3 ( 19 % ) , and for Mcl 1 in 2 ( 12 . 5 % ) , in contrast to Bax immunostaining , which was strong in 12 ( 75 % ) tumors . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Bax / Bak lethality was suppressed by coexpression of Bcl 2 family members that are anti apoptotic in vertebrates , namely Bcl xL , Bcl 2 , Mcl 1 , and A 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
To investigate the dual effects ( proliferation and apoptosis ) of IL 10 on B cells , the expression of a panel of bcl 2 protoncogene family members , bcl 2 , bcl 10 , mcl 1 , and bax , was analyzed when B cells were activated by SAC . ^^^ The apoptosis and proliferation of SAC activated B cells by IL 10 are associated with changes in Bcl 2 , Bcl xL , and Mcl 1 expression . ^^^ The addition of IL 2 further augmented the Bcl xL expression with the same kinetics , whereas Bcl 2 and Mcl 1 were expressed by resting B cells and enhanced by SAC stimulation . ^^^ However , the addition of IL 10 at the initiation of activation down regulated Bcl xL , Bcl 2 , and Mcl 1 expression . ^^^ In contrast , IL 10 failed to down regulate the Bcl xL and Bcl 2 expression but rather augmented the expression of Mcl 1 of B cells after preactivation for 48 hr with SAC and IL 2 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Interleukin 13 in combination with CD 40 ligand potently inhibits apoptosis in human B lymphocytes : upregulation of Bcl xL and Mcl 1 . ^^^ The combination of IL 13 with CD40L augmented the expression of the Bcl 2 homologues Bcl xL and Mcl 1 , suggesting this as a possible intracellular mechanism of induced survival . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 family members analyzed were Bcl 2 , Bcl 10 , Bax , Bad , Bak , A 1 , and Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We show here that treatment of human leukemia cells HL 60 with 1 , 25 dihydroxyvitamin D 3 ( 1 , 25D3 ) results in progressive increases in the levels of cellular antiapoptotic protein Mcl 1 , a transient increase in Al protein level , but no increases in Bcl 2 or Bcl XL proteins . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Other proteins , like bcl xL , A 1 or mcl 1 have the same anti apoptotic function , but several molecules of the same family , like bcl xS , bax alpha or bak can trigger the opposite effect . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
In the yeast two hybrid system , Bok interacted strongly with some ( Mcl 1 , BHRF 1 , and Bfl 1 ) but not other ( Bcl 2 , Bcl xL , and Bcl w ) anti apoptotic members . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
HL 60 / Bcl 2 cells displayed a 5 fold increase in Bcl 2 protein compared with empty vector counter parts ( HL 60 / pCEP4 ) but comparable levels of Bax , Mcl 1 , and Bcl xL . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Here we demonstrate that , in addition to the previously identified A 1 , four other members of the Bcl 2 family , Bcl 2 , Mcl 1 , Bcl 10 ( L ) , and Bax , are expressed in endothelial cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
FL cells express the death suppressor proteins bcl 2 , bcl xL , and mcl 1 ; whereas GC B cells express bcl xL and mcl 1 but also the proapoptotic proteins bax alpha and bad . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 , Bcl xL , and Mcl 1 are three related intracellular polypeptides that have been implicated as negative regulators of apoptosis . ^^^ Levels of Bcl 2 , Mcl 1 , Bcl xL , and Bax each varied over a more than 10 fold range in different pretreatment leukemia specimens . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of the Bcl 2 family proteins Bax , Mcl 1 , Bcl 2 , and Bcl xL , was examined in human peripheral blood eosinophils or in umbilical cord blood derived eosinophils . ^^^ Although cord blood derived eosinophils expressed easily detectable levels of Mcl 1 , Bcl 2 , and Bcl xL , only traces or no expression of these three antiapoptotic proteins were found in peripheral blood eosinophils . ^^^ Incubation of both eosinophil types for 1 to 3 days in a cytokine deprived medium led to apoptosis , without changes in the expression of Bax , Mcl 1 , Bcl 2 , or Bcl xL . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The anti apoptotic proteins Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 were present at immunodetectable levels in 7 , 10 , 10 , and 9 of the 11 lines . ^^^ Comparing these 11 cell lines among themselves revealed that steady state levels of Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 were present at relatively higher levels in 4 , 6 , 5 , and 5 of the lines , respectively . ^^^ Immunoblot analysis of primary adenocarcinomas revealed expression of the anti apoptotic proteins Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and BAG 1 , as well as the pro apoptotic proteins Bax , Bak , and CPP 32 , in at least 2 of the 3 tumors examined . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of several apoptosis regulating proteins , including the Bcl 2 family proteins Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , and BAD ; the Bcl 2 binding protein BAG 1 ; and the cell death protease Caspase 3 ( CPP 32 ) , was evaluated by immunoblotting using 58 peripheral blood B CLL specimens from previously untreated patients . ^^^ Expression of Bcl 2 , Mcl 1 , BAG 1 , Bax , Bak , and Caspase 3 was commonly found in circulating B CLL cells , whereas the Bcl XL and BAD proteins were not present . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Here we have examined the expression of several proteins involved in the susceptibility to apoptosis in 20 human gliomas , including the BCL 2 family proteins BCL 2 , BCL 10 , BAX and MCL 1 , as well as p 53 and RB . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Baseline levels of message were detected for 3 ced 3 ( CPP 32 , Ich 1 and ICE ) and 4 ced 9 homologs ( bcl 10 , MCL 1 , bcl 2 and bax ) in the frontal cortex . ^^^ Positive ( ICE , ICErel 2 , ICErel 3 , Ich 1L , CPP 32 , mch 2 , mch 3 , bcl xS , bax and bak ) and negative ( bcl 2 , bcl xL , MCL 1 and Ich 1S ) regulators of apoptosis were successively examined using a semi quantitative technique of reverse transcription polymerase chain reaction ( RT PCR ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Expression of the Bcl 2 family of apoptosis related genes ( bcl 2 , bcl 10 , mcl 1 , and bax ) and the proliferation and apoptosis related genes p 53 and cyclin D 1 were determined in 40 low T stage laryngeal carcinomas and in uvular epithelium from patients without SCC . ^^^ Among the antiapoptotic members of the Bcl 2 family , Bcl 10 and Mcl 1 showed more intense and widespread staining than Bcl 2 itself in both normal squamous mucosa and SCC . ^^^ Expression of Bcl 10 and Mcl 1 was greater in poorly differentiated than in well differentiated tumors ( P = . 014 and P = . 031 , respectively ) . ^^^ Bcl 10 and Mcl 1 appear to be the most abundantly expressed antiapoptotic proteins of the Bcl 2 family in both normal squamous mucosa and SCC of the larynx . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical analysis of bcl 2 , bax , mcl 1 , and bcl 10 expression in ovarian surface epithelial tumors . ^^^ The expression of bcl 2 family proteins was investigated in 28 ovarian surface epithelial tumors , including serous and mucinous benign , borderline , and malignant tumors by immunohistochemical staining with antibodies to bcl 2 , bax , bcl 10 , and mcl 1 proteins . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
In this study we have investigated by Western blotting the expression pattern of Bcl 2 and its homologues Bax , Bak , Bcl xL , Bcl xS , Mcl 1 and Bad in 12 distant lymph node metastases from patients who have been treated by different regimes , in nine newly established cell lines of these metastases , in three cell lines obtained from other sources and in primary melanocytic cell lines from three neonatal and two adult subjects . ^^^ Taken together , our data suggest that Bax , Bak , Bad , Bcl xL and Mcl 1 are expressed in addition to Bcl 2 in both normal melanocytes and in cell lines established from melanoma metastases . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Bcl 2 family proteins are key regulators of apoptosis and function as cell death antagonists ( e . g . , Bcl 2 , Bcl XL , and Mcl 1 ) or agonists ( e . g . , Bax , Bad , and Bak ) . ^^^ Here we report that among the Bcl 2 family of proteins tested ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bad , and Bak ) , Bcl XL was unique in that its protein levels were tightly regulated by hemopoietins in both immortal and primary myeloid progenitors . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We examined the expression of Bax , Bcl 2 , Bcl 10 , and Mcl 1 in human benign nevi , primary MM , and metastatic MM using immunohistochemistry . ^^^ Interestingly , in most MM samples there was overexpression of Mcl 1 or Bcl XL , both negative regulators of apoptosis . ^^^ Increased expression of Mcl 1 and Bcl XL was first observed in thin primary melanomas , suggesting that up regulation of these proteins represents a relatively early event associated with malignant transformation in MM . ^^^ We conclude that the apoptosis inhibitors Bcl XL or Mcl 1 , alone or in combination , may circumvent the normal cell death pathway , contributing to the pathogenesis and treatment resistance in metastatic MM . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
In the yeast cell assay , BOD interacts with diverse antiapoptotic Bcl 2 proteins [ Mcl 1 , Bcl 2 , Bcl xL , Bcl w , Bfl 1 , and Epstein Barr virus ( EBV ) BHRF 1 ] but not with different proapoptotic Bcl 2 proteins ( BAD , Bak , Bok , and Bax ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Our BAX deletion constructs and minimal domain constructs indicated that the BH 3 domain was required for BAX homodimerization and heterodimerization with BCL 2 , BCL XL , and MCL 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The proteins evaluated were p 53 and six members of the Bax / Bcl 2 family : three proapoptotic proteins ( Bax , Bak , and Bcl xS ) and three survival factors ( Bcl 2 , Bcl xL , and Mcl 1 ) . ^^^ In addition , expression levels of Bcl 2 , Bcl xL , Bcl xS , Bak , or Mcl 1 did not correlate with sensitivity or resistance to the four drugs . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Expression of the Bcl 2 , Mcl 1 , Bcl 10 , Bax , and Bak proteins was analyzed to determine whether the differences in MCF 7 cell sensitivity to apoptosis could be correlated to the differential expression of these proteins . ^^^ Whereas Bak , Bcl 10 , and Mcl 1 levels were identical between variants , the levels of Bcl 2 were 3 . 5 3 . 8 fold higher and the levels of Bax were 1 . 5 1 . 7 fold lower in the resistant variants ( M and L ) as compared with those of the sensitive variant ( N ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Consistent with this , Diva did not bind to cellular Bcl 2 family members including Bcl 2 , Bcl XL , Bcl w , Mcl 1 , and A1 / Bfl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical analysis of Bcl 2 , Bax , Bcl 10 , and Mcl 1 expression in pancreatic cancers . ^^^ We found that Bcl 2 was expressed in 23 % , Bax in 53 % , Bcl 10 in 90 % , and Mcl 1 in 90 % of the invasive ductal adenocarcinomas . ^^^ Immunoblot analysis identified Bcl XL as the predominant form of the Bcl 10 protein in both pancreatic cancer tissues and cell lines , and demonstrated that both Bcl XL and Mcl 1 protein levels were uniformly high in all cell lines . ^^^ In intraductal papillary mucinous adenocarcinomas , the expression rate of Bax was 44 % and those of Bcl XL and Mcl 1 were 88 % ; these values were higher than those for intraductal papillary mucinous adenomas . ^^^ These results suggest that an imbalance between antiapoptosis proteins ( such as Bcl 2 , Bcl XL , and Mcl 1 ) and proapoptotic proteins ( such as Bax and Bcl Xs ) is involved in the distinctive biologic features of adenocarcinomas of the pancreas . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
There was no correlation between the susceptibility to gemcitabine and the endogenous expression of the B cell lymphoma 2 ( BCL 2 ) family proteins BCL 2 , BCL XL , myeloid cell leukemia 1 ( MCL 1 ) , BCL 2 associated 10 protein ( BAX ) , BCL 2 homologous antagonist / killer ( BAK ) and BCL XS . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
All these events are prevented by p27Kip1 overexpression . p27Kip1 does not modulate Bcl 2 , Bcl 10 ( L ) , Mcl 1 and Bax protein level in leukemic cells but suppresses Mcl 1 expression decrease observed in mock transfected U 937 cells undergoing etoposide induced cell death . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl xL , A 1 , and Mcl 1 was detected in both embryos and hatched birds , whereas Nr 13 was expressed at high levels in embryonic bursa , and decreased significantly after hatching , correlating inversely with apoptosis . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
In addition , the expression of MCL 1 , an antiapoptotic member of the BCL 2 family , is downregulated during Na Sal induced cell death , whereas the expression of BCL 2 , BAX , and BCL XL is unchanged . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Using quantitative Western blotting we have determined the level of expression of BCL 2 , BAX , MCL 1 , and BCL 10 in lymphoblasts from 47 children with ALL ( 33 at presentation only , 4 at relapse only , and 10 at both presentation and on relapse ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We examined the expression of the bcl 2 family oncoproteins bax , bak , bcl 2 , bcl xL , and mcl 1 in the course of differentiation of human keratinocytes cultured at low ( 0 . 15 mM ) and high ( 1 . 87 mM ) calcium concentrations . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 family proteins ( Bcl 2 , Bcl 10 , Bcl XL , Bcl Xs , BAX , BAD , MCL 1 ) and of Interleukin 1 converting enzyme ( ICE ) related proteins ( ICE , CPP 32 , ICH 1 ) was analyzed in acute leukemia cells by flow cytometry . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The levels of other BCL 2 family members including BAX , BCL 2 , BCL 10 or MCL 1 were not consistently modulated by mutant or wild type p53val135 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Here we report that in erythroid cells , GATA 1 strongly induces the expression of the anti apoptotic protein bcl xL , but not the related proteins bcl 2 and mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Exposure of undifferentiated U 937 cells to 50 microM etoposide for 6 h , that triggers apoptosis in 80 % cells , activates procaspase 2L , 3 and 8 , induces the mitochondrial release of cytochrome c and decreases Mcl 1 expression without modifying Bcl 2 , Bcl xL and Bax protein levels . ^^^ Exposure of TPA differentiated U 937 cells to 0 . 8 microg / ml cycloheximide for 24 h , that triggers apoptosis in 50 % cells , activates procaspase 2L , 3 and 8 , induces the mitochondrial release of cytochrome c and decreases Bcl xL expression without modifying Bcl 2 , Mcl 1 and Bax protein levels . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of the pro apoptotic proteins ( Bax , Bak ) and anti apoptotic proteins ( Bcl 2 , Bcl 10 , Mcl 1 ) was studied by immunohistochemistry in 110 invasive ductal breast carcinomas . ^^^ Overall , Bcl 2 , Bcl 10 , Mcl 1 , Bax , Bak , ER , and p 53 were detected in 62 , 75 , 68 , 75 , 60 , 68 and 26 per cent of the cases respectively , but at different levels in each case . ^^^ No correlation was found between the apoptotic index and Bax , Bcl 10 , and Mcl 1 immunostaining results . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Interestingly , Bcl 2 , Mcl 1 and Bcl 10 ( L ) cumulative expressions were inversely correlated with apoptotic response . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Transcript levels of c erbB 2 , p 53 , p 21 , GADD 45 , bax , bcl 10 , mcl 1 , and c fos were also unaffected by EMF exposure . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Examination of expression levels of Bcl 2 protoncogene family members ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and Bax ) showed a downregulation of Bcl 10 ( L ) and Mcl 1 after CD 22 ligation . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Apaf 1 did not bind , however , to any of the six known mammalian prosurvival family members ( Bcl 2 , Bcl 10 ( L ) , Bcl w , A 1 , Mcl 1 , or Boo ) , or their viral homologs adenovirus E1B 19K and Epstein Barr virus BHRF 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The microtubule damaging antineoplastic drugs can kill tumor cells by inducing phosphorylation of antiapoptotic proteins such as Bcl 2 , Bcl xL or MCL 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We have found that , in addition to Bcl 2 and Bax , the expression levels of apoptosis inducers ( Bad , Bak ) and inhibitors ( Bcl xL , Mcl 1 ) were highly variable in blasts from 78 children with newly diagnosed acute lymphoblastic leukemia ( ALL ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Using the GM CSF dependent TF 1 myeloid leukaemia cell line , the authors show that the endogenous levels of BCL 2 and MCL 1 are downregulated upon GM CSF withdrawal , whereas the levels of BCL 10 ( L ) and Bax are unchanged . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bax , Bcl 10 , and Mcl 1 proteins and of the proliferation marker Ki 67 was evaluated by immunohistochemistry . ^^^ In tumors that had progressed from WHO Grade 3 anaplastic oligodendrogliomas , the authors found significantly more Bcl 10 positive ( P = 0 . 005 ) , Mcl 1 positive ( P = 0 . 002 ) , and Bax positive ( P = 0 . 03 ) cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The differences of expression of BCL 2 , BCL 10 , BAX , and MCL 1 proteins of paired first resection and recurrence glioblastoma specimens were examined . ^^^ RESULTS : In the whole group , we found a significant up regulation of antiapoptotic BCL 2 ( median cumulative score of 15 in the primary , 19 at recurrence ; p < 0 . 0001 in the Wilcoxon test ) , BCLX ( median scores 20 and 25 , respectively , p < 0 . 0001 ) , and MCL 1 ( median scores 11 and 14 , p=0 . 0395 ) , and a significant down regulation of proapoptotic BAX ( median scores 14 and 11 , p < 0 . 0001 ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Anti apoptotic proteins of the Bcl 2 family , notably Mcl 1 and Bcl XL , may be involved in mediating the response to E2F 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
In the yeast two hybrid system , Mcl 1 binds to the hypophosphorylated mutant of BAD and interacts preferentially with different proapoptotic ( Bax , Bak , Bok , Bik , and BOD ) compared with antiapoptotic Bcl 2 family members ( Bcl 2 , Bcl xL , Bcl w , Bfl 1 , CED 9 , and BHRF 1 ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Mcl 1 and Bcl xL are co regulated by IL 6 in human myeloma cells . ^^^ Expression of Bcl xL , Mcl 1 and Bcl 2 was found in most of the samples ; expression of Bcl xL and Mcl 1 seemed to be related on myeloma cells . ^^^ In a system of apoptosis by growth factor deprivation on myeloma cells , we showed that the effect of Bcl 2 seemed minimal whereas Mcl 1 and Bcl xL were tightly regulated by interleukin ( IL ) 6 . ^^^ These findings underline the important role of Mcl 1 and Bcl xL instead of Bcl 2 in IL 6 induced survival of myeloma cells . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Apoptosis and expression of apoptosis regulating proteins bcl 2 , mcl 1 , bcl 10 , and bax in malignant mesothelioma . ^^^ We investigated apoptosis and the expression of bcl 2 , mcl 1 , bcl 10 , and bax in histological sections from 35 malignant mesotheliomas and 21 metastatic adenocarcinomas . ^^^ Moreover , the expression of bcl 2 , mcl 1 , bcl 10 , and bax were assessed by Western blotting in nonmalignant human mesothelial cells ( Met5A ) and seven malignant cell lines . ^^^ Patients with mesotheliomas showing a high apoptotic index ( > or =0 . 75 % ) had a worse prognosis ( P = 0 . 008 ) . bcl 2 positivity was observed in only seven cases , but bcl 10 , mcl 1 , and bax positivity was seen in all of them . ^^^ In immunoblotting experiments , all mesothelioma cell lines were negative for bcl 2 but positive for bcl 10 , mcl 1 , and bax . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We have recently reported that Mcl 1 is expressed in human myeloma cells and that Mcl 1 and Bcl 10 ( L ) expression are correlated . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Other proteins important in apoptotic control , Bax , Mcl 1 , and Bcl 10 ( S ) , are unaffected by calcitriol treatment . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
In contrast , FcepsilonRI ligation enhances the expression of the antiapoptotic molecules Bcl 2 and Bcl xL , but not Mcl 1 , in monocytes . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
However , the basal levels of anti apoptotic proteins Bcl xL and Mcl 1 were 4 8 fold higher in A 2780 ( 100 ) than in A 2780 neither of which expressed Bcl 2 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We examined immunohistochemically 4 apoptosis regulating bcl 2 familial proteins ( bcl 2 , mcl 1 , bcl 10 , and bax ) in the biliary epithelium in 19 cases of primary biliary cirrhosis . ^^^ Bcl 2 and mcl 1 are inhibitors of apoptosis , bcl 10 , probably bcl XL in biliary epithelial cells , an inhibitor , and bax , a promoter of apoptosis . ^^^ Mcl 1 , bcl 10 , and bax were diffusely detectable at the any level of the intrahepatic biliary tree , with a staining pattern that was diffuse and cytoplasmic . ^^^ Expression levels of mcl 1 , bcl 10 , and bax were similarly reduced to that of bcl 2 in these 2 diseases . ^^^ These findings suggest that bax is not important as a proapoptotic factor in the damaged bile ducts and that downregulation of bcl 2 and mcl 1 , and probably that of bcl XL , leads to a decrease in the threshold of apoptosis and increase in the vulnerability to apoptotic stimuli in these bile ducts , followed by the progressive apoptotic loss of interlobular bile ducts , in primary biliary cirrhosis . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The BCL 2 family proteins ( BCL 2 , BCL 10 , MCL 1 , and BAX ) and p 53 expression were studied by immunohistochemistry on paraffin slides . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We observed baseline expression of the anti apoptotic Mcl 1 and pro apoptotic Bax proteins in immunoblots of eosinophil lysates , but not Bcl 10 , Bcl 2 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemical detection of Bcl 2 in Kaposi ' s sarcoma lesions varies according to histopathologic stage , whereas expression of Bcl 10 and Mcl 1 differs according to human immunodeficiency virus serologic status of patients . ^^^ Expression of Bcl 2 , Bcl 10 , and Mcl 1 was immunohistochemically evaluated in 33 cases of Kaposi ' s sarcoma ( KS ) of the skin . ^^^ In contrast , Bcl 10 and Mcl 1 staining intensity was unrelated to progression stage but was dependent on human immunodeficiency virus infection status . ^^^ Thus , whereas Bcl 10 expression was stronger in C KS cases , Mcl 1 immunostaining was more intense in AIDS KS instances . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We immunohistochemically examined the protein expression of Bcl 2 , Bcl XL , Mcl 1 , and Bax . ^^^ Among these proteins , Bcl XL and Mcl 1 may play an important role in the proliferation and differentiation of the embryonic and fetal pancreas . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Mcl 1 , Bcl 2 , Bcl 10 ( L ) , and glutathione S transferase ( GST ) expression were increased in a time dependent manner after heat shock . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The present study examined the expression of some Bcl 2 family members , including Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and Bax , in response to cytokine stimulation in TF 1 and JYTF 1 cells in which SCF costimulation is differentially required for optimal proliferation . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
MEK / ERK signaling pathway regulates the expression of Bcl 2 , Bcl 10 ( L ) , and Mcl 1 and promotes survival of human pancreatic cancer cells . ^^^ RESULTS : Herein , we showed that inhibition of ERK1 / 2 activities caused ( 1 ) a G 1 arrest ; ( 2 ) a down regulation of the expression levels of the anti apoptotic homologs Bcl 2 , Mcl 1 , and Bcl 10 ( L ) without affecting the pro apoptotic levels of Bax and Bak ; ( 3 ) a promotion of caspases 3 , 6 , 8 , and 9 activities ; ( 4 ) a stimulation of PARP cleavage ; and ( 5 ) a programmed cell death by apoptosis . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
METHODS AND RESULTS : By counting apoptotic biliary cells and by immunostaining apoptosis related proteins in normal liver , fatty liver , and those with acute viral hepatitis , chronic viral hepatitis , and hepatitis virus related cirrhosis , it was found that the larger the intrahepatic bile ducts became , the more biliary epithelial cells underwent apoptosis . bcl 2 , an inhibitor of apoptosis , was diffusely expressed in the interlobular bile ducts , but rarely detectable in the large and septal bile ducts . bcl XL and mcl 1 , inhibitors of apoptosis , and bax , a promoter of apoptosis , were diffusely expressed along the intrahepatic biliary tree . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
However , anti apoptotic factors including Bcl 2 , Bcl xL , and Mcl 1 were significantly induced in the adherent population whereas no induction was detectable in the suspension cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
PURPOSE : The present study was undertaken to investigate the prognostic and predictive relevance of the expression of apoptosis related proteins Bax , Bcl 10 ( L ) , and Mcl 1 in advanced ovarian cancer . ^^^ PATIENTS AND METHODS : Tumor biopsies from 185 consecutive and homogeneously treated patients with stage 3 ovarian cancer were examined immunohistochemically for the expression of Bax , Bcl 10 ( L ) and Mcl 1 proteins . ^^^ RESULTS : Sixty six percent of cancer cases expressed Bax , 62 % Bcl 10 ( L ) , and 53 % Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Our results indicate that the myeloma cell survival activity of IL 6 linked to Bcl xL regulation can not be generalized and emphasize that Mcl 1 is the main target of IL 6 and IFN alpha stimulation . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of other antiapoptotic proteins ( Bcl 10 ( L ) , Bag 1 , A 1 , and Mcl 1 ) did not prevent Bcl 2 AS induced apoptosis . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Since the Bcl 2 family of proteins constitutes a critical checkpoint in apoptosis , acting upstream of the apoptotic machinery , we investigated the expression of six Bcl 2 homologs ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak , Bad ) and one non homologous associated molecule ( Bag 1 ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Even though wild type BAD only interacted with selected numbers of antiapoptotic proteins , underphosphorylated mutant BAD interacted with all antiapoptotic Bcl 2 proteins tested ( Bcl 2 , Bcl w , Bcl xL , Bfl 1 / A1 , Mcl 1 , Ced 9 , and BHRF 1 ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Therefore , we studied the cell cycle proteins , Rb , E2F2 , Ki 67 , p 21 and p 53 and the apoptotic proteins , mcl 1 , hax , bcl xl , bcl 2 , Fas receptor , Fas ligand , caspase 3 , M 30 and PARP as potential predictive factors . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Using mid gestation human jejunum and colon organotypic cultures , we analyzed the impact of growth factors ( namely insulin ; 10 microg / ml ) and pharmacological compounds that inhibit signal transduction molecules / pathways ( namely tyrosine kinases , Fak , P 13 K / Akt , and MEK / Erk ) on cell survival and Bcl 2 homolog expression ( anti apoptotic : Bcl 2 , Bcl 10 ( L ) , Mcl 1 ; pro apoptotic : Bax , Bak , Bad ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
IL 10 decreased expression of bcl 2 , bcl 10 ( L ) , and mcl 1 but not bax mRNA in monocytes stimulated with GM CSF . ^^^ Addition of IL 10 after that time induced neither apoptosis nor a decrease in expression of bcl 2 , bcl 10 ( L ) , and mcl 1 mRNA . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic proteins , Bcl 2 and Mcl 1 , were not expressed in the giant cells , and Bcl 10 was infrequently expressed in these cells ( 11 % + / 4 % ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
After neutrophils were incubated with HPWE , expression of Bcl 2 family [ antiapoptotic ( Bcl 2 , Bcl XL and Mcl 1 ) and proapoptotic ( Bax , Bak and Bcl XS ) ] was determined by RT PCR and Western blotting , respectively . ^^^ The expression of Bax and Bak was upregulated and Bcl 2 , Bcl XL and Mcl 1 downregulated in HL 60 cells during neutrophilic differentiation . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Here , we show that A 1 , Mcl 1 , Bcl 10 ( L ) , and Bad are major transcripts in human neutrophils and that levels of these transcripts are cytokine regulated . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 in benign , dysplastic , and malignant biliary epithelium . ^^^ The antiapoptotic members of the Bcl 2 protein family ( Bcl 2 , Bcl 10 ( L ) , and Mcl 1 ) are important inhibitors of apoptosis , but have not been investigated extensively in cholangiocarcinoma . ^^^ METHODS : The expression of Bcl 2 , Bcl 10 ( L ) , and Mcl 1 was investigated in normal biliary epithelium ( 17 ) , biliary dysplasia ( three ) , and invasive cholangiocarcinoma ( 51 ) , in addition to three human cholangiocarcinoma cell lines , by immunohistochemistry and immunofluorescence . ^^^ In contrast , granular cytoplasmic Bcl 10 ( L ) and Mcl 1 staining was found in 60 100 % of cells in all normal , dysplastic , and malignant specimens , including the human cell lines examined in this study . ^^^ CONCLUSION : These findings indicate that Mcl 1 and Bcl 10 ( L ) , but not Bcl 2 , are involved in the survival of normal and neoplastic cells in the biliary tree . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Although inhibition of nuclear translocation of NF kappaB prevented endotoxemia induced increases in Bcl 10 ( L ) , A 1 , and A 20 in lung neutrophils , this intervention did not prevent endotoxemia associated elevation of Mcl 1 , an anti apoptotic protein primarily under the transcriptional regulation of CREB . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Although this was followed by the inhibition of Stat 5 phosphorylation and the down regulation of Bcl 10 ( L ) and Mcl 1 , only 7 % + / 3 % and 25 % + / 9 % of cells were apoptotic at 16 and 24 hours , respectively . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Synergistic potentiation of STI 571 mediated lethality by PD 184352 was associated with multiple perturbations in signaling and apoptotic regulatory pathways , including caspase dependent down regulation of Bcr Abl and Bcl 2 ; caspase independent down regulation of Bcl 10 ( L ) and Mcl 1 ; activation of JNK , p 38 MAPK , and p 34 ( cdc 2 ) ; and diminished phosphorylation of Stat 5 and CREB . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak in human uterine leiomyomas and myometrium during the menstrual cycle and after menopause . ^^^ To investigate the expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak proteins in human uterine leiomyomas and homologous myometrium during the menstrual cycle and after menopause . ^^^ The expression of Bcl 2 , Bcl 10 , Mcl 1 , Bax and Bak in leiomyomas ( n=24 ) and myometrial samples ( n=22 ) from women with leiomyomas was measured by immunohistochemistry and Western blot . ^^^ No significant differences were observed for the Bcl 10 or Bak proteins , whereas the Mcl 1 protein was significantly less abundant in secretory phase leiomyomas than in leiomyomas from menopausal women . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
On the other hand , the structurally most similar pro survival members , Bcl 2 , Bcl xL , and Bcl w , suppressed SNV induced apoptosis in the absence of Bad , whereas Mcl 1 and A 1 did not . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of thymidylate synthase ( TS ) , p 53 , retinoblastoma protein ( Rb ) , Fas receptor , Fas ligand , bcl 2 , mcl 1 , bax , and bcl 10 was measured using immunohistochemistry . ^^^ The expression of bax , mcl 1 , and bcl 10 in normal mucosa was more apical than that seen in malignant cells , where a more diffuse expression pattern was seen ( p < 0 . 04 ) . ^^^ CONCLUSIONS : These results demonstrate that proliferation and apoptosis are disturbed during colorectal cancer progression , and this is accompanied by loss of Rb and Fas expression , the accumulation of p 53 and TS , and changes in the expression patterns of bax , mcl 1 , and bcl xl . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Ribonuclease protection assays compared the effects of acetaminophen and E 2 on expression of selected genes ( c myc , c fos , cyclin D 1 , bcl 2 , bax , gadd 45 , mcl 1 , p 53 , p 21 ( CIP1 / WAF1 ) , and bcl xL ) in E 2 responsive breast cancer ( MCF 7 ) and endometrial adenocarcinoma ( Ishikawa ) cells as well as in E 2 nonresponsive ( MDA MB 231 ) breast cancer cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
STATs participate in oncogenesis through up regulation of genes encoding apoptosis inhibitors and cell cycle regulators such as Bcl 10 ( L ) , Mcl 1 , cyclins D1 / D2 , and c Myc . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
To investigate the potential role of the BCL 2 gene family ( BAX , BCL 2 , MCL 1 , and BCL XL ) in ovarian cancer development and progression , mRNA expression levels of these genes were measured using semi quantitative PCR in epithelial ovarian tumor tissues and normal ovaries . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Antisense strategy shows that Mcl 1 rather than Bcl 2 or Bcl 10 ( L ) is an essential survival protein of human myeloma cells . ^^^ The present study used an antisense strategy to elucidate the respective roles of Bcl 2 , Bcl 10 ( L ) , and Mcl 1 proteins in myeloma cell survival . ^^^ Each antisense oligonucleotide ( ASO ; Bcl 2 , Bcl 10 ( L ) , or Mcl 1 ASO ) introduced into human myeloma cell lines by electroporation induced a marked reduction in the level of the corresponding protein . ^^^ Mcl 1 ASO triggers an important decrease of viability in all myeloma cell lines tested and in 2 primary myeloma cells , whereas neither Bcl 2 nor Bcl 10 ( L ) ASO affected the viability of myeloma cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Following PMA treatment , expression of Mcl 1 and Bcl 10 increased while that of c Myc was significantly reduced . ^^^ Moreover , survivin expression decreased upon CH 11 or PMA treatment . c Myc , survivin and Bcl 10 modulation seems to be regulated at the transcriptional level while decrease in Mcl 1 protein in CH 11 treated cells resulted especially from a caspase dependent proteolysis . ^^^ Taken together , our data demonstrate that PMA mediated inhibition of apoptosis is a complex process that is integrated at both the transcriptional and post transcriptional level and point out to the potential role of Mcl 1 , Bcl 10 , c Myc and survivin in this process . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
By contrast , Bcl 2 , Bcl 10 and Mcl 1 proteins were highest in rapidly adhering keratinocytes and nearly absent in slowly adhering cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
RNase protection assay showed a negative correlation between bcl 10 ( L ) and mcl 1 mRNA expression levels and the sensitivity to 5 FU and gemcitabine after 5 FU and gemcitabine treatment . ^^^ The bax / bcl 2 ratio is predictive of chemotherapy sensitivity , whereas bcl 10 ( L ) and mcl 1 mRNA levels following repeated exposure to 5 FU or gemcitabine are associated with resistance to these drugs . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The oncogene derived protein Bcl 2 and its family members such as Bcl xL or Mcl 1 can confer negative control in the pathway of cellular suicide machinery . ^^^ Previous reports by others and us demonstrate that phosphorylation of anti apoptotic proteins such as Bcl 2 , Bcl xL or Mcl 1 can regulate their function depending on the apoptotic trigger or cell type . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Examination of the expression of several apoptosis regulatory proteins revealed that coculture with HK cells or DCs induced up regulation of the antiapoptotic Bcl 2 family protein Mcl 1 in CLL B cells , whereas CD 40 ligation increased expression of Bcl 10 ( L ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
To analyze the mechanisms of the apoptotic activity of Cl F araA , we sought to determine the effects of the drug on the levels of Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bak ) and cell survival signals via Akt . ^^^ Western blot analysis revealed that Cl F araA induced a dose and time dependent downregulation of Bcl 10 ( L ) and Mcl 1 proteins , and a dose and time dependent dephosphorylation of Akt and its downstream effectors ( Bad , FKHRL 1 ) , particularly in vivo . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We have investigated whether subsets of indolent B cell non Hodgkin ' s lymphoma ( IB NHL ) differ in the expression of the bcl 2 family members ; 116 cases of IB NHL , composed of chronic lymphocytic leukemia ( CLL , n = 48 ) , follicular lymphoma ( FL , n = 38 ) , marginal zone B cell lymphoma ( MZBCL , n = 15 ) , and mantle cell lymphoma ( MCL , n = 15 ) , were investigated for expression of bcl 2 , bcl 10 , mcl 1 , bax , and bak proteins by immunohistochemistry . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
STI571 / flavopiridol mediated apoptosis was associated with the caspase independent down regulation of Bcl 10 ( L ) and Mcl 1 , activation of extracellular signal regulated kinase and c Jun NH ( 2 ) terminal kinase , and the caspase dependent release of Smac / DIABLO and loss of deltapsi ( m ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Pk 11195 , a mitochondrial benzodiazepine receptor antagonist , reduces apoptosis threshold in Bcl 10 ( L ) and Mcl 1 expressing human cholangiocarcinoma cells . ^^^ BACKGROUND : Cholangiocarcinoma cells express high levels of the antiapoptotic proteins Bcl 10 ( L ) and Mcl 1 and are markedly chemo and radioresistant . ^^^ AIM : We evaluated the ability of the mBzR antagonist Pk 11195 to overcome preapoptotic mitochondrial dysfunction in Egi 1 and Tfk 1 , two human cholangiocarcinoma cell lines expressing high levels of Bcl 10 ( L ) and Mcl 1 . ^^^ CONCLUSION : This is the first study to demonstrate that functional antagonism of coexpressed Bcl 10 ( L ) and Mcl 1 proteins using the mBzR antagonist Pk 11195 can facilitate apoptosis in cholangiocarcinoma following chemotherapy and radiotherapy . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
CD 437 mediated apoptosis was not associated with the modulation of Bcl 2 , Bax , or Mcl 1 levels , but was associated with the cleavage of the antiapoptotic protein Bcl 10 ( L ) to a proapoptotic 18 kD form . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The Bcl 2 , Mcl 1 , Bcl xL / S , Bcl w , Bax , Bak , and Bad were shown to be expressed in both malignant and non neoplastic , normal plasma cells . ^^^ Furthermore , the anti apoptotic proteins Bcl 2 , Mcl 1 and Bcl xL were down regulated , while the expression of the pro apoptotic Bax protein was increased . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Blockade of Src or Stat 3 is also accompanied by down regulation of expression of the anti apoptotic genes , Bcl 10 ( L ) and Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Although STAT 3 activation is known to induce expression of Bcl 2 family proteins , PEL cell apoptosis was independent of Bcl 2 , Bcl 10 ( L ) , or Mcl 1 protein expression . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
IL 6 rescues the hyporesponsiveness of c Rel deficient B cells independent of Bcl xL , Mcl 1 , and Bcl 2 . ^^^ This increase in viability occurs independently of Bcl xL and Mcl 1 expression though , two survival genes reported to be downstream of IL 6 signaling . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
MM cells express multiple Bcl 2 family members , including Bcl 2 , Bcl XL , and Mcl 1 , which are thought to play a key role in the survival and drug resistance of myeloma . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in emodin treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bad remained unchanged . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Levels of the CREB dependent anti apoptotic protein Mcl 1 and of the NF kappaB dependent anti apoptotic mediator Bcl 10 ( L ) were significantly decreased in PI 3 Kgamma / neutrophils . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Janus kinase inhibitor AG 490 inhibits Stat 3 activation with a concomitant reduction in steady state levels of Bcl 10 ( L ) , Bcl 2 and Mcl 1 proteins and induces apoptosis in U 251 cells as revealed by Poly ( ADP ribose ) polymerase cleavage and Annexin 5 staining . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Our aim in this study is to investigate which anti apoptotic Bcl 2 family proteins ( Bcl 2 , Bcl XL , Mcl 1 ) and which signal transduction pathway ( JAK / STAT , Ras / MAPK , PI 3K / Akt ) can mediate the anti apoptotic effect of IL 6 on a human myeloma cell line XG 7 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Using cultured prostate cancer ( PC ) cell lines , LN CaP and ALVA 31 , we studied the effects of 1alpha , 25 ( OH ) 2 Vitamin D 3 ( VD 3 ) on expression of several apoptosis regulating proteins including : ( a ) Bcl 2 family proteins ( Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , and Bak ) ; ( b ) the heat shock protein 70 binding protein BAG1L ; and ( c ) IAP family proteins ( XIAP , cIAP 1 , and cIAP 2 ) . ^^^ VD 3 induced decreases in levels of antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 , BAG1L , XIAP , cIAP 1 , and cIAP 2 ( without altering proapoptotic Bax and Bak ) in association with increases in apoptosis . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The activation state of protein kinase ERK , which is involved in Ras / MAPK signal transduction pathway mediating cell survival and proliferation , and the expression of anti apoptotic Bcl 2 family proteins Bcl 2 , Bcl 10 ( L ) and Mcl 1 in Sko 007 cells with or without IFNalpha were determined by immunoblot assay . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
RNA and protein analyses revealed several candidate target genes of Stat 5 , including Bcl 10 , Mcl 1 , c Myc and cyclin D 2 , which were down regulated after treatment with PD 180970 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Treatment with FP also attenuated the mRNA and protein levels of XIAP , cIAP 2 , Mcl 1 , Bcl 10 ( L ) , and survivin . ^^^ Treatment with Epo B followed by FP induced more Bax conformational change and was associated with a greater decline in the levels of XIAP , cIAP 2 , Mcl 1 , and Bcl 10 ( L ) . ^^^ Taken together , these findings suggest that the superior sequence dependent anti breast cancer activity of Epo B followed by FP may be due to FP induced Bax conformational change and down regulation of the antiapoptotic IAP , Bcl 10 ( L ) , and Mcl 1 proteins , but this treatment may not overcome the resistance to apoptosis of breast cancer cells conferred by overexpression of Bcl 2 . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Treatment with G 3139 led to a sequence specific reduction of Bcl 2 protein levels within 4 days of exposure in 10 out of 11 clinical samples from patients with chemosensitive and multidrug resistant disease , without significant reduction of alpha Actin , Bax , Bcl XL , or Mcl 1 proteins . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Melanocytic cells expressed relatively high levels of Bcl 2 , Bcl 10 ( L ) , Mcl 1 , C IAP 1 , C IAP 2 , XIAP , Livin , and Apaf 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
This increased apoptosis was accompanied by decreased antiapoptotic bcl 2 mRNA expression among bcl 2 related genes ( bcl 2 , bax , bak , mcl 1 , and bcl 10 ( L / S ) ) , and the effect was also more prominent in the cagA ( + ) strains . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of apoptosis related genes BCL 2 , BAX , BCL2L1 , BCL2A1 , MCL 1 , DAPK 1 and MYC was studied by quantitative real time polymerase chain reaction on total RNA samples from patients with acute lymphoblastic leukaemia ( ALL , n = 16 ) , acute myeloid leukaemia ( AML , n = 27 ) , chronic myeloid leukaemia ( CML , n = 12 ) , mantle cell lymphoma ( MCL , n = 19 ) and chronic lymphoid leukaemia ( CLL , n = 32 ) . ^^^ BCL 2 , BCL2L1 , BCL2A1 and MCL 1 were overexpressed and DAPK 1 was underexpressed in CLL samples with a 11q23 deletion . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We report herein that human oocytes and preimplantation embryos possess abundant levels of transcripts encoding cell death suppressors , Mcl 1 , Bcl 10 and Bag 1 , and the cell death inducer genes , Bax and Caspase 2 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis was performed with anti ERK1 / 2 , Mcl 1 , Bak , Bcl 10 and Bax antibodies . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We therefore developed a four color flow cytometry method that enables establishment of apoptosis related protein expression such as Bcl 2 , Bcl 10 ( L ) , Mcl 1 and Bax at diagnosis and in MRD . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
All cell lines express high levels of cyclin E , c Myc , Bcl 2 , Bax , Bcl 10 ( L ) , and Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Immunohistochemistry was used on paraffin sections to detect LMP 1 / EBV , CD 15 and the apoptosis related proteins ( bcl 2 , bax , bcl 10 , mcl 1 and CD 95 ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The study aim was to investigate Stat 3 activation in a series of multiple myeloma ( MM ) cases and its effect on downstream targets such as the anti apoptotic proteins Bcl xL , Mcl 1 , and Bcl 2 , and the cell cycle protein cyclin D 1 . ^^^ Immunohistochemistry was performed on paraffin sections using antibodies against cyclin D 1 , Bcl 2 , Bcl xL , Mcl 1 , p 21 , Stat 3 , and Stat 3 phosphorylated ( P ) . ^^^ High levels of anti apoptotic proteins Bcl xL and Mcl 1 were identified in 89 % and 100 % of all cases , respectively . ^^^ In contrast to Bcl xL and Mcl 1 , the expression of Bcl 2 showed an inverse correlation with proliferation rate ( P : 0 . 0003 ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
RESULTS : We show that CD34+ AML fractions are more resistant to apoptosis than are corresponding CD 34 AML fractions , and that this is paralleled by higher Bcl 2 , Bcl xL , Mcl 1 , Pgp and lower Bax expression levels . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Hypoxia induced cell cycle arrest at the G0 / G1 phases and massive cell apoptosis after 24 hours through a reduction in the Bcl 2 to Bax ratio , downregulation of Bcl XL and Mcl 1 , and upregulation of caspase 3 and caspase 8 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The present study investigated expression levels of the anti apoptotic proteins BCL 2 , BCL XL and MCL 1 and the pro apoptotic proteins BAX and BCL XS in a series of 112 peripheral T cell lymphomas ( PTCLs ) classified according to the WHO classification . ^^^ Using immunohistochemical methods and a 10 % cut off , each protein was detected in a subset of PTCLs : BCL 2 in 46 % , BCL XS in 49 % , BAX in 57 % , BCL XL in 57 % , and MCL 1 in 65 % . ^^^ The proliferation index , assessed by the MIB 1 antibody , correlated with expression levels of MCL 1 ( R = 0 . 42 , p = 0 . 003 ) , BCL 2 ( R = 0 . 32 , p = 0 . 027 ) , BAX ( R = 0 . 33 , p = 0 . 014 ) , and BCL XL ( R = 0 . 34 , p = 0 . 015 ) ( Spearman rank ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The Bcl 10 , Mcl 1 , Bad , and Bax proteins were also expressed in all CTCL skin lesions tested . ^^^ This study examined cutaneous T cell lymphoma ( CTCL ) cell lines and cutaneous lesions for the presence of Bcl 2 gene family members and found that the two apoptosis inhibiting members Bcl xL and Mcl 1 and the two apoptosis supporting members Bad and Bax were expressed . ^^^ The expression of Bcl 2 , Bcl xL , and Mcl 1 may therefore be sufficient to guarantee the survival of malignant CTCL cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
It was revealed that LIGHT treatment resulted in down regulation of anti apoptosis Bcl 2 family member : Bcl 2 , Bcl 10 ( L ) , Bag 1 , and Mcl 1 ; up regulation of pro apoptosis Bcl 2 family member : Bak and Ser ( 112 ) phosphor Bad ; down regulation of pro apoptosis Bcl 2 member Bax ; the other pro apoptosis member Bid remains unaltered . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
These inhibitors were found to be Mcl 1 and Bcl xL , two antiapoptotic members of the Bcl 2 family . ^^^ Following UV treatment , Mcl 1 protein synthesis is blocked , the existing pool of Mcl 1 protein is rapidly degraded by the proteasome , and cytosolic Bcl xL translocates to the mitochondria . ^^^ These events are sequential ; the elimination of Mcl 1 is required for the translocation of Bcl xL . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
All ' multidomain ' anti apoptotic members ( Bcl 10 , Bcl 2 , Mcl 1 , Bcl w and Bcl2l10 / Diva / Boo ) except Bcl2a1 / A1 are expressed in OLC . ^^^ Semiquantitative and real time RT PCR revealed that Bcl xL and Mcl 1 mRNAs are the dominant anti apoptotic members and increase four and twofold , respectively , with maturation . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
At day 7 , in controls , vascular injury upregulated antiapoptotic mediator Mcl 1 and Bcl xL expression by 8 fold to 5 fold , respectively , versus sham , whereas proapoptotic Bax slightly increased by 1 . 5 fold versus sham . ^^^ AxCAdnSTAT 3 reversed the upregulated Mcl 1 and Bcl xL levels by 70 % and 37 % , respectively , while having no affect on Bax expression . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
With a serial of Western blot analysis , it is revealed that gossypol induced cell cycle arrest is involved in P 21 up regulation and cyclin D 1 down regulation ; gossypol induced apoptosis triggers down regulation of anti apoptosis Bcl 2 members : Bcl 10 ( L ) , Bag 1 and Mcl 1 , up regulation of pro apoptosis Bcl 2 member Bak , activation of caspase 3 , 6 , 7 , 8 , and 9 , up regulation of Apaf 1 , release of cytochrome c ( cyto c ) from mitochondria , and activation of both DFF 45 and PARP . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Remarkably , these events occurred in the absence of any reduction in the expression of the Bcl 2 family members Bcl 2 , Mcl 1 , and Bcl xL or any change in the proapoptotic molecules Bad or Bax . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The levels of Bcl 10 ( L ) and Mcl 1 remain unchanged . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in QUE treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bag remained unchanged . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
In the present study , we investigated whether inhibition of DEX induced apoptosis by PRL in Nb 2 T cells was accompanied by altered expression of Bcl 2 family members , mcl 1 , bad or bcl 10 ( L ) determined by Northern and immunoblot analysis . ^^^ Prolactin regulation of Bcl 2 family members : increased expression of bcl xL but not mcl 1 or bad in Nb 2 T cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We next established if IL 3 and FL activated antiapoptotic Bcl 2 and the related genes Bcl XL and Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
A decrease in the anti apoptotic protein , Mcl 1 , was detected in HT and NE treated HL 60 cells , whereas other Bcl 2 family proteins including Bax , Bcl 2 , Bcl XL , and Bag remained unchanged . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
These events were associated with Bcl 2 cleavage , Bax , Bak , and Bad accumulation , mitochondrial translocation of Bax , abrogation of Mcl 1 , Bcl xL , and XIAP upregulation , and a marked induction of JNK and p 53 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The latter include Bcl 2 , Bcl 10 ( L ) , Mcl 1 , NF ( K ) B , survivin , livin , and ML IAP . ^^^ Some of these molecules are of potential therapeutic use , such as : ( 1 ) p 53 , which influences resistance to chemotherapy ; ( 2 ) Mcl 1 and Bcl 10 ( L ) , which can override apoptosis ; ( 3 ) TRAIL , which has selective fatal effects on tumour cells ; ( 4 ) NF ( K ) B , which when downregulated sensitizes cells to TRAIL and TNF ; ( 5 ) the PITSLRE kinases , whose alteration appears to result in Fas resistance ; ( 6 ) interferons , which sensitize cells to other factors ; and ( 7 ) survivin and other IAPs that inhibit apoptosis . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Treatment with SBHA also resulted in down regulation of antiapoptotic members of the Bcl 2 family , Bcl 10 ( L ) and Mcl 1 , and the IAP member , XIAP . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Addition of exogenous erythropoietin to tumor cell lines expressing erythropoietin receptor increased nuclear DNA binding activity of nuclear factor kappa B and increased the expression of the antiapoptotic genes bcl 1 , bcl xL , and mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
While Bcl 2 , Bcl 10 ( L , ) , and Bax were not affected , Mcl 1 was induced by IL 6 in human esophageal carcinoma cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The general consensus in the literature is that pro apoptotic Bax is decreased with melanoma progression while anti apoptotic Bcl xL and Mcl 1 appear to increase with progression . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
To investigate the mechanisms responsible for survival and apoptosis / anoikis in normal human intestinal epithelial crypt cells , we analyzed the roles of various signaling pathways and cell adhesion on the expression of six Bcl 2 homologs ( Bcl 2 , Bcl XL , Mcl 1 , Bax , Bak , Bad ) in the well established HIEC 6 cell model . ^^^ For example , the inhibition of the PI 3 K / Akt 1 pathway down regulated Bcl XL , Mcl 1 , and Bad , while at the same time up regulating Bax , whereas the inhibition of Fak up regulated both Bax and Bak , down regulated Bad , and did not affect the other Bcl 2 homologs analyzed . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Defects in the mitochrondrial intrinsic pathway result from imbalances in expression levels of Bcl 2 , Bcl XL and Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We demonstrated that the G rich ODN T 40214 , which forms a G quartet structure at intracellular but not extracellular K+ ion concentrations , is delivered efficiently into the cytoplasm and nucleus of cancer cells where it inhibited IL 6 stimulated Stat 3 activation and suppressed Stat 3 mediated upregulation of bcl 10 and mcl 1 gene expression . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Of the apoptotic mediators tested , the anti apoptotic protein Bcl 10 ( L ) was strongly down regulated by combined treatment of the cells with SBHA and TRAIL but not by the HDAC inhibitor alone , while little or no change in the expression of other Bcl 2 family members highly expressed in MM cells , including Mcl 1 and Bax , was observed . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Resveratrol selectively down regulated the expression of antiapoptotic proteins Bcl 10 ( L ) and myeloid cell differentiation factor 1 ( Mcl 1 ) and up regulated the expression of proapoptotic proteins Bax and apoptosis protease activating factor 1 ( Apaf 1 ) . ^^^ Paclitaxel down regulated the expression of Bcl 10 ( L ) , Mcl 1 , and cellular inhibitor of apoptosis protein 1 antiapoptotic proteins and up regulated Bid and Apaf 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
While the levels of Bcl 2 and Bcl xL were relatively unchanged , these compounds induced a marked reduction in Mcl 1 level . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
IT treatment caused after 2 . 5 hr a significant decrease in the level of the antiapoptotic protein Mcl 1 but not of Bcl 2 and Bcl XL . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Aberrant Stat 3 promotes uncontrolled growth and survival through dysregulation of gene expression , including cyclin D 1 , c Myc , Bcl xL , Mcl 1 and survivin genes , and thereby contributes to oncogenesis . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Antiapoptotic Bcl 2 family proteins Bcl xL and Mcl 1 also increase mitochondrial H ( 2 ) O ( 2 ) release when overexpressed . ^^^ Our results indicate that chronic and mild elevations in H ( 2 ) O ( 2 ) release from Bcl 2 , Bcl xL , and Mcl 1 overexpressing mitochondria lead to enhanced cellular antioxidant defense and protection against death caused by acute oxidative stress . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Although mutations in Mcl 1 had little impact on binding , a single mutation in the BH 3 only ligand Bad enabled it to bind both Mcl 1 and A 1 while retaining its binding to Bcl 2 , Bcl xL , and Bcl w . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression of Bcl 2 family members , Bcl xL , Bcl 2 , Mcl 1 and Bax was investigated in delayed apoptosis of canine neutrophils induced by lipopolysaccharide ( LPS ) . ^^^ The levels of Bcl xL , Bcl 2 , Mcl 1 and Bax transcripts at 9 h incubation in neutrophils stimulated by LPS ( 100 ng / ml ) were increased by about 80 . 4 , 1 . 9 , 1 . 4 and 5 . 3 folds , in comparison to those in non stimulated neutrophils , respectively . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Cotreatment with 17 AAG and SAHA also induced down regulation of Mcl 1 , Bcl xL , and B Raf ; up regulation of Bak ; cleavage of 14 3 3 proteins ; and a profound conformational change in Bax accompanied by translocation to the membrane fraction . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Combined exposure to flavopiridol and HA 14 1 was associated with down regulation of Mcl 1 and Bcl xL , Bid cleavage , and mitochondrial translocation of Bax . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Here we showed that , besides the specific cleavage and activation of Bid by caspase 8 and caspase 3 , TRAIL induced apoptosis in Jurkat T cells required the specific cleavage of Mcl 1 at Asp 127 and Asp 157 by caspase 3 , while other prototypic antiapoptotic factors such as Bcl 2 or Bcl 10 ( L ) seemed not to be affected . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Bad , however , bound tightly to Bcl 2 , Bcl xL , and Bcl w but only weakly to A 1 and not to Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Several BH 3 peptides relieved the inhibition of Bax caused by the antiapoptotic Bcl 10 ( L ) and / or Mcl 1 proteins , some displaying a specificity for either Bcl 10 ( L ) or Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
In the current study , we demonstrated that in normal tonsil B cells the three major Bim isoforms are strongly associated with the anti apoptotic Bcl 2 family members Mcl 1 , Bcl 2 and Bcl 10 ( L ) . ^^^ Endogenous association of Bim BH 3 only protein with Mcl 1 , Bcl xL and Bcl 2 on mitochondria in human B cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Lung cancer cells overexpressing Mcl 1 are less sensitive to apoptosis induced by chemotherapeutic agents , ZD 1839 ( an inhibitor of EGFR tyrosine kinase ) and Bcl 2 or Bcl 10 ( L ) antisense oligonucleotides . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Coadministration of UCN 01 and rapamycin reduced the expression levels of the antiapoptotic members of the Bcl 2 family Mcl 1 and Bcl xL and diminished the expression of cyclin D 1 and p 34 ( cdc 2 ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
RA repressed c fos mRNA expression in control and irradiated SiHa cultures , but did not repress bcl 10 ( L ) , p 53 , GADD 45 , p 21 , bax , bcl 2 , or mcl 1 mRNA expression . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Chromatin immunoprecipitation assay employing anti Stat 3 antibody confirms the in vivo binding of activated Stat 3 to the promoters of genes that encode antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 . ^^^ IL 4 significantly up regulates of the steady state levels of Bcl 2 , Bcl 10 ( L ) , and Mcl 1 in GBM cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
G CSF treated patients showed higher apoptosis frequency , lower expression of bcl 2 and bcl xL , but higher expression of bfl 1 / A1 and mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
EXPERIMENTAL DESIGN : We studied whether Bcl 2 , Bcl xL , Mcl 1 , Bax as well as the Bcl 2 / Bax ratio and a combination of all ( antiapoptosis index , AAI ) are related to the frequency of malignant cells surviving the chemotherapy ( i . e . , minimal residual disease , MRD ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The PEITC induced apoptosis in TRAMP derived cells was associated with a marked increase in the level of proapoptotic protein Bak and / or a decrease in the levels of antiapoptotic protein Mcl 1 or Bcl xL and disruption of mitochondrial membrane potential . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We explored effects of oridonin on antiapoptotic Bcl 2 family members and found that it down regulated levels of Mcl 1 and BCL 10 ( L ) , but not Bcl 2 protein , in both MT 1 and RPMI 8226 cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Skin biopsies of LyP ( n = 20 ) and LTCL ( n = 19 ) and five CD30+ lymphoma cell lines were analysed by means of immunohistochemistry and Western blotting in order to evaluate the proliferation ( Ki 67 ) , apoptosis ( FragEl ) and expression of Bax , Bcl 10 , C kit and Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
RESULTS : High expression of Mcl 1 was seen in the Karpas 299 cell line , whereas the two other antiapoptotic Bcl 2 family members , Bcl 2 and Bcl 10 ( L ) , were not detected in the SAGE library . ^^^ Quantitative RT PCR confirmed the high expression of Mcl 1 mRNA and low expression of Bcl 2 and Bcl 10 ( L ) in Karpas 299 and in four other ALCL cell lines . ^^^ To expand on these initial observations , primary tissue samples were analysed for Mcl 1 , Bcl 10 ( L ) , and Bcl 2 by immunohistochemistry . ^^^ The high frequency of Mcl 1 , Bcl 2 , and Bcl 10 ( L ) positive ALCL cases in the ALK group compared with the ALK+ group indicates that ALK induced STAT 3 activation is not the main regulatory pathway in ALCL . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The upregulation of p 53 and the downregulation of Bcl XL and Mcl 1 by 1 mM SNP were reversed by 0 . 1 mM SNP pretreatment at the protein level by western blotting . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We have investigated the regulation of Bak and find that , in healthy cells , Bak associates with Mcl 1 and Bcl 10 ( L ) but surprisingly not Bcl 2 , Bcl w , or A 1 . ^^^ When cytotoxic signals activate BH 3 only proteins that can engage both Mcl 1 and Bcl 10 ( L ) ( such as Noxa plus Bad ) , Bak is displaced and induces cell death . ^^^ Accordingly , the BH 3 only protein Noxa could bind to Mcl 1 , displace Bak , and promote Mcl 1 degradation , but Bak mediated cell death also required neutralization of Bcl 10 ( L ) by other BH 3 only proteins . ^^^ The results indicate that Bak is held in check solely by Mcl 1 and Bcl 10 ( L ) and induces apoptosis only if freed from both . ^^^ Proapoptotic Bak is sequestered by Mcl 1 and Bcl xL , but not Bcl 2 , until displaced by BH 3 only proteins . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
This work describes the isolation of cDNA and genomic fragments from five sheep BCL 2 related genes : BCL 2 , BCL2L1 , BCL2L2 , BAX and MCL 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Activated STAT 3 leads to the induction of several genes such as Mcl 1 , Bcl 2 and Bcl 10 ( L ) , and tissue inhibitor of metalloproteinase ( TIMP ) 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Bcl 10 ( L ) , Mcl 1 and survivin ) , cell cycle regulators ( e . g . cyclin D 1 and c Myc ) and inducers of angiogenesis ( e . g . vascular endothelial growth factor ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Knockdown of p 53 levels in human keratinocytes accelerates Mcl 1 and Bcl 10 ( L ) reduction thereby enhancing UV light induced apoptosis . ^^^ The p 53 siRNA treated KCs were characterized by elevated E2F 1 levels accompanied by accelerated elimination of the Mcl 1 and Bcl 10 ( L ) antiapoptotic proteins , as well as enhanced Bax oligomerization . ^^^ Forced overexpression of either Mcl 1 or Bcl 10 ( L ) reduced the UV light enhanced apoptotic response in p 53 siRNA treated KCs . ^^^ We conclude that p 53 not only can provide proapoptotic signals but also regulates a survival pathway influencing Mcl 1 and Bcl 10 ( L ) levels . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Furthermore , Atiprimod inhibited signal transducer and activator of transcription ( STAT ) 3 activation , blocking the signalling pathway of interleukin 6 , which contributes to myeloma cell proliferation and survival , and downregulated the antiapoptotic proteins Bcl 2 , Bcl 10 ( L ) , and Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Further studies were conducted to compare these changes to the localization and expression of the bcl 2 group of proteins bcl 10 , bax and mcl 1 , and Fas Fas ligand in the same cells . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Cultured Nb cells were sensitized to alpha TOS by pre treatment with Bcl 2 , Bcl xL or Mcl 1 siRNAs , while the malignant cell line was more resistant to the vitamin E analogue when Bax was knocked down . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Western blot analysis localized Mcl 1 to mitochondria , ER , and cytosol of both MCF 7c3 and U 937 cells , suggesting that Mcl 1 protein , unlike Bcl 2 and Bcl xL , is not a target for Pc 4 PDT , probably due to its localization to sites removed from those of Pc 4 binding . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The expression levels of Mcl 1 and Bcl XL but not those of Bcl 2 , Bax , and Bak were suppressed by TSA or SK 7041 treatment . ^^^ SK 7041 or TSA induced apoptosis and G 2 M cell cycle arrest by up regulating p 21 and down regulating cyclin B 1 , Mcl 1 , and Bcl XL . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Anti apoptotic markers such as Bcl xL or Mcl 1 are constitutively expressed in these cells , and their expression is not affected by Sant 7 treatment . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
This pathway is regulated by bcl 2 family of anti apoptotic ( bcl 2 , bcl xl , mcl 1 ) and pro apoptotic proteins ( bax , bad , bak ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
This effect markedly elevated the expression of p 21 , p 53 and Bcl xS protein , while the Mcl 1 and Caspase 8 proteins were down regulated . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Our results also indicate that elevated levels of Stat 3 phosphorylation were significantly associated with increased expression of potential downstream targets of Stat 3 which include apoptosis inhibitors ( Survivin , Mcl 1 , HSP 27 , Adrenomedullin , and Bcl xL ) , cell cycle regulators ( c Fos , MEK 5 , and c Myc ) , and inducer of tumor angiogenesis ( VEGF , COX 2 , MMP 2 , MMP 10 , and MMP 1 ) in invasive breast cancer tissues . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Malfunctions in death pathways observed in human cancers are often due to overexpression of antiapoptotic proteins in the Bcl 2 protein family , i . e . , Bcl 2 , Mcl 1 , and Bcl xL . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
MEK activation led to increased expression of COX 2 , Bcl 10 ( L ) , Mcl 1 , and phosphorylated Bad and decreased expression of Bak . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
DEX treatment upregulated cellular FLICE inhibitory protein ( cFLIP ) expression , but did not alter the protein levels of Bcl 2 , Bcl xL , Mcl 1 , and cIAP as well as Akt activation . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
LAQ 824 induced lethality in U 937 cells did not involve the extrinsic apoptotic pathway , nor was it associated with death receptor up regulation ; instead , it was markedly inhibited by ectopic expression of Bcl 2 , Bcl 10 ( L ) , XIAP , and Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The blockade of JAK3 / STAT3 signaling significantly decreased viability of colon cancer cells due to apoptosis and cell cycle arrest through down regulation of Bcl 2 , Bcl 10 ( L ) , Mcl 1 , and cyclin D 2 and up regulation of p 21 ( waf1 / cip1 ) and p 27 ( kip 1 ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
In the present paper , we demonstrate that hydrodynamic gene delivery of IL 22 cDNA driven either by a liver specific albumin promoter or a human cytomegalovirus ( CMV ) promoter results in IL 22 protein expression , STAT 3 activation , and expression of several anti apoptotic proteins , including Bcl xL , Bcl 2 , and Mcl 1 in the liver . ^^^ Western blot analyses show that overexpression of IL 22 significantly enhances activation of STAT 3 and expression of Bcl xL , Bcl 2 , and Mcl 1 proteins in liver injury induced by Con A . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Of note , the BH 3 domain of LASU 1 interacted with Mcl 1 but not with Bcl 2 or Bcl Xl . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
HDAC inhibitors enhance the apoptosis inducing potential of TRAIL in leukemia cells ( HL 60 , Jurkat , K 562 , and U 937 ) through multiple mechanisms ; up regulation of DR 4 , DR 5 , Bak , Bax , Bim , Noxa and PUMA , down regulation of IAPs , Mcl 1 , Bcl 2 , Bcl XL and cFLIP , release of mitochondrial proteins ( cytochrome c , Smac / DIABLO and Omi / Htr2 ) to the cytosol , induction of p21WAF1 / CIP1 and p27KIP1 , activation of caspase 3 and cleavage of poly ( ADP ribose ) polymerase ( PARP ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
As it has been shown for Mcl 1 , Bcl xl and Bcl 2 , proteins of the Bcl 2 family play a crucial role during T cell development in the thymus . ^^^ Therefore , our results suggest that A 1 plays a specialized role in allowing survival of DP thymocytes and that its role can be distinguished from that of Mcl 1 , Bcl xl and Bcl 2 . . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Cytotrophoblasts also expressed a 2 fold higher level of p 53 , a 2 fold lower level of 60 kDa Mdm 2 protein , a 2 fold higher level of Bak , but no differences in the expression of 90 kDa Mdm 2 , Bcl 2 , Bcl 10 ( L ) , Mcl 1 , Bax , Bad , and Bad phosphorylated at the serine ( 112 ) , serine ( 136 ) , or serine ( 155 ) sites , compared to the syncytiotrophoblasts . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The pro apoptotic Bcl 2 family proteins , Bak , Bax , and Bim have been shown to be required for disruption of mitochondria and intrinsic cell death of self reactive B cells whereas the anti apoptotic Bcl 2 , Bcl xL , and Mcl 1 can prevent cell death by interfering with the action of Bax and Bak . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
To determine whether this phenomenon results from altered expression of Bcl 2 or related proteins , Northern and Western analysis was employed to assess the effects of bryostatin 1 and other PKC activators on steady state levels of Bcl 2 , Bax , Bcl 10 , and Mcl 1 mRNA and protein . ^^^ These effects were accompanied by unaltered expression of Bcl 2 , Bax , and Bcl 10 ( L ) , and by a further increase in Mcl 1 protein levels . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Moreover , in malignant cells harboring constitutively active Stat 3 , including human prostate cancer DU 145 cells and 5 Src transformed mouse fibroblasts ( NIH3T3 / v Src ) , resveratrol treatment represses Stat 3 regulated cyclin D 1 as well as Bcl xL and Mcl 1 genes , suggesting that the antitumor cell activity of resveratrol is in part due to the blockade of Stat 3 mediated dysregulation of growth and survival pathways . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Triptolide also decreased Mcl 1 but not Bcl 2 and Bcl 10 ( L ) levels . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Inhibition of p38alpha MAPK enhances proteasome inhibitor induced apoptosis of myeloma cells by modulating Hsp 27 , Bcl 10 ( L ) , Mcl 1 and p 53 levels in vitro and inhibits tumor growth in vivo . ^^^ Furthermore , we show that p 38 inhibition enhances the bortezomib induced MM apoptosis by upregulation of p 53 and downregulation of Bcl 10 ( L ) and Mcl 1 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Interestingly , Bcl 2 / Bcl xL bispecific ASO treatment also resulted in the down regulation of Mcl 1 and up regulation of Bax . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
We show that the antiapoptotic proteins BCL 2 , BCL XL , MCL 1 , BFL 1 , and BCL w each bear a unique pattern of interaction with a panel of peptides derived from BH 3 domains of BH 3 only proteins . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The proapoptotic proteins Bax and Bak are required for MOMP , while the antiapoptotic Bcl 2 proteins , including Bcl 2 , Bcl xL , Mcl 1 , and others , prevent MOMP . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
For anti apoptotic proteins , overexpression was recorded as follows : Bcl 2 40 % ( 22 / 54 ) , Bcl XL 24 % ( 13 / 54 ) , Mcl 1 92 % ( 50 / 54 ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
However , the expressions of p 53 or pro or antiapoptotic Bcl 2 family proteins ( Bax , Bcl 2 , Bcl 10 ( L ) and Mcl 1 ) were not affected in any of the cell lines even after prolonged exposure to FB ( 1 ) at high doses . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Its three factions of interacting proteins include the BH 3 only proteins ( e . g . , Bim , Puma , Bad , Noxa ) , which transduce diverse cytotoxic signals to the mammalian pro survival proteins ( Bcl 2 , Bcl 10 ( L ) , Bcl w , Mcl 1 , A 1 ) , whereas Bax and Bak , when freed from pro survival constraint , provoke the mitochondrial permeabilization that triggers apoptosis . ^^^ Furthermore , Mcl 1 and Bcl 10 ( L ) , but not Bcl 2 , directly sequester Bak in healthy cells , and Bak is freed only when BH 3 only proteins neutralize both its guards . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
JSI 124 decreased the phosphorylated STAT 3 and Janus kinase 3 ( JAK 3 ) levels in a dose dependent fashion , and these changes were coupled with significant decreases in several STAT 3 downstream targets , including mcl 1 , bcl 2 , bcl xL and cyclin D 3 . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
In addition to murine ( m ) bcl xL and mbcl xS , we have cloned a novel cDNA isoform that we designate mbcl 10 delta TM . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The large isoform of bcl 10 ( bcl xL ) , detected using RT PCR , decreased in whole hippocampus by 24 72 h after ischemia relative to the putative short ( bcl xS ) and transmembrane deleted ( bcl 10 delta TM ) forms . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Deletion mapping of BNIP 3 excluded its BH 3 like domain and identified the NH ( 2 ) terminus ( residues 1 49 ) and TM domain as critical for Bcl 2 heterodimerization , and either region was sufficient for Bcl 10 ( L ) interaction . ^^^ Substitution of the BNIP 3 TM domain with that of cytochrome b ( 5 ) directed protein expression to nonmitochondrial sites and still promoted apoptosis and heterodimerization with Bcl 2 and Bcl 10 ( L ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
The ceBNIP 3 TM domain mediates interaction with both CED 9 and BCL XL . ceBNIP 3 interacts with CED 3 but co expression of CED 3 and ceBNIP 3 does not significantly enhance induction of cell death in the presence or absence of CED 4 . ceBNIP 3 kills mammalian cells by a caspase independent mechanism . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Mitochondrial targeting of Bcl 10 ( L ) requires the COOH terminal transmembrane ( TM ) domain flanked at both ends by at least two basic amino acids . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Experiments with BNIP 3 have implicated the transmembrane ( TM ) domain in its proapoptotic function , homodimerization , and interactions with Bcl 2 and Bcl xL . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
According to prediction methods , there are only two putative TM fragments in Bcl 10 ( L ) and Bax ( the C terminal alpha helix and alpha helix 5 ) and one in activated tBid ( alpha helix 6 ) . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
Apoptosis induced by each TM was associated with a significant ( approximately 400 % ) increase in caspase 8 activity , but no change in caspase 9 activity , and Western analyses revealed a marked up regulation of Fas ( approximately 500 % ) and FADD ( approximately 300 % ) with no change in expression of Bax , Bcl 2 , or Bcl xL . ^^^
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q07820 and Q07817	Pubmed	SVM Score :0.0
NA